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1 α-galactosylceramide (α-galcer) or the common name of KRN7000 was isolated from an extract of the Okinawan marine sponge Agelas mauritianus. The Alpha-GalCer structure consist of a galactose combined with a ceramide in an alpha-configuration. Alpha-GalCer is a specific ligand for human and mouse natural killer T (NKT) cells and KRN7000 exhibits potent anti-tumor activity with murine in vivo experiments including subcutaneous implanted model and metastatic models in the liver and lung. In the liver metastatic models, treatment with KRN7000 suppressed the growth of tumors and prolonged the survival term of the tumor-bearing mice. KRN7000 has been reported to show various immunological effects in infectious diseases, autoimmune disease and graft verse host disease in mice. agalcer a1 Ceramide GSL001 (2S,3S,4R)-1-O-(α-D-Galactopyranosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol α-galcer, α-galactosylceramide, KRN7000 C 50 H 99 NO 9 Selected References: Molecular Weight: Aline Banchet-Cadeddu et.al The stimulating adventure of KRN 7000 Organic & Biomolecular Chemistry, 9(9), (2011) 2. Linda V Sinclair et. al Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation Nature Immunology, 14(5), (2013) GSL002 Neu5Aca2,3-D-Galactopyranosyl-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol Neu5Aca2,3-D-Galactosyl Ceramide C 61 H 116 N 2 O 17 Molecular Weight: GSL003 Neu5Aca2,6-D-Galactopyranosyl-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol Neu5Aca2,6-D-Galactosyl Ceramide C 61 H 116 N 2 O 17 Molecular Weight: GSL004 Neu5Gca2,3-D-Galactopyranosyl-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol Neu5Gca2,3-D-Galactosyl Ceramide C 61 H 116 N 2 O 18 Molecular Weight:
2 GSL005 Neu5Gca2,6-D-Galactopyranosyl-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol Neu5Aca2,6-D-Galactosyl Ceramide C 61 H 116 N 2 O 18 Molecular Weight: GSL006 KDNa2,3-D-Galactopyranosyl-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol KDNa2,3-D-Galactosyl Ceramide C 59 H 113 NO 17 Molecular Weight: GSL006 KDNa2,6-D-Galactopyranosyl-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol KDNa2,3-D-Galactosyl Ceramide C 59 H 113 NO 17 Molecular Weight: Continued
3 GSL101 (2S,3S,4R)-1-O-b-D-Galactopyranosyl-1,1 -N-hexacosanoyl-2 -hexacosamide-4 -octadecene-1,3 -diol b-galcer, b-galactosylceramide C 50 H 97 NO 8 Molecular Weight: GSL102 aneu5ac2,3-b-d-galactopyranosyl-1,1 -N-hexacosanoyl-2 -hexacosamide-4 -octadecene-1,3 -diol GM4 C 61 H 114 N 2 O 16 Molecular Weight: GSL103 aneu5ac2,6-b-d-galactopyranosyl-1,1 -N-hexacosanoyl-2 -hexacosamide-4 -octadecene-1,3 -diol Neu5Aca2,6-D-Galactosyl Ceramide C 61 H 114 N 2 O 16 Molecular Weight: GSL104 aneu5gc2,3-b-d-galactopyranosyl-1,1 -N-hexacosanoyl-2 -hexacosamide-4 -octadecene-1,3 -diol aneu5gc2,3-d-galactosyl Ceramide C 61 H 114 N 2 O 17 Molecular Weight: GSL105 aneu5gc2,6-d-galactopyranosyl-n-hexacosanoyl-2-amino-1,3,4-octadecanetriol Neu5Aca2,6-D-Galactosyl Ceramide C 61 H 116 N 2 O 17 Molecular Weight: GSL106 akdn2,3-b-d-galactopyranosyl-n-hexacosanoyl-2-amino-1,3,4-octadecanetriol KDNa2,3-D-Galactosyl Ceramide C 59 H 111 NO 16 Molecular Weight:
