THINK TANK MEETING ON RESEARCH CHALLENGES IN BREAST CANCER. 1-3 March 2018 Palazzo Bernabei, Assisi - Italy. Under the patronage
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1 THINK TANK MEETING ON RESEARCH CHALLENGES IN BREAST CANCER 1-3 March 2018 Palazzo Bernabei, Assisi - Italy Under the patronage
2 AIMS - to identify grey zones in daily clinical practice in breast cancer treatment by detecting where the evidence is not so firm, - to brainstorm on issues in combined treatment modalities, - to identify affordable trial proposals to address the issues and put them forward to the scientific community, public and private sponsors - to promote cure and enhance patients quality of life.
3 METHOD To achieve these aims the Meeting will take the following steps: 1. The Scientific Organizers (SO) nominated an international Expert Board (EB) and identified the main clinical situations demanding investigation; 2. The SO chose the Chairs and Speakers for each topic; 3. Clinical cases with questions on treatment options were prepared; 4. The EB voted on different clinical choices in a monkey questionnaire before the meeting; 5. At the meeting, on Day 1 (Thursday afternoon, 1 March 2018), the EB will: a) discuss the monkey survey results and the outstanding clinical issues b) select the trial proposals to be debated on the following days 6. On Day 2 (Friday, 2 March 2018), trial proposals will be presented and debated by the EB. Meeting attendees, who will act as the first validation group, will comment on the proposals from their perspective. Moreover, potential public and private research sponsors will attend and decide whether they are interested in funding the research proposals. 7. On Day 3 (Saturday, 3 March 2018), the EB will a) review protocol drafts to outline the final proposals b) deliver a set of trial proposals for each topic, each of which will include: 1. Aim 2. Primary and secondary endpoints 3. Patient selection 4. Treatment modalities to be tested 5. Research method: prospective study (expected benefit should be defined so as to set the accrual number and timing) or large data base collection c) plan the outline of the white paper to be written about ATTM and trial proposals d) set topics for future meetings. TOPICS 1. Primary systemic therapy, mastectomy and breast reconstruction, post mastectomy radiation therapy 2. Therapeutic options in ductal carcinoma in situ 3. De-escalated therapies in early breast cancer
4 PROGRAM Thursday, 1 March 2018 Participants: Expert Board Morning: arrival; welcome lunch Meeting aims and methodology: Why this meeting? Why this methodology? What follow-up? Philip Poortmans, Cynthia Aristei, Vincenzo Valentini Report the results of the clinical case monkey questionnaire - Topics 1,2 and 3 Room A: Topic 1 : Primary systemic therapy, mastectomy and breast reconstruction, post mastectomy radiation therapy Team Chairs: Bruno Cutuli, Lurdes Trigo Secretary: Elisabetta Perrucci Monkey-survey results and on-site tele-voting Elisabetta Perrucci Review the main evidence Icro Meattini Review ongoing clinical trials Liesbeth Boersma Discussion Coffee Break Scouting for trial proposal: which goal? All Expert Board Group Room B : Topic 2 : Therapeutic options in ductal carcinoma in situ Team Chairs: Meritxell Arenas, Céline Bourgier Secretary: Fabio Marazzi Monkey-survey results and on-site tele-voting Fabio Marazzi Review the main evidence Angel Montero Luis Review ongoing clinical trials Cristina Leonardi Discussion Coffee Break
5 Scouting for trial proposal: which goal? All Expert Board Group Room C : Topic 3: De-escalated therapies in early breast cancer Team Chairs: Ugur Selek, Raphael Pfeffer Secretary: Valeria Masiello Monkey-survey results and on-site tele-voting Valeria Masiello Review the main evidence Pierfrancesco Franco Review ongoing clinical trials Vassilis Kouloulias Discussion Coffee Break Scouting for trial proposal: which goal? All Expert Board Group Presentations of working group proposals
