ROBERT V. COONEY, PhD

Transcription

1 ROBERT V. COONEY, PhD EDUCATION 1976 WASHINGTON UNIVERSITY - St. Louis, Missouri B.A. in Chemistry 1981 UNIVERSITY OF CALIFORNIA, SAN DIEGO - La Jolla, California Ph.D. in Chemistry PROFESSIONAL APPOINTMENTS 2015-Present PROFESSOR Public Health Sciences, University of Hawaii at Manoa ASSOCIATE PROFESSOR Public Health Sciences, University of Hawaii at Manoa ASSOCIATE DIRECTOR FOR SCIENTIFIC ADMINISTRATION Cancer Research Center of Hawaii ASSOCIATE RESEARCHER University of Hawaii at Manoa Cancer Research Center ASSISTANT RESEARCHER Cancer Research Center of Hawaii POSTDOCTORAL FELLOW UCLA-Harbor Medical Center, Torrance, CA

2 Page 2 COMMUNITY & UNIVERSITY SERVICE Representative, Pearl City Neighborhood Board Chairman, Pearl City Neighborhood Board Coach, Pearl City Pearl City Youth Soccer Organization Elected Representative, UH Manoa Faculty Senate Member, Senate Executive Committee of the Faculty Senate Member, Board of Directors, American Heart Association Member, Cancer Research Center of Hawaii Executive Committee Member, CRCH-Guam U-56 Partnership Internal Advisory Committee Elected Representative, UH Manoa Faculty Senate Member, UH Manoa Faculty Senate Committee on Research Chair, UH Manoa Faculty Senate Committee on Research Member, Board of Directors, University of Hawaii Professional Assembly Treasurer, University of Hawaii Professional Assembly 2011 Chair, American Chemical Society, Hawaii Section Chair, University of Hawaii at Manoa Faculty Senate Co-Chair, All Campus Council of Faculty Senate Chairs Member University of Hawaii, Manoa Chancellor Search Committee Associate Chair, Dept. Public Health Sciences 2012 Present Associate Editor, Nutrition and Cancer Present Elected Representative, UH Manoa Faculty Senate Vice Chair, UH Manoa Faculty Senate Chair, UH Manoa Faculty Senate Co-Chair, All Campus Council of Faculty Senate Chairs 2016 Member University of Hawaii, Manoa Chancellor Search Committee Present Board of Directors, Hawaii Cord Blood Bank 2017 Present Member, Board of Directors, University of Hawaii Professional Assembly PEER REVIEW SERVICE American Cancer Society Institutional Grants American Heart Association Western Region 1995 NIH Colon Cancer Chemoprevention Program Project Cluster Review 2005 NIH Tumor Microenvironment Study Section 2005 NIH Special Emphasis Panel 2006 NIH CDP Special Emphasis Panel 2007

3 Page 3 PEER REVIEW SERVICE, cont. NIH Oncology Translational Clinical Integrated Review Group 2010 OD : Recovery Act Limited Competition: NIH Director's Opportunity for Research in Five Thematic Areas (RC4) Review Section May 2010 Drug Discovery and Molecular Pharmacology (DMP) Study Section Sept 2010 Cancer Epidemiology, Prevention and Population Studies Program Project (P01) Special Emphasis Panel Jan 2011 NIH Chemo/ Dietary Prevention Study Section Nov 2005 Feb 2006 June 2006 Nov 2006 Feb 2007 June 2007 Oct 2007 Feb 2008 June 2008 Oct 2008 Feb 2009 June 2009 Oct 2009 Oct 2010 Oct 2012 June 2014 Feb 2015 CSR review Panel Cancer Drug Development and Therapeutics (CDDT) ZRG1 OTC- Study Section March 2010 July 2010 Nov 2010 Mar 2011 July 2011 Nov 2011 March 2012 July 2012 Nov 2012 March 2013 Peer Reviewer for: July 2013 Nov 2013 March 2014 Nov 2014 Nov 2015 March 2016 June 2016 March 2017 June 2017 Nutrition Research Nutrition & Cancer (Associate Editor) Nutrients J. Medicinal Chemistry J Marine Biotechnology Journal of Nutrition American J. Clinical Nutrition Carcinogenesis Cancer Research PNAS J. Agriculture and Food Chemistry Int J Obesity COURSES TAUGHT Courses Taught Public Health 792E Fall 2011 Public Health 304/340 Fall/Spring 2012-Present Public Health 341 Fall/Spring Public Health 411 Spring Present Public Health 681 Summer Public Health 684 Public Health 789 Fall 2012-Present Spring , Present

