Database: Ovid MEDLINE(R) <1946 to January Week >
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1 Supplementary Material SEARCH STRATEGIES Database: Ovid MEDLINE(R) <1946 to January Week > (The search was updated mid June 2013 using the same strategy) Search Strategy: Cancer terms 1 exp Neoplasms/ ( ) 2 cancer*.mp. (918157) 3 tumor*.mp. ( ) 4 tumour*.mp. (182078) 5 carcin*.mp. (680376) 6 neoplas*.mp. ( ) 7 lymphoma*.mp. (168417) 8 melanoma*.mp. (84949) 9 melanotic*.mp. (2330) 10 metasta*.mp. (325449) 11 non small cell.mp. (32689) 12 nonsmall cell.mp. (1580) 13 (nonsmall adj2 cell).mp. (1582) 14 nsclc.mp. (14497) 15 adenocarcin*.mp. (161281) 16 osteosarcom*.mp. (20120) 17 phyllodes.mp. (1633) 18 cystosarcom*.mp. (585) 19 fibroadenom*.mp. (3330) 20 hepatoma*.mp. (22857) 21 hepatoblastom*.mp. (2625) 22 plasmacytoma*.mp. (8887) 23 myeloma?.mp. (41406) 24 blastoma*.mp. (940) 25 lymphangioma*.mp. (5561) 26 lymphangiomyoma*.mp. (459) 27 lymphangiosarcoma*.mp. (379) 28 lymphoblastoma*.mp. (261) 29 lymphocytoma*.mp. (252) 30 lymphosarcoma*.mp. (4457) 31 lymphoma?.mp. (166795) 32 immunocytoma?.mp. (481) 33 angiosarcoma*.mp. (4081) 34 malignan*.mp. (357535) 35 astrocytoma*.mp. (17018) 36 neuroma?.mp. (9198) 37 cytoma?.mp. (38) 38 gist.mp. (2994) 39 neurocytoma?.mp. (590) 40 oncolog*.mp. (76393) 41 exp Medical Oncology/ (13110) 42 exp Radiation Oncology/ (2308) 43 neoplasm staging/ (109394) 44 staging.mp. (132756) 45 squamous cell?.mp. (111612) 46 cytosarcoma*.mp. (10)
2 47 sarcoma*.mp. (90462) 48 hodgkin*.mp. (71929) 49 non-hodgkin*.mp. (43110) 50 nonhodgkin*.mp. (102) 51 incidentaloma?.mp. (1098) 52 retinoblastoma?.mp. (17086) 53 plasmacytoma*.mp. (8887) 54 cholangiocarcinoma*.mp. (6649) 55 leiomyoblastoma*.mp. (384) 56 leiomyocarcinoma*.mp. (1) 57 leiomyosarcoma*.mp. (9077) 58 sc.fs. ["secondary" floating subheading] (115420) 59 melanosis.mp. (3101) 60 (hutchinson* adj2 freckle*).mp. (458) 61 melanoameloblastom*.mp. (10) 62 melanoblastom*.mp. (445) 63 melanocarcin*.mp. (91) 64 melanomalign*.mp. (44) 65 naevocarcin*.mp. (31) 66 nevocarcin*.mp. (66) 67 adamantinom*.mp. (670) 68 ameloblastom*.mp. (3140) 69 adenosquam*.mp. (2534) 70 teratoma*.mp. (17033) 71 leukemia*.mp. (234339) 72 metaplas*.mp. (18220) 73 or/1-72 ( ) Prognosis terms 74 exp cohort studies/ ( ) 75 exp prognosis/ (970625) 76 exp morbidity/ (329154) 77 exp mortality/ (255906) 78 exp survival analysis/ (158744) 79 exp models, statistical/ (232272) 80 prognos*.tw. (309920) 81 predict*.tw. (741403) 82 course*.tw. (409148) 83 diagnosed.tw. (286902) 84 cohort*.tw. (208208) 85 death.tw. (393354) 86 or/74-85 ( ) Lymphocyte terms 87 exp Lymphocytes/ (408335) 88 lymphocyte?.mp. (496430) 89 (lymphoid adj2 cell?).mp. (20471) 90 (killer adj4 cell?).mp. (44434) 91 (nk adj2 cell?).mp. (26268) 92 (lak adj2 cell?).mp. (2546) 93 b-lymphocyte?.mp. (84215) 94 t-lymphocyte?.mp. (256922) 95 b-lymphoid.mp. (1849) 96 t-lymphoid.mp. (1069) 97 (plasm adj2 cell?).mp. (29) 98 plasmacyte?.mp. (295) 99 (immune adj3 cell?).mp. (44483) 100 (immunocompetent adj2 cell?).mp. (3261) 101 immnunocyte?.mp. (0) 102 lymph cell?.mp. (170) 103 null cell?.mp. (2967) 104 immunological* competent cell?.mp. (145)
