Comprehensive Human Cancer and Normal Tissue Products
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1 Comprehesive Huma Cacer ad Normal Tissue Products Likig gees ad proteis to cacer biology Cacer Tissue Total RNAs Cacer Tissue Sectios ad Blocks Cacer Tissue cdna Arrays OriGee Biorepository Cacer Tissue Microarrays (TMAs) Cacer Tissue Geomic DNAs Cacer Tissue Protei Lysates ad Arrays Over 140,000 huma tissue collectios from major US istitutios Broad coverage of >20 cacer types at differet stages Paired cacer ad ormal tissue products from same doors Each sample is pathologist-verified ad aotated with cliical data Applicatio/Assay-ready i idividual ad array formats
2 Huma Cacer ad Normal Tissue Products Likig gees ad proteis to cacer biology COMPREHENSIVE HUMAN TISSUE PRODUCTS OriGee has the comprehesive huma cacer ad ormal tissue products developed from its biorepository of over 140,000 huma tissues represetig over 12,000 doors. TissueSca Arrays: cdna arrays, geomic DNA arrays, protei lysate arrays (RPAs), ad tissue microarrays (TMAs) TissueFocus idividual products: total RNAs, geomic DNAs, protei lysates, sectios, ad blocks All products are provided i assay/applicatio ready formats Tissue cdna Arrays for gee expressio aalysis ad validatio Tissue Geomic DNA Arrays for mutatio aalysis ad validatio Tissue RNAs & cdnas Tissue Geomic DNAs >140,000 Huma Tissues Tissue Protei Lysates Tissue Sectios & Block Tissue Lysate Arrays (RPAs) for protei expressio aalysis ad validatio Tissue Microarrays (TMAs) for multiplex histological aalysis ad validatio UNPARALLELED QUALITY OF HUMAN TISSUE PRODUCTS All tissue products are developed from OriGee s high quality tissues, which are baked uder strict collectio protocols ad udergo rigorous quality cotrol to esure each source block s uparalleled quality. Collected from major US istitutios uder strict IRB ad ethical cosetig practices Maitaied i a moitored eviromet ad bar-coded for trackig purposes Each tissue source block icludes followig cliical iformatio Abstracted pathology report Disease stagig Digital H&E image Door s basic demographic iformatio More cliical data available for review through a o-lie database
3 TissueSca Cacer Tissue cdna Arrays qpcr gee expressio results of hudreds of tissues i 2 hours TissueSca Cacer Tissue cdna Arrays are developed for differetial gee expressio aalysis ad validatio amog hudreds of differet tissues. Tissue cdnas of each array are sythesized from high quality total RNAs of pathologist-verified tissues, ormalized ad validated with ß-acti i two sequetial qpcr aalyses, ad provided with QC data. Cacer survey array cotais over 20 differet cacer types from 381 doors Cacer specific arrays cover almost all major cacers Normal tissue arrays iclude major tissues from huma, mouse, rat, ad Drosophila RNA isolatio Add primers Covert RNA to cdna qpcr i 2 hours Select from 1000s of high quality cacer tissue samples 50 cacer ad ormal TissueSca paels i apcr plates OriGee Save You Moths to Years Geerate gee expressio data i hudreds of examples Data i 2 hours qpcr-ready TissueSca cdna ARRAYS FOR IMMEDIATE DELIVERY Cacer Survey Paels Cacer Specific Paels Normal Paels Coverage Adreal glad, Breast, Cervix, Colo, Edometrium, Esophagus, Gastroesophageal, Kidey, Liver, Lug, Lymphoid, Ovary, Pacreas, Prostate, Stomach, Testis, Thyroid glad, Uriary bladder, Uterus, etc. Bladder, Brai, Breast, Colo, Crohs, Edometrium, Gastroesophageal, Kidey, Liver, Lug, Lymphoma, Melaoma, Ovaria, Pacreas, Prostate, Sarcoma, Thyroid Huma Normal, Huma Brai, Mouse Normal, Mouse Developmet, Rat Normal, Drosophila Paels Format 384- or 96-well 96-well 96-well KEY PUBLICATIONS 1. Liu Y, et al. (2010). The protei kiase Pak4 disrupts mammary aciar architecture ad promotes mammary tumorigeesis. Ocogee doi: /oc Origial Article [Cacer Survey Pael] 2. Trimmer C, et al. (2010). CAV1 Ihibits Metastatic Potetial i Melaomas through Suppressio of the Itegri/Src/FAK Sigalig Pathway. Cacer Res., 70: [Melaoma Pael] 3. Noor A, et al. (2010). Disruptio at the PTCHD1 Locus o Xp22.11 i Autism Spectrum Disorder ad Itellectual Disability. Sciece Traslatioal Medicie, 2: 49ra68 [Brai Normal Pael] 4. Beverly LJ ad Varmus HE (2009). MYC-iduced myeloid leukemogeesis is accelerated by all six members of the atiapoptotic BCL family. Ocogee doi: /oc
