LUCIAN NEGREANU MD, PhD Professional situation: Head of Department of Internal Medicine II, University Hospital Bucharest Associate Professor in

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1 LUCIAN NEGREANU MD, PhD Professional situation: Head of Department of Internal Medicine II, University Hospital Bucharest Associate Professor in Internal Medicine and Gastroenterology, Internal Medicine II and Gastroenterology Department, University Hospital, Bucharest Research Assistant at the Romanian Academy of Medical Sciences Specialist in Gastroenterology (2010) and in Internal Medicine (2006) Professional address: Internal Medicine II and Gastroenterology Department, University Hospital Bucharest 169, Splaiul Independentei Street, Sector 5, Bucharest, Romania Fax: Phone: Studies: A translational approach in gastroenterology, Habilitation Thesis, Habilitated Professor, Carol Davila University, 2016 Recurrence of esophageal varices following endoscopic treatment and its impact on rebleeding: comparison between sclerotherapy and ligation banding - PhD, Internal Medicine and Gastroenterology Department, University Hospital Bucharest, François Rabelais University, Tours, France (Attestation formation spécialisée en Gastrœntérologie) Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, (MD) Activities and continuous medical education: ASGE advanced endoscopy course 2016 ASGE endoscopy Course 2014 DDW postgraduate courses in gastroenterology 2011, 2013, 2015,2017 AASLD postgraduate course 2016, 2013 WEO/OMED Advanced training in therapeutic endoscopy June 2011, St Laurent du Var, France (with dr. JF REY)

2 ESGE endoscopy grant: Advanced training in Digestive Endoscopy, March-April 2010, St Laurent du Var, France (with dr. JF REY) Training in Endoscopy at the Gastroenterology Department, Trousseau Hospital, Tours, France, March, 2009 Course on the Management of an Endoscopy Unit at the Endoscopy and Gastroenterology Department, Trousseau Hospital, Tours, France, July 2007(with Prof EH METMAN). Postgraduate Diploma in Digestive Endoscopy diagnostic and therapeutic, Bucharest, september 2007 (with Prof DICULESCU and Prof C GHEORGHE) Digestive endoscopy course, Colentina Hospital, may-june 2007(with Prof R VOIOSU) Digestive Endoscopy and Gastroeneterology Internship, Francois Rabelais University, Gastroenterology Department, Trousseau Hospital, Tours, France, November 2005-May 2006 (Prof EH METMAN, Prof E DORVAL) Grant from the French National Society of Gastroenterology (SNFGE), april 2005 Doctoral studies in Gastroenterology at the Gastroenterology Department, Trousseau Hospital, Francois Rabelais University, Tours, France, May-August 2003 (with Prof EH METMAN). Postgraduate training in clinical studies, Barcelona, Spain, October 2004 Diploma in Digestive Endoscopy, Bucharest, Colentina Hospital, may 2002(Prof R VOIOSU) Scientific activity: Papers Books/ book chapters: International 1. Metman EH, Aubourg A, Negreanu L., Barbieux JP. Cap 16 Gestion du risque et qualite. Explorations fonctionnelles digestives in F Zerbib (ed) Troubles digestives fonctionelles, ed Masson Paris 2010 ISBN Metman EH, Negreanu L, Godart B. What are the absolute manometric criteria for diffuse esophageal spasm? pages in R Giulli editor, The foregut. Function. Dysfunction. Ed John Libbey 2009 ISBN :

