Circulating Tumor Cells (CTC) Technologies

Transcription

1 Table of Contents MIR036 I. SCOPE AND METHODOLOGY Scope of the Study Analytics and data presented in this report pertain to several parameters such as - Research Methodology This report is uniquely researched and the methodology includes: Units and Currency 2. REPORT SYNOPSIS 2.1 Circulating Tumor Cells (CTC) Technologies - Introduction Circulating Tumor Cells (CTC) Technologies - Timeline Biomarkers CTC as a Biomarker Process of Metastatic Development, CTCs and Cancer Stem Cells CTCs in Blood and DTCs in Bone Marrow Circulating Tumor Cells and Their Clinical Significance Detection of CTCs and its Significance Epithelial Mesenchymal Transition (EMT) Technologies for Isolation and Characterization of CTCs Cell Free Nucleic Acids based CTC detection CTC Detection on Physical Properties Basis Antibody Capture Technology Miscellaneous CTC Detection Strategies CTC and Prostate Cancer CTC in Breast Cancer CTCs in Ovarian Cancer CTC Diagnosis & Prognosis CTCs as Therapy Response Marker 2.2 Segmentation Exhibit 1. Segmentation of Global CTC Technologies Market by Cancer Type and by Function Page 1

2 2.3 CTC Technologies - Global Market Analysis Exhibit 2. CTC Technologies - Global Market - Historic, Current, and Forecast ( ) in US$ Billion Exhibit 3. List of Major Global Companies - CTC Technologies 3. MARKET DYNAMICS 3.1 CTCs - FOREWORD CTC Technologies can be done by - CTCs - Impact 3.2 Global CTC Technologies Market Analysis Exhibit 4. CTC Technologies - Global Market - Historic, Current, and Forecast ( ) in US$ Million for North America, Europe, Asia-Pacific and Rest of World Exhibit 5. CTC Technologies - Global Market Shares (2012, 2018 & 2022) for North America, Europe, Asia-Pacific and Rest of World Exhibit 6. Circulating Tumor Cells - Global Market Analysis ( ) for Per Test Cost, Number of Tests and Cancer Incidence Cancer - The Global Scene Exhibit 7. List of Product/Technologies for CTC Analysis 3.3 North American CTC Technologies Market Analysis Exhibit 8. CTC Technologies - North American Market - Historic, Current, and Forecast ( ) in US$ Million United States Market Analysis Exhibit 9. CTC Technologies - United States Market - Historic, Current, and Forecast ( ) in US$ Million Cancer Statistics Exhibit 10. United States Cancer Incidence - Estimated Cases and Deaths in 2012 Cancer Care Cost Exhibit 11. Cancer Care - National Cost by Cancer Site in US$ Billion Exhibit 12. Cancer Care - Annual Costs (2010) in US$ Competitor Overview 3.4 European CTC Technologies Market Exhibit 13. CTC Technologies - European Market - Historic, Current, and Forecast ( ) in US$ Million Market Snapshots Page 2

3 Cancer Statistics Exhibit 14. European Union Cancer Incidence - Reported Cases and Deaths in 2012 Competitor Overview United Kingdom Germany France Switzerland 3.5 Asia-Pacific CTC Technologies Market Exhibit 15. CTC Technologies - Asia-Pacific Market - Historic, Current, and Forecast ( ) in US$ Million Exhibit 16. Cancer Incidence in China - Reported Cases and Deaths in 2012 Competitor Overview Japan Rest of Asia-Pacific 3.6 Rest of World CTC Technologies Market Exhibit 17. CTC Technologies - Rest of World Market - Historic, Current, and Forecast ( ) in US$ Million Competitor Overview 3.7 Analysis by Cancer Type Exhibit 18. CTC Technologies by Type - Global Market - Historic, Current, and Forecast ( ) in US$ Million for Prostate Cancer, Breast Cancer and Others Exhibit 19. CTC Technologies by Type - Global Market Shares (2012, 2018 & 2022) for Prostate Cancer, Breast Cancer and Others United States Market for CTC Technologies in Cancer Types Exhibit 20. CTC Technologies by Type - United States Market - Historic, Current, and Forecast ( ) in US$ Million for Prostate Cancer, Breast Cancer and Others Exhibit 21. CTC Technologies by Type - United States Market Shares (2012, 2018 & 2022) for Prostate Cancer, Breast Cancer and Others 3.8 Analysis by Function Exhibit 22. CTC Technologies by Function - Global Market - Historic, Current, and Forecast ( ) in US$ Million for Prognostics, Diagnostics and Therapy Management Page 3

4 Exhibit 23. CTC Technologies by Function - Global Market Shares (2012, 2018 & 2022) for Prognostics, Diagnostics and Therapy Management United States Market for CTC Technologies in Cancer Function Exhibit 24. CTC Technologies by Function - United States Market - Historic, Current, and Forecast ( ) in US$ Million for Prognostics, Diagnostics and Therapy Management Exhibit 25. CTC Technologies by Function - United States Market Shares (2012, 2018 & 2022) for Prognostics, Diagnostics and Therapy Management 3.9 Circulating Tumor Cells (CTC) Technologies - Market Outlook 4. COMPETITOR DYNAMICS 4.1 CTC Technologies Providers - Competitor Profiles ANGLE plc (UK) ApoCell, Inc. (USA) Applied Spectral Imaging, Inc. (USA) BioCEP Ltd. (Israel) BioCytics, Inc. (USA) BioFluidica, Inc. (USA) BioView Ltd. (Israel) Cancer Research UK Manchester Institute (UK) Canopus Bioscience Ltd. (Canada) CellTraffix, Inc. (USA) Celsee Diagnostics (USA) Clearbridge BioMedics (Singapore) Creatv MicroTech, Inc. (USA) Cynvenio Biosystems, Inc. (USA) DTU Fotonik (Denmark) More Significant Market Developments Fluxion Biosciences and University of Texas Health Science Center Enter into Collaboration Menarini-Silicon Biosystems Releases DEPArray NxT Digital Cell-Sorting System Abnova Obtains Exclusive Global License to CSV Monoclonal Antibody to Detect Cancer-Specific Circulating Page 4

