Biological Activities for Extracts of Mullaca (Physalis angulata)
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1 Biological Activities for Extracts of Mullaca (Physalis angulata) IN VIVO RESEARCH Antitumor ETOH(95%)Ext IP Mouse 75 mg/kg Leukemia -P388 K07329 Leaf Not Stated Antitumor Fraction: Physalin F IP Mice Not stated P388 lymphocytic leukemia. AC1009 Part Not Stated China Cytotoxic Fraction: IP Rat Not stated In 9L rat brain tumor cells inhibited Topoisomerase II AC1011 Leaf USA Cytotoxic Cat IC50=3.93 mcg/ml Cancer cells: CA-A549 H28598 Root Not Stated Antileukemic Fraction: Physalin B Mouse Not stated Weak 3PS murine leukemia AC1016 Protein Synthesis inhibition ETOH(95%)Ext IP Mouse 20 mg/kg Leukemia -P388 K07329 Entire Plant USSR Immunomodulatory Not stated IP Mouse 50 mg/kg Blastogenic transformation of human lymphocytes was assayed. M30421 Entire Plant USSR Blastogenesis Inhibition Not stated IP Mouse 50 mg/kg M30421 Entire Plant Samoa CNS Effects(general) Not stated Gastric Mouse IP Mouse 1 gm/kg 1 gm/kg Hippocratic Screen Hippocratic Screen J11102 Entire Plant Samoa Spasmolytic Not stated Guinea Pig Illeum 2 mg/ml vs. electrical stimulation. J11102 Fruit Brazil Contracting Effect (non-specific) Rat Not stated Blocked by gallamine or atropine. Fruit Brazil Contracting Effect (non-specific) Toad Not stated Isotonic contraction of isolated rectus abdominis. Fruit Brazil Contracting Effect (non-specific) Toad (Heart) Not stated Blocked by gallamine or atropine
2 Fruit Brazil Hypotensive Cat Not stated Blocked by gallamine or atropine Not Stated Brazil Colony-stimulating factor production stimulation Infusion IP Mouse 0.5 ml/animal Equivocal vs. lps-induced proliferation L07194 Entire Plant Surinam Binding Effect ETOH(80%)Ext Human Adult Inhibited radioligand binding to adrengeric-receptor in human frontal cortex. Entire Plant Surinam Binding Effect ETOH(80%)Ext Human Adult Inhibited radioligand binding to serotonin receptor in human frontal cortex. Entire Plant Surinam Binding Effect ETOH(80%)Ext Human Adult Inhibited radioligand binding to dopamine receptor in human frontal cortex. Entire Plant Surinam Binding Effect ETOH(80%)Ext Human Adult Inhibited radioligand binding to muscarinic receptor in human hippocampus tissues. Entire plant Surinam Binding Effect ETOH(80%)Ext Human Adult Inhibited radioligand binding to adenosine nmdr receptor channel complex. Entire plant Surinam Binding Effect ETOH(80%)Ext Human Adult Inhibited radioligand binding to beta-2-adrenergic receptor. Entire plant Surinam Serotonin (5-ht) receptor binding activity Calf 100mcg/ml Weak Hippocampus J0986 Root Not Stated Antihyperglycemic Intragastric Mouse Not stated Weak J17961
3 IN VITRO RESEARCH Not Stated Brazil Mitogenic Infusion Not stated Mouse splenocytes L07194 Cytotoxic ETOH(95%)Ext 10.0 mg/ml 100 mcg/ml 100 mcg/ml Equivocal Equivocal CA-9KB CA-HUMAN-COLON CA-HUMAN-LUNG LU-1 HELA CELLS HEPATOMA-2 HEPATOMA-HA22T GLIOMA-8401 MELANOMA-H1477 K07329 Leaf USA Cytotoxic IC50=2.5 mcg/ml Leukemia cells: LEUK-P388 H28598 Leaf USA Cytotoxic IC50=3.15 mcg/ml Cancer cells: CA-KB-16 H28598 Aerial Parts Indonesia Cytotoxic Cells-MT-4 Cells-MT-4 K21579 Not Stated Thailand Cytotoxic Not stated Not stated CA-9KB (Data incomplete from abstract) P00044 Root Not Stated Cytotoxic Fraction: Physalin B Not stated 9KB and 9PS tumor