3 105 immunoreactive cell?.mp. (5867) 106 prolymphocyte?.mp. (208) 107 pro lymphphocyte?.mp. (0) 108 or/ (570014) Platelet terms 109 Blood platelets/ (63588) 110 platelet count/ (16304) 111 exp Thrombocytosis/ (4436) 112 platelet?.mp. (194569) 113 Thrombocyte?.mp. (5479) 114 or/ (198287) and 114 (8974) 116 (platelet? adj5 lymphocyte?).mp. (1669) 117 plr.mp. (343) or 116 or 117 (9303) Combined results and 86 and 118 (823) 120 remove duplicates from 119 (823) ***************************
4 Database Database: Embase <1974 to 2013 January 28> (The search was updated mid June 2013 using the same strategy) Search Strategy: Cancer terms 1 exp Neoplasm/ ( ) 2 exp oncology/ (68850) 3 exp cancer staging/ (156257) 4 cancer*.mp. ( ) 5 tumor*.mp. ( ) 6 tumour*.mp. (247851) 7 carcin*.mp. ( ) 8 neoplas*.mp. (559952) 9 lymphoma*.mp. (211748) 10 melanoma*.mp. (121086) 11 melanotic*.mp. (2323) 12 metasta*.mp. (486106) 13 non small cell.mp. (55239) 14 nonsmall cell.mp. (2379) 15 (nonsmall adj2 cell).mp. (2380) 16 nsclc.mp. (25026) 17 adenocarcin*.mp. (164343) 18 osteosarcom*.mp. (28052) 19 phyllodes.mp. (1544) 20 cystosarcom*.mp. (1975) 21 fibroadenom*.mp. (4969) 22 hepatoma*.mp. (29855) 23 hepatoblastom*.mp. (3845) 24 plasmacytoma*.mp. (10178) 25 myeloma?.mp. (62395) 26 blastoma*.mp. (1771) 27 lymphangioma*.mp. (7873) 28 lymphangiomyoma*.mp. (581) 29 lymphangiosarcoma*.mp. (489) 30 lymphoblastoma*.mp. (2098) 31 lymphocytoma*.mp. (2342) 32 lymphosarcoma*.mp. (6321) 33 lymphoma?.mp. (208597) 34 immunocytoma?.mp. (689) 35 angiosarcoma*.mp. (8599) 36 malignan*.mp. (517009) 37 astrocytoma*.mp. (22679) 38 neuroma?.mp. (9290) 39 cytoma?.mp. (78) 40 gist.mp. (5772) 41 neurocytoma?.mp. (693) 42 oncolog*.mp. (167543) 43 exp Medical Oncology/ (68850) 44 exp Radiation Oncology/ (68850) 45 neoplasm staging/ (156257) 46 staging.mp. (192451) 47 squamous cell?.mp. (127349) 48 cytosarcoma*.mp. (30) 49 sarcoma*.mp. (116343) 50 hodgkin*.mp. (81929) 51 non-hodgkin*.mp. (38372) 52 nonhodgkin*.mp. (45999) 53 incidentaloma?.mp. (1959) 54 retinoblastoma?.mp. (21583)