3 3. Metman EH, Picon L, Negreanu L. Timed barium esophagogram as a predictor of the results after endoscopic therapy in achalasia. pages in R Giulli editor, The foregut. Function. Dysfunction. Ed John Libbey 2009 ISBN : Metman E-H, Debabbi S, Negreanu L. Troubles moteurs de l œsophage, chapter in Encyclopédie medico-chirurgicale 4 th volume, A-10, pages ISSN : , ed Elsevier 2006 National 1. Negreanu L Diculescu M Diareea cronica in Gastroenterologie si hepatologie Clinica 2018, Ed Medicala 2. Negreanu L Dumitrascu D. Bolile functionale esofagiene in Gastroenterologie si hepatologie Clinica 2018, Ed Medicala 3. Negreanu L SingeamAM Videocapsula endoscopica in Gastroenterologie si hepatologie Clinica 2018, Ed Medicala 4. Negreanu L Ioan P Bolile Inflamatorii intestinale in Bolile digestive curs universitar. Ed Universitara Carol Davila Culegere de teste grila pentru rezidentiat 2016 ediția a II-a. Sub coordonarea: Ioanel Sinescu, Mircea Beuran, Adrian Strainu Cercel. Editura Universitara "Carol Davila" ISBN: Capitolul III - Gastroenterologie si Hepatologie. Tudor Elena Silvia, Spulber Geanina, Dan Ionut Gheonea, Lucian Negreanu 6. Mateescu B, Negreanu L, Voiosu T Scoruri si clasificari in endoscopia digestiva editura Editgraph ISBN Negreanu L Concepte actuale si controverse in diagnosticul si terapia hipertensiunii portale Ed Universitara Carol Davila 2014 ISBN: Negreanu L, Calinescu I Nutritia la pacientul neurologic pg in Recomandari Nutritionale in Gastroenterologie si Hepatologie, Ed Pim ISBN Negreanu L Echipamente medicale specifice folosite in gastroenterologie. in Purcarea V Aparatura si dispozitive medicale pg Ed Universitara Carol Davila 2013 ISBN: Negreanu L Tripla terapie in VHC-dileme etice si constrangeri economice pg in Grigorescu M(ed) Actualitati in diagnosticul si tratamentul hepatitelor virale.ed Universitara Iuliu Hatieganu 2012 ISBN

4 11. Negreanu L Diagnosticul, profilaxia si tratamentul varicelor esofagiene.pg , in Badescu T(ed) Tehnici moderne de investigatie si prspective terapeutice in bolile digestive. Ed Medicala 2011 ISBN Dan Andronescu, Carmen Fierbinţeanu Braticevici, Corina Pop, Sorina Diaconu, Lucian Negreanu, Monica Purcărea Actualizări în gastroenterologie: note de curs Editura Universitară Carol Davila 2010 ISBN: Dictionary of Medical Immunology, Ed. Carol Davila, prize of Romanian Academy; prize of the National Physician s College. ISI publications: 1. Goran L, Negreanu AM, Stemate A, Negreanu L.Capsule endoscopy: Current status and role in Crohn's disease. World J Gastrointest Endosc Sep 16;10(9): Preda CM, Popescu CP, Baicus C, Constantinescu I, Oproiu A, Voiosu T, Diculescu M, Negreanu L, Gheorghe L, Sporea I, Trifan A, Ceausu E, Proca D, Manuc M. Risk of hepatitis B virus reactivation in hepatitis B virus + hepatitis C virus-co-infected patients with compensated liver cirrhosis treated with ombitasvir, paritaprevir/r + dasabuvir + ribavirin. J Viral Hepat Jul;25(7): Goran L, Negreanu L, Negreanu AM Role of new endoscopic techniques in inflammatory bowel disease management: Has the change come? World J Gastroenterol Jun 28;23(24): doi: /wjg.v23.i Yung DE, Rondonotti E,Giannakou A, AvniT, Rosa B,Toth E, Lucendo AJ,Sidhu R, Beaumont H, Ellul P, Negreanu L, Jiménez-Garcia VA,McNamara D, Kopylov U, Elli L, Triantafyllou K, Shibli F, Riccioni ME, Bruno M, Dray X, Plevris JN, A Koulaouzidis, Capsule endoscopy in young patients with iron deficiency anaemia and negative bidirectional gastrointestinal endoscopy. UEG Journal DOI: / First Published February 1, Preda CM, Fulger LE, Negreanu L, Manuc M, Sandra I, Diculescu MM.Adalimumab versus infliximab in treating post-operative recurrence of Crohn's disease: a national cohort study. Rev Esp Enferm Dig Oct;108(10):64 6. Preda CM, Fulger LE, Gheorghe C, Gheorghe L, Manuc M, Negreanu L, Meianu C, Slavulete BI, Diculescu MM. Tuberculin skin test and Quantiferon TB Gold in Romanian BCG vaccinated, immunosuppressed patients with moderate-to-severe Crohn's disease: a