4 GSL107 KDNa2,3-D-Galactopyranosyl-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol KDNa2,3-D-Galactosyl Ceramide C 59 H 111 NO 16 Molecular Weight: GSL201 b-d-glucopyranosyl-1,1 -N-hexacosanoyl-2 -hexacosamide-4 -octadecene-1,3 -diol b-glccer C 50 H 97 NO 8 Molecular Weight: GSL202 b-d-glucopyranosyl-1,1 -N-Tetracosanoyl-2 -Tetracosanamide-4 -octadecene-1,3 -diol GSL203 b-d-glucopyranosyl-1,1 -N-Docosanoyl-2 -Docosanamide-4 -octadecene-1,3 -diol Molecular Weight: C 48 H 93 NO C 46 H 89 NO 8 Molecular Weight: GSL204 b-d-glucopyranosyl-1,1 -N-Hexadecanoyl-2 -Hexadecanamide-4 -octadecene-1,3 -diol D-Glucosyl-β-1,1'-N-palmitoylsphingosine C 40 H 77 NO 8 Molecular Weight: GSL205 b-d-glucopyranosyl-1,1-2 -amino-4 -octadecene-1,3 -diol Glucosylsphingosine C 24 H 47 NO 7 Molecular Weight:
5 GSL206 N-Glycinated glucosylsphingosine N-Glycine glucopsychosine C 26 H 50 N 2 O 8 Molecular Weight: GSL207 N-Hexanoyl-glucosylceramide N-C6:0-Glucocerebroside C 30 H 55 NO 8 Molecular Weight: GSL208 N-Hexanoyl-biotin-glucosylceramide N-C6:0-Biotin-glucosylceramide C 42 H 76 N 4 O 10 S Molecular Weight: GSL209 N-(1-Adamantaneacetyl)-glucosylceramide C 36 H 63 NO 8 Molecular Weight: GSL301 b-lactosyl-1,1 -N-hexacosanoyl-2 -hexacosamide-4 -octadecene-1,3 -diol b-laccer C 56 H 107 NO 13 Molecular Weight: GSL302 Neu5Aca2,3GalGlc Ceramide GM3 Cer C 67 H 124 N 2 O 21 Molecular Weight:
6 GSL303 Neu5Gca2,3GalGlc Ceramide C 67 H 124 N 2 O 21 Molecular Weight: GSL304 KDNa2,3GalGlc Ceramide C 65 H 121 NO 21 Molecular Weight: GSL305 Neu5Aca2,6GalGlc Ceramide GM3 Cer C 67 H 124 N 2 O 21 Molecular Weight: GSL306 Neu5Gca2,6GalGlc Ceramide C 67 H 124 N 2 O 21 Molecular Weight: GSL307 KDNa2,3GalGlc Ceramide C 65 H 121 NO 21 Molecular Weight: GSL308 Neu5Aca2,3(GalNAc)GalGlc Ceramide GM2 Cer C 75 H 137 N 3 O 26 Molecular Weight:
7 GSL309 Neu5Gca2,3(GalNAc)GalGlc Ceramide C 75 H 137 N 3 O 27 Molecular Weight: GSL310 KDNa2,3(GalNAc)GalGlc Ceramide C 73 H 134 N 2 O 26 Molecular Weight: GSL311 Neu5Aca2,3(GalGalNAc)GalGlc Ceramide GM1 Cer C 81 H 147 N 3 O 31 Molecular Weight: GSL312 Neu5Gca2,3(GalGalNAc)GalGlc Ceramide C 81 H 147 N 2 O 32 Molecular Weight: GSL313 KDNa2,3(GalGalNAc)GalGlc Ceramide C 79 H 144 N 2 O 31 Molecular Weight: GSL314 Neu5Aca2,3(Neu5Aca2,3GalGalNAc)GalGlc Ceramide GD1aCer C 92 H 164 N 4 O 39 Molecular Weight:
8 GSL315 Neu5Aca2,3(Neu5Gca2,3GalGalNAc)GalGlc Ceramide C 92 H 164 N 4 O 40 Molecular Weight: GSL316 Neu5Aca2,3(KDNa2,3GalGalNAc)GalGlc Ceramide C 90 H 161 N 3 O 39 Molecular Weight: GSL317 Neu5Gca2,3(Neu5Aca2,3GalGalNAc)GalGlc Ceramide C 92 H 164 N 4 O 40 Molecular Weight: GSL318 Neu5Gca2,3(Neu5Gca2,3GalGalNAc)GalGlc Ceramide C 92 H 164 N 4 O 41 Molecular Weight: GSL319 Neu5Gca2,3(KDNa2,3GalGalNAc)GalGlc Ceramide C 90 H 161 N 3 O 40 Molecular Weight: GSL320 KDNa2,3(Neu5Aca2,3GalGalNAc)GalGlc Ceramide C 90 H 161 N 3 O 39 Molecular Weight:
9 GSL321 KDNa2,3(Neu5Gca2,3GalGalNAc)GalGlc Ceramide GM1 Cer C 90 H 161 N 3 O 40 Molecular Weight: C 88 H 158 N 2 O 39 Molecular Weight: GSL323 Neu5Aca2,8Neu5Aca2,3GalGlc Ceramide GD3Cer C 78 H 141 N 3 O 29 Molecular Weight: GSL324 Neu5Gca2,8Neu5Aca2,3GalGlc Ceramide GSL325 KDNa2,8Neu5Aca2,3GalGlc Ceramide GSL326 Neu5Aca2,8Neu5Aca2,6GalGlc Ceramide Molecular Weight: Molecular Weight: C 78 H 141 N 3 O C 76 H 138 N 2 O C 78 H 141 N 3 O 29 Molecular Weight:
10 GSL327 Neu5Gca2,8Neu5Aca2,6GalGlc Ceramide C 78 H 141 N 3 O 30 Molecular Weight: GSL328 KDNa2,8Neu5Aca2,6GalGlc Ceramide C 76 H 138 N 2 O 29 Molecular Weight: GSL329 Neu5Aca2,8Neu5Aca2,3(GalNAc)GalGlc Ceramide GM2 Cer C 86 H 154 N 4 O 34 Molecular Weight: GSL330 Neu5Gca2,8Neu5Aca2,3(GalNAc)GalGlc Ceramide C 86 H 154 N 4 O 35 Molecular Weight: GSL331 KDNa2,8Neu5Aca2,3(GalNAc)GalGlc Ceramide C 84 H 151 N 3 O 34 Molecular Weight: GSL332 Neu5Aca2,8Neu5Aca2,3(GalGalNAc)GalGlc Ceramide GD1bCer C 92 H 164 N 4 O 39 Molecular Weight:
11 GSL333 Neu5Gca2,8Neu5Aca2,3(GalGalNAc)GalGlc Ceramide C 92 H 164 N 4 O 40 Molecular Weight: GSL334 KDNa2,8Neu5Aca2,3(GalGalNAc)GalGlc Ceramide C 90 H 161 N 3 O 39 Molecular Weight: GSL335 Neu5Aca2,8Neu5Aca2,8Neu5Aca2,3GalGlc Ceramide GT3Cer C 89 H 158 N 4 O 39 Molecular Weight: GSL336 KDNa2,8KDNa2,8Neu5Aca2,3(GalNAc)GalGlc Ceramide GT2Cer C 93 H 165 N 3 O 42 Molecular Weight: GSL337 KDNa2,8KDNa2,8Neu5Aca2,3(GalGalNAc)GalGlc Ceramide GT1cCer C 99 H 175 N 3 O 47 Molecular Weight:
12 GSL333 Neu5Gca2,8Neu5Aca2,3(GalGalNAc)GalGlc Ceramide C 92 H 164 N 4 O 40 Molecular Weight: GSL334 KDNa2,8Neu5Aca2,3(GalGalNAc)GalGlc Ceramide C 90 H 161 N 3 O 39 Molecular Weight: GSL335 Neu5Aca2,8Neu5Aca2,8Neu5Aca2,3GalGlc Ceramide GT3Cer C 89 H 158 N 4 O 39 Molecular Weight: GSL336 KDNa2,8KDNa2,8Neu5Aca2,3(GalNAc)GalGlc Ceramide GT2Cer C 93 H 165 N 3 O 42 Molecular Weight: GSL337 KDNa2,8KDNa2,8Neu5Aca2,3(GalGalNAc)GalGlc Ceramide GT1cCer C 99 H 175 N 3 O 47 Molecular Weight:
13 (Neo)lacto-series GSLs have been found on the surface of human hematopoietic cells and involve in the differentiation of hematopoietic cells. Among the members studied, nlc 4, nlc 6, and nlc 8 containing 1-3 repeating b1-3-linked LacNAc sequences have been found in elevated levels on tumor cells and in sera of cancer patients. The levels of nlc 4, nlc 6, and nlc 8 can be elevated during corneal epithelial cell migration, indicating their