Newly Diagnosed Cases Cancer Related Death NCI 2006 Data
|
|
- Augusta Stewart
- 6 years ago
- Views:
Transcription
1 Multi-Disciplinary Management of Esophageal Cancer: Surgical and Medical Steps Forward Alarming Thoracic Twin Towers UCSF UCD Thoracic Oncology Conference November 21, Lung Pierre R. Theodore Van Auken Endowed Chair in Thoracic Oncology Division of Thoracic Surgery University of California at San Francisco Newly Diagnosed Cases Cancer Related Death NCI 2006 Data Esophagus Esophageal Cancer Widespread 6 th most common cause of cancer death worldwide 16,500 new cases expected per year in the U.S. Increasing Incidence of esophageal adenoca has increased >3 fold since 1975, Deadly 5-year survival historically < 10% 14,300 deaths expected per year in the U.S. Van Soest et al. Increasing incidence of Barrett s oesophagus in the general population Gut August; 54(8): Source: Sources: Mariette et al. Lancet 2007, Khushalani Mayo Clin Proc
2 Anatomy Designed for Metastasis Hofstetter et al. Proposed Modification of Nodal Status in AJCC Esophageal Cancer Staging System. Ann. Thor. Surg 2007 Balance in Approach to the Esophagus Chemoradiation Surgery Adopted with Permission from Harrison: Is Esophageal Cancer a Surgical Disease? Journal of Surgical Oncology (2000) EUS can Predict Survival in Patients Treated with Neoadjuvant ChemoXRT (Chak et al, Cancer 2000) 59 patients with resectable esoph. ca treated with neoadjuvant chemoradiation EUS performed at baseline and again after chemorads prior to planned surgical resection EUS responders defined as those with > 50% reduction in cross- sectional area (MAX) = 34/59 (58%) 2
3 Competing Approaches? Regardless of Stage, Number of Nodes Resected Influences Survival Peyre et al. The Number of Lymph Nodes Removed Predicts Survival in Esophageal Cancer: An International Study on the Impact of Extent of Surgical Resection. Ann. Surg 2008 Novel Surgical Reconstruction Techniques Thirty-five patients Three patients had stricture at 14, 21 and 25 days post-operatively, operatively, and were successfully treated with endoscopic dilation No leaks or perioperative mortality Adjuvant Therapies in Esophagus Cancer A SAFE AND REPRODUCIBLE ANASTOMOTIC TECHNIQUE FOR MINIMALLY INVASIVE IVOR LEWIS OESOPHAGECTOMY: THE CIRCULAR STAPLED ANASTOMOSIS WITH THE TRANS-ORAL ANVIL G. Campos, D. Jablons, C. Rabl, R. Ramirez, S. Peeva, P. Theodore Eur Journal of Cardiothoracic Surgery (2009) 3
4 Esophageal Adenocarcinoma: Consensus on Adjuvant Therapy Something more than surgery alone should be done Preoperative chemotherapy ECF, CF improves overall survival MAGIC: 13% improvement at 5 yr (25% pts esoph) MRC 0E0-2: 9% improvement at 2 yr (66% adeno) 5 year update: 6% improvement (7% adeno, 5% squamous) No clear impact on rate of R0 resection MRC Lancet 359: 1727; 2002 Cunningham NEJM 355: 11; 2006 Esophageal Cancer: Preop Chemotherapy Positive trials U.K. MRC OEO-2 (n=802) 2 preop cycles of 5-FU + Cisplatin Adeno 66%, Squamous 31% 6% increase 5 yr OS U.K. MAGIC: pre and post op ECF in gastric cancer (n=503) Adeno only 11% GE junction 15% distal esophageal adeno No improvement in R0 resection rate, 13% increase in 5 year OS No Path CRs MRC Lancet 359: 1727; 2002 Cunningham NEJM 355: 11; 2006 Met Analysis Preop Chemo in Esophageal Cancer: Thirion et al, Abs 4512 (2007) Individual patient data from preop chemo trials: esophageal squamous and adenocarcinoma 9 trials OS: 2102 pts 2 dominant trials: U.S. INT 113 (467 pts) U.K. MRC OEO-2 (802 pts) Preop Chemo: Overall survival improvement with a HR of 0.87 (p = ) Translates into 4.3% improvement in OS at 5 yrs Primary End-point: Overall Survival Survival Absolute benefit at 5 years: 4.3 % Time (years) Patients at risk Control Chemo pre-op Squamous: 4% Adeno: 7% 4