5 55 plasmacytoma*.mp. (10178) 56 cholangiocarcinoma*.mp. (8620) 57 leiomyoblastoma*.mp. (641) 58 leiomyocarcinoma*.mp. (0) 59 leiomyosarcoma*.mp. (12542) 60 sc.fs. ["secondary" floating subheading] (94719) 61 melanosis.mp. (3529) 62 (hutchinson* adj2 freckle*).mp. (75) 63 melanoameloblastom*.mp. (83) 64 melanoblastom*.mp. (528) 65 melanocarcin*.mp. (100) 66 melanomalign*.mp. (49) 67 naevocarcin*.mp. (44) 68 nevocarcin*.mp. (71) 69 adamantinom*.mp. (759) 70 ameloblastom*.mp. (4024) 71 adenosquam*.mp. (5142) 72 teratoma*.mp. (26228) 73 leukemia*.mp. (328753) 74 metaplas*.mp. (26972) 75 or/1-72 ( ) Prognosis terms 76 cohort analysis/ (139340) 77 exp prognosis/ (416073) 78 exp morbidity/ (186710) 79 exp mortality/ (584664) 80 exp survival/ (506403) 81 model, statistical/ (0) 82 prognos*.tw. (453621) 83 predict*.tw. ( ) 84 course*.tw. (557972) 85 diagnosed.tw. (430596) 86 cohort*.tw. (318334) 87 death.tw. (535952) 88 or/76-87 ( ) Lymphocyte terms 89 exp Lymphocyte/ (546154) 90 lymphocyte?.mp. (664557) 91 (lymphoid adj2 cell?).mp. (27972) 92 (killer adj4 cell?).mp. (66075) 93 (nk adj2 cell?).mp. (34587) 94 (lak adj2 cell?).mp. (2849) 95 b-lymphocyte?.mp. (118144) 96 t-lymphocyte?.mp. (359327) 97 b-lymphoid.mp. (1810) 98 t-lymphoid.mp. (1128) 99 (plasm adj2 cell?).mp. (65) 100 plasmacyte?.mp. (395) 101 (immune adj3 cell?).mp. (61622) 102 (immunocompetent adj2 cell?).mp. (24046) 103 immnunocyte?.mp. (0) 104 lymph cell?.mp. (230) 105 null cell?.mp. (4335) 106 immunological* competent cell?.mp. (160) 107 immunoreactive cell?.mp. (6466) 108 prolymphocyte?.mp. (1054) 109 pro lymphphocyte?.mp. (0) 110 or/ (773657) Platelet terms 111 exp thrombocyte/ (76423)
6 112 thrombocyte count/ (37474) 113 thrombocytosis/ (5234) 114 Thrombocyte?.mp. (190543) 115 Platelet?.mp. (215442) 116 or/ (270974) and 116 (15475) 118 (platelet? adj5 lymphocyte?).mp. (2100) 119 plr.mp. (574) or 118 or 119 (16004) Combined results and 88 and 120 (2167) 122 limit 121 to embase (2015) 123 remove duplicates from 122 (2013) ***************************
7 Database: EBM Reviews - Cochrane Database of Systematic Reviews <2005 to December 2012> (The search was updated mid June 2013 using the same strategy) Search Strategy: Cancer terms 1 cancer*.mp. (1650) 2 tumor*.mp. (460) 3 tumour*.mp. (867) 4 carcin*.mp. (658) 5 neoplas*.mp. (832) 6 lymphoma*.mp. (191) 7 melanoma*.mp. (65) 8 melanotic*.mp. (1) 9 metasta*.mp. (423) 10 non small cell.mp. (52) 11 nonsmall cell.mp. (4) 12 (nonsmall adj2 cell).mp. (5) 13 nsclc.mp. (35) 14 adenocarcin*.mp. (174) 15 osteosarcom*.mp. (28) 16 phyllodes.mp. (1) 17 cystosarcom*.mp. (0) 18 fibroadenom*.mp. (0) 19 hepatoma*.mp. (17) 20 hepatoblastom*.mp. (20) 21 plasmacytoma*.mp. (11) 22 myeloma?.mp. (51) 23 blastoma*.mp. (1) 24 lymphangioma*.mp. (1) 25 lymphangiomyoma*.mp. (0) 26 lymphangiosarcoma*.mp. (3) 27 lymphoblastoma*.mp. (2) 28 lymphocytoma*.mp. (0) 29 lymphosarcoma*.mp. (1) 30 lymphoma?.mp. (191) 31 immunocytoma?.mp. (2) 32 angiosarcoma*.mp. (3) 33 malignan*.mp. (1097) 34 astrocytoma*.mp. (14) 35 neuroma?.mp. (30) 36 cytoma?.mp. (0) 37 gist.mp. (4) 38 neurocytoma?.mp. (1) 39 oncolog*.mp. (523) 40 staging.mp. (281) 41 squamous cell?.mp. (100) 42 cytosarcoma*.mp. (0) 43 sarcoma*.mp. (96) 44 hodgkin*.mp. (95) 45 non-hodgkin*.mp. (60) 46 nonhodgkin*.mp. (9) 47 incidentaloma?.mp. (1) 48 retinoblastoma?.mp. (18) 49 plasmacytoma*.mp. (11) 50 cholangiocarcinoma*.mp. (24) 51 leiomyoblastoma*.mp. (0) 52 leiomyocarcinoma*.mp. (0) 53 leiomyosarcoma*.mp. (9)
8 54 melanosis.mp. (2) 55 (hutchinson* adj2 freckle*).mp. (0) 56 melanoameloblastom*.mp. (0) 57 melanoblastom*.mp. (0) 58 melanocarcin*.mp. (0) 59 melanomalign*.mp. (0) 60 naevocarcin*.mp. (0) 61 nevocarcin*.mp. (0) 62 adamantinom*.mp. (2) 63 ameloblastom*.mp. (2) 64 adenosquam*.mp. (11) 65 teratoma*.mp. (20) 66 leukemia*.mp. (111) 67 metaplas*.mp. (41) 68 or/1-67 (2572) Prognosis terms 69 morbidity.mp. (2921) 70 mortality.mp. (3613) 71 surviv*.mp. (2152) 72 prognos*.mp. (1305) 73 predict*.mp. (2070) 74 course*.mp. (2256) 75 diagnosed.mp. (2573) 76 cohort*.mp. (1546) 77 death.mp. (3550) 78 or/69-77 (6732) Lymphocyte terms 79 lymphocyte?.mp. (290) 80 (lymphoid adj2 cell?).mp. (8) 81 (killer adj4 cell?).mp. (64) 82 (nk adj2 cell?).mp. (25) 83 (lak adj2 cell?).mp. (1) 84 b-lymphocyte?.mp. (28) 85 t-lymphocyte?.mp. (97) 86 b-lymphoid.mp. (0) 87 t-lymphoid.mp. (0) 88 (plasm adj2 cell?).mp. (1) 89 plasmacyte?.mp. (0) 90 (immune adj3 cell?).mp. (132) 91 (immunocompetent adj2 cell?).mp. (3) 92 immnunocyte?.mp. (0) 93 lymph cell?.mp. (0) 94 null cell?.mp. (0) 95 immunological* competent cell?.mp. (0) 96 immunoreactive cell?.mp. (0) 97 prolymphocyte?.mp. (0) 98 pro lymphphocyte?.mp. (0) 99 or/79-98 (386) Platelet terms 100 platelet?.mp. (507) 101 Thrombocyte?.mp. (28) or 101 (516) and 102 (37) 104 (platelet? adj5 lymphocyte?).mp. (2) 105 plr.mp. (1) or 104 or 105 (38) Combined results and 78 and 106 (31) ***************************
9 LEGENDS TO SUPPLEMENTARY FIGURES Supplementary Figure 1. Funnel plot of hazard ratio for overall survival for high neutrophil-to-lymphocyte ratio (horizontal axis) and the standard error for the hazard ratio (vertical axis). Each study is represented by one circle. The vertical line represent the pooled effect estimate. A. Group 1, dichotomized cut-offs for platelet to lymphocyte ratio (PLR); B. Group 2, two cut-offs for PLR. Supplementary Figure 2. Study-level (i.e., at the individual publication level) association study quality and the hazard ratio for overall survival. Each study is represented by a circle and the area of the circle is proportional to the number of patients enrolled in each study. The solid line represents the results of the metaregression. A. Group 1, dichotomized cut-offs for platelet to lymphocyte ratio (PLR); B. Group 2, two cut-offs for PLR.
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exp neoplasms/ OR cancer*.mp. OR neoplasm*.mp. OR 3,363,037 Publication type: observational studies (cohorts and case-controls)
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