Epithelial dysplasia in lichenplanus
|
|
- Myles Blankenship
- 5 years ago
- Views:
Transcription
1 Epithelial dysplasia in lichenplanus Girish HC* Sanjay Murgod**Savita JK*** *M.D.S, Professor & Head, **M.D.S, Professor,***M.D.S, Senior Lecturer,Dept of Oral Pathology, Raja Rajeswari Dental College & Hospital, Bangalore, India. Abstract: The presence of dysplastic features in oral Lichen planus is a well-known and documented feature. A retrospective study was carried out to correlate the dysplastic features with age, gender, site of the lesion and also the grades of dysplasia encountered. A significant correlation between the above mentioned factors was noticed which was comparable to other similar studies. However, the author suggests more longitudinal studies to differentiate the dysplastic features with regards to prognostic value. Keywords: Oral lichen planus, epithelial dysplasia Introduction: Lichen planus is a relatively common chronic dermatological disease that often affects the oral mucosa. The strange name of this condition was provided by British Physician Erasmus Wilson in Lichens are primitive plants composed of algae and fungi. The term planus in Latin is for flat and Wilson probably thought that the skin lesions looked similar enough to the lichens growing on the rocks to merit this designation (1). Lichen planus is a chronic disease lasting for 2-4 years affecting the oral cavity from 0.1 to about 4% of the individuals. Oral lichen planus generally is a disease of the middle age and elderly, and the female to male ratio is about 2:1 (2). However, different opinions have been expressed about the premalignant potential of oral lichen planus (3, 4). The possible premalignant potential of oral lichen planus is the subject of contrasting views (5). The dermatologic literature documents a number of cases of histologically proven or clinically suspected skin lichen planus cases in which carcinoma subsequently developed. Serial Listing: Print-ISSN ( ) Online-ISSN ( ) Bibliographic Listing: Index Copernicus. EBSCO Publishing Database. In a report of the World Health organization, it is stated that there remains considerable uncertainty about the frequency of cancer arising in oral lichen planus. In the same report, it was mentioned that some epithelial dysplasia may be seen in lichen planus. However, there is a valid question whether carcinomatous degeneration is part of the natural evolution of the lesion or due to extrinsic factors (4). Shafer et al (6), Regezi Joseph and Sciubba James J (7), Eversole Lewis R (8) reported the characteristic histological features of oral lichen planus as hyperkeratosis, presence of civatte bodies, liquefaction degeneration of basal layer, saw tooth rete ridges and a band of inflammatory cell infiltrate below the basement membrane in the connective tissue. However, McDonald and Rennie J S (3) in their study on oral epithelial atypia in denture induced hyperplasia, lichen planus and squamous cell carcinoma found that lichen planus cases showed irregular epithelial stratification, loss of polarity of cells and pleomorphic cells and nuclei. Jong De W.F.B (5) et al in their study on epithelial dysplasia in oral lichen planus found 87% of cases had more than one layer having a basaloid appearance. Other common factors included nuclear hyperchromatism (60%), enlarged nucleoli (45%), loss of polarity of basal cells (33%) and keratinization of single cells or cell groups in the spinous layer in 27% of cases. However, Sigrgesson and Lindelof (6) found no increased risk of malignancy in skin lichen planus but found an increased risk of 0.4% in oral lichen planus. Therefore people diagnosed with oral lichen planus appear to be at a greater risk of developing oral cancer than in general population. Therefore, it was thought fit to study the prevalence of dysplastic feature in oral lichen planus. A study was designed to retrospectively review all the cases of oral lichen planus and evaluate the changes. Aims and objectives: The aim of the present study was to study the following parameters of the disease and note the correlation among the related parameters, if any; 1. Age of the patient and gender predilection. 2. Most frequented site of the lesion. 3. Evaluation of dysplastic changes. Objectives of the study 1. To suggest views on whether lichen planus is a begnin or premalignant lesion. 2. To know the prognosis of these lesions. 19
2 TABLE 1: AGE AND SEX WISE DISTRIBUTION OF ORAL LICHENPLANUS AGE (YRS) MALES (%) FEMALES (%) TOTAL (%) (24) 2 (4) 14 (28) (10) 9 (18) 14 (28) (16) 2 (4) 10 (20) (0) 1 (2) 1 (2) (6) 4 (8) 7 (14) (8) - 4 (8) TOTAL 32 (64) 18 (36) 50 TABLE 2: SITE WISE DISTRIBUTION OF ORAL LICHEN PLANUS SITE NO. OF CASES PERCENTAGE Buccal Mucosa Tongue Labial Mucosa 4 8 Palate 4 8 Gingiva 4 8 Floor of mouth 1 2 TABLE 3: DYSPLASTIC FEATURES PRESENT IN ORAL LICHEN PLANUS DYSPLASTIC FEATURES PERCENTAGE Presence of more than one layer having basaloid appearance 32 Enlarged nucleoli 22 Increased nuclear-cytoplasmic ratio 12 Increased number of mitotic figures 6 Mitotic figures in superficial layer 2 TABLE 4: GRADES OF DYSPLASIA-DISTRIBUTION IN ORAL LICHEN PLANUS GRADES NO. OF CASES PERCENTAGE TOTAL TABLE 5: DISTRIBUTION OF MEAN GRADES OF EPITHELIAL DYSPLASIA BY GENDER IN ORAL LICHEN PLANUS GRADES OF OCCURRENCE IN OCCURRENCE IN DYSPLASIA MEN (%) WOMEN (%) TOTAL (%) 0 15 (30) 13 (26) 28 (56) 1 16 (32) 5 (10) 21 (42) 2 1 (2) 0 1 (2) TOTAL (100) 20
3 TABLE 6: DISTRIBUTION OF MEAN GRADES OF EPITHELIAL DYSPLASIA BY AGE IN ORAL LICHEN PLANUS GRADES OF DYSPLASIA AGE GROUP 0 (%) 1 (%) 2 (%) 3 (%) PROPORTION OF PATIENTS WITH ANY GRADES OF DYSPLASIA (14%) 7 (14%) (14%) (12%) 6 (12%) (12%) (10%) 5 (10%) 1 (2%) 0 6 (12%) (2%) (16%) (2%) 3 (6%) (6%) TOTAL 28 (56%) 21 (42%) 1 (2%) TABLE 7: DISTRIBUTION OF GRADES OF EPITHELIAL DYSPLASIA BY SITE IN ORAL LICHEN PLANUS GRADES SITE 0 (%) 1 (%) 2 (%) 3 (%) TOTAL (%) Buccal 18 (38) 15 (30) 1 (2) 0 34 (68) mucosa Tongue 10 (20) 2 (4) (24) Labial mucosa 1 (2) 3 (6) (8) Palate 3 (6) 1 (2) (8) Gingiva 2 (4) 2 (4) (8) Floor of mouth 0 1 (2) (2) Materials and methods: This retrospective study was undertaken by retrieving the records and the paraffin blocks of the confirmed cases of oral lichen planus from the Department of Oral Pathology and Microbiology, Bapuji Dental College and Hospital, Davangere. The paraffin blocks of oral lichen planus were sorted out and cut sections were prepared and stained with Hematoxylin and Eosin. Totally, 50 blocks and records were included in the study. Methodology: The cases of oral lichen planus involved in this study were retrieved from the files of Department of Oral Pathology and Microbiology, Bapuji Dental College and Hospital, Davangere The relevant clinical details and the histopathological report were recorded. The nature of dysplastic features to be evaluated was formatted in a proforma and the study was done by criteria given by Jong et al (5). The Hematoxylin and Eosin stained sections were studied under 5X, 10X and 45 X magnifications for evaluation of dysplastic features, namely 1. Loss of polarity of basal cells. 2. Basal cell hyperplasia. 3. Increased nuclear cytoplasmic ratio. 4. Drop shaped rete pegs. 5. Irregular epithelial stratification. 6. Increased number of mitotic figures. 7. Abnormal mitotic figures. 8. Cellular pleomorphism. 9. Nuclear hyperchromatism. 10. Enlarged nucleoli. 11. Reduction of cellular cohesion. 12. Keratinization of single cells or cell groups in spinous layer. The grading of the dysplastic features was done according to the method followed by Odukoya O et al (9). The grading is as follows Grade 0: No feature of dysplasia seen. Grade I: One or two features of dysplasia seen. Grade II: Three or four features of dysplasia seen. Grade III: More than four features of dysplasia seen. Results and observations: A total number of 50 oral lichen planus cases have been retrieved from the files of the Department of Oral Pathology, Bapuji Dental College & Hospital, Davangere. 21