5 Induction Chemoradiotherapy 64 Gy /32 fractions (in follow up Int 0123) Addition of RT to chemotherapy Improves rates of curative resection in some trials Achieves pathologic complete responses in 10-30% Phase III: small, inconclusive (< patients) Curative Resection rates increased RT + chemo in some trials Local Recurrence reduced Trends toward Survival Path CR: Survival Only 2 of 5 Randomized Trials indicate survival benefit Preop ChemoRT: Phase III Trial FFCD Therapy Patients % Adeno %R0 Resection Path CR OS / Med Survival Surgery 282 0% 69% -- 26% 5 yr Poet Trial Chemoradiotherapy Fig. 1 versus Chemo Induction Walsh* CRT 81% 26% 26% Surgery % NS -- 6% 3 yr* Urba Burmeister Tepper (CALGB) CRT NS 25% 32%* Surgery % 90% -- 16% 3 yr CRT 88% 28% 32% Surgery % 59% mos CRT 80% 16% 22 mos Surgery 56: 475 planned CRT 75% NS yr NS 33% 4.5 yr Metanalysis Translates into 19% mortality risk reduction with neoadjuvant CRT of 30 Gy was given at 2.0 Gy per fraction, 5 fractions per week Stahl, M. et al. J Clin Oncol; 27: Gy Photon radiotherapy in 5 fractions per week 5
6 Overall survival Who Responds, Lives. Fig % 27.7% Stahl, M. et al. J Clin Oncol; 27: Stahl, M. et al. J Clin Oncol; 27: small Surgery needed at all? Fédération Francophone de Cancérologie Digestive 9102 Overall survival No discernible difference SCC Responders 25% CR Bedenne, L. et al. J Clin Oncol; 25: Bedenne, L. et al. J Clin Oncol; 25:
7 Esophageal Cancer: Preop Chemo, or ChemoRT? Conclusions Conclusions Esophageal Adeno Preop Chemo improves survival RT + Chemo: trends toward improved OS, more path CR s At the cost of greater toxicity? Esophageal Squamous RT + Chemo: As primary therapy without surgery is acceptable 20-25% 25% 5 year survival Surgery after chemo rt: in selected patients Improved local control no improvement in survivalval No Clearly Demonstrated Advantage of Post-operative operative Chemotherapy Who Responds, Wins (better post induction assessments) More Nodes in Resection, Improved Overall Survival 7
The following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only.
The following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only. If you have any ques7ons, please contact Imedex via email at:
More informationGastroesophag Gastroesopha eal Junction Adenocarcinoma: What is the best adjuvant regimen? Michael G. G. H addock Haddock M.D.
Gastroesophageal Junction Adenocarcinoma: What is the best adjuvant regimen? Michael G. Haddock M.D. Mayo Clinic Rochester, MN Locally Advanced GE Junction ACA CT S CT or CT S CT/RT Proposition Chemoradiation
More informationManagement of Squamous Cell Cancer of the Esophagus: Surgery Should Follow Chemo + RT
Management of Squamous Cell Cancer of the Esophagus: Surgery Should Follow Chemo + RT David H. Ilson, MD, PhD Gastrointestinal Oncology Service Memorial Sloan Kettering Cancer Center Disclosure Consulting
More informationAre we making progress? Marked reduction in operative morbidity and mortality
Are we making progress? Surgical Progress Marked reduction in operative morbidity and mortality Introduction of Minimal-Access approaches for complex esophageal cancer resections Significantly better functional
More informationEsophageal and GEJ Adenocarcinoma: Chemo + RT is the Preferred Treatment
Esophageal and GEJ Adenocarcinoma: Chemo + RT is the Preferred Treatment David H. Ilson, MD, PhD Gastrointestinal Oncology Service Memorial Sloan-Kettering Cancer Center Preop Therapy in Esophageal and
More informationEsophageal Cancer. Wesley A. Papenfuss MD FACS Surgical Oncology Aurora Cancer Care. David Demos MD Thoracic Surgery Aurora Cancer Care
Esophageal Cancer Wesley A. Papenfuss MD FACS Surgical Oncology Aurora Cancer Care David Demos MD Thoracic Surgery Aurora Cancer Care No Disclosures Learning Objectives Review the classification scheme
More informationManagement of Esophageal Cancer: Evidence Based Review of Current Guidelines. Madhuri Rao, MD PGY-5 SUNY Downstate Medical Center
Management of Esophageal Cancer: Evidence Based Review of Current Guidelines Madhuri Rao, MD PGY-5 SUNY Downstate Medical Center Case Presentation 68 y/o male PMH: NIDDM, HTN, hyperlipidemia, CAD s/p stents,
More information1. Epidemiology of Esophageal Cancer 2. Operative Strategies 3. Minimally Invasive Esophagectomy 4. Video
Minimally Invasive Esophagectomy Guilherme M Campos, MD, FACS Assistant Professor of Surgery Director G.I. Motility Center Director Bariatric Surgery Program University of California San Francisco ESOPHAGEAL
More informationMedicinae Doctoris. One university. Many futures.