roles in corneal epithelial cell migration and wound healing by influencing cell-cell and cell-matrix interactions. nlc 4, nlc 6, and nlc 8 also serve as receptors for some bacteria and bacterial products. nlcs are also common core structures for more complex glycolipids. They can serve as precursors for Lex-GSLs which have been shown to mediate cell-cell interactions. Lacto-Series b1 Ceramide Neolacto-Series b1 Ceramide b1 Ceramide b1 Ceramide GSL401 GlcGalGlc Ceramide C 64 H 120 N 2 O 18 Molecular Weight: GSL402 GalGlcNAcGalGlc Ceramide C 70 H 130 N 2 O 23 Molecular Weight: GSL403 GlcNAcGalGlcNAcGalGlc Ceramide C 78 H 143 N 3 O 28 Molecular Weight: GSL404 GalGlcNAcGalGlcNAcGalGlc Ceramide C 84 H 153 N 3 O 33 Molecular Weight:
14 GSL405 GlcNAcGalGlcNAcGalGlcNAcGalGlc Ceramide C 92 H 166 N 4 O 38 Molecular Weight: GSL406 Galb1.4GlcNAcGalGlcNAcGalGlcNAcGalGlc Ceramide C 98 H 176 N 4 O 43 Molecular Weight: GSL407 Neu5Aca2,3GalGlcNAcGalGlc Ceramide C 81 H 147 N 3 O 31 Molecular Weight: GSL408 Neu5Aca2,6GalGlcNAcGalGlc Ceramide C 81 H 147 N 3 O 31 Molecular Weight: GSL409 Neu5Aca2,3GalGlcNAcGalGlcNAcGalGlc Ceramide C 95 H 170 N 4 O 41 Molecular Weight: GSL410 Neu5Aca2,6GalGlcNAcGalGlcNAcGalGlc Ceramide C 95 H 170 N 4 O 41 Molecular Weight:
15 GSL411 Neu5Aca2,3Gal(GalNAc)GlcNAcGalGlc Ceramide C 89 H 160 N 4 O 36 Molecular Weight: GSL412 Neu5Aca2,8Neu5Aca2,3GalGlcNAcGalGlc Ceramide C 92 H 164 N 4 O 39 Molecular Weight: GSL413 Neu5Aca2,8Neu5Aca2,3GalGlcNAcGalGlcNAcGalGlc Ceramide C 106 H 187 N 5 O 49 Molecular Weight: GSL414 Gala1,3GalGlcNAcGalGlc Ceramide C 76 H 140 N 2 O 28 Molecular Weight: GSL415 Gala1,4GalGlcNAcGalGlc Ceramide C 92 H 164 N 4 O 39 Molecular Weight: GSL416 Gala1,3GalGlcNAcGalGlcNAcGalGlc Ceramide C 90 H 163 N 3 O 38 Molecular Weight:
16 GSL411 Neu5Aca2,3Gal(GalNAc)GlcNAcGalGlc Ceramide C 89 H 160 N 4 O 36 Molecular Weight: GSL412 Neu5Aca2,8Neu5Aca2,3GalGlcNAcGalGlc Ceramide C 92 H 164 N 4 O 39 Molecular Weight: GSL413 Neu5Aca2,8Neu5Aca2,3GalGlcNAcGalGlcNAcGalGlc Ceramide C 106 H 187 N 5 O 49 Molecular Weight: GSL414 Gala1,3GalGlcNAcGalGlc Ceramide C 76 H 140 N 2 O 28 Molecular Weight: GSL415 Gala1,4GalGlcNAcGalGlc Ceramide C 92 H 164 N 4 O 39 Molecular Weight: GSL416 Gala1,3GalGlcNAcGalGlcNAcGalGlc Ceramide C 90 H 163 N 3 O 38 Molecular Weight:
17 Chemily, LLC Glycolipids GSL411 Neu5Aca2,3Gal(GalNAc)GlcNAcGalGlc Ceramide C 89 H 160 N 4 O 36 Molecular Weight: GSL412 Neu5Aca2,8Neu5Aca2,3GalGlcNAcGalGlc Ceramide C 92 H 164 N 4 O 39 Molecular Weight: GSL413 Neu5Aca2,8Neu5Aca2,3GalGlcNAcGalGlcNAcGalGlc Ceramide C 106 H 187 N 5 O 49 Molecular Weight: GSL414 Gala1,3GalGlcNAcGalGlc Ceramide C 76 H 140 N 2 O 28 Molecular Weight: GSL415 Gala1,4GalGlcNAcGalGlc Ceramide C 92 H 164 N 4 O 39 Molecular Weight: GSL416 Gala1,3GalGlcNAcGalGlcNAcGalGlc Ceramide C 90 H 163 N 3 O 38 Molecular Weight: Contact us for different quantities and costumer synthesis DEDICATED TO Phone: +1 (404) sales@chemilyus.com GLYCOSCIENCE