5 comparison with a Hungarian cohort. J Gastrointestin Liver Dis Jun;25(2): Nechita AM, Pituru S, Radulescu D, Peride I, Negreanu L, Niculae A Ferechide D, Checherita IA, Sinescu R. INFLUENCE OF RESIDUAL DIURESIS ON CARDIAC BIOMARKER NTproBNP IN CHRONIC HEMODIALYSIS PATIENTS. Farmacia 2016;3: Filimon AM, Negreanu L, Doca M, Ciobanu A, Preda CM, Vinereanu D. Cardiovascular involvement in inflammatory bowel disease: Dangerous liaisons World J Gastroenterol (33): ISI 2, Gheorghe C, Seicean A, Saftoiu A, Tantau M, Dumitru E, Jinga M, Negreanu L, Mateescu B, Gheorghe L, Ciocirlan M, Cijevschi C, Constantinescu G, Dima S, Diculescu M. Romanian guidelines on the diagnosis and treatment of exocrine pancreatic insufficiency. J Gastrointestin Liver Dis Mar;24(1): doi: /jgld app. ISI IF 2,202 Influence score: Nica S, Grecescu L, Negreanu L. Non Adherence to the current guidelines in acute pancreatitis: a single center experience on early computed tomography (CT) use. Bothalia Journal 2014; Nov-Dec 44(12) ISSN ISI IF 1,267, influence score 0, Preda CM, Baicus C, Negreanu L, Tugui L, Olariu SV, Andrei A, Zambatu I, Diculescu MM. Effectiveness of entecavir treatment and predictive factors for virologic response. Rev Esp Enferm Dig 2014;106: ISI IF 1, Negreanu L, Bataga S, Cijevschi Prelipcean C, Dobru D, Diculescu M, Dumitru E, Gheonea DI, Gheorghe L, Gheorghe C, Goldis A, Mateescu BR, Tantau M, Trifan A. Excellence centers in inflammatory bowel disease in Romania: a measure of the quality of care. J Gastrointestin Liver Dis Sep;23(3): doi: /jgld ln1. ISI IF 2,202 Influence score: Negreanu L, Smarandache G, Mateescu RB. Role of capsule endoscopy Pillcam COLON 2 in patients with known or suspected Crohn's disease who refused colonoscopy or underwent incomplete colonoscopic exam: a case series. Tech Coloproctol Mar;18(3): doi: /s Epub 2013 Aug 21. ISI IF 2, Hulpuş R, Constantinoiu S, Bratu D, Dumitra A, Sabău A, Sabău D, Ursache E, Negreanu L, Smarandache C. Superior socio-medical alternative to feeding gastrostomy

6 and jejunostomy in advanced esophago-gastric junction adenocarcinoma. Chirurgia (Bucur). 2013;108(4):451-5 ISI IF 0, Fierbinteanu-Braticevici C, Negreanu L, Tarantino G. Is fatty liver always benign and should not consequently be treated? J Physiol Pharmacol. 2013;64(1):3-9. ISI IF 2, Negreanu L, Poepscu BO, Ene A, Bajenaru AO. Duodopa infusion in Parkinson's disease.experience of a single center. J Gastrointestin Liver Dis Sep;20(3): ISI IF 2, Dumitra A, Sabău A, Maniu D, Grosu F, Smarandache G, Ursache E, Negreanu L, Sava M, Sabău D. Particular aspects of endoprosthesis in malignant advanced pharingealesophageal stenosis Chirurgia (Bucur). 2011;106(3): , ISI IF 0,7 pubmed listed 18. Fierbinteanu-Braticevici C, Dina I, Petrisor A, Tribus L, Negreanu L, Carstoiu C Noninvasive investigations for non alcoholic fatty liver disease and liver fibrosis.world J Gastroenterol Oct 14;16(38): ISI 2, Negreanu LM, Assor P, Mateescu B, Cirstoiu C. Interstitial cells of Cajal in the gut - A gastroenterologist's point of view.world J Gastroenterol Nov 7;14(41): ISSN CN /R ISI, IF Negreanu L, Baty G, Dubois F, de Muret A, Bacq Y. Hepatitis B virus reactivation after a resolutive acute hepatitis leading to a diagnosis of T cell lymphoma.dig Liver Dis Sep 24. [Epub ahead of print], ISSN: , ISI IF 2.577, Elsevier-Saunders influence factor Assor P, Negreanu L, Picon L, de Muret A, Gilbert B, Metman E-H. Pandysautonomie aiguë lentement régressive associée à une achalasie du sphincter inférieur de l oesophage: à propos d un cas, Gastrœntérologie clinique et biologique 2008;32:46-50, Elsevier Masson, ISSN , ISI quoted, IF 1,033 influence factor Negreanu L, Assor P, Bumsel F, Metman E-H. An endoscopic view in gastric linitis-a case report. J Gastrointestin Liver Dis.2007;16(2): ISI IF 1,81 pubmed listed 23. Fierbinteanu-Braticevici C, Dragomir P, Tribus L, Negreanu L, Bengus A, Usvat R, Andronescu D. The role of Valsartan, an Angiotensin II receptor antagonist, on portal and systemic hemodynamics and on renal function in liver cirrhosis. J Gastrointestin Liver Dis Dec;15: ISI quoted, pubmed listed

7 24. Negreanu L, Assor P, Bumsel F, Metman E-H. Infectious gastritis caused by a mixed fungal and bacterial infection, Endoscopy, 2006; 38: E91-E92, Springer Verlag ISI impact factor 6.091, ISSN X influence factor Metman E-H, Negreanu L, Godart B. Troubles moteurs primitifs de l œsophage (en dehors de l achalasie), Acta Endoscopica,2006;36: Springer Verlag,ISI IF0.0741, ISSN X 26. Metman E-H, Negreanu L, Debbabi S. Traitement de l achalasie de l oesophage, Acta Endoscopica 2006; 36: , Springer Verlag, ISI IF , ISSN X 27. Metman E-H, Negreanu L, Debbabi S. Treatment of esophageal achalasia, Acta Endoscopica 2006; 36: , Springer Verlag, ISI IF , ISSN X 28. Metman E-H, Negreanu L, Godart B. Primary esophageal motility disorders (excluding achalasia), Acta Endoscopica,2006;36: Springer Verlag,ISI IF , ISSN X CNCSIS or pubmed/ other datbases listed: 1. Negreanu L, Filimon A,.Stemate A, Voiosu T, Mateescu B. The Role of Capsule Endoscopy in Obscure GI Bleeding: Experience of a Tertiary Center in Romania. Modern Medicine 2016; 23(2): Rimbaş M, Negreanu L, Ciobanu L, Benguş A, Spada C, Băicuş CR, Costamagna G.Is virtual chromoendoscopy useful in the evaluation of subtle ulcerative small-bowel lesions detected by video capsule endoscopy? Endosc Int Open Dec;3(6):E Negreanu L Preda C, Ionescu D, Ferechide D. Progress in digestive endoscopy: Flexible Spectral Imaging Colour Enhancement (FICE)-technical review accepted in J Med Life Oct-Dec 4. Stemate A, Filimon AM, Tomescu M, Negreanu L.Colon capsule endoscopy leading to gastrointestinal stromal tumor (GIST) diagnosis after colonoscopy failure. BMC Res Notes. 2015;12;8: Voiosu T, Busuioc B, Voiosu A, Benguş A, Rimbaş M, Dinu R, Mateescu B, Negreanu L.Factors Influencing Complication Rates at Colonic Polypectomy: A Prospective Study from a Tertiary-Referral Center. Rom J Intern Med Jan-Mar;53(1):50-3. CNCSIS B+, Pubmed listed 6. Lupușoru MO, Burcea CC, Văcăroiu IA, Pițuru S, Peride I, Brezean I, Negreanu L,Niculae A,Georgescu L, Lupusoru GE, Ionescu T,Ferechide D. The Rehabilitation of Elderly Institutionalized Patients with Osteoarthritis (Multiple Joint Involvement) Using Alternative Methods Associated to Drug Therapy. Modern Medicine. 2015;22(4) : Burcea C C, Lupușoru MO, Negreanu L, Văcăroiu IA, Pițuru S, Niculae A, Brezean I, Ileana Peride I,Georgescu L,Lupușoru GE,Ferechide D. Identification of Osteoarthritis with Multiple Joint Involvement