Medicinae Doctoris The Before and The After: Can chemotherapy revise the trajectory of gastric and esophageal cancers? Dr. David Dawe MD, FRCPC Medical Oncologist Assistant Professor Disclosures None All
More informationWhich Treatment Approach is Most Appropriate for Primary Therapy of Gastric Cancer: Neoadjuvant Chemotherapy
Which Treatment Approach is Most Appropriate for Primary Therapy of Gastric Cancer: Neoadjuvant Chemotherapy Joseph Chao, M.D. Assistant Clinical Professor Department of Medical Oncology & Therapeutics
More informationThe following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only.
The following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only. If you have any ques7ons, please contact Imedex via email at:
More informationintent treatment be in the elderly?
Gastric cancer: How strong can curative intent treatment be in the elderly? Caio Max S. Rocha Lima, M.D. Professor of Medicine University of Miami & Sylvester Cancer Center Gastric cancer: epidemiology
More informationResectable locally advanced oesophagogastric cancer
Resectable locally advanced oesophagogastric cancer Clinical Case Discussion Florian Lordick University Cancer Center Leipzig University Clinic Leipzig Leipzig, Germany esmo.org DISCLOSURES Honoraria for
More informationAdvances in gastric cancer: How to approach localised disease?
Advances in gastric cancer: How to approach localised disease? Andrés Cervantes Professor of Medicine Classical approach to localised gastric cancer Surgical resection Pathology assessment and estimation
More informationThe role of chemoradiotherapy in GE junction and gastric cancer. Karin Haustermans
The role of chemoradiotherapy in GE junction and gastric cancer Karin Haustermans Overview Postoperative chemoradiotherapy Preoperative chemoradiotherapy Palliative radiation Technical aspects Overview
More informationRadiotherapy for Gastric Cancer. Nitin Ohri, M.D. Montefiore Medical Center Albert Einstein College of Medicine 12/15/2012
Radiotherapy for Gastric Cancer Nitin Ohri, M.D. Montefiore Medical Center Albert Einstein College of Medicine 12/15/2012 Disclosures I have no conflicts of interest to disclose. Outline Background Treatment
More informationUpdated Apr 2017 by Dr. Jenny Ko (Medical Oncologist, Abbotsford Cancer Centre)
Local Esophageal Cancer Summary Updated Apr 2017 by Dr. Jenny Ko (Medical Oncologist, Abbotsford Cancer Centre) Reviewed by Dr. Yoo-Joung Ko (Medical Oncologist, Sunnybrook Odette Cancer Centre, University
More informationMini J.Elnaggar M.D. Radiation Oncology Ochsner Medical Center 9/23/2016. Background
Mini J.Elnaggar M.D. Radiation Oncology Ochsner Medical Center 9/23/2016 Background Mostly adenocarcinoma (scc possible, but treated like anal cancer) 39, 220 cases annually Primary treatment: surgery
More informationPre- Versus Post-operative Radiotherapy
Postoperative Radiation and Chemoradiation: Indications and Optimization of Practice Dislosures Clinical trial support from Genentech Inc. Sue S. Yom, MD, PhD Associate Professor UCSF Radiation Oncology
More informationPerioperative chemotherapy: individualized therapy or same treatment for all? Prof. Dr. med. Salah-Eddin Al-Batran
Perioperative chemotherapy: individualized therapy or same treatment for all? Prof. Dr. med. Salah-Eddin Al-Batran Institute of Clinical Cancer Research Krankenhaus Nordwest UCT - University Cancer Center
More informationTristate Lung Meeting 2014 Pro-Con Debate: Surgery has no role in the management of certain subsets of N2 disease
Tristate Lung Meeting 2014 Pro-Con Debate: Surgery has no role in the management of certain subsets of N2 disease Jennifer E. Tseng, MD UFHealth Cancer Center-Orlando Health Sep 12, 2014 Background Approximately
More informationNeo- and adjuvant treatment for gastric cancer: The role of chemotherapy
Neo- and adjuvant treatment for gastric cancer: The role of chemotherapy Priv. Doz. Dr. Dr. med. T.O. Götze Institute of Clinical Cancer Research Director: Prof. Dr. S.-E. Al- Batran University Cancer
More informationDetermining the Optimal Surgical Approach to Esophageal Cancer
Determining the Optimal Surgical Approach to Esophageal Cancer Amit Bhargava, MD Attending Thoracic Surgeon Department of Cardiovascular and Thoracic Surgery Open Esophagectomy versus Minimally Invasive
More informationUpper Gastrointestinal. Friday, March 2, :00 p.m. 2:45 p.m.
