An Update on the Bowel Cancer Screening Programme. Natasha Djedovic, London Hub Director 17 th September 2018
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1 An Update on the Bowel Cancer Screening Programme Natasha Djedovic, London Hub Director 17 th September 2018
2 NHS Bowel Cancer Screening Programme 2006: yr old men & women offered guaiac Faecal Occult Blood test 2013: phased roll-out of Bowel scope screening (flexible sigmoidoscopy) to 55 yr olds 2014: age extension (70-74 yr olds) for gfobt completed 2015: UK National Screening Committee recommended that FIT replace gfobt 2018: UK National Screening Committee recommended lowering the age of bowel cancer screening in England to the age of 50
3 FOBt Pathway Eligibility criteria: men and women aged registered with a General Practice entitled to NHS care have a functioning bowel Identification of participants through Bowel Cancer Screening System (national IT system) Invited within 6 weeks of their 60 th birthday Men & women 75 yrs old can self-refer.
4 Communication of abnormal results (~43,000 per year) & booking appointments at Screening Centres Admin Mailing Hub Dispatch of pre-invitation materials & invitation packs (~4.5m pre-invites & ~4.9m test kits per year) Laboratory Deal with telephone enquiries to national helpline (~800,000 per year) Call Centre Analysis of completed test kits (~2.9m per year, ~59% uptake)
5 Hub FOBt Pathway 1 week later Invitation sent Kit dispatched Reminder sent if no return within 4 weeks Receipt & development of used test kit Normal result (6 negative samples) Abnormal result (5 or 6 positive samples) Unclear result (1-4 positive samples) Spoilt kit or technical fail FOBt offered in 2 years if <75 SSP appointment offered within 14 days of abnormal result 1 or 2 repeat kits dispatched 1 repeat kit dispatched
6 Faecal Immunochemical Test (2016)
7 Haem Guaiac + 2H 2 O 2 Quinone + 2H O 2
8 Haemoglobin - Globin Antibody recognition of the tertiary structure produced by the folding of the amino acid chain in the globin protein. Globin Haem Guaiac test gfobt Slide from Stephen P Halloran
9 Faecal Immunochemical Test Slide from Sally Benton
10 Faecal Immunochemical Test Gut, 2016 FIT in place of guaiac FOBT 1 in 28 invitations 40,000 FIT tests 2 Hubs Single kit
11 FIT trial (2014) Slide from Stephen P Halloran
12 gfobt Uptake in London
13 FIT trial (London, 2015/2016) 9.7% 7.4% 8.5%
14 FIT trial (London, 2015/2016) 9.8%
15 FIT trial (London, 2015/2016) 5.4% 9.7% 13.7%
16 Hub FIT Pathway (60 74 yr) 1 week later Invitation sent Kit dispatched Reminder sent if no return within 4 weeks Receipt & analysis of completed test kit Normal result <120 µg Hb/g faeces Abnormal result 120 µg Hb/g faeces Unclear result (1-4 positive samples) Spoilt kit or technical fail FIT offered in 2 years if <75 SSP appointment offered within 14 days of abnormal result 1 or 2 repeat kits dispatched 1 repeat kit dispatched
17 Positivity 12% 6.5% 4.5% 2.4% Scotland S-Ireland Canada Uraguay Taiwan Spain Slovenia S-Ireland Singapore Malta Korea Italy Iceland Hungary Denmark Canada (most) Norway New Zealand Netherlands Belgium Sweden Latvia Israel Scotland England Wales Cut-Off Concentration (ug Haemoglobin/g Faeces) Slide from Stephen P Halloran
18 % Detection Rate 4.0% 3.5% 3.0% 2.5% 2.0% 1.5% 1.0% 0.5% 0.0% gfobt FIT FIT FIT FIT FIT Cancer 0.12% 0.27% 0.24% 0.16% 0.15% 0.13% Ad. Adenoma 0.35% 1.74% 1.30% 0.68% 0.50% 0.43% All Neoplasms 0.76% 3.74% 2.63% 1.30% 0.94% 0.80% Slide from Stephen P Halloran
19 Faecal Immunochemical Test vs Guaiac Test FIT Single faecal sample Sample put into a plastic bottle Higher participation rate than with gfobt Sample can be analysed more than once Automated objective instrument analysis Measures human blood Higher detection of cancers and adenomas Adjustable Hb cut-off concentration gfobt Six faecal samples from three bowel motions Sample put onto cardboard Lower participation rate than with FIT One-time only analysis Subjective visual assessment Measures any blood, including that in the diet Lower detection of cancers and adenomas Non-adjustable Hb cut-off concentration
20 Impact of FIT 120 µg/g Based on PHE modelling data, ~15,663 extra screening colonoscopies per year on top of FOBt 36,589 colonoscopies ~1,427 more cancers detected
21 Implementation of FIT for yr olds National procurement process is underway 1 single supplier for England Assessment of screening centre capacity in progress Interim solution before April 2019: 1 in n (by Hub/screening centre) Full roll-out anticipated in April 2019
22 Age extension to yr olds
23 Bowel Scope (Flexible Sigmoidoscopy) Multi-centre randomised trial (UK Flexible Sigmoidoscopy Screening Trial) , n = 170,432 (55 64 yrs) 17 years follow up: Colorectal cancer incidence reduced by 33% Colorectal cancer mortality reduced by 43% The Lancet, 2017
24 Bowel Scope Pathway Eligibility criteria: men and women aged 55 yrs registered with a General Practice entitled to NHS care have a functioning bowel Identification of participants through Bowel Cancer Screening System (national IT system) Men & women yrs old can self-refer if GP practice live for Bowel scope
25 Mailing Dispatch of pre-invitation materials & invitation/ confirmation/nonresponse letters (~2 2.5m per year) Hub Process response slips, organise dispatch of enemas from central distribution centre once confirmation of attendance is received, maintain maps Admin Call Centre Deal with telephone enquiries to national helpline appointment rebookings & cancellations
26 Bowel Scope Pathway ~47.5% of GPs rolled out in England (100% expected by 2021) Challenges: 40 45% uptake Screening centre resources
27 Future Full roll out of FIT to yr olds at 120 µg/g Lowering starting age to 50 yr old Using screening history to determine risk Lowering cutoff to 20 µg/g Changing the screening interval Different cutoffs for men & women Withdrawal of Bowel scope
28 Acknowledgements Prof Stephen Halloran Sally Benton Prof Sue Moss Dr Chris Matthews Thank you for your attention
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