4 Page 4 PUBLICATIONS 1. Welgus, H.G., Stricklin, G.P., Eisen, A.Z., Bauer, E.A., Cooney, R.V. and Jeffrey, J.J. (1979) A specific inhibitor of vertebrate collagenase produced by human skin fibroblasts. Journal of Biological Chemistry 254: Cooney, R.V. and Benson, A.A. (1980) Arsenic metabolism in Homarus americanus. Chemosphere 9: Benson, A.A., Cooney, R.V. and Herrera-Lasso, J.M. (1981) Arsenic metabolism in algae and higher plants. Journal of Plant Nutrition. 3: Benson, A.A., Cooney, R.V. and Summons, R.E. (1981) Arsenic metabolism - A way of life in the sea. In: Proc. Int. Arsen and Nickel Symp. III. M. Anke and H.J. Scheider, eds., pp Cooney, R.V., Herrera-Lasso, J.M. and Benson, A.A. (1982) Arsenate detoxication by Dunaliella tertiolecta. In: Biosaline Research, A. San Pietro, ed., pp Cooney, R.V., Nemhauser, J. and Morin, R.J. (1984) Inhibition of human lecithin-cholesterol acyltransferase by monoterpenes. Lipids 19: Cooney, R.V., Ross, P.D. and Bartolini, G.L. (1986) N-nitrosation and N-nitration of morpholine by nitrogen dioxide: Inhibition by ascorbate, glutathione and α-tocopherol. Cancer Letters, 32: Cooney, R.V., Ross, P.D. and Bartolini, G.L. (1986) Artifactual nitrosation in the lung perfusion apparatus. Carcinogenesis 7(5): Cooney, R.V. and Ross, P.D. (1987) N-nitrosation and N-nitration of morpholine by nitrogen dioxide in aqueous solution: effects of vanillin and related phenols. Journal of Agricultural and Food Chemistry 35: Cooney, R.V., Ross, P.D., Bartolini, G.L. and Ramseyer, J. (1987) N-nitrosamine and N-nitramine formation: Factors influencing the aqueous reaction of nitrogen dioxide with morpholine. Environmental Science and Technology 21: Laborde, N.P., Buenaflor, G., Cooney, R., George-Nascimento, C. and Fisher, D.A. (1987) Characterization of human NGF-like material (hngf) from human placenta. American Federation of Clinical Research. 35(1): Cooney, R.V., Ramseyer, J. and Ross, P.D. (1988) Amine nitrosation by sodium nitroprusside. Cancer Letters 40: Boynton, A.L., Cooney, R.V., Hill, T.D., Nilsson, T. Arkhammar, P. and Berggren, P.O. (1989) Extracellular ATP mobilizes intracellular Ca 2+ in, T51B liver epithelial cells, a study involving single cell measurements. Experimental Cell Research 181: Cooney, R.V. and Scott, S.M. (1990) α 2 -Macroglobulin (α 2 -M) binding of NGF in serum: Extraction of NGF from α-m in biological fluids for direct assay. Asia-Pacific Communications in Biochemistry. 15. Bertram, J.S., Pung, A., Churley, M., Kappock, T.J, Wilkens, L.R. and Cooney, R.V. (1991) Diverse carotenoids protect from chemically-induced neoplastic transformation. Carcinogenesis 12: Zhang, L.-X., Cooney, R.V. and Bertram, J.S. (1991) Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: Relationship to their cancer chemopreventive action. Carcinogenesis 12(11): Cooney, R.V., Bertram J.S., Hankin, J.H., Kolonel, L.N., Miyake, A., Billings, K. and Bourne, W. (1991) Relationship between dietary, serum and tissue levels of carotenoids. Cancer Letters 61: Arroyo, P.L., Hatch-Pigott, V., Mower, H.F. and Cooney, R.V. (1992) Mutagenicity of nitric oxide and its inhibition by antioxidants. Mutation Research 281:

5 Page 5 PUBLICATIONS, cont. 20. Le Marchand, L., Wilkens, L.R., Harwood, P. and Cooney, R.V. (1992) Use of breath hydrogen and methane as markers of colonic fermentation in epidemiologic studies: Circadian patterns of excretion. Environmental Health Perspectives 98: Cooney, R.V., Hatch-Pigott, V., Ramseyer, J. and Ross, P.D. (1992) Carcinogenic N-Nitrosamine formation: A requirement for nitric oxide. Journal of Environmental Science and Health A27: Cooney, R.V., Pung, A., Harwood, P.J., Boynton, A.L., Zhang, L.-X., Hossain, M.Z. and Bertram, J.S. (1992) Inhibition of cellular transformation by triphenylmethane: A novel chemopreventive agent. Carcinogenesis 13: Zhang, L.