Upper Gastrointestinal Friday, March 2, 2018 2:00 p.m. 2:45 p.m. Social Q&A Use your phone, tablet, or laptop to Submit questions to speakers and moderators Answer interactive questions / audience response
More informationControversies in management of squamous esophageal cancer
2015.06.12 12.47.48 Page 4(1) IS-1 Controversies in management of squamous esophageal cancer C S Pramesh Thoracic Surgery, Department of Surgical Oncology, Tata Memorial Centre, India In Asia, squamous
More informationLung Cancer Epidemiology. AJCC Staging 6 th edition
Surgery for stage IIIA NSCLC? Sometimes! Anne S. Tsao, M.D. Associate Professor Director, Mesothelioma Program Director, Thoracic Chemo-Radiation Program May 7, 2011 The University of Texas MD ANDERSON
More informationSurgery for Gastric and Oesophageal Cancer
Surgery for Gastric and Oesophageal Cancer Trends in cancer mortality, England and Wales SMR base 1980 Oesophago-Gastric Cancer The National Problem 5 th commonest malignancy 4 th commonest cause of death
More informationMinimally Invasive Esophagectomy- Valuable. Jayer Chung, MD University of Colorado Health Sciences Center December 11, 2006
Minimally Invasive Esophagectomy- Valuable Jayer Chung, MD University of Colorado Health Sciences Center December 11, 2006 Overview Esophageal carcinoma What is minimally invasive esophagectomy (MIE)?
More informationESOPHAGEAL CANCER. Dr. Paul Gardiner December 17, 2002 Discipline of Surgery Rounds
ESOPHAGEAL CANCER Dr. Paul Gardiner December 17, 2002 Discipline of Surgery Rounds ESOPHAGEAL CANCER I. EPIDEMIOLOGY INCIDENCE, DIAGNOSIS & STAGING II. TREATMENT OPTIONS Current role of induction therapies
More informationEpidemiology, aetiology and the patient pathway in oesophageal and pancreatic cancers
Epidemiology, aetiology and the patient pathway in oesophageal and pancreatic cancers Dr Ian Chau Consultant Medical Oncologist Women's cancers Breast cancer introduction 3 What profession are you in?
More informationTratamiento Multidisciplinar de Estadios Localmente Avanzados en Cáncer de Pulmón
Tratamiento Multidisciplinar de Estadios Localmente Avanzados en Cáncer de Pulmón Santiago Ponce Aix Servicio Oncología Médica Hospital Universitario 12 de Octubre Madrid Stage III: heterogenous disease
More informationNeo- and adjuvant treatment for gastric cancer: The role of chemotherapy
Anna Dorothea Wagner, PD & MER Department of Oncology University of Lausanne Neo- and adjuvant treatment for gastric cancer: The role of chemotherapy Structure 1. Background and overview 2. Adjuvant chemotherapy:
More information3/8/2014. Case Presentation. Primary Treatment of Anal Cancer. Anatomy. Overview. March 6, 2014
Case Presentation Primary Treatment of Anal Cancer 65 year old female presents with perianal pain, lower GI bleeding, and anemia with Hb of 7. On exam 6 cm mass protruding through the anus with bulky R
More informationDe-Escalate Trial for the Head and neck NSSG. Dr Eleanor Aynsley Consultant Clinical Oncologist
De-Escalate Trial for the Head and neck NSSG Dr Eleanor Aynsley Consultant Clinical Oncologist 3 HPV+ H&N A distinct disease entity Leemans et al., Nature Reviews, 2011 4 Good news Improved response to
More informationWHO BENEFITS FROM ADJUVANT CHEMOTHERAPY RADIATION CHEMORADIATION? Dr. Paul Gardiner April 23, 2001 Discipline of Surgery Grand Rounds
WHO BENEFITS FROM ADJUVANT CHEMOTHERAPY RADIATION CHEMORADIATION? Dr. Paul Gardiner April 23, 2001 Discipline of Surgery Grand Rounds LUNG Dr. Greenland ESOPHAGUS Dr. Gardiner ESOPHAGEAL CANCER 1200 new
More informationDisclosures. Preoperative Treatment: Chemotherapy or ChemoRT? Adjuvant chemotherapy helps. so what about chemo first?