8 in Elderly Institutionalized Patients Concomitant with Psycho-Kinesiotherapeutic Intervention Strategies - A Preliminary Study. Modern Medicine. 2015;22 (4 ): Buşegeanu C, Negreanu L, Fierbinţeanu Braticevici C. Modificări Hepatice În Sarcina Normală. Medicina Interna 2014 ;IX(5):51-57 CNCSIS B+ 9. Busegeanu C, Filimon A, Stemate A, Negreanu L. A series of images of digestive cancers using Pill Cam COLON2 video capsule endoscopy. J Med Life Oct-Dec;7(4): Negreanu L, Babiuc R, Bengus A, Sadagurschi R. PillCam Colon 2 capsule in patients unable or unwilling to undergo colonoscopy. World J Gastrointest Endosc Nov 16;5(11): Pubmed listed 11. Babiuc R, Purcarea M, Sadagurschi R, Negreanu L, Nastasescu T. Role of colon capsule Pillcam 2 in obscure gastrointestinal bleeding - case report. J Med Life Sep 15;6(3): Epub 2013 Sep 25. CNCSIS B+ Pubmed listed 12. Babiuc R, Purcarea M, Sadagurschi R, Negreanu L. Use of Hemospray in the treatment of patients with acute UGIB - short review. J Med Life. 2013; 15;6(2): Epub 2013 Jun 25. CNCSIS B+ 13. Mateescu BR, Bengus A, Marinescu M, Staniceanu F, Micu G, Negreanu L. First Pillcam Colon 2 capsule images of Whipple's disease: Case report and review of the literature. World J Gastrointest Endosc :16;4(12): ISI pubmed listed 14. Negreanu LM, Popescu BO, Babiuc RD, Ene A, Andronescu D, Băjenaru OA Cutting the Gordian knot: the blockage of the jejunal tube, a rare complication of Duodopa infusion treatment.j Med Life Apr- Jun;3(2):191-2 CNCSIS B+ 15. Negreanu L, Tribus L, Purcarea M, Fierbinteanu Braticevici C.Spontaneous esophageal mucosal dissection in a patient with upper digestive bleeding and esophageal varices. J Med Life May 15;4(2): Epub 2011 May 25.. CNCSIS B+ 16. Negreanu L, Popescu BO.Evaluation of successful treatment in achalasia with timed barium esophagogram: revisiting an old friend.j Med Life Jan-Mar;3(1):64-6. CNCSIS B+ 17. Negreanu L, Busegeanu C et al. Portal hypertensive gastropathy. Romanian Journal of Internal Medicine 2005; 43 :3-8. CNCSIS B, Pubmed listed Abstracts ISI/ISBN 1. Negreanu L, Ionescu D Impact of flexible spectral imaging color enhancement in minimal esophagitis J Gastrointestin Liver Dis. 2015;24(1):21 2. Nica S, Grecescu L, Negreanu L. Non adherence to the current guidlines in acute pancreatitis : a single center experience on early CT use J Gastrointestin Liver Dis. 2015;24(1):34 3. Filimon AM, Stemate A, Doca M, Negreanu L Dangerous liaisons: the cardiovascular involvement in IBD. J Gastrointestin Liver Dis. 2015;24(1):50 4. M Rimbas, L Negreanu, L Ciobanu, A Bengus, C Spada, CR Băicus,Mo1591 Usefulness of Flexible Spectral Imaging Color Enhancement (FICE) in the Evaluation of Subtle Small Bowel Ulcerative Mucosal Lesions Detected by Videocapsule Endoscopy. Gastrointestinal Endoscopy 2015;81 (5), AB C Preda, L Fulger, C Tieranu, M Ionescu, L Gheorghe, C Gheorghe, M Manuc, A Goldis, G Constantinescu, M Tantau, L Negreanu, B Mateescu, A Trifan, S Bataga, R Iacob, M DiculescuEfficacy, safety and predictors of response to Adalimumab in Crohn's disease (CD)-a nation-wide cohort study.journal Of Crohns & Colitis , S126-S127