4 J. Adv Dental Research ORIGINAL RESEARCH There were 32 (64%) males and 18 (36%) females in the study with the age ranging from 17 to 75 years and a mean age of years (Table 1) No of Cases Percentage Mitotic figure in superficial layer increased nno. Of mitotic figures Increased nuclearcytoplasmic ratio Enlarged nucleoli Presence of >1 layer having basaloid appearance GRAPH 1: SITEWISE DISTRIBUTION PLANUS OF ORAL LICHEN Buccal mucosa was the most common site affected with 34 (68%) cases. The tongue was involved in 12 (12%) of the subjects while palate, gingival and labial mucosa each had 4 (8%) distribution. The floor of the mouth was affected only in 1 (2%) of the subjects (Table 2, Graph 1). Out of 50 lichen planus cases 22 (44%) showed dysplastic features and 28 (56%) did not show them.the dysplastic features found in the present study were in the form of basilar hyperplasia 32% (Photographs 1 & 2), enlarged nucleoli 22% (Photographh 3) and increased nuclear cytoplasmic ratio in 12% (Photograph 4 & 5). This was followed by increased number of mitotic figures in 6% and mitotic figures confined tosuperficial layer in 2% (Photograph 6) (Table 3, Graph 3). Among the 50 oral lichen planus cases Grade I dysplastic features were observed in 21 (42%) and Grade II in 1 (2%) while Grade III were absent (Table 4, Graph 2) Graph 3: Dysplastic features in oral lichen planus Figure 1- Basilar Hyperplasia(40x). Grade 1, 42% Grade 2, 2% Grade 3, 0% Grade 0, 56% Grade 0 Grade 1 Grade 2 Grade 3 Figure 2- Basilar Hyperplasia(40x). Graph 2: Grades Of Dysplasia
5 Figure 3-Enlarged Nucleoli(40x) In the present study 22 (44%) showed dysplastic features out of which 17 (34%) were males and 5 (10%) were females. Grade I dysplastic features were seen in 16 (32%) of males and 5 (10%) of females. Grade II dysplasia was seen in only 1 (2%) of male patients (Table 5). A maximum of 7 (14%) Grade I dysplastic features was found in year age group followed by 6 (12%) in 26-35, 5 (10%) in 36-45, 3 (6%) in age groups and 1 (2%) of grade II in age group (Table 6) No dysplasia was seen in 18 (36%) of buccal mucosa, 10 (20%) on tongue, 1 (2%) of labial mucosa, 3 (6%) of palate and 2 (4%) of gingiva. Grade I dysplasia was noted in 15 (30%) of buccal mucosa, 2 (4%) of tongue, 3 (6%) of labial mucosa, 1 (2%) of palate, 2 (4%) of gingiva and 1 (2%) of the floor of the mouth. Grade II dysplasia was noted in 1 (2%) of the left buccal mucosa (Table 7) Figure 4- Altered Nuclear cytoplasmic Ratio (40x) Discussion: Lichen planus is a relatively common chronic dermatological disease that often affects the oral mucosa (1). The prognostic significance of an individual lesion is difficult to determine, and none of the currently available molecular markers have proved to be prognostically significant and none have yet been evaluated in large prospective studies. At present therefore, the gold standard for the assessment of oral potentially malignant lesions is microscopic evaluation of haematoxylin and eosin stained sections for the presence of architectural and cytological changes, which are generally referred to as epithelial dysplasia (10). The possible premalignant potential of oral lichen planus is the subject of contrasting views (5). In a report of World Health Organization, it was stated that there was considerable uncertainty about the frequency of cancer arising in oral lichen planus. However, there was a valid question whether carcinomatous degeneration was a part of the natural evolution of the lesion or was due to extrinsic factors (4). Shafer et al (6), Regezi, Joseph and Sciubba, James (7), Eversole Lewis (8), Prabhu SR (11), Hedberg et al (12), have reported the histopathology of oral lichen planus as typical with the following features without mentioning the presence of dysplastic features. 1. The surface epithelium may show varying degrees of hyperorthokaratosis or hyperparakeratosis with thickening of granular layer and with intracellular edema of spinous cells. 2. Civatte bodies, hyaline bodies, fibrillar bodies are often present in the epithelium. 3. Liquefaction degeneration of the basal layer. 4. Replacement of basal layer by eosinophilic coagulum. 5. Saw-toothed rete ridges. 6. Infiltration of lymphocytes and plasma cells into the subepithelial layer of connective tissue. 7. Focal separation of epithelium and connective tissue. 8. Dilated vessels in the connective tissue Nevertheless McDonald and Rennie (3) in their study on oral epithelial atypia in denture induced hyperplasia, lichen planus and squamous cell papilloma found that lichen planus cases showed irregular epithelial stratification, loss of polarity and pleomorphic cells and nuclei. Jong De et al (5) evaluated epithelial dysplasia in oral lichen planus and observed that 87% of cases had more than one cell layer having basaloid appearance followed by 60% with nuclear hyperchromatism 45% with enlarged nucleoli, 15% basilar hyperplasia and 12% nuclear hyperchromatism. They added that these cases had an increased risk of cancer development and follow up should be carried out. Odukoya et al (9) studied epithelial dysplasia in oral lichen planus and reported enlarged nucleoli in 49%, hyperplasia of basal layer and nuclear hyperchromatism in 15% and increased number of mitotic figures in 11%. Because of the above stated contrasting and interesting features a study was designed to retrospectively review 50 histologically confirmed cases of oral lichen planus and evaluate the dysplastic features with correlation to age, gender and site of the lesion. In the present study the age of the subjects ranged from 17 to 75 years. This is in accordance with 13 to 78 years of McCarthy and Shklar (13), 19 to 81 years of De Jong et al (5) and 17 to 81 years of Allen Carl et al (14). It was observed in the present study that there were 32 (64%) males and 18 (36%) females showing a male predominance with a ratio of 1.7:1. This finding is in agreement with the gender incidence of 2.1:1 observed in the study of Mehta et al (15). 23
