Ecole doctorale Biologie-Médecine. Programme

Transcription

1 Ecole doctorale Biologie-Médecine Programme

2 Cancer September 2016 Prof. Dominique Belin, Dépt de Pathologie et immunologie, Prof. A.-P. Sappino, Division d Oncologie Proto-oncogenes network (Tyrosine Kinases Abl, PML-RAR, Ras) Tumor suppressor genes (p53, telomerase). Cell cycle (Retinoblastoma, cyclins and cyclin inhibitors) Colon cancer (APC & familial polyposis, mismatch repair genes) and angiogenesis, Sonic Hedgehog and pancreas. Virus, bacteria and cancer. Metabolism, hepatocarcinoma and intestinal microbiota. Dates : Tuesday 6, 13, 20 and 27th of September 2016, from 2.00 pm to 5.30 pm

3 Metabolism October 2016 Ø ORGANISERS: Mirko TRAJKOVSKI (MT)& Pierre MAECHLER (PM) Thierry BRUN (TB) & Roberto COPPARI (RC) & Valérie SCHWITZGEBEL (VS) & Michelangelo FOTI (MF) Ø Friday at 9.30am Ø Session 1: Human and mouse anatomy in the context of metabolism (2.5h, MT) Ø Wednesday at 2pm Ø Session 2: The endocrine pancreas (3.5h, PM + TB) Ø Tuesday at 2pm Ø Session 3: Fat metabolism (3.5h, MT) Ø Friday at 1.30pm Ø Session 4: Liver, muscle and brain (3h, RC +MF) Ø Monday Ø Session 5: Clinical Overview on the Metabolic diseases. (VS) Ø + oral exam by (MT) + (PM)

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6 Cardiovascular Physiology and Disease January February 2017 Dr C. MONTESSUIT, Division of Cardiology;; Prof. Brenda KWAK, dept of Pathology & Immunology, and Division of Cardiology;; Dr Marie-Luce PIALLAT, Dept of Pathology & Immunology;; Dr Georg EHRET, Division of Cardiology. Tuesday January 10th 2017 : Christophe MONTESSUIT Basics of heart physiology (lecture) Tuesday January 17th 2017 : Christophe MONTESSUIT Experimental models in cardiac research ( short lecture & TP Langendorff perfusion) Tuesday January 24th 2017 : Brenda KWAK Basics of Vascular physiology (lecture) Tuesday January rst : Brenda KWAK Atherosclerosis (short lecture & TP histo-pathology) Tueday February 7th 2017 :Marie-Luce PIALLAT Cardiovascular pathology illustrated (short lecture & TP anatomo-pathology) Tuesday February 21rst 2017 : Georg EHRET Cardiovascular Genomics TUESDAY 28 FEBRUARY 2017 : ORAL EXAM The module will take place upon a minimum participation of 5 students from 14 to 17h.

7 BACTERIOLOGY (from classical bacterial genetics to modern medicine) February 2017 Profs. Patrick LINDER & Patrick VIOLLIER, Dépt of Microbiology & Molecular Medicine Teachers are : Patrick VIOLLIER(PV), Thilo KOEHLER(TK), William KELLEY(WK), Patrick LINDER(PL), Adriana RENZONI (AR) and proposed subjects are ( subjects may change, accoording to speakers we will be able to attract for the seminars) : Two Component Systems, TCS (WK) Toxin/antitoxin systems, (AR) Cell envelope, peptidoglycan / cell division (PV) Secretion, motility, conjugation (PV, TK) Persistence, dormancy (PV, PL) SOS, repair (PL) Quorum sensing, single cell behavior (TK) The course will be held on Monday 30 January 2017, 06 February 2017, 13 February 2017, 20 February 2017 from 14h to 16h. / ROOM A February 2017, from 14h to 18h / EXAM / ROOM E Discussion of a classic paper and a recent paper, one review for understanding. The 4 courses will be combined with a Monday seminar

8 Medical GENETICS March 2017 Prof. S. E. Antonarakis, Département de Médecine Génétique et Développement Prof. S. E. Antonarakis invites you to a first meeting on Friday 3rd of March 2017, from 2pm to 4pm, room E A (ex 9078), 9 e floor CMU. Courses from 2pm to 4pm, room E A, 9 e floor on the following dates : March 3, 2017 : Introduction Prof. S. E. Antonarakis March 7, 2017 : Genetic Variation Prof. E. Dermitzakis March 10, 2017 : Mendelian Disorders Prof. S. E. Antonarakis March 14, 2017 : Cytogenetics Dre F. Bena March 17, 2017 : Technology Dr. M. Guipponi March 21, 2017 : Comparative Genomics Prof. E. Zdobnov March 24, 2017 : Complex Disorders / Traits Prof. Dermitzakis March 28, 2017 : Epigenetics Prof. R. Murr March 31, 2017 : EXAM Prof. S. E. Antonarakis

9 Statistics course March-May 2017 PD Christophe COMBESCURE, Service d épidémiologie clinique, Direction médicale et qualité, HUG Prof. Thomas V. PERNEGER, Service d épidémiologie clinique, Direction médicale et qualité, HUG The aim of this course is to provide to the students a general knowledge of statistical inference, methods to describe data, to test hypotheses and to characterize associations between two variables. In addition to the theory, students will put into practice statistical methods with a statistical software and will conduct a critical appraisal of the statistical methodology in a selection of published articles. CONTACT : Thomas PERNEGER & Christophe COMBESCURE. The course will close with a maximum of 14 participants Sessions (Room E A from 2.15pm to 5.15pm): Descriptive statistics and introduction to GraphPad ( ) Statistical inference and confidence intervals ( ) Basic principles of statistical hypothesis testing ( ) Common statistical tests ( ) Statistical power and sample size ( ) Correlation and regression models ( ) Reporting statistical analyses / Exam ( )