-X., Cooney, R.V., and Bertram, J.S. (1992) Carotenoids up-regulate connexin43 gene expression independent of their pro-vitamin A or antioxidant properties. Cancer Research 52: Cooney, R.V., Kappock, T.J., Pung, A., and Bertram, J. S. (1993) Solubilization, cellular uptake and activity of ß- carotene and other carotenoids as inhibitors of neoplastic transformation in cultured cells. Methods in Enzymology 214: Cooney, R.V., Franke, A.A., Harwood, P.J., Hatch-Pigott, V., Custer, L., and Mordan, L.J. (1993) Gammatocopherol detoxification of nitrogen dioxide: Superiority to alpha-tocopherol. Proceedings of the National Academy of Sciences 90: Franke, A.A., Custer, L.J. and Cooney, R.V. (1993) Quantitation of lipid-phase micronutrients with synthetic carotenoids as internal standards. Journal of Chromatography 614: Mordan, L.J., Burnett, T.S., Zhang, L.-X., Tom, J., and Cooney, R.V. (1993) Inhibitors of endogenous nitric oxide formation block the promotion of neoplastic transformation in C3H 10T1/2 fibroblasts. Carcinogenesis 14: Le Marchand, L., Wilkens, L.R., Harwood, P. and Cooney, R.V. (1993) Breath hydrogen and methane in populations at different risk for colon cancer. International Journal of Cancer 55: Wilkens, L.R., Le Marchand, L., Harwood, P. and Cooney, R.V. (1994) Use of breath hydrogen and methane as markers of colonic fermentation in epidemiologic studies: variability in excretion. Cancer Epidemiology, Biomarkers and Prevention 3: Le Marchand, L., Hankin, J.H., Carter, F.S., Essling, C., Luffey, D., Franke, A.A., Wilkens, L.R., Cooney, R.V., and Kolonel, L.N. (1994) A pilot study on the use of plasma carotenoids and ascorbic acid as markers of compliance to a high fruit and vegetable dietary intervention. Cancer Epidemiology Biomarkers and Prevention 3: Franke, A.A., Harwood, P.J., Shimamoto, T., Lumeng, S., Zhang, L.-X., Bertram, J.S., Wilkens, L.R., Le Marchand, L. and Cooney, R.V. (1994) Effects of micronutrients and antioxidants on lipid peroxidation in human plasma and in cell culture. Cancer Letters 79: Cooney, R.V., Franke, A.A., Mordan, L.J., Harwood, P.J., Hatch-Pigott, V. and Custer, L.J. (1994) Tocopherol inhibition of NO 2 - -mediated nitrosation: The in vitro and biological superiority of γ-tocopherol. In: ACS Symposium Series No Nitrosamines and Related N-Nitroso Compounds. Eds: R.N. Loeppky and C.J. Michejda. ACS, Washington, D.C., pp Cooney, R.V., Harwood, P.J., Custer, L.J. and Franke, A.A. (1994) Light-mediated conversion of nitrogen dioxide to nitric oxide by carotenoids. Environmental Health Perspectives 102: Cooney, R.V., Franke, A.A., Hankin, J.H., Custer, L.J., Wilkens, L.R., Harwood, P.J., and Le Marchand, L. (1995) Seasonal variations in plasma micronutrients and antioxidants. Cancer Epidemiology, Biomarkers and Prevention, 4:

6 Page 6 PUBLICATIONS, cont. 35. Cooney, R.V. and Mordan, L.J. (1995) Cellular nitrogen oxide production: Its role in endogenous mutation and carcinogenesis. In: Oxidative Stress and Aging. Eds.: R.G. Cutler, L. Packer, J. Bertram and A. Mori. Birkhauser Verlag, Basel, pp Kucuk, O., Pung, A., Franke, A.A., Custer, L.J., Wilkens, L.R., Le Marchand, L., Higuchi, C.M., Cooney, R.V., and Hsu, T.C. (1995) Correlations between mutagen sensitivity and plasma nutrient levels of healthy individuals. Cancer Epidemiology, Biomarkers and Prevention, 4: Cooney, R.V., Harwood, P.J., Franke, A.A., Narala, K., Sundström, A.-K., Berggren, P.O., and Mordan, L.J. (1995) Products of γ-tocopherol reaction with NO 2 and their formation in rat insulinoma (RINm5F) cells. Free Radical Biology and Medicine, 19: Le Marchand, L., Sivaraman, L., Franke, A.A., Custer, L.J., Wilkens, L.R., Lau, A.F., and Cooney, R.V. (1996) Predictors of N-acetyltransferase activity: should caffeine phenotyping and NAT2 genotyping be used interchangeably in epidemiological studies? Cancer Epidemiology, Biomarkers and Prevention, 5: Le Marchand, L., Franke, A.A., Custer, L., Wilkens, L.R., and Cooney, R.V. (1997) Lifestyle and nutritional correlates of cytochrome CYP1A2 activity: inverse associations with plasma lutein and alpha-tocopherol. Pharmacogenetics 7: Cooney, R.V., Mordan, L.J., and Franke, A.A. Multiple mechanisms of cancer prevention by phytochemicals: interaction between cellular proliferation and endogenous mutagens. In: Food Factors for Cancer Prevention. H. Ohigashi, T. Osawa, J. Terao, S. Watanabe, and T. Yoshikawa eds., Springer, Tokyo, 1997, pp Cooney, R.V. and Harwood, P.J. Effects of arsenic compounds on proliferation and nitric oxide synthesis in C3H 10T1/2 murine fibroblasts. Applied Organometalic Chemistry, 11: , Loo, S., Lesoon-Wood, L. and Cooney, R.V. Effects of tamoxifen on nitric oxide synthesis and neoplastic transformation in C3H 10T1/2 fibroblasts. Cancer Letters, 122:67-75, Burnett, T.S., Tanaka, Y., Harwood, P.J., and Cooney, R.V. Mechanisms of phytochemical inhibition of carcinogenesis: Elucidating the role of γ-tocopherol in nutrition. In: Functional Foods: Overview and Disease Prevention. T. Shibamoto, ed., ACS Books, Washington, D.C., 1998, pp Franke, A.A., Cooney, R.V., Custer, L.J., Mordan, L.J., and Tanaka, Y. Inhibition of neoplastic transformation and bioavailability of dietary flavonoid agents. In: Flavonoids in the Living System. J.A. Manthey and B.S. Buslig, eds., Plenum Press, New York, 1998, p Kolonel, L.N., Nomura, A.M.Y., and Cooney, R.V. (1999) Dietary fat and prostate cancer: Current status. Journal of the National Cancer Institute, 91: Nerurkar, P.V., Le Marchand, L., and Cooney, R.V. (1999) Effects of marinating with Asian marinades or Western barbecue sauce on PhIP and MeIQx formation in barbecued beef. Nutrition and Cancer, 34: , Maskarinec, G., Chan, C.L.Y., Meng, L., Franke, A.A., and Cooney, R.V. (1999) Effects of high fruit and vegetable diet on plasma carotenoids, total phenols, and a marker of oxidative damage. Cancer Epidemiology Biomarkers & Prevention, 8: Lesoon-Wood, L.A., Pierce, L.M., Lau, A.F., Cooney, R.V. (1999) Enhancement of methylcholanthrene-induced neoplastic transformation in murine C3H 10T1/2 fibroblasts by anti-sense phosphorothioate oligodeoxynucleotide sequences. Cancer Letters, 147: Burnett, T., Pung, A., Bertram and Cooney, R.V. (2000) The role of nitric oxide in neoplastic transformation of C3H 10T1/2 embryonic fibroblasts. Carcinogenesis, 21:

7 Page 7 PUBLICATIONS, cont 50. Sjöholm, A., Berggren, P.-O., Cooney, R.V. (2000) Gamma-tocopherol partially protects insulin-secreting cells against functional inhibition by nitric oxide. BBRC, 277: Cooney, R.V., Custer, L.J., Okinaka, L., Franke, A.A. (2001) Effects of dietary sesame seeds on plasma tocopherol levels. Nutrition and Cancer, 39: Cooney, R.V., Maskarinec, G.M., Franke, A.A., Okinaka, L., Karkoszka, J., Wilkens, L.R., and Frenkel, K. (2001) Association of tocopherols with circulating autoantibody levels against and oxidized DNA nucleoside in humans. Free Radical Biology & Medicine, 31: Williamson, K.S., Gabbita, S.P., Mou, S. West, M., Pye, Q.N., Markesbery, W.R., Cooney, R.V., Gramas, P., Reimann-Philipp, U., Floyd, R.A., and Hensley, K. (2002) The nitration product 5-nitro-γ-tocopherol is increased in the Alzheimer brain. Nitric Oxide, 6: Franke, A.A., Custer, L.J., Cooney, R.V., Tanaka, Y., Xu, M., and Dashwood, R.H. (2002) Inhibition of colonic aberrant crypt foci formation by the dietary flavonoids (+)-catechin and hesperidin. In: Flavonoids in Cell Function. Eds: B. Buslig and J. Manthey. Kluwer Academic/Plenum Publishers, New York. 55. Franke, A.A., Cooney, R.V., Henning, S.M., and Custer, L.J. (2005) Bioavailability and antioxidant effects of orange juice components in humans. Journal of Agricultural and Food Chemistry. 53: Tanaka Y, Lesoon Wood LA. and Cooney RV (2007) Enhancement of intracellular γ-tocopherol levels in cytokinestimulated C3H 10T1/2 fibroblasts: Relation to NO synthesis, isoprostane formation, and tocopherol oxidation. BMC Chemical Biology, 7: Cooney M, Cooney RV. (2007) The ancestry of Nina Eliza Cummings. Aardvark Global Publishing Co., Salt Lake City, UT. 180 pages. 58. Tanaka Y, Cooney, RV. (2007) Chemical and biological properties of tocopherols and their relation to cancer incidence and progression. In: The Encyclopedia of Vitamin E. V.R. Preedy and R.R. Watson, eds. CABI Publishing, UK pp Cooney RV, Franke AA, Wilkens LR, Gill J, Kolonel LN. (2008) Elevated plasma γ-tocopherol and decreased α- tocopherol in men are associated with inflammatory markers and decreased plasma 25-OH vitamin D. Nutrition and Cancer, 60(S1): Maetani M, Maskarinec G, Franke AA, and Cooney RV. (2009) Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women. Nutrition & Cancer, 61(2): Epplein, M, Franke AA, Cooney RV, Morris JS, Wilkens LR, Goodman MT Murphy SP Henderson BE Kolonel LN, LeMarchand L. (2009) Association of plasma micronutrient levels and urinary isoprostane with risk of lung cancer: The Multiethnic Cohort Study. Cancer Epid Biomarkers and Prev, 18: Gill JK, Franke AA, Steven Morris J, Cooney RV, Wilkens LR, Le Marchand L, Goodman MT, Henderson BE, Kolonel LN. (2009) AssHHociation of selenium, tocopherols, carotenoids, retinol, and 15- isoprostane F(2t) in serum or urine with prostate cancer risk: the multiethnic cohorhht. Cancer Causes Control, 20: Epplein M, Shvetsov YB, Wilkens LR, Franke AA, Cooney RV, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT. (2009) Plasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control study. Breast Cancer Research. 11(4):R Maskarinec G, Steude JS, Franke AA, Cooney RV. (2009) Inflammatory markers in a 2-year soy intervention among premenopausal women. Journal of Inflammation, 6:9-16.

8 Page 8 PUBLICATIONS, cont. 65. Maskarinec G, Woolcott C, Steude JS, Franke AA, Cooney RV. (2010) The relation of leptin and adiponectin with breast density among premenopausal women. European Journal of Cancer Prevention 19: Park S-Y, Cooney RV, Wilkens LR, Murphy SP, Henderson BE, Kolonel LN. (2010) Plasma 25-hydroxyvitamin D and prostate cancer risk: The Multiethnic Cohort. European Journal of Cancer 46: Franke AA, Morrison CM, Bakke JL, Custer LJ, Li X, Cooney RV. (2010) Coenzyme Q10 in human blood: native levels and determinants for oxidation during processing and storage. Free Radical Biology & Medicine 48: Chai W, Maskarinec, GM, Franke AA, Cooney RV. (2010) Serum 25-hydroxyvitamin D levels and mammographic density among premenopausal women in a multiethnic population. European Journal of Clinical Nutrition 64, Chai W, Conroy SM, Maskarinec G, Franke AA, Pagano IS, Cooney RV. (2010) Associations between obesity and serum lipid soluble micronutrients among premenopausal women. Nutrition Research 30: Chai W, Cooney RV, Franke AA, Shvetsov YB, Caberto CP, Wilkens LR, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT. (2010) Plasma coenzyme Q10 levels and postmenopausal breast cancer risk: the Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev 19: Conroy SM, Chai W, Lim U, Franke AA, Cooney RV, Maskarinec G. (2011) Leptin, adiponectin, and obesity among Caucasian, Hawaiian, and Asian women. Mediators of Inflammation 2011: Chai W, Cooney RV, Franke AA, Caberto CP, Wilkens LR, Le Marchand L Goodman MT, Henderson BE, Kolonel LN. (2011) Plasma Coenzyme Q10 levels and Prostate Cancer Risk: The Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev, 20(4): Cooney RV, Dai Q, Gao YT, Chow WH, Franke AA, Shu XO, Li H, Ji B, Cai Q, Chai W, Zheng W. (2011) Low plasma coenzyme Q10 levels and breast cancer risk in Chinese women. Cancer Epidemiol Biomarkers Prev 20(6): Chai W, Bostick RM, Franke AA, Ahern TU, Custer LJ, Cooney RV. (2012) Effects of vitamin D 3 and calcium supplementation on serum tocopherols, retinol, and vitamin D metabolites. Nutr Cancer 64(1): Sen C, Morimoto Y, Heak S, Cooney RV, Franke AA, Maskarinec G. (2012) Soy foods and urinary isoprostanes: Results from a randomized study in premenopausal women. Food Funct. 3(5): Cooney RV. (2012) Modern medicine and the road to prevention: a long and tortuous path. Hawaii J Med Public Health 71(2): Ollberding NJ, Maskarinec G, Conroy SM, Morimoto Y, Franke AA, Cooney RV, Wilkens LR, Le Marchand L, Goodman MT, Hernandez BY, Henderson BE, Kolonel LN. (2012) Prediagnostic circulating carotenoid levels and the risk of non-hodgkin lymphoma: the Multiethnic Cohort. Blood 119(24): Lim U, Turner SD, Franke AA, Wilkens LR, Ernst T, Cooney RV, Albright CL, Novotny R, Chang L, Kolonel LN, Murphy SP, Le Marchand L. (2012) Predicting Total, Abdominal, Visceral and Hepatic Adiposity with Circulating Biomarkers. PLOS1 2012;7(8):e Ollberding NJ, Kim Y, Shvetsov YB, Wilkens LR, Franke AA, Cooney RV, Maskarinec G, Hernandez BY, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT. (2013) Prediagnostic adiponectin. leptin, C-reactive protein and the risk of postmenopausal breast cancer: the Multiethnic Cohort Study. Cancer Prev Res 6(3):

9 Page 9 PUBLICATIONS, cont. 80. Conroy SM, Maskarinec G, Morimoto Y, Franke AA, Cooney RV, Wilkens LR, Goodman MT, Hernadez BY, Le Marchand L, Henderson BE, Kolonel LN. (2013) Non-Hodgkin Lymphoma and Circulating Markers of Inflammation and Adiposity in a Nested Case-Control Study: The Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev 2013;22(3): Cooney RV, Chai W, A. A. Franke, Caberto C, Wilkens LR, Kolonel LN, Custer LJ, Morrison CM, Le Marchand L. (2013) Plasma Lipid-soluble Micronutrients, C-Reactive Protein and Survival in Colorectal Cancer Patients. Cancer Epidemiol Biomarkers Prev 22(7): Morimoto Y, Ollberding NJ, Cooney RV, Wilkens LR, Franke AA, Le Marchand L, Goodman MT, Hernandez BY, Kolonel LN, Maskarinec G. (2013) Prediagnostic serum tocopherol levels and the risk of Non-Hodgkin Lymphoma: The Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev 22(11): Chai W, Bostick RM, Franke AA, Cooney, RV. (2014) Effects of Vitamin D and Calcium Supplementation on Blood Pressure and Serum Lipids and Carotenoids: A Randomized, Double-blind, Placebo-controlled, Clinical Trial. Annals of Epidemiology 23: Kim Y, Franke AA, Shvetsov YB, Wilkens LR, Lurie G, Cooney RV, Maskarinec G, Hernandez BY, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT. (2014) Plasma 25-hydroxyvitamin D3 is associated with decreased risk of postmenopausal breast cancer in whites: a nested case-control study in the Multiethnic Cohort Study. BMC Cancer 14: Morimoto Y, Maskarinec G, Conroy SM, Cooney RV, Franke AA, Kim Y, Lim U, Wilkens LR, Hernandez BY, Goodman MT, Henderson BE, Kolonel LN, Le Marchand L. (2014) Ethnic differences in serum adipokine and C- reactive protein levels in relation to body mass index: The Multiethnic Cohort. Int J Obes, 38(11): Halm BF, Lai JF, Morrison CM, Pagano I, Custer LJ, Cooney RV, Franke AA. (2014) In vivo changes in plasma coenzyme Q10, carotenoid, tocopherol, and retinol levels in children after computer tomography. Arch Biochem Biophys 547: Chai W, Novotny R, Maskarinec G, Le Marchand L, Franke AA, Cooney RV. (2014) Serum coenzyme Q 10, α- tocopherol, γ-tocopherol, and C-reactive protein levels and body mass index in adolescent and premenopausal females. J Am Coll Nutr 8: Morimoto Y, Beckford F, Cooney RV, Franke AA, Maskarinec G. (2015) Adherence to cancer prevention recommendations and antioxidant and inflammatory status in premenopausal women. Br J Nutr, 114(1): Halm BM, Franke AA, Lai JF, Li X, Custer LJ, Pagano I, Cooney RV, Turner HC, Brenner DJ. (2015) Pilot study for the establishment of biomarkers for radiation damage after computed tomography in children. Hawaii J Med Public Health, 74(3): Roberson EK, Hurwitz EL, Li D, Cooney RV, Katz AR, Collier AC. (2016) Depression, Anxiety, and Pharmacotherapy Around the Time of Pregnancy in Hawaii. Int J Behav Med, 23(4): Chai W, Morimoto Y, Cooney RV, Franke AA, Wilkens LR, Le Marchand L, Henderson BE, Maskarinec G. (2017) Dietary Red and Processed Meat Intake and Markers of Adiposity and Inflammation: The Multiethnic Cohort Study J Am Coll Nutr, 36(5): Nonomura AM, Holtz B, Biel KY, Cooney R, Lorimer G, Govindjee. (2017) The paths of Andrew A. Benson: a radio-autobiography. Photosynth Res. doi: /s y. [Epub ahead of print]