6 The male predominance of the present study is contradictory to the observations made by Cawson (16), Lacy et al (17), Neville et al (1) and Scully et al (2) who have reported a female predilection. Even though the male predominance in the study is contradictory to the above authors, it appears to be less significant since Laufer and Kuffer (16), Shafer et al (6), Regezi and Sciubba (18), Rose and Kaye (19) have reported no dramatic sex predilection in their study. Buccal mucosa was the most common site affected with 34 (68%) followed by tongue 12 (24%), gingiva, palate, labial mucosa each 4 (8%) and floor of mouth 1 (2%) of cases. The above findings are consistent with 90% of buccal mucosa, 27% tongue and 7% on palate of Tydesly (1974), 90% on buccal mucosa and 28% on tongue of Axell and Rendquist (18). Batsakis et al (20) and Gorsky (21) observed that most cases occurred on buccal mucosa followed by tongue, gingiva and lips. In the present study 56% showed no dysplastic features, while 42% showed grade I and 2% grade II dysplasia. Grade II dysplasia was not observed. The study by Odukoya et al (9) revealed no dysplastic features in 32%, Grade I in 57%, Grade II in 9% and Grade III in 2%. The difference in grades could be attributed to their methodology of multiple sections and evaluation of dysplastic features by more than one investigator. Basilar hyperplasia of 32% was the most common dysplastic feature observed in this study. This figure is contradictory to that of 87% reported by De Jong et al (5). This variation could be attributed to their higher sample size, study from two different places namely Amsterdam and Budapest, and surveying of multiple sections when compared to single section of this study. Enlarged nucleoli was the next common feature observed in 22% of cases in this study. This is very much low when compared to 45% of De Jong et al (5) and 49% of Odukoya (9). The marked disparity could have been due to differences in methodology. In the present study random single section was surveyed when the above authors have followed a different methodology wherein they have surveyed multiple selected sections, as also a different grading system of dysplasia. They have selected those sections which showed most dysplastic features. The other dysplastic features like increased nuclear cytoplasmic ratio of 12%, abnormal mitotic figures of 6% and mitotic figures only in the superficial layer in 2% were found in this study. These figures are compatible with that of 9%, 5% and 1% respectively of De Jong et al (5). In the present study 44% dysplastic features and 56% without dysplastic features were observed. Therefore it could be inferred that dysplastic features also could be observed in Lichen planus. This inference is in agreement with the authors as stated in the beginning. However some studies have reported a lack of dysplastic features but report the presence of other features such as hyperplasia, hyperkeratosis, acanthosis and the presence of necrotic keratinocytes (22). In the present study Grade I dysplasia was observed in 7 (14%) of 16-25, 6 (12%) of 26-35, 6 (12%) of and 3 (6%) of years age group. Grade II dysplasia was present only in 1 (2%) of the year age group. It appears that grade I and II dysplastic features to be more in the younger and middle age group respectively than in older age. Grade I dysplasia was observed in 16 (32%) males and 5 (10%) in females. Grade II dysplasia was noted in 1 (2%) of males. The study shows a strong predilection for dysplastic features to occur in males but was not statistically significant. Odukoyo et al (9) observed 78.8% of males and 62.7% of females with any grade of dysplasia. This disparity may be due to the larger sample size, significantly higher number of female subjects in their study which included 67% females and 33% males and a different methodology in grading of dysplasia. The cheek was the most common site affected 15 (30%) with grade I dysplasia followed by 3 (6%) on labial mucosa. These figures are compatible with 28% and 1% of Odukoya et al (9) who observed in 28% and 1% on labial mucosa. This was followed by 4% on tongue and 3% on floor of the mouth in the present study which is compatible with 3% incidence at each site in the study of Odukoya et al (9). However Odukoya et al (9) observed Grade I dysplasia in 19% of gingiva whereas it was 2% in this study. This variation may be due to involvement of gingiva in more number of cases (33%) in their study by oral lichen planus. Grade II dysplasia was observed only in 2% in this study on the buccal mucosa and is in agreement with 2% incidence of Odukoya et al (9). Studies have also been conducted with regard to the relation between candida and dysplastic lesions such as lichen planus but did not report an association between the two (23). Morphometric analysis of cells in oral lichen planus has revealed an increase in cell dimension compared to other white lesions (24). In conclusion, this study reveals that dysplastic features of mild degree could be present often than moderate to severe degree. The histopathologic diagnosis of oral lichen planus, mainly when differentiated against epithelial dysplasia, is quite difficult, as some cell disorders indicative of malignant disease such as increased nuclearcytoplasmic ratio, nuclear hyperchromatism, and irregular chromatin distribution may be seen in either of the lesions (25). Whether these dysplastic features are benign as observed in denture hyperplasia, squamous cell papilloma (McDonald and Rennie (3) Darrier s disease (Shafer (6), Neville (1), Keratoacanthoma (Shafer (6), Regezi and Sciubba (7) and Neville (1) and hereditary intraepithelial dyskeratosis (Shafer (6), Regezi and Sciubba (7) and Neville (1) or potentially a premalignant change is uncertain. Lichen planus as a lesion at risk for malignant change has been disproved by some studies though the authors have suggested that this be confirmed by the use of other genetic markers (26). While the malignant transformation potential of oral lichen planus is not confirmed, the fact that its cell proliferation rate is inferior to epithelial dysplasia s and oral squamous cell carcinoma s might explain why its malignant transformation potential is lower than epithelial dysplasia s (27). 24
7 Future studies are directed towards advanced methods for cytological and histological evaluation like micronucleus test, computer aided studies, stereological techniques, histochemical stains, enzyme histochemistry, immunohistochemistry, studies like surface antigens, intracellular components/products, basement membrane zone, stromal changes. In situ hybridization RNA/DNA TM and SEM studies for viral, fungal infection and advanced methods for functional evaluation studies like cellular proliferation, DNA histograms, DNA cytophotometry, analysis of immune status, biochemical studies of tissue homogenates, body fluids and analysis of circulating cell products (28) on a larger sample of longitudinal study to ascertain whether these dysplastic features are potentially premalignant or not. In the absence of conclusive evidence it is suggested that chemoprevention could be tried in those cases which shows dysplastic features followed by a biopsy to study whether such epithelium has reverted to normalcy on intervention with the treatment. Future longitudinal studies with advanced morphological and functional investigations are necessary to differentiate the dysplastic features of lichen planus from benign or potentially premalignant one. References: 1. Neville B et al: Oral and Maxillofacial Pathology. First edition, WB Saunders Company. 