10 CELL INTERACTION March April 2017 Dr. B. WEHRLE-HALLER, Dépt. Physiologie Cellulaire & Métabolisme / contact: bernhard.wehrle-haller@unige.ch Dr. S. Garrido-Urbani, Dépt.de Pathologie et Immunologie;; Dr. L. Fontao, Dépt. de Neurosciences Clinique & Dermatologie;; Dr. P. Soulie, Dépt. Physiologie Cellulaire et Métabolisme ;; Prof. Marc Chanson, Dépt. Physiologie Cellulaire et Métabolisme;; Prof. W. Kelley, Dépt. de Microbiologie. The course aims to introduce students to the biology of cell interaction, from pathogen-host to cell-cell communication, and from molecular and genetic factors to tissue function and disease. The course involves attending 6 sessions held in a three week period, guided by experts in their respective fields. Each session lasts no more than 2 hours and is focused on discussing current knowledge and techniques used in studying cell interactions, using as reference pre-assigned research articles relevant to the chosen topics (see below). It is essential for students to read the material before class and to actively engage in the discussions. Student evaluation is achieved through a 30 minutes oral examination and the format will be explained during the first session. «Adhesion, Integrins and Signaling», Dr. B. Wehrle-Haller «Tight Junctions : a Dynamic Fence», Dr. S. Garrido-Urbani «Epithelium-Substrate Adhesion», Dr. Lionel Fontao «Direct Communication : Gap Junctions», Prof. M. Chanson «From Cells to Tissues», Dr. P. Soulie «Bacterial Interactions», Prof. W. Kelley SCHEDULED DATES: Friday / Wed. 29 March 2017 / Friday 31 March 2017/ Wed. 5 April 2017 / Friday /12 April 2017 from 14pm to 16pm (CMU/Room 5000) ORAL EXAM : for the 26 or 27 April 2017

11 HISTOLOGY April-May 2017 NB: THIS MODULE IS NOT OPENED TO MD-PhD STUDENTS Number of students : 18 max Contact : Dre Marie-Luce BOCHATON-PIALLAT, (MLBP) Dpt of Pathology and Immunology Prof. M. Foti (MF) Dpt of Cellular Physiology and Metabolism;; Dre P. Soulié (PS) Dpt of Cellular Physiology and Metabolism;; Dre J. Perrin-Simonnot (JPS) Dpt of Cellular Physiology and Metabolism;; Dre. S. Clément(SC) Dpt of Clinical Pathology;; Dr J-C Tille(JCT) Dpt Clinical pathology HISTOLOGY (2 sessions): study of primary tissues(epithelium, connective tissue, muscles, vessels, nervous tissue, lymphoid tissue) and some representive organs. HISTOPATHOLOGY (2 sessions): study of the main concepts of general pathology (cell death: necrosis and apoptosis, inflammation, tissue repair, tumor) and some representive organs with typical pathological alterations. HISTOLOGY AND RESEARCH (2 sessions): study of different microscopic approaches (optical, immuno-fluorescence, confocal and electron microscopy) and their applications in research (autoradiography, in situ hybridization, immunohisto/cytochemistry, live imaging). NB : PhD students are required to attend all sessions. Introduction : MLBP/PS Monday April 24, 2017 Session 1 : PS/JPS-Tuesday April 25, 2017 Session 2 : PS/JPS - Friday April 28, 2017 Session 3 : JCT-Thursday May 4, 2017 Session 4 : JCT-Monday May 8, 2017 Session 5 : MLBP/SC-Wednesday May 10, 2017 Session 6 : MF-Friday May 12, 2017 ORAL EXAM : will be organized from Thursday May 18 to Wednesday May 24, 2017.

12 VIROLOGY May-June 2017 Dr. D. Garcin, Dépt de Microbiologie et Médecine Moléculaire Virus cycle (entry, replication, budding ) RNA viruses : genetic variability, quasi-species, adaptation and evolution.. Anti-viral innate immunity, detection, interferon system and viral counter measures. An introductory course in each topic, articles to read and present, discussions, critical analysis (sort of «battle» over the article J ). 4 sessions of 3 to 4 hours plus one session for the exam. The course will be held on: Monday May : Introduction virology introduction viral cycle. Monday May : Viral cycle (presentation 3 publications) Introduction quasi-species Monday May : Quasi-species (presentation 3 publications) Introduction innate immunity Monday May : Innate immunity (presentation 3 publications) Monday JUNE :EXAM Location : Room MIMO 7172, 7 ème floor from 2pm to 6pm

13 Developmental Biology May-June 2017 Prof. P. Herrera, Dr. F. Thorel (dépt. de médecine génétique & développement CMU). M.N. Steiner, Service de Transgénèse (cours pratique sur la production de souris transgéniques). Transgenics and mouse molecular genetics Sex determination Regenerative medicine : ES and IPS cells;; cell reprogramming Pancreas development and regeneration Courses will be held on, in English, Every Wednesday of May ( ) & June (07/14/ );; room 9112C, from 2pm to 5pm. (4 sessions) EXAM DATE TO CONFIRM The course will only take place with a minimum of 4 and a maximum of 12 students. Attendance at all sessions is mandatory