10 INVITED PRESENTATIONS Curriculum Vitae: Robert V. Cooney, Ph.D. Page Cooney RV, and Ross PD. (1988) Methodologic considerations in the study of nitrogen dioxide chemistry and its effects on health. Presented at the Conference on Advances in the Biology and Chemistry of N-Nitroso and Related Compounds. Omaha, Nebraska, May 19-23, Cooney RV, Franke AA, Harwood P, Custer LJ, Hatch-Pigott V, and Mordan LJ. (1992) Tocopherol inhibition of NO 2 -mediated nitrosation: The in vitro and biological superiority of gamma-tocopherol. 204th Meeting of the American Chem. Soc., Washington, D.C., August Cooney RV. Oxidant Stress and Genotoxicity. American Society of Preventive Oncology Meeting, Tucson, Arizona, March 20-23, Cooney RV. Perspectives on the molecular epidemiology of nitric oxide-mediated carcinogenesis. Fifth Heidelberger Conference. Honolulu, Hawaii, February Cooney RV and Mordan LJ. Oxidative Stress and Aging. Society for Free Radical Research, Asia and Oxygen Society, Kona, Hawaii, March Cooney RV. Southwest Oncology Group Meeting. San Francisco, California, April Cooney RV, Mordan LJ, and Franke AA. Multiple mechanisms of cancer prevention by phytochemicals: Interaction between cellular proliferation and endogenous mutagens. International Conference on Food Factors: Chemistry and Cancer Prevention. Shizuoka, Japan, December 10-15, Cooney RV, Mordan LJ, Franke AA, Burnett TS, and Harwood PJ. Considerations in the clinical use of vitamin E: functional differences in the chemistry and biology of naturally occurring tocopherols International Chemical Congress of Pacific Basin Societies. Honolulu, Hawaii, December 17-22, Cooney RV, Tanaka Y, Burnett TS, Harwood PJ, Lesoon-Wood LA, Mordan L, and Franke A Mechanisms of phytochemical inhibition of carcinogenesis. American Chemical Society Meeting, San Francisco, CA April Cooney RV. Interactions of Coenzyme Q10 and tocopherols: relation with prostate cancer incidence and all-cause mortality. Stony Brook University. Stony Brook, New York. June 18, Cooney RV, Franke AA, Kolonel LN. Lipid-phase micronutrient interactions in the prevention of cancer incidence and mortality. 12 th World Congress in Advances in Oncology & 10 International Symposium on Molecular Medicine. Hersonissos, Crete, Greece October 11-13, Cooney RV. Lipid antioxidants and the prevention of chronic disease and early mortality University of Louisville. Louisville, Kentucky June 10, Cooney RV. Gamma and alpha tocopherols: mediators and markers of human health. International Symposium on Novel Strategies for Targeted Prevention and Treatment of Cancer. Jawaharlal Nehru University, New Delhi, India. December 19-20, Cooney RV. Recent developments in the field of vitamin E research. Stony Brook University. Stony Brook, New York. March 25, Cooney RV. The potential of gamma-tocopherol as a biomarker of mortality risk: associations with its unique chemistry and biology. North Carolina State University October 6, MEETINGS ORGANIZED & SESSIONS CHAIRED Oxidant Stress and Genotoxicity Session. American Society of Preventive Oncology Meeting, Tucson, Arizona, March 20-23, Session on Chemistry & Cancer Prevention at the International Conference on Food Factors for Cancer Prevention. Shizuoka, Japan, December 10-15, Cancer Centers Administrators Forum. Honolulu, Hawaii October 4-6, 2001