9 6. M. Rimbas, L. Negreanu, L. Ciobanu, C. Spada, A. Bengus, C.R. Baicus, G. Costamagna P0793 Usefulness Of Flexible Spectral Imaging Color Enhancement (Fice) In Difficult To Interpret Mucosal Ulcerative Lesions Of The Small Bowel,UEGW UEG journal;2014:2s1 A349 ISSN Negreanu L; Filimon A; MateescuB Capsule Endoscopy For Obscure Gastrointestinal Bleeding- Experience Of A Tertiary Centre. Semana Panamericana de las Enfermedades Digestivas Iacob R, Guinea L, Vadan R, Greere M, Preda C, Dobru D, Cijevschi Prelipcean C, Tantau A, Goldis A, Ilie M, Andrei M, Negreanu L, Gheorghe C, Diculescu M, Gheorghe Extraintestinal manifestations in Romanian IBD patients evaluation of a cohort of over 1000 patients Journal of Crohn's and Colitis 8, S331, RB Mateescu, R Vadan, L Negreanu, A Bengus Opportunistic infections in anti-tnf treated IBD patients: analysis from three tertiary centers in Romania Journal of Crohn's and Colitis, 8, S331, Negreanu L, Filimon A, Ionescu D Low volume same day preparation for same day colonoscopy J Gastrointestin Liver Dis. 2014;23(1): Iacob R, Guinea L, Vadan R, Greere M, Preda C, Dobru D, Cijevschi Prelipcean C, Tantau A, Goldis A, Ilie M, Andrei M, Negreanu L, Gheorghe C, Diculescu M, Gheorghe L Extraintestinal manifestations in Romanian IBD patients-evaluation of a cohort of over 1000 patients.. J Gastrointestin Liver Dis. 2014;23(1): Negreanu L, Stemate A, Filimon A, Dragomir C, Fierbinteanu C, Utility of Bifidoplus in constipation subtype IBS patients. J Gastrointestin Liver Dis. 2014;23(1): Negreanu L, Stemate A, Postelnicu I, Filimon A, Fierbinteanu C,The role of FICE in characterisation of small bowel lesions by capsule endoscopy. J Gastrointestin Liver Dis. 2014;23(1): Fierbinteanu C, Petrisor A, Negreanu L, Tribus L, Moldoveanu A, Oprea G, Usvat R, Munteanu L,Scrieciu E, Sarbu E Non invasive methods to predict portal hypertension in cirrhotic patients. J Gastrointestin Liver Dis. 2014;23(1): Fierbinteanu C Hodina C, Petrisor A, Moldoveanu A, Purcareanu A, Negreanu L, Necula A. The role of non invasive methods for risk stratification of patients with NAFALD. J Gastrointestin Liver Dis. 2014;23(1):4 16. Rimbas M, NegreanuL, Ciobanu L, Baicus C. Performance of two different reviewers using virtual chromoendoscopy settings in difficult to interpret VCE mucosal ulcerative lesions of the small bowel.j Gastrointestin Liver Dis. 2014;23(1): Negreanu L Tulburarile de coagulare din ciroza. Medicina Interna, 2014, vol IX : Negreanu L, Mateescu B Role of capsule endoscopy pillcam 2 in patiets with known or suspected Crohn s disease:a case series J Gastrointestin Liver Dis. 2013;22(1): Negreanu L, Babiuc R, Bengus A, Sadagurschi R A new regimen of bowel preparation for pillcam colon 2 capsule endoscopy J Gastrointestin Liver Dis. 2013;22(1): Mateescu BR, Schipor A, Marinescu M, Bengus A, Negreanu L Immunosupresive drugs in IBD:experience of a tertiary center J Gastrointestin Liver Dis. 2013;22(1): Negreanu L, Sztogrin W, Babiuc R Short timed Remicade infusions. J Gastrointestin Liver Dis. 2013;22(1): Negreanu L, Calinescu I, Bengus A, Use of pillcam colon 2 in patients unable, unwilling or with incomplete colonoscopy. Journal of Gastroenterology and Hepatology 2012:Vol 27, S5: P Negreanu L, Calinescu I, Bengus A, Sadagurschi R,. Babiuc R. Second-generation colon capsule endoscopy for colorectal cancer screening in patients unable or unwilling to perform colonoscopy Endoscopy 2012; 44 (S1) A Negreanu L,Babiuc R, Tribus L, Pop C, Andronescu D Endoscopic band ligation-experience of a single center in J Gastrointestin Liver Dis. 2012;21(2): Bucurica S, Negreanu L, Dragomir P, Mateescu B. Utility of laser confocal endomicroscopy in clinical practice. J Gastrointestin Liver Dis. 2012;21(2): Negreanu L, Stoica L,Sadagurschi R, Babiuc R. Study of minimal change esophagitis using FICE. J Gastrointestin Liver Dis. 2012;21(2): Negreanu L, Sadagurschi R, Babiuc R, Bengus A The role of capsule enscopy in CCR risk patients unable or unwilling to perform colonoscopy J Gastrointestin Liver Dis. 2012;21(2):202

