GENReports: Market & Tech Analysis

Transcription

1 GENReports: Market & Tech Analysis > Gary Oosta, Ph.D. Biotechnology Analyst, Select Biosciences, Inc. > Enal Razvi, Ph.D. Managing Director Select Biosciences, Inc. GENReports: Market & Tech Analysis, Produced by Oosta and Razvi 2015

2 Deep Analysis of Exosomes Marketplace from the BoBom- Up Scope of this Report: There is the unmet need to characterize the dynamics of the exosomes and broader extracellular vesicles marketplace as it is rapidly evolving and highly granular with lots of market segments Select Biosciences has been tracking this field for the past several years and our conenuing industry coverage allows us to pinpoint trends in this space In this report, we present a snapshot of this complex space and map its evolueon this is part I of a three- part report in this part I we present the macro landscape of exosomes We Present Here: An overall landscape of Exosome publicaeon acevity Trends in specific segments within the exosome landscape An ideneficaeon of segments (disease classes, tools and methods in exosome research) that are responsible for growth Data and Analysis are up- to- date as of June 2015

3 Based on PublicaUon AcUvity, Interest in Exosomes is Growing at a Nearly ExponenUal Pace We will focus the analysis presented here on the years , where the publicaeon rates are highest.

4 The Exosome Space is Composed of 35,730 PublicaUons The Exosomes Word Cloud: A Picture is &W orth a Thousand Words GENReports: Market Tech Analysis, Produced by Oosta and Razvi 2015

5 Trends in Exosome Terminology suggests that the Overlapping Terminology Star%ng to Clarify Exosome Extracellular Vesicle One Metric for the EvoluEon/MaturaEon of the Exosomes Field is the Clarity of Nomenclature

6 Trends in DetecUon Methods for Exosome Research in the Academic Literature. Flow Cytometry: Growing in Penetrance GENReports: in Market the Exosomes & Tech Analysis, Space Produced by Oosta and Razvi 2015 Analysis of Individual Exosomes and Exosome Subsets Defined by Surface Phenotype

7 Trends in Tool Usage for Exosome Research in the Academic Literature Expanding Segments Flow Cytometry Western BloYng Imaging Mass Spectrometry UltracentrifugaEon

8 PCR remains a Key Tool: qpcr is an Emerging trend in Exosome Research The InterrogaUon of RNA Cargo in Exosomes

9 Micro- & Nano- in Exosomes The Impact of Microfluidics on Exosome Research is SEll Small We however believe that the InterrogaEon of CirculaUng Biomarkers via Microfluidics, Lab- on- a- Chip Approaches will ConsEtute an Emerging Theme Going Forward

10 Exosome Research Market SegmentaUon by Biofluid Class Top Classes Blood Plasma Serum Emerging Biofluid Classes Various Biofluid Classes Enable the Development of Biofluid Biopsies (Liquid Biopsies)

11 Next- Gen Sequencing & Whole Genome Amp. Surprisingly Limited Impact on Exosome Research to Date NGS: Only Beginning to Impact Exosome Research Whole Genome Analysis: Not Applicable GENReports: since Market Exosomes & Tech Analysis, Don t Produced Carry by Oosta the and Whole Razvi Genome 2015

12 Classes of Cargo Analyzed in Exosomes Nucleic Acids and Proteins are the Top Currently EpigeneEc Analyses and Lipid Analyses are Nascent

13 Conclusions and Outlook for the Field The analysis presented here is the most up- to- date market analysis of the exosomes space this is the first of 3 reports we will be publishing on this topic Given the fact that the exosomes field is highly- fragmented across several thousand researchers over several conenents, the only way to analyze the field en bloc is to study the enere current academic literature in the field and then draw conclusions based on trends operaeve therein Our system has enabled us to analyze all of the 35,730 publicaeons that together comprise the extracellular vesicles (EV) field therefore, we can view major trends as well as minueae as they are developing We document the expansion of specific methodologies such as flow cytometry that are expanding in penetrance in the exosomes field We also analyze here the various analyte classes that are being studied in the exosomes space some of these analytes today represent circulaeng biomarkers of the future

14 Select Biosciences bring all the key opinion leaders (KOLs) in the Liquid Biopsies Space Together Focus on Exosomes, CirculaUng DNA, CirculaUng RNA, CirculaUng Tumor Cells (CTCs) For More InformaEon About the Conference, Please Scan the QR Code to the Right with your Mobile Device (iphone, ipad, Android) For More InformaUon, Please Contact: