PROVISIONAL PROGRAMME British Toxicology Society Annual Congress

Transcription

1 DAY 1: Sunday 3 rd April 2016 PROVISIONAL PROGRAMME British Toxicology Society Annual Congress Registration desk open for CEP and Congress delegates Lunch available for CEP delegates Continuing Education Programme: An update on carcinogenicity testing: hazard identification and human risk assessment Chair: Introduction overview/scene setter Chemical carcinogenicity: Past, present, future Hazard identification and risk assessment based on epidemiology and animal data, the example of perfluorinated compounds. Dr Tony Fletcher (Public Health England, UK) Mode of Action/Human Relevance Framework for carcinogens Dr Richard Currie (Syngenta, UK) Refreshments Anticipating hazard: Carcinogenicity assessment documents Pharmaceuticals and Biologics Dr Tim MacLachlan (Novartis, UK) Round-up session Congress Programme: Welcome by the BTS President Professor Heather Wallace (University of Aberdeen, UK) Hot Topic Lecture The microbiome in toxicology Dr Muireann Coen (Imperial College, UK) Chair: Professor Tim Gant (Public Health England Centre for Radiation, Chemical and Environmental Hazards, UK) Early Career Oral Communications Chair: Dr Chris Powell (GlaxoSmithKline, UK) late Wine reception and buffet supper Early Career Networking BTS SSC Meeting DAY 2: Monday 4 th April Registration desk opens Plenary Lecture Why are we not using more replacement in vitro models for human risk assessment to disease uncertainties? Professor Martin van den Berg (Utrecht University, Netherlands)

2 Chair: Professor Heather Wallace (University of Aberdeen, UK) Symposium 1: New Frontiers in Predictive Approaches to Safety Assessment (BTS Regulatory Toxicology Speciality Section) Chairs: Dr Henry Stemplewski (MHRA, UK) Professor Andrew Smith (MRC Toxicology Unit, UK) Toxicology predictions: present issues, future challenges Modelling of the toxicity of small molecules as an aid in designing new drugs Professor Hans Westerhoff (University of Manchester, UK) Refreshments Systems biology in toxicology Professor Steve Oliver (University of Cambridge, UK) Application of transgenic models in metabolism and toxicity Dr Colin Henderson (University of Dundee, UK) Lunch and Trade Exhibition MRC Path Meeting for New Trainees for RCPath Symposium 2: New Technologies in Discovery Toxicology: Case Studies in Optimising Drug/Chemical Design (BTS Discovery Toxicology Speciality Section) Chair: Dr Pete Newham (AstraZeneca, UK) and Professor Heather Wallace (University of Aberdeen, UK) Improving toxicity predictions to design safer acidic molecules Dr Nigel Swaine (Pfizer, UK) Applying data from exploratory omics experiments for early safety screening Dr Hinrich Goehlmann (Janssen Pharmaceutical Companies of J&J, Belgium) Refreshments Exploiting the promise of advanced 2D and 3D cell systems for selection of safe and efficacious drugs Professor Magnus Ingelman-Sundberg (Karolinska Institute, Sweden) Combining in vitro and in vivo PK/PD (TK/TD) modelling data to guide patient-centric risk assessments Dr Teresa Collins (AstraZeneca, UK) Symposium 3: Cancer Pathology (British Society of Toxicological Pathology) Chairs: Dr Catherine Ross (Covance Laboratories, UK) Dr Chris Powell (GlaxoSmithKline, UK) The two-year bioassay: pros/cons/provisos Dr John Foster (Independent Consultant, UK) Animal models of cancer Dr Jennifer Morten (Cancer Research, UK) Refreshments Translation of animal carcinogenicity data to humans Dr Chris Powell (GlaxoSmithKline, UK)

