The Benefits of Active Hexose Correlated Compounds (AHCC) in Cancer

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1 The Benefits of Active Hexose Correlated Compounds (AHCC) in Cancer Dr. Geo Espinosa, ND, LAc *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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3 Fast Facts About Cancer Cancer is a global epidemic and a leading cause of death worldwide, accounting for 7.6 million deaths or around 13% of all deaths in 2008.

4 The Worldwide Burden of Cancer in Men (Top 10 Cancer Sites) Total: 6,629,100 Total: 4,225,700 Data Source: Jemal, A. et al., CA CANCER J CLIN 2011;61:69 90

5 The Worldwide Burden of Cancer in Women (Top 10 Cancer Sites) Total: 4,225,700 Total: 3,345,800 Data Source: Jemal, A. et al., CA CANCER J CLIN 2011;61:69 90

6 AHCC Production Facility Sapporo, Japan

7 Manufacturing flow of AHCC Mycellium on plate Mycellium in cultivation tank Cultivation tank End Product Mushroom mycelium Liquid culture Separation & concentration Freeze dry

8 AHCC Development First, researchers identified specific mushroom subspecies with superior NK cell activity. Next, they cultured mycelia to ensure each batch was genetically identical to the original. Then, they developed a unique process, (AHCC) is extracted using hot water following an enzyme pretreatment, to significantly reduce the molecular weight. Final product contains polysaccharides with peak molecular weight of just 5,000 Daltons 8

9 The IMMUNE SYSTEM

10 The IMMUNE SYSTEM The immune system is a diffuse, complex network of interacting cells, cell products, and cell-forming tissues that protects the body from pathogens and other foreign substances, destroys infected and malignant cells, and removes cellular debris: the system includes the thymus, spleen, lymph nodes and lymph tissue, stem cells, white blood cells, antibodies, and lymphokines.

11 Function of the Immune System Seek out and destroy what is considered to be non-self The two main targets are: Pathogens: bacteria, fungi, parasites, viruses Abnormal cells: Cancer and defective cells

12 Improves natural killer cell activity Increases cytokine production Improves T cell activity Improves macrophage activity AHCC & Immune Response Increases dendritic cell activity and numbers 12

13 Why AHCC is Compelling to Physicians Offers an effective balance between high levels of stimulation of the NK cell mediated pathways Documented clinical and basic science research at prestigious hospitals around the world Documented efficacy studies Significant anecdotal evidence / positive response of patients Documented safety studies No toxicity No observed side-effects after 20 years of use

14 AHCC Cancer-Related Research Used in Asia and the U.S. to reduce side-effects of chemotherapy Reduce toxicity Improve quality of life Research supports the following modes of action: Increases Tumor Necrosis Factor Increases Gamma Interferon Increases IL-12 (all decrease when undergoing chemotherapy) Decreases circulating level of IAP (Immunosuppressive acidic protein) Decreases circulating level of IAP and TGF-B (tumor growth factor Beta)

15 - Yaganimoto et al. Nutr Cancer; 2016 AHCC on Pancreatic Cancer 75 subjects, RCT, Pancreas ductal adenocarcinoma (PDAC) patients receiving gemcitabine treatment (GEM). Dose 6g on the AHCC group The C-reactive protein (CRP) elevation and albumin decline of the AHCC group were significantly suppressed as compared to the control group during the GEM administration (P = , P = ). Patients in the AHCC group had less frequency of taste disorder caused by GEM (17% vs. 56%, P = ). Glasgow Prognostic Score (mgps) during chemotherapy was found significantly less in the AHCC group (14%) than the control group (53%, P = ). AHCC intake can be effective in reducing the adverse events associated with chemotherapy and may contribute to maintaining the QOL of patients with PDAC during GEM administration.

16 AHCC and Breast Cancer Forty-one women who were treated with anthracyclines and taxanes at from October 2004 to March 2011 were selected for this study. AHCC has the potential to reduce the severity of neutropenia induced by breast cancer chemotherapy during chemotherapy. Hangai et al. J Altern Complement Med; 2013

17 AHCC Research: Published Clinical Studies 269 liver cancer patient prospective cohort study ( ) showed longer no recurrence period and increased survival rate (Journal of Hepatology) stomach cancer patients showed enhanced 5-yr survival rate liver cancer patient placebo-controlled study showed prolonged survival and improved Quality of Life healthy elderly patient study at Yale Medical School showed increased cytokine production (TNF-γ and IFN-α) 4

18 AHCC: Modes of Action Multi-model action to regulate the immune system Significantly increases NK cell activity in immune-compromised patients Stimulates T-cells Stimulates Macrophages Stimulates Cytokines Increases number and activity of dendritic (DC) cells Modulates, not just stimulates, the immune system:

19 Other Uses of AHCC in Clinical Practice Raise CD-4 counts an important immune system cellular component Post-Chemotherapy HIV Lyme Disease Chronic Fatigue Cold and Flu Prevention Cold and Flu Treatment Modulation of the cytokine defense mechanism Chronic Sinusitis Fibromyalgia Hives Rashes Seasonal Disorders

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21 Usage and Dosage Preventatively Health-conscious adults seeking to heighten their immune activity Recommended preventative/therapeutic dose: 1,000mg daily Translational studies indicate efficacy at above 500mg/day Therapeutically Patients with highly comprised immune systems Cancer patients, HEP-C patients and other serious conditions Recommended therapeutic dose: 3,000mg daily

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23 Thank you for hanging outwith me! RESOURCES Natural Medicine Journal - You can find ingredients and human research More on men s health and prostate cancer Prostate Cancer Specific Nutrition