cells AC1016 Leaf China Antitumor Fraction: 0.5 ul 20 ul Acts on Topoisomerase IImediated DNA damage. AC1012 Antibody Formation Enhancement Blastogenesis Stimulant ETOH(95%)Ext 10 mcg/well s-b K09956 ETOH(95%)Ext 0.39 mcg/well CA-HTB43 K09956 Blastogenesis Stimulant ETOH(95%)Ext T s 0.39 mcg/well T lymphocytes lipopolysaccharide induced blastogenesis was enhanced by treatment with extract K09956 Blastogenesis Stimulant ETOH(95%)Ext T s 0.39 mcg/well Phytohemagglutinin induced blastogenesis was enhanced by treatment with extract. K09956
4 blastogenesis stimulant ETOH(95%)Ext 20 mcg/well s-b K09956 RNA Polymerase I stimulation ETOH-H2O (1:1) Ext Cells-rat-liver 1.0 Mg/ml vs. PGE-1-induced pedal edema T14999 Not Stated China Phosphorylation Enhancement Fraction: Not Stated 9L rat brain tumor cells AC1021 Not Stated Phosphorylation Enhancement Fraction: ul Concentration dependent alteration of vimentin molecules. AC1022 Leaf Not Stated Antimycobacterial ETOH Ext + fractions 32 mcg/ml Mycobacterium tuberculosis H(37)Rv strain AC1010 Aerial Parts Brazil Antimycobacterial mcg/ml mcg/ml 32.0 mcg/ml mcg/ml 78.1 mcg/ml 400 mg/ml mcg/ml mcg/ml 2500 mcg/ml 2500 mcg/ml Equivocal Mycobacterium intracellulare Mycobacterium malmoense Tubercule bacillus H-37-RV Mycobacterium avium Mycobacterium kansasi Mycobacterium intracellulare Tubercule bacillus H-37-RV Mycobacterium malmoense Mycobacterium avium Mycobacterium kansasi L09660 Aerial Parts Indonesia Antiviral Virus- HTLV-I K21579 Aerial Parts Japan Antiviral Hot H20 Ext Hot H20 Ext Hot H20 Ext 0.1 mg/ml 0.5 mg/ml 0.5 mg/ml Virus- Poliovirus I Virus- Herpes simplex 1 Virus-Measles K16835 Aerial Parts Indonesia Protease(HIV) Inhibition Not stated Not stated 500 mcg/ml 340 mcg/ml K08273 Aerial Parts Indonesia Reverse Transcriptase Inhibition 1000 mcg/ml 1000 mcg/ml Virus-avian myeloblastosis K08721
5 Entire Plant Nigeria Antibacterial Corynebacterium diphtheriae Klebsiella species Neisseria species Pseudomonas aeruginosa Staphylococcus aureus Streptococcus species Salmonella species Streptobacillus species M27767 Leaf Guatemala Antibacterial ETOH-H2O (1:1) Ext 50 ul / disc Neisseria gonorrhea K27236 Leaf Nigeria Antibacterial MEOH(50%)Ext Broth Culture Not stated Bacillus subtilis Escherichia coli Proteus species Pseudomonas aeruginosa Staphylococcus albus Staphylococcus aureus J00209 Entire plant Taiwan Glutamate-Pyruvate- Transaminase Inhibition ETOH-H2O (1:1) Ext Cells-rat-liver 1.0 Mg/ml vs. CCL4-induced hepatotoxicity T14999 Entire Plant Samoa Prostaglandin Synthesis Inhibition ETOH(100%)Ext Not stated mcg/ml vs. COX-1 catalysed prostaglandin biosynthesis L14626 Entire Plant Puerto Rico Molluscicidal Aqueous Slurry Not stated LD100 >1M ppm Fruits, roots and leaves were tested vs Lymnaea columella and Lymnaea cubensis T04621 Aerial Parts Tanzania Antitrypanosomal CH2CL2 Ext 56 mcg/ml Leaf Tanzania Antitrypanosomal CH2CL2 Ext 56 mcg/ml Root Tanzania Antitrypanosomal CH2CL2 Ext 56 mcg/ml
6 Fruit Tanzania Antitrypanosomal CH2CL2 Ext 167 mcg/ml Leaf Ivory Coast Anticoagulant not stated Blood-humanwhole 50% T15327 Return to the Mullaca Plant Database File Copyrighted 2004 Raintree Nutrition, Inc. Carson City, Nevada All rights reserved. Please read the Conditions of Use and Copyright Statement for this web page and website.
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