3 Genetic diagnosis and treatment of cancer: the answers in our genes Professor Mark Caulfield (Genomics England, UK) BTS AGM onwards Wine reception and networking BTS Speciality Section Networking BTS Executive Meeting DAY 3: Tuesday 5 th April Registration desk opens BTS Ambassadors Symposium 4 Novel Psychoactive Agents and Drugs of Abuse: Where are we now? (Human Toxicology Speciality Section) Chair: Dr John Thompson (Cardiff University, UK) Novel Psychoactive agents Legal highs : what s out there? How do we know? Dr John Thompson (Cardiff University, UK) Legal highs clinical effects Dr David Wood (Guy s and St Thomas NHS Foundation Trust, UK) Severe clinical toxicity caused by unlicenced weight loss agents including dinitrophenol Professor Simon Thomas (Newcastle University, UK) Drugs of abuse: regulatory challenges Dr Paul Griffiths (European Monitoring Centre for Drugs and Drug Addiction, Portugal) Symposium 5 In Vitro Methods for Genotoxicity and Carcinogenicity (In Vitro Toxicology Society): Chairs: De Ray Boughton (Delphic HSE Solutions Ltd, UK) Dr Jonathan Welch (Charles River Preclinical Services, UK) Industry considerations for in vitro modelling of genotoxicity and carcinogenicity Dr Ann Doherty (AstraZeneca, UK) Investigating the potential of nanofibre physico-chemical properties to elicit genotoxicity in vitro Dr Martin Clift (Swansea University, UK) An integrated "in vitro carcinogenicity predictive tool", utilising in vitro cell signalling and cell behaviour assessment coupled with in vitro genotoxicity data Professor Gareth Jenkins (Swansea University, UK) Adverse Outcome Pathways in genotoxicity & carcinogenicity Dr Andrew Scott (Unilever, UK) Lunch and Trade Exhibition Paton Prize Lecture Biochemical mechanisms and biomarkers of toxicity to the kidney: advances over the last 4 years Professor Ted Lock (Liverpool John Moores University, UK) Refreshments Chair: Dr Ernie Harpur (Newcastle University, UK)

4 Study Director/Study Monitor Workshop Chair: Karen Laidlaw (Charles River Laboratories, UK) The new and improved Morris Maze Lisa Burdett (Charles River, UK) JET telemetry on toxicology studies Stuart Purbrik (AstraZeneca, UK) The SD and SM Role, out of the frying pan, into the fire Clare Horne (GWPharm, UK) Oral Communications Chair: Dr Tina Mehta (Dow Agrosciences, UK) Poster session Pre-dinner wine reception The Midland, 16 Peter Street, Manchester late Congress Dinner and presentation of oral and poster prize winners The Midland, 16 Peter Street, Manchester DAY 4: Wednesday 6 th April Registration desk opens Early Career Investigator Prize Lecture: TBD TBD (TBD, UK) Chair: Professor Tim Gant (Public Health England Centre for Radiation, Chemical and Environmental Hazards, UK) Symposium 6 Assessing the Safety of Naturals (BTS Risk Assessment Speciality Section) Chair: Dr Carol Courage (Unilever, UK) What are natural compounds are they all safe? Dr Anne Constable (Nestle, Switzerland) Natural product characterization separating the wheat from the chaff Dr Paul Russell (Unilever, UK) Novel food approach to safety assessment Dr Patrick O Mahony (Food Safety Authority of Ireland, Ireland) History of safe use a Unilever approach to assessing naturals Dr Theresa Neely (Unilever, UK) Symposium 7 Therapeutic Cancer Vaccines (BTS Regulatory Toxicology Speciality Section) Chairs: Dr Henry Stemplewski (MHRA, UK) Professor Paul Baldrick (Covance Laboratories, UK) Therapeutic cancer vaccines: where are we now? Professor Farzin Farzaneh (Kings College London, UK) Regulatory considerations for clinical and non-clinical development of therapeutic cancer vaccines Dr Bridget Heelan (Parexel, UK)

5 Selecting pre-clinical models for cancer immunotherapy Professor Michael Lisanti (University of Manchester, UK) Immuno-oncology: investigating cancer therapies powered by the immune system Professor Hardev Pandha (University of Surrey, UK) Technology Lecture: The application of novel genome engineering techniques in health and disease Dr Hamid Dolatshad (Nuffield Division of Clinical Laboratory Sciences, University of Oxford UK) Chair: Dr Ernie Harpur (Newcastle University, UK) Lunch and End of Congress Continuing Professional Development (self-accredited) Continuing Education Program 3 CPD points (provisional) Main Congress 19 CPD points (provisional) Dates: Abstract deadline 25 th January 2016 BTS Bursary deadline 30 th January 2016 Registration: Registration forms will be available online at As an alternative, please contact the Conference Secretariat (contact details below). Conference Secretariat: Address: British Toxicology Society C/O EBS Davidson Road Lichfield Staffordshire WS14 9DZ Tel: meetings@thebts.org