Disclosures Preoperative Treatment: Chemotherapy or ChemoRT? Advisory boards Genentech (travel only), Pfizer Salary support for clinical trials Celgene, Merck, Merrimack Matthew Gubens, MD, MS Assistant
More informationThe Learning Curve for Minimally Invasive Esophagectomy
The Learning Curve for Minimally Invasive Esophagectomy AATS Focus on Thoracic Surgery Mastering Surgical Innovation Las Vegas Nevada Oct. 27-28 2017 Scott J Swanson, M.D. Professor of Surgery Harvard
More informationMeta analysis in Rectal Cancer
Meta analysis in Rectal Cancer Dr. Monica Irukulla Professor and Head Department of Radiation Oncology Nizam s Institute of Medical Sciences hyderabad Areas of meta analysis in rectal cancers Epidemiology
More informationPerioperative versus adjuvant management of gastric cancer, update 2013
Perioperative versus adjuvant management of gastric cancer, update 2013 Cornelis J.H. van de Velde, MD, PhD,FRCPS and FACS,Hon. Professor of Surgery President ECCO - the European Cancer Organization Past-President
More informationEsophageal cancer: Biology, natural history, staging and therapeutic options
EGEUS 2nd Meeting Esophageal cancer: Biology, natural history, staging and therapeutic options Michael Bau Mortensen MD, Ph.D. Associate Professor of Surgery Centre for Surgical Ultrasound, Upper GI Section,
More informationCase Conference. Craig Morgenthal Department of Surgery Long Island College Hospital
Case Conference Craig Morgenthal Department of Surgery Long Island College Hospital Neoadjuvant versus Adjuvant Radiation Therapy in Rectal Carcinoma Epidemiology American Cancer Society statistics for
More informationOverview on Gastric Cancer
Chapter 5 Role of postoperative chemoradiotherapy in the therapeutic management of adenocarcinomas of the stomach and oesogastric junction Ben Salah H*; Bahri M; Dhouib F; Sallemi N; Bourmèche M; Daoud
More informationThe International Federation of Head and Neck Oncologic Societies. Current Concepts in Head and Neck Surgery and Oncology
The International Federation of Head and Neck Oncologic Societies Current Concepts in Head and Neck Surgery and Oncology www.ifhnos.net The International Federation of Head and Neck Oncologic Societies
More informationSingle centre outcomes from definitive chemo-radiotherapy and single modality radiotherapy for locally advanced oesophageal cancer
Original Article Single centre outcomes from definitive chemo-radiotherapy and single modality radiotherapy for locally advanced oesophageal cancer Ben Alexander Fulton 1, Joanna Gray 2, Alexander McDonald
More informationOverall survival analysis of neoadjuvant chemoradiotherapy and esophagectomy for esophageal cancer
Original Article Overall survival analysis of neoadjuvant chemoradiotherapy and esophagectomy for esophageal cancer Faisal A. Siddiqui 1, Katelyn M. Atkins 2, Brian S. Diggs 3, Charles R. Thomas Jr 1,
More informationRobotic Surgery for Esophageal Cancer
Robotic Surgery for Esophageal Cancer Kemp H. Kernstine, MD PhD Division of Thoracic Surgery City of Hope Medical Center and Beckman Research Institute May 1, 2010 Esophageal Cancer on the Rise JNCI 2005,
More informationPreoperative adjuvant radiotherapy
Preoperative adjuvant radiotherapy Dr John Hay Radiation Oncology Program BC Cancer Agency Vancouver Cancer Centre The key question for the surgeon Do you think that this tumour can be resected with clear
More informationNon-small Cell Lung Cancer: Multidisciplinary Role: Role of Medical Oncologist
Non-small Cell Lung Cancer: Multidisciplinary Role: Role of Medical Oncologist Vichien Srimuninnimit, MD. Medical Oncology Division Faculty of Medicine, Siriraj Hospital Outline Resectable NSCLC stage
More informationThe Role of Radiation Therapy in Upper Gastrointestinal Cancers
The Role of Radiation Therapy in Upper Gastrointestinal Cancers David H. Ilson, MD, PhD David H. Ilson, MD, PhD, is an attending physician at the Memorial Sloan Kettering Cancer Center and a professor
More informationThe CROSS road in neoadjuvant therapy for esophageal cancer: long-term results of CROSS trial
Editorial The CROSS road in neoadjuvant therapy for esophageal cancer: long-term results of CROSS trial Ian Wong, Simon Law Division of Esophageal and Upper Gastrointestinal Surgery, Department of Surgery,
More informationEsophageal Cancer. What is the value of performing PET scan routinely for staging of esophageal cancers
Esophageal Cancer What is the value of performing PET scan routinely for staging of esophageal cancers What is the sensitivity and specificity of PET scan for metastatic lesions When should PET scan be
More informationSurgical Management of Pancreatic Cancer
I Congresso de Oncologia D Or July 5-6, 2013 Surgical Management of Pancreatic Cancer Michael A. Choti, MD, MBA, FACS Department of Surgery Johns Hopkins University School of Medicine, Baltimore, MD Estimated
More informationPancreatic Adenocarcinoma
Pancreatic Adenocarcinoma AProf Lara Lipton 28 April 2018 Percentage alive 5 years after diagnosis for men and women Epidemiology 6% of cancer related deaths worldwide 4 th highest cause of cancer death
More informationMINIMALLY INVASIVE ESOPHAGECTOMY FOR CANCER: where do we stand?
MINIMALLY INVASIVE ESOPHAGECTOMY FOR CANCER: where do we stand? Ph Nafteux, MD Copenhagen, Nov 3rd 2011 Department of Thoracic Surgery, University Hospitals Leuven, Belgium W. Coosemans, H. Decaluwé, Ph.