1995:252-53, Scully C et al. Update on oral Lichen planus: Etiopathogenesis and management Crit Rev Oral Biol Med; 9(1): MacDonald DG &Rennie JS. Oral epithelial atypia in denture induced hyperplasia, Lichen planus and squamous cell papilloma Int Journal of Oral Surgery; 4: Kaurgars E George &Svirsty A John. An update on the dysplastic/carcinomatous transformation of oral lichen planus Journal of Oral Medicine; 37(3): Jong De WFB et al. Epithelial dysplasia in oral lichen planus Int J of Oral Surg; 13: Shafer William G, Hine Maynard K and Levy Barnet M. A text book of Oral Pathology. Fourth edition, WB Saunders company, 1983: Regezi Joseph A &Sciubba James J. Oral Pathology; Clinico-pathologic correlation. WB Saunders company, 1989: Eversole Lewis R. Clinical outline of Oral Pathology; Diagnosis and Treatment, Second edition 9. OdukoyaOnatolu et al. A histological study of epithelial dysplasia in oral lichen planus Arch Dermatol; 121: Paul M. Speight. Update on Oral Epithelial Dysplasia and Progression to Cancer Head and Neck Pathol (2007) 1: Prabhu SR. Oral disease in the tropics. Oxford Community Press, 1993: Hedberg N. A semi quantitative assessment of histopathology of oral lichen planus J Oral Pathol; 15: McCarthy L, Philip &Shklar Gerald. Diseases of the oral mucosa Second edition, Lea and Febiger, Philadelphia: Allen Carl M. Relation of stress and anxiety to oral lichen planus Oral Surg, Oral Med, Oral Path; 61: Kovesi G &Banoczy J. Follow up studies in oral lichen planus Int J Oral Surg; 2(1): Scully C & El Kom. Lichen planus: Review and update on pathogenesis J Oral Pathol; 14: Lacy MF et al. A theory of pathogenesis Oral Surgery; 56(5): RundquistAxell T. Oral lichen planus-a demographic study Community Dent Oral Epidemiol; 15: Rose LF & Kaye D. Internal Medicine for Dentistry The CV Mosby company, second edition, Batsakis JG et al. Lichen planus and lichenoid lesions of the oral cavity Annals of Otology, Rhinology and Laryngology; 103(6): Gosky M et al. Clinical characteristics and treatment of patients with oral lichen planus in Israel Oral Surg, Oral Med, Oral Path; 82(6): Francisca Fernandez-Gonzalez et al. Histopathological findings in oral lichen planus and their correlation with the clinical manifestations. Med Oral Patol Oral Cir Bucal Aug. 23. Spolidorio LC, Martins VR, Nogueira RD, Spolidorio DM. PesquiOdontol Bras. The frequency of Candida sp in biopsies of oral mucosal lesions Jan-Mar;17(1): Virdi M, Sachdev A, Gupta A &AggarwalK : Lichen Planus Or Lichenoid Dysplasia : Is It Premalignant!. The Internet Journal of Head and Neck Surgery Volume 4 Number Sousa FA, Paradella TC, Brandão AA, Rosa LE. Braz J Otorhinolaryngol. Oral lichen planus versus epithelial dysplasia: difficulties in diagnosis Sep-Oct;75(5): Zhang L, Michelsen C, Cheng X, Zeng T, Priddy R, Rosin MP. Molecular analysis of oral lichen planus. Apremalignant lesion? Am J Pathol Aug; 151(2): De Sousa FA, Paradella TC, Carvalho YR, Rosa LE. Med Oral Patol Oral Cir Bucal. Comparative analysis of cell proliferation ratio in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma Nov 1;14(11): Burkhardt A. Advanced methods of evaluation of premalignant lesions and carcinomas of the oral mucosa J Oral Path; 14:
8 26
Diagnostic difficulties with lesions of the oral mucosa
BDIAP London, November 2010 School of Clinical Dentistry University of Sheffield Diagnostic difficulties with lesions of the oral mucosa Paul M Speight Dept Oral & Maxillofacial Pathology University of
More information04/09/2018. Squamous Cell Neoplasia and Precursor Lesions. Agenda. Squamous Dysplasia. Squamo-proliferative lesions. Architectural features
Squamous Cell Neoplasia and Precursor Lesions Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory Medicine University of Arkansas for Medical
More informationSquamous Cell Neoplasia and Precursor Lesions
Squamous Cell Neoplasia and Precursor Lesions Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory Medicine University of Arkansas for Medical
More informationPremalignant lesions may expose to a promoting. factor & may be induced to undergo malignant. Carcinoma in situ displays the cytologic features of
بسم رلاهللا Def. Premalignant lesions may expose to a promoting factor & may be induced to undergo malignant transformation. Carcinoma in situ displays the cytologic features of malignancy without invasion
More informationDysplasia, Mimics and Other Controversies
Dysplasia, Mimics and Other Controversies Mary S. Richardson, MD Dept. of Pathology Medical University of South Carolina Charleston, SC Notice of Faculty Disclosure In accordance with ACGME guidelines,
More informationA QUANTITATIVE EVALUATION OF EPITHELIUM AND INFLAMMATORY INFILTRATE OF LICHEN PLANUS AND LICHENOID REACTIONS
A QUANTITATIVE EVALUATION OF EPITHELIUM AND INFLAMMATORY INFILTRATE OF LICHEN PLANUS AND LICHENOID REACTIONS 1 2 Usha Balan Nitin Gonsalves Maji Jose 1 Departments of Oral & Maxillofacial Pathology, KMCT
More informationJMSCR Vol 05 Issue 10 Page October 2017
www.jmscr.igmpublication.org Impact Factor 5.84 Index Copernicus Value: 71.58 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v5i10.125 Histomorphological Study of Lichen Planus
More informationOral Manifestations of Dermatologic Disease: A Focus on Lichenoid Lesions. Proceedings of the NASHNP Companion Meeting, March, 2011, San Antonio, TX
1 Oral Manifestations of Dermatologic Disease: A Focus on Lichenoid Lesions Proceedings of the NASHNP Companion Meeting, March, 2011, San Antonio, TX Susan Müller, DMD, MS Professor Department of Pathology
More informationA Clinicohistopathologic Study and Probable Mechanism of Pigmentation in Oral Lichen Planus
10.5005/jp-journals-10015-1184 Rubina Anjum et al ORIGINAL RESEARCH A Clinicohistopathologic Study and Probable Mechanism of Pigmentation in Oral Lichen Planus Rubina Anjum, Jasmin Singh, Shailesh Kudva
More informationWHITE LESIONS OF THE ORAL CAVITY - diagnostic appraisal & management strategies
WHITE LESIONS OF THE ORAL CAVITY - diagnostic appraisal & management strategies * Joshy V.R ** Hari.S * Reader, Dept of Oral Pathology, Yenepoya Dental College, Yenepoya University, Mangalore 575 018.
More informationSQUAMOUS ODONTOGENIC TUMOUR: REPORT OF FIVE CASES FROM NIGERIA AND REVIEW OF LITERATURE
African Journal of Oral Health Volume 3 Numbers 1&2, 2006:1-5 REFEREED ARTICLE SQUAMOUS ODONTOGENIC TUMOUR: REPORT OF FIVE CASES FROM NIGERIA AND REVIEW OF LITERATURE Adebiyi K.E., Odukoya O., Taiwo, E.O.
More informationNEOPLASMS OF THE SURFACE EPITHELIUM (KERATINOCYTES)
NEOPLASMS OF THE SURFACE EPITHELIUM (KERATINOCYTES) Papillary Lesions Precancerous Lesions Keratinocyte Proliferations Carcinomas Melanotic Lesions Melanomas Normal Mucosa Keratin layer Spinous layer Basal
More informationBenign and malignant epithelial lesions: Seborrheic keratosis: A common benign pigmented epidermal tumor occur in middle-aged or older persons more
Benign and malignant epithelial lesions: Seborrheic keratosis: A common benign pigmented epidermal tumor occur in middle-aged or older persons more common on the trunk; but extremities, head and neck are
More informationClinical behaviour of malignant transforming oral lichen planus
EJSO 2002; 28: 838±843 doi:10.1053/ejso.2002.1302, available online at http://www.idealibrary.com on 1 Clinical behaviour of malignant transforming oral lichen planus M. D. Mignogna*, L. Lo Russo*, S.