4 TissueSca cdna Arrays For Biomarker Discovery DISCOVERY OF A NEW CANCER BIOMARKER FOR A NEW SUBTYPE OF BREAST CANCER Researchers at Washigto Uiversity School of Medicie discovered a ew cacer biomarker that could defie a ew subtype of breast cacer as well as offer a potetial way to treat it ad their work was published i the Proceedigs of the Natioal Academy of Scieces. LRP6 expressio is frequetly up-regulated i a subset of huma breast cacer tissues ad cell lies LRP6 was sigificatly over-expressed i 20-36% of huma breast cacer tissue samples LRP6 was icreased more frequetly i triple (ER, HER2 ad PR) egative breast tumor samples 45 Relative mrna level Normal/ Stage 0 Liu C et al. PNAS 2010;107: Stage I Stage IIA Stage IIB Stage IIIA Stage IIIC Stage IIIA Stage IIIC Stage IIIA TissueSca cdna Array results clearly idicated LRP6 expressio was up-regulated i a subset of huma breast cacer tissues. ** P < DISCOVERY OF A NEW PROGNOSIS BIOMARKER FOR LUNG CANCER Scietists at Natioal Jewish Health have discovered the Adeosie A2A (ADORA2A) receptor as a progosis ad compaio diagostic marker for lug cacer ad their work was published i the Proceedigs of the Natioal Academy of Scieces. ADORA2A receptor was sigificatly over-expressed durig the early, stages of tumor growth ADORA2A receptor was expressed oly i respose to HIF-2alpha activatio A potetial ew target for a ati-agiogeic approach to treatig lug cacer A Log (Relative A 2A /CD31) Normal Tumor Ahm ad A etal. PNAS 2009;106: Lug Tumor Stages B IV IIIB IIIA IIIB IIA IB IA Normal Relative adeosie A 2A receptor/cd31 TissueSca cdna Array results clearly idicated Adeosie A2A receptor expressio was icreased i lug tumor samples at differet stages. *Statistically differet from the ormal lug tissue.
5 1, , , , , , Cacer Tissue Protei Lysate Arrays Large scale, quatitative tools for protei biomarker discovery ad validatio Cacer Lysate Arrays are high-desity reverse-phase protei arrays (RPPA, or RPA) assembled from 432 cacer ad ormal tissue protei lysates. With protei-specific atibodies, TissueSca Cacer Lysate Arrays eable quatitative idetificatio ad validatio of protei expressio profiles ad post-traslatio modificatios amog ormal tissues ad 11 types of cacer i a sigle experimet. UTILITIES High desity array cotaiig triplet of four dilutios of 432 tissue lysates coverig 11 types of cacer Differetial protei expressio profilig amog ormal ad differet cacers o a sigle slide Protei biomarker ad drug target discovery ad validatio Easy to follow protocols for ehaced colorimetric ad flouremetric assays No special equipmet eeded ad validated detectio kits are available for purchase SIMPLE PROTOCOL If you ca do Wester blot, you ca do RPPA easily. Step 1: Primary atibody Figure 2 Simple aalysis of cacer differetial expressio idex (sample readout divided by media of the tissue ormal samples) for four differet proteis preseted i heat map format. Colum 1 ERBB2, Colum 2 BIRC5, Colum 3 TP53, Colum 4, Phospho cmyc Step 2: Secodary atibody Step 3: Sigal amplificatio (e.g., TSA system) Step 4: Read ad aalyze results Figure 1 Ati TP53 reactivity with cacer RPPAs tested with colorimetric TSA ehacemet protocol. ProteoSca Cacer Lysate Array Colo Normal Colo Cacer Breast Normal Breast Cacer < > Kidey Cacer Kidey Normal Lug Cacer Lug Normal Liver Cacer Liver Normal Lymphoma Cacer Lymphoma Normal Melaoma Cacer Melaoma Normal Ovarria Cacer Ovary Normal Pacreas Cacer Pacreas Normal Prostate Cacer Proatate Normal Stomach Cacer Stomach Normal