More informationTwo Cycles of Chemoradiation: 2 Cycles is Enough. Concurrent Chemotherapy / RT Regimens
1 Two Cycles of Chemoradiation: 2 Cycles is Enough Heather Wakelee, M.D. Assistant Professor of Medicine, Oncology Stanford University Concurrent Chemotherapy / RT Regimens Cisplatin 50 mg/m 2 on days
More informationThe Royal Marsden. Surgery for Gastric and GE Junction Cancer: primary palliative when and where? William Allum Consultant Surgeon
The Royal Marsden Surgery for Gastric and GE Junction Cancer: primary palliative when and where? William Allum Consultant Surgeon Any surgeon can cure Surgeon - dependent No surgeon can cure EMR D2 GASTRECTOMY
More informationWhen to Integrate Surgery for Metatstatic Urothelial Cancers
When to Integrate Surgery for Metatstatic Urothelial Cancers Wade J. Sexton, M.D. Senior Member and Professor Department of Genitourinary Oncology Moffitt Cancer Center Case Presentation #1 67 yo male
More informationT2N0 Esophageal Cancer: Does it Exist? Should we give Preop Therapy?
T2N0 Esophageal Cancer: Does it Exist? Should we give Preop Therapy? Traves D. Crabtree Associate Professor of Surgery Washington University School of Medicine I am a consultant for Ethicon Endo-Surgery
More informationSurgical Management of Advanced Stage Colon Cancer. Nathan Huber, MD 6/11/14
Surgical Management of Advanced Stage Colon Cancer Nathan Huber, MD 6/11/14 Colon Cancer Overview Approximately 50,000 attributable deaths per year Colorectal cancer is the 3 rd most common cause of cancer-related
More informationUpper Gastrointestinal Cancers in the Elderly. Choo Su Pin Senior Consultant Medical Oncology National Cancer Centre Singapore
Upper Gastrointestinal Cancers in the Elderly Choo Su Pin Senior Consultant Medical Oncology National Cancer Centre Singapore Gastric Cancer --High Global Burden Global Cancer Deaths % of all cancer (2008)
More informationSurgical strategies in esophageal cancer
Gastro-Conference Berlin 2005 October 1-2, 2005 Surgical strategies in esophageal cancer J. Rüdiger Siewert Department of Surgery, Klinikum rechts der Isar Technische Universität München Esophageal Cancer
More informationTHE ROLE OF RADIATION THERAPY IN MANAGEMENT OF PANCREATIC ADENOCARCINOMA. TIMUR MITIN, MD, PhD
THE ROLE OF RADIATION THERAPY IN MANAGEMENT OF PANCREATIC ADENOCARCINOMA TIMUR MITIN, MD, PhD RESECTABLE DISEASE MANAGEMENT: RESECTABLE DISEASE Resection offers the only possibility of long term survival
More informationThe Royal Marsden. Surgery for Gastric and GE Junction Cancer: primary palliative when and where? William Allum
The Royal Marsden Surgery for Gastric and GE Junction Cancer: primary palliative when and where? William Allum The Royal Marsden William Allum Conflict of Interest None Any surgeon can cure Surgeon - dependent
More informationStage III Non-Small Cell Lung Cancer, Is There Any Progress? HARMESH R NAIK, MD. KARMANOS CANCER INSTITUTE 2/24/99
Stage III Non-Small Cell Lung Cancer, Is There Any Progress? HARMESH R NAIK, MD. KARMANOS CANCER INSTITUTE 2/24/99 Introduction 1/3 of the total lung cancer cases few patients are cured with single modality
More informationAdjuvant Chemotherapy for Rectal Cancer: Are we making progress?
Adjuvant Chemotherapy for Rectal Cancer: Are we making progress? Hagen Kennecke, MD, MHA, FRCPC Division Of Medical Oncology British Columbia Cancer Agency October 25, 2008 Objectives Review milestones
More informationImpact of esophageal cancer staging on overall survival and disease-free survival based on the 2010 AJCC classification by lymph nodes
Journal of Radiation Research, 2013, 54, 307 314 doi: 10.1093/jrr/rrs096 Advance Access Publication 2 November 2012 Impact of esophageal cancer staging on overall survival and disease-free survival based
More informationSupplementary appendix
Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: James RD, Glynne-Jones R, Meadows HM, et al.