More informationA Speckled Lesion. Angela C. Chi, DMD; Michele Carter Ravenel, DMD
A Speckled Lesion Angela C. Chi, DMD; Michele Carter Ravenel, DMD The following Case Challenge is provided in conjunction with the American Academy of Oral and Maxillofacial Pathology. Case Summary This
More informationReproducibility of grading systems in oral epithelial dysplasia
Med Oral Patol Oral Cir Bucal. 2011 Nov 1;17 (6):e935-42. Journal section: Oral Medicine and Pathology Publication Types: Research doi:10.4317/medoral.17749 http://dx.doi.org/doi:10.4317/medoral.17749
More informationLARYNGEAL DYSPLASIA. Tomas Fernandez M; 3 rd year ENT resident, Son Espases University Hospital
LARYNGEAL DYSPLASIA Tomas Fernandez M; 3 rd year ENT resident, Son Espases University Hospital INTRODUCTION Laryngeal cancer constitutes 1-2% of all malignancies diagnosed worldwide Survival is related
More informationHistopathology: Cervical HPV and neoplasia
Histopathology: Cervical HPV and neoplasia These presentations are to help you identify basic histopathological features. They do not contain the additional factual information that you need to learn about
More informationSquamous Cell Carcinoma of the Head and Neck (SCCHN)
Squamous Cell Carcinoma of the Head and Neck (SCCHN) Part 1 Bruce M. Wenig, M.D. Dept. of Pathology & Laboratory Medicine Continuum Health Partners New York, NY College of American Pathologists 2004. Materials
More informationIJCMR 1. Jay Ashokkumar Pandya, 1 Srikant Natarajan, 2 Karen Boaz, 3 Nidhi Manaktala, 4 Amitha J Lewis, 5 Supriya Nikita Kapila 1 ABSTRACT
IJCMR 1 ORIGINAL RESEARCH Assessment And Comparison of Keratin, Epithelial And Inflammatory Thickness In Oral Lichen Planus And Oral Reaction Using Picrosirius Red Stain Jay Ashokkumar Pandya, 1 Srikant
More informationSmoking Habits Among Patients Diagnosed with Oral Lichen Planus
TOBACCO INDUCED DISEASES Vol. 2, No. 2: 103-108 (2004) PTID Society Smoking Habits Among Patients Diagnosed with Oral Lichen Planus Meir Gorsky, 1 Joel B. Epstein, 2 Haya Hasson-Kanfi, 1 Eliezer Kaufman
More informationR. Diagnostic criteria in proliferative verrucous leukoplakia: Evaluation.
Journal section: Oral Medicine and Pathology Publication Types: Research doi:10.4317/medoral.19424 http://dx.doi.org/doi:10.4317/medoral.19424 Diagnostic criteria in proliferative verrucous leukoplakia:
More informationHistopathological evaluation of oral lichen planus
Histopathological evaluation of oral lichen planus Layla S. Yas, B.D.S. M.Sc. (1) ABSTRACT Background: Oral lichen planus( OLP) is a chronic inflammatory disorder affecting mucosal surfaces, which can
More informationPapillary verrucous lesion of the oral mucosa: A need for detailed histopathological examination
Case report DOI: http://dx.doi.org/10.18320/jimd/201502.03163 JOURNAL OF INTERNATIONAL MEDICINE AND DENTISTRY To search..to know...to share p-issn: 2454-8847 e-issn: 2350-045X Papillary verrucous lesion
More informationQuantification of Colloid Bodies in Oral Lichen Planus and Oral Lichenoid Reaction - A Histochemical Study
Journal section: Oral Medicine and Pathology Publication Types: Research doi:0.437/jced.3.e207 Quantification of Colloid Bodies in Oral Lichen Planus and Oral Lichenoid Reaction - A Histochemical Study
More informationPACIFIC JOURNAL OF MEDICAL SCIENCES {Formerly: Medical Sciences Bulletin} ISSN:
PACIFIC JOURNAL OF MEDICAL SCIENCES {Formerly: Medical Sciences Bulletin} ISSN: 2072 1625 Pac. J. Med. Sci. (PJMS) www.pacjmedsci.com. Email: pacjmedsci@gmail.com. EROSIVE LICHEN PLANUS A CASE REPORT *Prathima
More informationComparative Study of Expression of Smad3 in Oral Lichen Planus and Normal Oral Mucosa
IJMCM Autumn 2013, Vol 2, No 4 Original Article Comparative Study of Expression of Smad3 in Oral Lichen Planus and Normal Oral Mucosa Shima Nafarzadeh 1, Samad Ejtehadi 2, Pouyan Amini Shakib 1, Majid
More informationActinic keratosis (AK): Dr Sarma s simple guide
Actinic keratosis (AK): Dr Sarma s simple guide Actinic keratosis is a very common lesion that you will see in your day-to-day practice. First, let me explain the name Actinic keratosis. It means keratosis
More informationPattern of oral lesions Cytohistopathological study in tertiary care centre.
International Journal of Current Research in Medical Sciences ISSN: 2454-5716 P-ISJN: A4372-3064, E -ISJN: A4372-3061 www.ijcrims.com Original Research Article Volume 3, Issue 10-2017 Pattern of oral lesions
More informationGastrooesophageal reflux disease. Jera Jeruc Institute of pathology, Faculty of Medicine, Ljubljana, Slovenia
Gastrooesophageal reflux disease Jera Jeruc Institute of pathology, Faculty of Medicine, Ljubljana, Slovenia Reflux esophagitis (RE) GERD: a spectrum of clinical conditions and histologic alterations resulting
More informationChapter 5. Oxygenated Hemoglobin Diffuse Reflectance Ratio for In Vivo Detection of oral Pre-cancer
Chapter 5 Oxygenated Hemoglobin Diffuse Reflectance Ratio for In Vivo Detection of oral Pre-cancer This work is published in: JB0 (SPIE) 13(4):041306 (1-10), 2008 Oxygenated Hemoglobin Diffuse Reflectance
More informationWhen Immunostains Can Get You in Trouble: Gynecologic Pathology p16: Panacea or Pandora s Box?