11 Page 11 PAST RESEARCH SUPPORT NIH/NCI RO3 CA Interactions of coenzyme Q10 with plasma tocopherols and their role in breast cancer prevention. Description: This grant studies the epidemiology of coenzyme Q10 in the prevention of breast cancer in a multiethnic cohort. Project Period: 09/25/07 08/30/10 NIH/NCI R03 CA Inflammatory Markers in a 2-Year Soy Intervention among Pre-menopausal Women Description: This small grant examines the effects of two daily servings of soy during a 2-year nutritional trial on inflammatory markers in stored serum samples. Principal Investigator, G. Maskarinec; Co-Investigator RV Cooney, responsible for assays of cytokines and interpretation of data. Project Period: 09/01/07-07/31/10 NIH/NCI P30 CA Cancer Center Support Grant Principal Investigator, C Vogel; R Cooney, Co-Investigator (40% FTE) Project Period: 07/01/ /30/2006 NIH/NCI U56 CA University of Guam/Cancer Research Center of Hawaii Partnership Principal Investigator, C Vogel; R Cooney, Co-Investigator (10% FTE) Project Period: 09/01/03 06/30/06 Department of Defense W81XWH Collaborative Cancer Research between Tripler Army Medical Center and the Cancer Research Center of the U. of Hawaii Principal Investigator, C Vogel; R Cooney, Co-Investigator (20% FTE) Project Period: 05/19/06 06/30/06 NIH/NCI P30 CA CURE Supplement Principal Investigator, C Vogel; R Cooney, Co-Investigator (5% FTE) Project Period: 05/19/03 06/30/06 Health Resources & Services Administration 4C76 HF00853 Cancer Research Center of Hawaii Building Grant Principal Investigator, C Vogel; RV Cooney responsible for preparation of initial grant and progress reports. Project Period: 09/01/03 06/30/06 National Institute of Standards & Technology 60 NANB5D1247 Cancer Research Center of Hawaii Planning Grant for new Building Principal Investigator, C Vogel; RV Cooney responsible for preparation of initial grant and progress reports. Project Period: 09/01/05 06/30/06 American Cancer Society Mechanisms of tocopherol inhibition of carcinogenesis Project Period: 07/01/ /30/2000 American Heart Association Nitrate as a marker of nitric oxide-mediated pathology Project Period: 07/01/94 06/30/96 NIH/NCI CA55874 A multidisciplinary study of lung cancer in Hawaiians Principal Investigator, Loic Le Marchand; RV Cooney, Co-Investigator Project Period: 09/01/92 08/01/96

12 Page 12 PAST RESEARCH SUPPORT, cont. NIH/NCI CA59637 Dietary intervention trial among lung & head & neck cancer patients Principal Investigator, Loic Le Marchand; RV Cooney, Co-Investigator Project Period: 01/01/94 12/31/98 NIH/NCI Genetic susceptibility to aromatic amines and colon cancer risks Principal Investigator, Loic Le Marchand; RV Cooney, Co-Investigator Project Period: 05/01/94 04/30/98 American Cancer Society Genetic susceptibility markers for lung cancer among ethnic populations Principal Investigator, Loic Le Marchand; RV Cooney, Co-Investigator Project Period: 01/01/94 12/31/96 NIH/NIEHS ES04302 Analysis of carcinogen formation by inhaled nitrogen dioxide Project Period: 09/01/88 08/31/94 Leahi Foundation Cytokine induction and modulation of nitric oxide synthesis in human lung fibroblasts Principal Investigator L. Mordan, RV Cooney, Co Investigator Project Period: 01/01/94 12/31/94 Robert C. Perry Fund Mode of action for cancer chemoprevention by tamoxifen and related compounds Project Period: 01/01/94 04/25/95 Leahi Foundation The role of γ-tocopherol in preventing nitrosative deamination Project Period: 01/01/93 12/31/93 NIH/NCI RO3 CA Breath markers of colonic fermentation Principal Investigator, L Le Marchand; RV Cooney, Co-Investigator Project Period: 09/30/90 08/31/92 American Cancer Society Institutional Research Grant Principal Investigators B. Issell, C Vogel; RV Cooney was a reviewer & preceptor in early years and responsible for grant administration from 1999 to Project Period: 06/08/92-06/30/2002 Queens Medical Center β-carotene supplementation and its effect on tissue and serum levels of carotenoids. Project Period: 07/01/90 08/31/90 Cancer Research Center of Hawaii Support for Molecular Epidemiology Laboratory Project Period: 10/01/90 06/30/93 American Cancer Society Oxidative damage, neoplastic transformation and carotenoids Principal Investigator, JS Bertram; RV Cooney, Co-Investigator Project Period: 07/01/89 06/30/92