6 TissueFocus Tissue Derivative Products Tissue total RNAs, geomic DNAs, ad protei lysates OriGee s TissueFocus tissue total RNA, geomic DNA, ad protei lysate samples are produced from our pathologist-verified high quality tissue blocks ad udergo rigorous quality cotrol testig to esure the sample itegrity ad preservatio. TISSUE TOTAL RNAs AND GENOMIC DNAs A proprietary set of stadard operatig procedures is utilized to extract RNA or DNA from tissues to esure itact total RNA, geomic DNA, free of protei cotamiatio. Paired ormal ad cacer total RNAs ad geomic DNAs from same patiets Over 5,000 searchable tissue RNAs ad geomic DNAs available for immediate delivery Agilet Bioaalyzer 28S/18S ratio, Electropherogram, A260/A280 ratio ad PCR images Abstracted pathology report for each sample TISSUE PROTEIN LYSATES OriGee s Tissue Protei Lysates are obtaied from froze OCT-embedded tissue samples i the Biorepository. Lysates are routiely geerated usig a Modified RIPA buffer (o SDS) i the presece of protease ad phosphatase ihibitors. Protei quatificatio is performed usig the BCA Protei Assay. Paired ormal ad cacer tissue protei lysates from same patiets Qualificatio data provided A PAGE gel image visualized by SYPRO Ruby A Wester Blot image usig a beta-acti moocloal atibody CUSTOMIZED TissueSca cdna, GENOMIC DNA, AND PROTEIN LYSATE ARRAYS OriGee has built a state-of-the-art facility to quickly tur our TissueFocus derivative products ito customized TissueSca cdna, geomic DNA, protei lysate arrays upo request.
7 Tissue Sectios ad Blocks Quality tissues for your research eeds OriGee s high quality tissues are baked uder strict ad rigorous collectio protocols ad are available i either formali-fixed, paraffi embedded (FFPE) or froze, OCT-embedded formats. >140,000 cacer, ormal ad other diseased tissues available for immediate delivery All sectios ad blocks iclude pathology verificatio data, cliical aotatio, abstracted pathology reports ad digital H&E images of the source block Ideal for immuohistochemistry (IHC), i-situ hybridizatio (ISH), laser capture microscopy (LCM) ad RNA/DNA/Protei extractios Cacer Tissue Microarray (TMAs) Quality tissue microarrays for your high-throughput molecular aalysis Tissue microarrays (TMAs) are developed from formali-fixed paraffi-embedded (FFPE) tissue samples selected from the OriGee s tissue biorepository of over >140,000 tissue samples, which represet hudreds of pathology diagoses. Sample cores selected by board-certified pathologists TMA Datasheet/Map icludes H&E images ad detailed pathology reports Fully qualified for IHC aalysis ad suitable for i situ hybridizatio (ISH) aalysis TMA sectios freshly-cut prior to shipmet AVAILABLE TMAs FOR IMMEDIATE DELIVERY Cacer Survey Tissue Microarray: FFPE, 165 x 1 mm cores, 110 tumors ad 55 ormals, Coverig 11 cacer types: Breast, Colo, Lug, Kidey, Ovaria, Edometrial, Stomach, Prostate, Melaoma, Liver, Lymphoma. (5 um sectio x 1 slide) Breast Cacer Tissue Microarray: FFPE, 42 x 1 mm cores, 36 tumors ad 6 ormals. (5 um sectio x 1 slide) Ovaria Cacer Tissue Microarray: FFPE, 48 x 1 mm cores, 41 tumors ad 7 ormals. (5 um sectio x 1 slide)
8 OriGee, Your Parter i Gee Research ad Beyod KEY TECHNOLOGIES AND PRODUCTS Full-legth cdna cloes, ORF cloes i expressio-ready vectors Gee sythesis: ay gee, ay variat, ay vector RNAi research reagets: shrna, sirna, ad mirna fuctio ad detectio SYBR Gree qpcr assays for mrna ad mirna detectio, primer paels Recombiat huma proteis TrueMAB moocloal atibodies Lumiex multiplex immuoassays Cacer tissue biorepository, TMA, RPPA, ad TissueSca qpcr arrays PO Box 520 HA9 7YN, UK Tel: (0) Fax: (0) ifo@isightbio.com Web:
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