10 28. Negreanu L, Filimon A, Bengus A, Busegeanu C.Andronescu D. Tratamentul ectaziilor vasculare antrale(eva) prin coagulare cu plasma de argon (CPA)-reevaluare dupa trei ani de terapie. J Gastrointestin Liver Dis. 2008;17(1) 29. Negreanu L, Filimon Ana, Smarandache CG, Bengus Andreea, Busegeanu C, Andronescu D Aplicabilitatea scorului Rockall la pacientii cu hemoragie digestiva superioara J Gastrointestin Liver Dis. 2008;17(1) 30. D. Sabau, D. Bratu, M. Antonescu, A. Dumitra M. Sava, A. Sabau, C. Smarandache, L.Negreanu. Minimally invasive original technique of palliation in inoperable esophageal and esophagogastric neoplasms. OESO proceedings Monaco Smarandache GC, Negreanu L, Ana Stemate, Pantu BS. Afectarea pancreatica in soc. J Gastrointestin Liver Dis. 2007;16(1): Negreanu L, Busegeanu C, Cojocaru A, Andronescu D. Tratamentul ectaziilor vasculare antrale(eva) prin coagulare cu plasma de argon (CPA) J Gastrointestin Liver Dis. 2007;16(1): Negreanu L, Busegeanu C, Cojocaru A, Andronescu D.Riscul degenerativ al polipilor colonici de mici dimensiuni. J Gastrointestin Liver Dis. 2007;16(1): Negreanu L, Ana Stemate, Ana Filimon, Andreea Bengus, Andronescu D.Tratamentul peritonitei bacteriene spontane: comparatie intre ceftriaxona si amoxicilina-clavulanat. J Gastrointestin Liver Dis. 2007;16(1): Fierbinteanu-Braticevici CG, Negreanu L, Bengus A, Usvat R, Andronescu D. Ultrasound evaluation in diagnosis and follow-up of acute colonic diverticulitis. Neurogastroenterologia; 2006: 12(1):p Fierbinteanu-Braticevici C.G., Tribus L, Negreanu L., Bengus A., Usvat R., Andronescu D. The hemodynamic role of albumin in type II hepatorenal syndrome. Gastroenterology 2006:130:4 supl 2 M Fierbinteanu-Braticevici C.G., Negreanu L., Bengus A., Usvat R., Andronescu D. The hemodynamic impairment in cirrhotic patients with spontaneous bacterial peritonitis Gut 2005; 54 (Suppl VII) A197 cotata ISI, ISSN Fierbinteanu C, Dragomir P,Negreanu L, Tribus L, Udeanu M, Usvat R, Cardiac abnormalities in patients with cirrhosis C. Rom J of Gastroenterology 2005:14(1): Negreanu L, Dragomir P, Busegeanu C, Fierbinteanu C, Andronescu D Reccurence of esophageal varices following endoscopic treatment and its impact on rebleeding :comparison of sclerotherapy and ligation Rom J of Gastroenterology 2005:14(1): Fierbinteanu C, Negreanu L, Bengus A, Andronescu D Predictive factors of steatosis in chronic hepatitis C. Rom J of gastroenterology 2005:14(1): Andronescu D, Fierbinteanu C, Dragomir P Negreanu L Nonalcoholic steatohepatitis Rom J of Gastroenterology 2004:13(1): Fierbinteanu C, Tribus L, Negreanu L, Dragomir P, Andronescu D The effects of carvedilol a non selective beta blocker on portal hemoynamics. Rom J of Gastroenterology 2004:13(1): Andreea Bengus, RB Mateescu, LNegreanu, Roxana Dinu, B Busuioc, Roxana Vadan, Liana Gheorghe Infections in anti TNF treated IBD patients: analysis from three tertiary centers in Romania 44. Dinu R, Voiosu T, Negreanu L., Bengus A, Mateescu B The