18 Chemily, LLC Glycolipids GSL417 Gala1,4GalGlcNAcGalGlcNAcGalGlc Ceramide C 90 H 163 N 3 O 38 Molecular Weight: GSL418 Fuca1,3(Gal)GlcNAcGalGlc Ceramide C 76 H 140 N 2 O 27 Molecular Weight: GSL419 Fuca1,3(Neu5Aca2,3Gal)GlcNAcGalGlc Ceramide C 87 H 157 N 3 O 35 Molecular Weight: Contact us for different quantities and costumer synthesis DEDICATED TO Phone: +1 (404) sales@chemilyus.com GLYCOSCIENCE
19 Chemily, LLC Glycolipids Globo- and isoglobo-series GSLs are membrane-associated antigens. They are recognized by both adhesive proteins such as proteins of pathogenic E. coli in human epithelial cells of the urinary tract and toxins including bacterial lectins. Many globo-gsls have been identified as tumor-specific antigens, exemplified by the observation of elevated globotriaosylceramide levels in Burkitt s lymphoma. Tumor-associated Globo H antigen was initially identified from human breast cancer cell line MCF-7120 and later found in several human cancers. Globo H-based synthetic vaccines have shown promising results in clinical trials for breast and prostate cancers. Globo-Series a1,4 b1 Ceramide Isoglobo-Series a1,3 b1 Ceramide a1,4 b1 Ceramide a1,3 b1 Ceramide a1,4 b1 Ceramide a1,3 b1 Ceramide GSL501 Gala1,4GalGlc Ceramide Gb3Cer C 62 H 117 NO 18 Molecular Weight: GSL502 Gala1,3GalGlc Ceramide igb3cer C 62 H 117 NO 18 Molecular Weight: GSL503 GalNAcGala1,4GalGlc Ceramide Gb4Cer C 70 H 130 N 2 O 23 Molecular Weight: GSL504 GalNAcGala1,3GalGlc Ceramide igb4cer C 70 H 130 N 2 O 23 Molecular Weight: Contact us for different quantities and costumer synthesis DEDICATED TO Phone: +1 (404) sales@chemilyus.com GLYCOSCIENCE
20 Chemily, LLC Glycolipids GSL505 GalGalNAcGala1,4GalGlc Ceramide Gb5Cer C 76 H 140 N 2 O 28 Molecular Weight: GSL506 GalGalNAcGala1,3GalGlc Ceramide igb5cer C 70 H 130 N 2 O 23 Molecular Weight: GSL507 Neu5Aca2,3GalGalNAcGala1,4GalGlc Ceramide C 87 H 157 N 3 O 36 Molecular Weight: GSL508 Neu5Aca2,3GalGalNAcGala1,3GalGlc Ceramide C 87 H 157 N 3 O 36 Molecular Weight: GSL509 Neu5Aca2,8Neu5Aca2,3GalGalNAcGala1,4GalGlc Ceramide C 98 H 174 N 4 O 44 Molecular Weight: GSL510 Neu5Aca2,8Neu5Aca2,3GalGalNAcGala1,3GalGlc Ceramide C 98 H 174 N 4 O 44 Molecular Weight: Contact us for different quantities and costumer synthesis DEDICATED TO Phone: +1 (404) sales@chemilyus.com GLYCOSCIENCE
21 Chemily, LLC Glycolipids GSL511 Fuca1,2GalGalNAcGala1,4GalGlc Ceramide C 82 H 150 N 2 O 32 Molecular Weight: GSL512 Fuca1,2GalGalNAcGala1,3GalGlc Ceramide C 82 H 150 N 2 O 32 Molecular Weight: Contact us for different quantities and costumer synthesis DEDICATED TO Phone: +1 (404) sales@chemilyus.com GLYCOSCIENCE
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