6 Friday, 2 March Aims and methodology of the day Philip Poortmans, Cynthia Aristei, Vincenzo Valentini Lecture: Epidemiology of breast cancer Philip Poortmans Lecture: Biological subtypes and their impact on survival Cynthia Aristei Lecture: Learning from large data base in breast cancer: state of the art Vincenzo Valentini Question time All participants Primary systemic therapy, mastectomy and breast reconstruction, post mastectomy radiation therapy Team Chairs: Bruno Cutuli, Lurdes Trigo Secretary: Elisabetta Perrucci Case presentation (on-site televoting) Elisabetta Perrucci Review the main evidence Icro Meattini Coffee Break Review ongoing clinical trials Liesbeth Boersma Trial proposal presentation by working group delegates Voting to rank trial proposals All participants Therapeutic options in ductal carcinoma in situ Team Chairs: Meritxell Arenas, Céline Bourgier Secretary: Fabio Marazzi Case presentation (on-site televoting) Fabio Marazzi Review the main evidence Angel Montero Luis Lunch Review ongoing clinical trials Cristina Leonardi Trial proposal presentation by working group delegates Voting to rank trial proposals All participants
7 De-escalated therapies in early breast cancer Team Chairs: Ugur Selek, Raphael Pfeffer Secretary: Valeria Masiello Case presentation (on-site televoting) Valeria Masiello Review the main evidence Pierfrancesco Franco Coffee Break Review ongoing clinical trials Vassilis Kouloulias Trial proposal presentation by working group delegates Voting to rank trial proposals All participants Closing Remarks Philip Poortmans, Cynthia Aristei, Vincenzo Valentini Saturday, 3 March 2018 Participants: Expert Board Finalize Trial Proposals for Topic Finalize Trial Proposals for Topic Coffee Break Finalize Trial Proposals for Topic Plan outline of white paper and propose topics for next meeting Closing remarks
8 Scientific Organizers: Philip Poortmans, Cynthia Aristei, Vincenzo Valentini Executive Committee: Scientific organisers, Meritxell Arenas, Céline Bourgier, Orit Kaidar-Person, Icro Meattini Advisory members from Northern Europe: Liesbeth Boersma (NL), Charlotte Coles (UK), Birgitte Offersen (DK) Expert Board (apart from the executive Ctee): France: Bruno Cutuli (Reims), Sofia Rivera (Villejuif) Spain: Angel Montero Luis (Madrid) Portugal: Lurdes Trigo (Oporto) Greece: Vassilis Kouloulias (Athens) Turkey: Ugur Selek (MD Anderson, Istanbul) Israel: Raphael Pfeffer (Ramat-Gan) Italy: Antonella Ciabattoni, Lorenzo Falcinelli, Pierfrancesco Franco, Giovanni Frezza, Domenico Genovesi, Marco Krengli, Valentina Lancellotta, Cristina Leonardi, Fabio Marazzi, Valeria Masiello, Nadia Pasinetti, Elisabetta Perrucci, Luigi Pirtoli, Riccardo Santoni, Daniela Smaniotto, Vincenzo Tombolini, Cristiana Vidali Local Organizers: Lorenzo Falcinelli, Valentina Lancellotta, Fabio Marazzi, Valeria Masiello, Elisabetta Perrucci, Daniela Smaniotto
9 Expert Board Group 1 Liesbeth Boersma Bruno Cutuli Domenico Genovesi Marco Krengli Valentina Lancellotta Icro Meattini Birgitte Offersen Elisabetta Perrucci Riccardo Santoni Lurdes Trigo Expert Board Group 2 Meritxell Arenas Céline Bourgier Lorenzo Falcinelli Cristina Leonardi Fabio Marazzi Angel Montero Luis Sofia Rivera Daniela Smaniotto Vincenzo Tombolini Cristiana Vidali Expert Board Group 3 Antonella Ciabattoni Charlotte Coles Pierfrancesco Franco Giovanni Frezza Vassilis Kouloulias Valeria Masiello Nadia Pasinetti Raphael Pfeffer Luigi Pirtoli Ugur Selek ORGANIZING SECRETARIAT CONSULTA UMBRIA SRL Tel fax info@consultaumbria.com
10 NOTE
11 Sponsored by:
12 ULTIMATE GOAL: TO BE BACK HOME WITH A TRIAL PROPOSAL IN YOUR POCKET!
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