More informationEsophageal cancer located at the cervical and upper thoracic
ORIGINAL ARTICLE Esophageal Cancer Located at the Neck and Upper Thorax Treated with Concurrent Chemoradiation: A Single- Institution Experience Shulian Wang, MD,* Zhongxing Liao, MD, Yuan Chen, MD, Joe
More informationWhat Is The Optimal Adjuvant Therapy in Pancreatic Adenoca: Intensified Chemotherapy March 28 th, 2015
What Is The Optimal Adjuvant Therapy in Pancreatic Adenoca: Intensified Chemotherapy March 28 th, 2015 Eileen M. O Reilly, M.D. Associate Director David M. Rubenstein Center Pancreatic Cancer Research
More informationPreoperative chemoradiotherapy for locally advanced gastric cancer
Pepek et al. Radiation Oncology 2013, 8:6 RESEARCH Preoperative chemoradiotherapy for locally advanced gastric cancer Open Access Joseph M Pepek 1, Junzo P Chino 1, Christopher G Willett 1, Manisha Palta
More informationOutline. WBRT field. Brain Metastases. Whole Brain RT Prophylactic WBRT Stereotactic radiosurgery (SRS) 1 fraction Stereotactic frame
Radiation Therapy for Advanced NSC Lung Ca Alexander Gottschalk, M.D., Ph.D. Associate Professor Director of CyberKnife Radiosurgery Department of Radiation Oncology University of California San Francisco
More informationCONTROVERSIES IN THE PREOPERATIVE RADIOTHERAPEUTIC MANAGEMENT OF RESECTABLE ESOPHAGEAL CANCER
SA-CME INFORMATION SA CME Information CONTROVERSIES IN THE PREOPERATIVE RADIOTHERAPEUTIC MANAGEMENT OF RESECTABLE ESOPHAGEAL CANCER Description This review examines the role of trimodality therapy in the
More informationAATS Focus on Thoracic Surgery: Minimally Invasive Esophagectomy: Are We Still Getting Better in 2017?
AATS Focus on Thoracic Surgery: Mastering Surgical Innovation Las Vegas, NV October 28, 2017 Session VIII: Video Session Minimally Invasive Esophagectomy: Are We Still Getting Better in 2017? James D.
More informationClinical Aspects of Multimodality Therapy for Resectable Locoregional Esophageal Cancer
Review Clinical Aspects of Multimodality Therapy for Resectable Locoregiol Esophageal Cancer Masayuki Shinoda, MD, Shunzo Hatooka, MD, Shoichi Mori, MD, and Tetsuya Mitsudomi, MD Radical resection has
More informationAccuracy of endoscopic ultrasound staging for T2N0 esophageal cancer: a national cancer database analysis
Review Article Accuracy of endoscopic ultrasound staging for T2N0 esophageal cancer: a national cancer database analysis Ravi Shridhar 1, Jamie Huston 2, Kenneth L. Meredith 2 1 Department of Radiation
More informationSalvage esophagectomy for persistent or recurrent disease after definitive chemoradiation
Perspective Salvage esophagectomy for persistent or recurrent disease after definitive chemoradiation Stephen G. Swisher 1, Jenifer Marks 2, David Rice 1 1 Department of Thoracic and Cardiovascular Surgery,
More informationAdjuvant Chemotherapy
State-of-the-art: standard of care for resectable NSCLC Adjuvant Chemotherapy JY DOUILLARD MD PhD Professor of Medical Oncology Integrated Centers of Oncology R Gauducheau University of Nantes France Adjuvant
More informationRob Glynne-Jones Mount Vernon Cancer Centre
ESMO Preceptorship Programme Colorectal Cancer Valencia May 2018 State of the art: Standards of care in preoperative treatment for rectal cancer Rob Glynne-Jones Mount Vernon Cancer Centre My Disclosures:
More informationDetermining the optimal number of lymph nodes harvested during esophagectomy
Original Article Determining the optimal number of lymph nodes harvested during esophagectomy Khaldoun Almhanna, Jill Weber, Ravi Shridhar, Sarah Hoffe, Jonathan Strosberg, Kenneth Meredith Department
More informationEsophageal Cancer: A Multimodality Approach to Detection and Staging
Esophageal Cancer: A Multimodality Approach to Detection and Staging, MBA Topic: Esophageal Cancer Imaging: A multimodality approach Conference: Society of Thoracic Imaging Location: Date/Time: March 14,
More informationAIOM POST-ASCO GI 2018 HIGHLIGHTS ESOPHAGUS AND STOMACH CANCER
Mario Scartozzi Oncologia Medica Università degli Studi Azienda Ospedaliero-Universitaria Cagliari AIOM POST-ASCO GI 2018 HIGHLIGHTS ESOPHAGUS AND STOMACH CANCER (WE CAN T GET NO) SATISFACTION LET THEM
More information(Neo-) adjuvant Treatment of Gastric Cancer. - The European View
(Neo-) adjuvant Treatment of Gastric Cancer - The European View Florian Lordick, MD Professor of Oncology Director of the University Cancer Center Leipzig (UCCL) University of Leipzig, Germany My Conflict
More informationEVIDENCE BASED MANAGEMENT OF STAGE III NSCLC MILIND BALDI
EVIDENCE BASED MANAGEMENT OF STAGE III NSCLC MILIND BALDI Overview Introduction Diagnostic work up Treatment Group 1 Group 2 Group 3 Stage III lung cancer Historically was defined as locoregionally advanced
More informationThis article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and
This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution
More informationPERIOPERATIVE TREATMENT OF NON SMALL CELL LUNG CANCER. Virginie Westeel Chest Disease Department University Hospital Besançon, France
PERIOPERATIVE TREATMENT OF NON SMALL CELL LUNG CANCER Virginie Westeel Chest Disease Department University Hospital Besançon, France LEARNING OBJECTIVES 1. To understand the potential of perioperative
More informationPneumonectomy After Induction Rx: Is it Safe?