5 Tumor Cells from MD Anderson Cancer Center Biocept and MedStar Georgetown University Hospital Enter into Collaboration for Liquid Biopsy Study Biocept Enters into Agreement with Quest Diagnostics Mexico to Continue Global Expansion Biocept Enters into Collaboration for Clinical Trial by a Biopharmaceutical Company; To Identify Biomarkers in Cerebral Spinal Fluid of Lung Cancer Patients with Cancer Spread to the Brain RareCyte Enters into CRADA with NCI in Immunology/Oncology Fluxion Biosciences Launches New Range of Circulating Tumor Cell (CTC) Recovery Kits - First Commercial Kit Targeting EMT Cells Avera Medical and Epic Sciences Enter into Collaboration on Cancer Therapy Clinical Trial Epic Sciences Enters into 35th Collaboration to Advance Companion Diagnostics for New Targeted Therapeutics More PRODUCT/TECHNOLOGY RESEARCH Circulating Tumor Cells (CTCs) - Key Observations CTC Detection The Hampering Facts CTC Detection - Molecular Targets CTC Enumeration Exhibit 26. Novel Methods for Circulating Tumor Cell Identification and Main Conclusion(s) CTC Enrichment Exhibit 27. CTC Enrichment Methods CTC Capture CTC Isolation Microfluidic Devices CTCs and Cancer Stem Cells (CSCs) Signaling Pathways Surface Markers Cancer Biomarkers Tumor Marker Cells as Biomarkers Circulating Tumor Cells (CTCs) - Cancer Biomarkers Page 5

6 Functions of Biomarkers Metronomic Chemotherapy for Cancer Treatment Dispersal of Tumor Cells Biology of Circulating Tumor Cells Potential and Proliferative activity of Circulating Tumor Cells CTCs and Epithelial Marker Genes CTCs and Mesenchymal Transition Stem Cell-like phenotype of CTCs Changed Geno/Phenotype of CTCs when compared to Primary Tumor Epithelial Mesenchymal Transition (EMT) Presence of CTCs in Epithelial Mesenchymal Transition and Disseminated Disease Mesenchymal and Cancer Stem Cells qpcr Expression Markers Forms of CTCs Frequency of CTCs Characterization of Protein Expression and Signaling in CTCs Significance of Circulating Tumor Cells Categorizing CTCs Advanced Categorization of CTC Detection of CTCs and its Significance CTC-Receptors Major Causes of Metastasis Cancer Progesterone receptor Positive HER-2 Positive Receptor Triple Negative Type of Tumor Epic Sciences Procedure Maintrac CTCs as Early Diagnosis for Recurrence of Cancer Other methods Page 6

7 Mice models for CTC studies CTC Count Prominence Recent Technique on Cancer Prognosis Immunofluorescent Staining Technique FAST scanning SERS Technology CellSearch System Biochip Platforms Photoacoustic Spectroscopy Immunomagnetic Separation Immunohistochemistry CISH Technique FISH Technique Nanotechnology Tagged- Amplicon Sequencing Technique CTC Technologies Techniques for Detection and Manipulation Function-Based Methods Nonfunction-Based Techniques In Vivo CTC Manipulation Techniques Challenges to In Vivo Manipulation Devices Advanced CTC Detection Technologies Based on Genomics CTC and Cancer Type Introduction Breast Cancer Therapy using Circulating Tumor Cells CTC found in Early Metastasis CTC Detection Methods CTCs as a Biomarker in Advanced Breast Cancer Detection of CTCs in Prostate & Colorectal Cancers CTCs in Ovarian Cancer Page 7

8 Exhibit 28. Cancer Type and Respective Detection Methods and Markers CTC Diagnosis and Prognosis Circulating Tumor Cell based PSA as a Biomarkers in Prostate Cancer Prognosis Exhibit 29. Clinical Studies Evaluating Circulating Tumor Cells as a Prognostic Tool CTCs as Therapy Response Marker CTCs in Custom-Made Medicine Circulating Tumor Cells (CTC) Technologies - Research Briefs Metastasis -Promoting Circulating Tumor Cell Group Cross Capillary-Sized Vessels Better Liquid Biopsy Method Improves Detecting of Tumor DNA in Blood Circulating Tumor Cells and Treatment Resistance and Response in Prostate Cancer Patients Two Years after Chemotherapy, Circulating Tumor Cells are Harbingers of Shorter Survival Scientists Discover How Cancer Cells Escape Blood Vessels Researchers Isolate Cells Implicated with Breast Cancer- Derived Brain Tumors More CORPORATE DIRECTORY 7. PATENTS Page 8