short inflammatory bowel disease Questionnaire (SIBDQ) is a good predictor of mucosal healing in patients with ulcerative colitis and Crohn s diseas 45. Negreanu L Stemate A, Filimon A, Mateescu B Role Of Capsule endoscopy Pillcam COLON 2 in patients with known or suspected Crohn s disease: a case serie 46. Negreanu L, Filimon A, Stemate A, Calinescu I, Babiuc R,Sztogrin W Terapia biologica cu Remicade (Infliximab) in perfuzie rapida graba nu strica treaba 47. Negreanu L, Filimon A, Postelnicu I, Stemate A, Calinescu I Diagnosis Of Crohn s disease using capsule endoscopy for obscure gastrointestinal bleeding Others 1. Negreanu L, Andronescu D. Tulburarile de motilitate esofagiana cu exceptia acalaziei. Noutatea Medicala 2008;16(2):67-70 issn

11 Other activities 2. Andronescu D, Dragomir P, Fierbinteanu-Braticevici CG, Negreanu L. Tratamentul actual al hepatitei cronice virale C Noutatea medicala 2005; 3: Fierbinteanu- Braticevici CG, Dragomir A, Dragomir P, Negreanu L, Andronescu D. Fiziopatologia si tratamentul actual al sindromului de detresã respiratorie acutã Noutatea medicala 2005 ; 3 : Andronescu D, Dragomir P, Negreanu L, Fierbinteanu- Braticevici CG. Sphincter of Oddi dyfunction. Noutatea medicala 2005; 4: Dragomir P, Negreanu L, Fierbinteanu- Braticevici CG, Andronescu D. Acute pancreatitis. Diagnosis and treatment. Noutatea medicala 2004;3: Negreanu L, Andronescu D, Particular aspects of the chronic hepatitis C treatment, Noutatea medicala, 3/ Mateescu BR, Negreanu L et al. Asthma: classification and treatment. Noutatea Medicala 2002;2:40-42 member of editorial committees for national and international journals World Journal Of Gastroenterology and World Journal Of Gastrointestinal Endoscopy Reviewer: World Journal Of Gastroenterology, World Journal Of Gastrointestinal Endoscopy, Digestion, Endoscopy, Endoscopy International Open, Journal of Cellular and Molecular Medicine, Maedica Member of the Romanian society of endoscopy Member of the board of Romanian Society of Gastroenterology Member of the board of Romanian Crohn Colitis organization RCCC Member of the French National Society of Gastroenterology (SNFGE) Member of European Society of Gastrointestinal Endoscopy (ESGE) Member of American Gastroenterology Association (AGA) Member of European Crohn and Colitis Organisation (ECCO) Member of European pancreatology Association EPA Grants: Director: Director, young researcher s grant: Endothelial dysfunction in IBD patients, UMF Carol Davila European Society of Gastroenterological Endoscopy ESGE-Given European Research Grant, Screening of high risk colorectal cancer patients unable or unwilling to take a colonoscopy using Pillcam2 videocapsule 3. The new SB3 capsule-a feasability study, PI Member in research group:

12 2014- Implementarea unei solutii pilot de teledermatologie ca instrument suport pentru activitatea medicala si de cercetare, granta national oferit de SRD, valoare 4000 euro, membru in echipa de cercetare Program structural european POSDRU: "Tehnici de histologie in vivo"', expert Corelarea manifestarilor clinice, paraclinice si morfologice cu manifestarile genomice in cancerul epitelial scuamos de esofag, PNCDI, Program 4, parteneriate in domeniile prioritare, member : Expresia si functia proteinelor jonctiunilor strânse studiu în modele experimentale si la pacientii cu dementa. Grant PNCD II, member Clinical studies, Principal Investigator>30 studies mostly in IBD