Pneumonectomy After Induction Rx: Is it Safe? David J. Sugarbaker, M.D. Director, Chief, Division of Thoracic Surgery The Olga Keith Weiss Chair of Surgery of Medicine at, Pneumonectomy after induction
More informationThe Impact of Body Mass Index on Esophageal Cancer
Obesity does not appear to affect the morbidity of treatments for esophageal cancer. Samuel Bak. BK1464 Added Perspective I. Oil on canvas, 12ʺ 16ʺ. The Impact of Body Mass Index on Esophageal Cancer Joyce
More informationHeterogeneity of N2 disease
Locally Advanced NSCLC Surgery? No. Ramaswamy Govindan M.D Co-Director, Section of Medical Oncology Alvin J Siteman Cancer Center at Washington University School of Medicine St. Louis, Missouri Heterogeneity
More informationHISTORY SURGERY FOR TUMORS WITH INVASION OF THE APEX 15/11/2018
30 EACTS Annual Meeting Barcelona, Spain 1-5 October 2016 SURGERY FOR TUMORS WITH INVASION OF THE APEX lung cancer of the apex of the chest involving any structure of the apical chest wall irrespective
More informationTreatment results of proton beam therapy with chemo-radiotherapy for stage I-III esophageal cancer
Treatment results of proton beam therapy with chemo-radiotherapy for stage I-III esophageal cancer Nobukazu Fuwa 1, Akinori Takada 2 and Takahiro Kato 3 1;Departments of Radiology, Hyogo Ion Beam Medical
More informationQuiz Adenocarcinoma of the distal stomach has been increasing in the last 20 years. a. True b. False
Quiz 1 1. Which of the following are risk factors for esophagus cancer. a. Obesity b. Gastroesophageal reflux c. Smoking and Alcohol d. All of the above 2. Adenocarcinoma of the distal stomach has been
More informationRadiotherapy Management of Breast Cancer Treated with Neoadjuvant Chemotherapy. Julia White MD Professor, Radiation Oncology
Radiotherapy Management of Breast Cancer Treated with Neoadjuvant Chemotherapy Julia White MD Professor, Radiation Oncology Agenda Efficacy of radiotherapy in the management of breast cancer in the Adjuvant
More information11/21/ M with LUL Mass Case Presentation / Round Table Discussion. Multiple-choice question What stage is this tumor?
MS 62M with LUL Mass Case Presentation / Round Table Discussion Dr. Jasleen Kukreja and Johannes Kratz Department of Thoracic Surgery University of California, San Francisco 62M, presented to clinic 6/2009
More informationIndex. Note: Page numbers of article titles are in boldface type.
Index Note: Page numbers of article titles are in boldface type. A Abdominal drainage, after hepatic resection, 159 160 Ablation, radiofrequency, for hepatocellular carcinoma, 160 161 Adenocarcinoma, pancreatic.
More informationVATS after induction therapy: Effective and Beneficial Tips on Strategy
VATS after induction therapy: Effective and Beneficial Tips on Strategy AATS Focus on Thoracic Surgery Mastering Surgical Innovation Las Vegas Nevada Oct. 27-28 2017 Scott J. Swanson, M.D. Professor of
More informationColon Cancer Liver Metastases: Liver-Directed Therapy
Colon Cancer Liver Metastases: Liver-Directed Therapy Shishir K. Maithel, MD FACS Assistant Professor of Surgery Division of Surgical Oncology Winship Cancer Institute Emory University August 10, 2014
More information肺癌放射治療新進展 Recent Advance in Radiation Oncology in Lung Cancer 許峰銘成佳憲國立台灣大學醫學院附設醫院腫瘤醫學部
肺癌放射治療新進展 Recent Advance in Radiation Oncology in Lung Cancer 許峰銘成佳憲國立台灣大學醫學院附設醫院腫瘤醫學部 Outline Current status of radiation oncology in lung cancer Focused on stage III non-small cell lung cancer Radiation
More informationRadiotherapy & Cervical Cancer Dr Mary McCormack Consultant Clinical Oncologist University College Hospital, London,UK
Lead Group Log Radiotherapy & Cervical Cancer Dr Mary McCormack Consultant Clinical Oncologist University College Hospital, London,UK Cervical Cancer treatment Treatment planning should be made on a multidisciplinary
More informationNeoadjuvant chemoradiation
Neoadjuvant chemoradiation followed by surgery for treatment of esophageal cancer Chawalit Lertbutsayanukul MD. Division of Therapeutic Radiation and Oncology Department of Radiology Faculty of medicines
More informationIntroduction. Original Article
Original Article A nomogram that predicts pathologic complete response to neoadjuvant chemoradiation also predicts survival outcomes after definitive chemoradiation for esophageal cancer Steven H. Lin
More information