When Immunostains Can Get You in Trouble: Gynecologic Pathology p16: Panacea or Pandora s Box? Teri A. Longacre, MD Stanford Medicine Stanford California pi6 in Gynecologic Pathology: Panacea or Pandora
More informationMANSOURA UNIVERSITY FACULTY OF DENTISTRY ORAL PATHOLOGY DEPT
MANSOURA UNIVERSITY FACULTY OF DENTISTRY ORAL PATHOLOGY DEPT THIRD YEAR Course Director: Dr. Nadia M. Lotfy Professor of Oral Pathology Dr. Manal Mohamed Zyada Associate Professor of Oral Pathology Oral
More informationLEUKOPLAKIA Definition Epidemiology Clinical presentation
LEUKOPLAKIA Definition Leukoplakia is the most common premalignant or "potentially malignant" lesion of the oral mucosa. Leukoplakia is a predominantly white lesion of the oral mucosa than cannot be clinicopathologically
More informationARTICLE INFO ABSTRACT
Melanocytic Pigmentation: A Single Manifestation of Myriad of Pathologies [PP: 05-09] Dr. Swapna Honwad Department of Oral Pathology dr.swapnahonwad@gmail.com Dr. Elsy P. Simon Department of Endodontics
More informationA Rare case of Tubercular Gingivitis Case Report
Case Report A Rare case of Tubercular Gingivitis Case Report *Dr. Ansh Chugh 1, Dr. Firoz A Hakkim 2, Dr. Rajesh. V 3, Dr. Raghava Sharma 4 1: JUNIOR RESIDENT IN GENERAL MEDICINE 2: SENIOR RESIDENT IN
More informationA five year study on differential diagnosis of verruciform penile lesions
Original Research Article A five year study on differential diagnosis of verruciform penile lesions S. Sujatha 1, V. Srinivas Kumar 2*, K. Durga 3 1 Associate Professor, 2 Assistant Professor, 3 Professor
More informationHistopathological Findings in Oral Lichen Planus: A Three-Year Report from Western Iran
Journal of Research in Medical and Dental Science 2018, Volume 6, Issue 1, Page No: 274-278 Copyright CC BY-NC-ND 4.0 Available Online at: www.jrmds.in eissn No. 2347-2367: pissn No. 2347-2545 Histopathological
More informationIMMUNOPATHOLOGY OF ORAL LEUKOPLAKIA
442 IMMUNOPATHOLOGY OF ORAL LEUKOPLAKIA T. LEHNER From the Department of Oral Medicine and Pathology, Guy's Hospital Medical School, London, S.E.1 Received for publication April 17, 197 SUMMARY.-The lymphocyte
More informationProblem diagnoses. Current issues in Anatomic pathology. Problem Diagnoses in Tumors of the Oral Cavity 5/29/2009
Current issues in Anatomic pathology Problem Diagnoses in Tumors of the Oral Cavity Richard Jordan DDS PhD FRCPath Professor of Oral Pathology & Pathology Director, UCSF Oral Pathology Diagnostic Laboratory
More informationNeoplasia 2018 Lecture 2. Dr Heyam Awad MD, FRCPath
Neoplasia 2018 Lecture 2 Dr Heyam Awad MD, FRCPath ILOS 1. List the differences between benign and malignant tumors. 2. Recognize the histological features of malignancy. 3. Define dysplasia and understand
More informationPapillary Lesions of the breast
Papillary Lesions of the breast Emad Rakha Professor of Breast Pathology The University of Nottingham Papillary lesions of the breast are a heterogeneous group of disease, which are characterised by neoplastic
More informationPAP SMEAR by Dr.Shantha Krishnamurthy MD Senior Consultant Pathology Fortis Hospitals
PAP SMEAR by Dr.Shantha Krishnamurthy MD Senior Consultant Pathology Fortis Hospitals Historical Named after George Papanicolaou, a Greek American Studied cervical epithelium in menstrual cycle of guinea
More informationHistopathological study of neoplastic lesions of oral cavity and oropharynx
International Journal of Research in Medical Sciences Gupta M et al. Int J Res Med Sci. 2016 May;4(5):1506-1510 www.msjonline.org pissn 2320-6071 eissn 2320-6012 Research Article DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20161219
More informationReview Article- Leukoplakia: A mysterious white patch.
International Journal Of Scientific Research And Education Volume 2 Issue 9 Pages 1824-1830 September-2014 ISSN (e): 2321-7545 Website: http://ijsae.in Review Article- Leukoplakia: A mysterious white patch.
More informationIN THE NAME OF GOD. Dr.kheirandish DDS,MSC Oral and maxillofacial pathology
IN THE NAME OF GOD Dr.kheirandish DDS,MSC Oral and maxillofacial pathology Dermatologic Diseases Chapter 16 ECTODERMAL DYSPLASIA o Two or more ectodermally derived anatomic structures fail to develop o
More informationClinically Microscopically Pathogenesis: autoimmune not lifetime
Vulvar Diseases: Can be divided to non-neoplastic and neoplastic diseases. The neoplastic diseases are much less common. Of those, squamous cell carcinoma is the most common. most common in postmenopausal
More informationComparison and Evaluation of Mitotic Figures in Oral Epithelial Dysplasia using Crystal Violet and Feulgen Stain
Comparison and Evaluation of Mitotic Figures in Oral Epithelial Dysplasia using 10.5005/jp-journals-10024-1527 Crystal Violet and Feulgen Stain Original research Comparison and Evaluation of Mitotic Figures
More informationCINtec p16 INK4a Staining Atlas
CINtec p16 INK4a Staining Atlas Rating Rating Positive The rating positive will be assigned if the p16 INK4a -stained slide shows a continuous staining of cells of the basal and parabasal cell layers of
More informationClinical Relevance: Identification of various cell markers may provide valuable information of diagnostic and prognostic significance.
ORAL MEDICINE An Overview of the Prevention of Oral Cancer and Diagnostic Markers of Malignant Change: 2. Markers of Value in Tumour Diagnosis M. MACLUSKEY AND G.R. OGDEN Abstract: Earlier diagnosis of
More informationHistopathology: skin pathology
Histopathology: skin pathology These presentations are to help you identify, and to test yourself on identifying, basic histopathological features. They do not contain the additional factual information
More informationOriginal Research Article
ASSESSMENT OF HUMAN PAPILLOMA VIRUS SUBTYPES BY POLYMERASE CHAIN REACTION AND THEIR IMPACT ON THE DEGREE OF DYSPLASIA IN ORAL LEUKOPLAKIA Submitted on: XXXX Dr. N. Kannan, Dr Teja Srinivas, Dr. Rakesh
More informationA DIAGNOSTIC DILEMMA: ORAL LICHEN PLANUS OR LICHENOID REACTION - A SERIES OF CASE REPORTS
CASE REPORT A DIAGNOSTIC DILEMMA: ORAL LICHEN PLANUS OR LICHENOID REACTION - A SERIES OF CASE REPORTS Chanchal Sareen 1, Aparna Pathak 2, Puneet Ahuja 3, Moulshree Kohli 4 1 Senior Lecturer, 3 Prof & Head,
More informationPathology of bladder cancer in Egypt; a current study.
Pathology of bladder cancer in Egypt; a current study. Thesis Submitted for partial fulfillment of Master degree in urology By Mohamed Atef Mohamed Ahmed M.B.B.CH Supervised by Prof.Dr.: Omar Mohamed Abdel-
More informationProliferative Verrucous Leukoplakia of the Gingiva: A Rare Palatal Presentation
CASE REPORT Proliferative Verrucous Leukoplakia of the Gingiva: A Rare Palatal Presentation M. Shaurya*, S. Ravindra, Sarvani Murthy *Post Graduate Student, Professor and Head, Department of Periodontics,
More informationA neoplasm is defined as "an abnormal tissue proliferation, which exceeds that of adjacent normal tissue. This proliferation continues even after
NEOPLASIA Neoplasia is a very important topic in pathology because neoplasms are both common and serious diseases. A neoplasm literally means a new growth, and this term is used interchangeably with a
More informationBasal cell carcinoma 5/28/2011
Goal of this Presentation A practical approach to the diagnosis of cutaneous carcinomas and their mimics Thaddeus Mully, MD University of California San Francisco To review common non-melanoma skin cancers
More informationCase Report A Giant Cell Fibroma and Focal Fibrous Hyperplasia in a Young Child: A Case Report
Hindawi Publishing Corporation Case Reports in Dentistry Volume 2012, Article ID 370242, 5 pages doi:10.1155/2012/370242 Case Report A Giant Cell Fibroma and Focal Fibrous Hyperplasia in a Young Child:
More informationnumber Done by Corrected by Doctor Maha Shomaf
number 16 Done by Waseem Abo-Obeida Corrected by Zeina Assaf Doctor Maha Shomaf MALIGNANT NEOPLASMS The four fundamental features by which benign and malignant tumors can be distinguished are: 1- differentiation
More informationPrepared By Jocelyn Palao and Layla Faqih
Prepared By Jocelyn Palao and Layla Faqih The structure of the suspected atypical cell should always be compared to the structure of other similar, benign, cells which are present in the smears. The diagnosis
More informationTHE ROLE OF HUMAN PAPILLOMA VIRUS IN THE DEVELOPMENT OF ORAL LEUKOPLAKIA
Oral biology THE ROLE OF HUMAN PAPILLOMA VIRUS IN THE DEVELOPMENT OF ORAL LEUKOPLAKIA Yu. G. KOLENKO 1 1 Associate Prof., PhD, Dept. Operative Dentistry, Faculty of Medical Dentistry, Bogomolets National
More informationReceived, June 29, 1904; accepted for publication
THE AMEBICAN JOURNAL OF CLINICAL PATHOLOGY Copyright 1964 by The Williams & Wilkins Co. Vol. 42, No. 0 Printed in U.S.A. CARCINOMA IN SITU OF THE ENDOMETRIUM ISABELLE A. BUEHL, M.D., PRANK VELLIOS, M.D.,
More informationEpidemiology of Oral Lichen Planus in a Cohort of South Indian Population: A Retrospective Study
JOURNAL OF CANCER PREVENTION Vol. 21, No. 1, March 2016 http://crossmark.crossref.org/dialog/?doi=10.15430/jcp.2016.21.1.55&domain=pdf&date_stamp=2016-3-30 http://dx.doi.org/10.15430/jcp.2016.21.1.55 pissn
More informationProliferative Verrucous Leukoplakia of the Gingiva, Report of two Cases with Malignant Transformation
Journal of Clinical and Anatomic Pathology Case Report Open Access Proliferative Verrucous Leukoplakia of the Gingiva, Report of two Cases with Malignant Transformation Nadereh Ghanee DMD, Selene Saraf
More informationNasal mucosal melanosis may act as a harbinger of melanoma: A case report
Nasal mucosal melanosis may act as a harbinger of melanoma: A case report The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Citation
More informationACCURATE DIAGNOSIS IS THE ONLY TRUE CORNERSTONE ON WHICH RATIONAL TREATMENT CAN BE BUILT. C Noyek
ACCURATE DIAGNOSIS IS THE ONLY TRUE CORNERSTONE ON WHICH RATIONAL TREATMENT CAN BE BUILT. C Noyek Oral diagnostics Definition of the discipline That area of dentistry, the which deals with gathering, recording
More informationOn 180 Biopsies of Oral Carcinomas in Our Department of Pathology. Yasuyuki AWAZAWA * and Itaru MORO * Introduction
On 180 Biopsies of Oral Carcinomas in Our Department of Pathology by Yasuyuki AWAZAWA * and Itaru MORO * Introduction Carcinomas in the oral region, like those found in other regions of human body, have
More informationNew Diagnoses Need New Approaches: A Glimpse into the Near Future of Gynecologic Pathology
New Diagnoses Need New Approaches: A Glimpse into the Near Future of Gynecologic Pathology United States and Canadian Academy of Pathology 102 nd Annual Meeting Baltimore, Maryland Christina S. Kong, M.D.
More informationImmunoflourescent assessment of Herpes Simplex Virus (HSV) type 1 in oral lichen planus
Immunoflourescent assessment of Herpes Simplex Virus (HSV) type 1 in oral lichen planus Muthanna K. Ali, B.D.S., M.Sc. (1) ABSTRACT Background: Oral lichen planus is one of the most common dermatological
More informationChapter 6 Squamous Cell Carcinoma: Variants and Challenges
Chapter 6 Squamous Cell Carcinoma: Variants and Challenges Michael B. Morgan EPIDEMIOLOGY: Second most common skin cancer, rare in the dark-skinned races. ETIOLOGY: Ultraviolet light, HPV infection. PATHOGENESIS:
More informationInternational Journal of Scientific Research and Innovative Technology ISSN: Vol. 4 No. 12; December 2017
THE FREQUENCY OF ORAL LICHEN PLANUS IN SAMPLES SENT TO PATHOLOGY DEPARTMENT OF TABRIZ DENTAL SCHOOL (2006-2016) AND ITS RELATION WITH AGE, SEX, LESION TYPE AND LOCATION Farzaneh Pakdel 1, Parya Emamverdizadeh
More informationDemystifying Endometrial Hyperplasia
Demystifying Endometrial Hyperplasia A review from Diagnostic Histopathology 19:7 Dr R Hadden ST5 Histopathology Derriford Hospital Plymouth Endometrium Target for sex-steroid hormones Glands Stroma Proliferate
More informationBiliary tract tumors
Short Course 2010 Annual Fall Meeting of the Korean Society for Pathologists Biliary tract tumors Joon Hyuk Choi, M.D., Ph.D. Professor, Department of Pathology, Yeungnam Univ. College of Medicine, Daegu,
More informationAmong the benign intraepithelial melanocytic proliferations, Inflamed Conjunctival Nevi. Histopathological Criteria. Resident Short Reviews
Resident Short Reviews Inflamed conjunctival nevi (ICN) may suggest malignancy because of their rapid growth and atypical histology. The objective of this study was to characterize the diagnostic features
More informationVulvar squamous cell carcinoma
The Clinical Significance of Stratifying Vulval Squamous Carcinoma into HPV and Non-HPV Related Variants C. BLAKE GILKS MD FRCPC Dept of Pathology, University of British Columbia Vulvar squamous cell carcinoma
More informationCONCURRENT EXTRAVASATION MUCOCELE AND EPIDERMOID CYST OF THE LOWER LIP: A CASE REPORT
Mucocele and epidermoid cyst CONCURRENT EXTRAVASATION MUCOCELE AND EPIDERMOID CYST OF THE LOWER LIP: A CASE REPORT Wen-Chen Wang, Li-Min Lin, Yee-Hsiung Shen, 1 Yu-Ju Lin, and Yuk-Kwan Chen Departments
More informationMody. AIS vs. Invasive Adenocarcinoma of the Cervix
Common Problems in Gynecologic Pathology Michael T. Deavers, M.D. Houston Methodist Hospital, Houston, Texas Common Problems in Gynecologic Pathology Adenocarcinoma in-situ (AIS) of the Cervix vs. Invasive
More informationUNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA FACULTY OF MEDICINE DOCTORAL THESIS SUMMARY
UNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA FACULTY OF MEDICINE DOCTORAL THESIS SUMMARY CLINICAL, HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF THE EPITHELIAL PRECANCEROUS LESIONS PRECURSORS OF
More informationAmeloblastic Carcinoma of the Mandible: a Rare Case Report
IBIMA Publishing Journal of Research and Practice in Dentistry http://www.ibimapublishing.com/journals/dent/dent.html Vol. 2015 (2015), Article ID 672596, 6 pages DOI: 10.5171/2015.672596 Case Report Ameloblastic
More informationAbstract Background: A wide variety of white lesions are encountered in general population and specially those people
Original Article Assessment of white lesion in known population group: A Pilot Study Vandana Katoch 1, Sandeep Sidhu 2, Amit Kour 3, Saurav Saini 4, Priyanka Sharma 5 1 MDS, Department Of Oral and Maxillofacial
More informationDIAGNOSIS OF ORAL PREMALIGNANT AND MALIGNANT LESIONS USING CYTOMORPHOMETRY
DIAGNOSIS OF ORAL PREMALIGNANT AND MALIGNANT LESIONS USING CYTOMORPHOMETRY T. RAMAESH 1, B.R.R.N. MENDIS 2, N. RATNATUNGA 3, R.O. THATTIL 4 INTRODUCTION Oral cancer is a major health problem in South East
More informationJ Interdiscipl Histopathol. Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on Diagnosis and Treatment
J Interdiscipl Histopathol Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on Diagnosis and Treatment Journal Name : Journal of Interdisciplinary Histopathology Manuscript ID : JIHP-2016-05-032
More informationMAST CELLS IN ORAL LICHEN PLANUS
MAST CELLS IN ORAL LICHEN PLANUS Mahija Janardhanan* V.Ramesh. ** *Reader, Department of Oral Pathology & Microbiology, Amrita school of Dentistry, Kochi. **Professor & HOD, Department of Oral Pathology
More informationInt.J.Curr.Microbiol.App.Sci (2016) 5(7):
International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 5 Number 7 (2016) pp. 558-564 Journal homepage: http://www.ijcmas.com Original Research Article http://dx.doi.org/10.20546/ijcmas.2016.507.061
More informationSynonyms. Nephrogenic metaplasia Mesonephric adenoma
Nephrogenic Adenoma Synonyms Nephrogenic metaplasia Mesonephric adenoma Definition Benign epithelial lesion of urinary tract with tubular, glandular, papillary growth pattern Most frequently in the urinary
More informationالطلاوة = Leukoplakia LEUKOPLAKIA
LEUKOPLAKIA Leukoplakia is a clinical term that refers to a predominantly white lesion of the oral mucosa that cannot be rubbed off or characterized by any other definable lesion or known disease. 130
More informationSarcomatoid (spindle cell) carcinoma of the cricopharynx presenting as dysphagia
Case Report Sarcomatoid (spindle cell) carcinoma of the cricopharynx presenting as dysphagia Jagtap Sunil V. 1, Shukla Dhirajkumar B. 2, Jagtap Swati S. 3, Havle Abhay D. 4 1 Associate Professor, Department
More informationLESIONS OF THE ORAL CAVITY ORAL CAVITY. Oral Cavity Subsites 4/10/2013 LIPS TEETH GINGIVA ORAL MUCOUS MEMBRANES PALATE TONGUE ORAL LYMPHOID TISSUES
LESIONS OF THE ORAL CAVITY David I. Kutler, MD, FACS Associate Professor Division of Head and Neck Surgery Department of Otolaryngology HNS Weill Cornell Medical Center ORAL CAVITY LIPS TEETH GINGIVA ORAL
More informationClinical profile of 108 cases of oral lichen planus
43 Journal of Oral Science, Vol. 58, No. 1, 43-47, 2016 Original Clinical profile of 108 cases of oral lichen planus Pritam K. Mankapure, Jayanti G. Humbe, Mandakini S. Mandale, and Jyoti D. Bhavthankar
More informationCytyc Corporation - Case Presentation Archive - March 2002
FirstCyte Ductal Lavage History: 68 Year Old Female Gail Index: Unknown Clinical History: Negative Mammogram in 1995 6 yrs. later presents with bloody nipple discharge Subsequent suspicious mammogram Suspicious
More informationMucous and ciliated cell metaplasia in epithelial linings of odontogenic inflammatory and developmental cysts
77 Journal of Oral Science, Vol. 47, No. 2, 77-81, 2005 Original Mucous and ciliated cell metaplasia in epithelial linings of odontogenic inflammatory and developmental cysts Yasunori Takeda, Yuko Oikawa,
More informationLeukoplakia is a white patch on the oral mucous membrane, which is undeliable and can not diagnose neither clinically nor pathologically as an other
Leukoplakia Leukoplakia is a white patch on the oral mucous membrane, which is undeliable and can not diagnose neither clinically nor pathologically as an other disease. (Pindborg. 1978) Precancerous lesion
More informationHPV induced Proliferative verrucous Leukoplakia : Case Report
Case Report: HPV induced Proliferative verrucous Leukoplakia : Case Report Dr Gopal Sharma, Dr Deepa Das, Dr Prachi Naik, Dr Jaya Mukherjee Oral Medicine and Radiology Department, YMT Dental College and
More informationOriginal article J Bas Res Med Sci 2018; 5(3):49-51.
Age related changes in clinicopathologic features of oral squamous cell carcinoma (OSCC) in Iranian patients: An epidemiologic study Ramin Ghafari 1, Noushin Jalayer Naderi 2*, Amirnader Emami Razavi 3
More informationThe Pathologist s Role in the Diagnosis and Management of Neoplasia in Barrett s Oesophagus Cian Muldoon, St. James s Hospital, Dublin
The Pathologist s Role in the Diagnosis and Management of Neoplasia in Barrett s Oesophagus Cian Muldoon, St. James s Hospital, Dublin 24.06.15 Norman Barrett Smiles [A brief digression - Chair becoming
More informationImmunohistochemical studies (ER & Ki-67) in Proliferative breast lesions adjacent to malignancy
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 13, Issue 3 Ver. IV. (Mar. 2014), PP 84-89 Immunohistochemical studies (ER & Ki-67) in Proliferative
More informationDERMATITIS CHRONICA HELICIS
J. clin. Path. (1957), 10, 46. THE HISTOLOGICAL APPEARANCES OF CHONDRO- DERMATITIS CHRONICA HELICIS BY E. M. McCONNELL From the Department of Pathology, Liverpool Radium Institute, Liverpool (RECEIVED
More informationProliferative Epithelial lesions of the Breast. Sami Shousha, MD, FRCPath Charing Cross Hospital & Imperial College, London
Proliferative Epithelial lesions of the Breast Sami Shousha, MD, FRCPath Charing Cross Hospital & Imperial College, London Amman, November2013 Proliferative Epithelial Lesions of the Breast Usual type
More informationCASE REPORT PLAQUE TYPE ORAL VERRUCOUS HYPERPLASIA AND IRRITATIONAL FIBROMA: A REPORT OF CONJOINT OCCURRENCE
CASE REPORT PLAQUE TYPE ORAL VERRUCOUS HYPERPLASIA AND IRRITATIONAL FIBROMA: A REPORT OF CONJOINT OCCURRENCE Alphy Alphonsa Sebastian, Hasan Subhi 1. Phd student, Department of Oral Medicine and Oral Pathology,
More informationSUBMUCOSA PRECEDES LAMINA PROPRIA IN INITIATING FIBROSIS IN ORAL SUBMUCOUS FIBROSIS - EVIDENCE BASED ON COLLAGEN HISTOCHEMISTRY.
SUBMUCOSA PRECEDES LAMINA PROPRIA IN INITIATING FIBROSIS IN ORAL SUBMUCOUS FIBROSIS - EVIDENCE BASED ON COLLAGEN HISTOCHEMISTRY. *Anna P. Joseph ** R. Rajendran Abstract Oral submucous fibrosis is a chronic
More information