October 6th - 9th, 2016 Las Vegas, Nevada

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1 T H E I N T E N S I V E C L I N I C A L C O U R S E Ocober 6h - 9h, 2016 Las Vegas, Nevada Topics Include Clinical Therapeuics Towards Correcion of Epigeneics, Miochondrial and Peroxisomal Dysfuncion in Neurological Disorders Microbiome Inerruped: The Vagal Sysem a he Cener of he Sorm Addressing he Cell Danger Response wih Lipids & Resolvins Opimizing Cell Membranes and Neuromeabolic Funcion Through The Membrane Sabilizing Lipid Proocol Resoluion of Mehylaion and Membrane Derangmen Following Fumonisin / Mycooxin Exposure MEMBRANE MEDICINE NeuroLipid r e s e a r c h f o u n d a i o n Includes: Exensive Biomedical Manual, research, sysemaic clinical proocols, medical forms, paien dieary and supplemen suppor, books and supplies Nurien dense food provided hroughou he conference NONDISCLOSURE REQUIRED LIMITED REGISTRATION SPACE AVAILABLE

2 Clinical Courses - Ocober 6h & 9h, 2016 MEMBRANE MEDICINE CLINICAL DAY- MICROBIOME BIOMEDICAL COLONIC THURSDAY, OCTOBER 6TH Full day session wih Virginia Marson, RN, ND, MD on sabilizing he microbiome including he biomedical lipid colonic procedure. This is a rare opporuniy for professionals o boh experience and learn how o opimize he microbiome by biohacking biofilm and reseing Second Brain funcion. 9:30 am 10:00 am Regisraion 10:00 am 12:00 pm Clinical Model of Membrane Medicine 12:00 pm 1:00 pm Priming he Human Microbiome 1:00 pm 1:30 pm Membrane Sabilizing Lunch 1:30 pm 4:00 pm Clinical Biomedical Lipid Colonic Therapy MEMBRANE STABILIZING IV THERAPY SUNDAY, OCTOBER 9TH Full day session wih Paricia Kane, PhD, Carolyn Mazinger, MD and Virginia Marson, RN, ND, MD on he applicaion of he Membrane Sabilizing IV Therapy. Course is open o licensed medical professionals. 8:00 am 8:30 am Power Breakfas 8:30 am 9:30 am US Model of a Membrane Medicine Clinic Carolyn Mazinger, MD 9:30 am 11:00 am Membrane Sabilizing IV Therapy Paricia Kane, PhD 11:00 am 12:30 pm Model of Membrane Medicine Clinic Virginia Marson, RN, ND, MD 12:30 pm 1:30 pm Membrane Sabilizing Lunch 1:30 pm 3:30 pm Clinical Inravenous Pracicum 3:30 pm 4:30 pm Clinical Case Sudies: Oral, Colonic and IV Proocols

3 Membrane Medicine Academic Symposium Ocober 7h 8h, 2016 MEMBRANE MEDICINE ACADEMIC DAY ONE FRIDAY, OCTOBER 7TH 8:00 am 8:30 am Power Breakfas and Regisraion 8:30 am 10:00 am Life on he Phospholipid Membrane Edward Kane 10:00 am 12:00 pm Membrane Medicine: A Phospholipid Approach o Illness Paricia Kane, PhD 12:00 pm 12:30 pm Membrane Sabilizing Lunch 12:30 pm 2:00 pm Disurbed Mehylaion, Epigeneics, Cell Danger Response, Biomedical Deoxx Paricia Kane, PhD 2:00 pm 3:00 pm Lipid Whiskers, Cardiolipin, Phospholipids and Microubules Edward Kane 3:00 pm 3:30 pm Clinical Impac of Pulsed Magneic Simulaion on Membranes Damien Downing, MD 3:30 pm 3:45 pm Power Break, Le Them Ea Cake viva Paleo 3:45 pm 5:00 pm Chronic Illness Unraveled wih Membrane Sabilizing Therapy Krisine Gedroic, MD 5:00 pm 6:00 pm Alzheimer s as a NeuroMeabolic Model Paricia Kane, PhD and Edward Kane 6:00 pm 6:30 pm Quesions and Commens MEMBRANE MEDICINE ACADEMIC DAY TWO SATURDAY, OCTOBER 8TH 8:00 am 8:30 am Power Breakfas 8:30 am 9:30 am Auism and Meabolic Disorders are Treaable Annee Caraxo, MD 9:30 am 10:00 am Phospholipids and Refracory Seizure Disorders Carolyn Mazinger, MD 10:00 am 12:00 pm Neuromeabolic Disease: MS, ALS, Parkinson s, Sroke, ASD, Seizures Paricia Kane, PhD 12:00 pm 12:30 pm Membrane Sabilizing Lunch 12:30 pm 2:00 pm Epigeneics, Neurooxiciy, Clinical Sraegies for he Brain on Fire Damien Downing, MD 2:00 pm 3:00 pm Neuro-deoxificaion, he Microbiome, and Second Brain Drs. Kane and Gedroic 3:00 pm 3:30 pm Power Break, Feed Your Miochondria and Microbiome 3:30 pm 4:30 pm Clinical Case Sudies, Char review, Clinical Progress Drs. Mazinger, Gedroic, Downing, Kane 4:30 pm 6:00 pm Innovaive Evaluaion & Biomedical esing, Forming Oral and IV Proocols 6:00 pm 6:30 pm Membrane Medicine in a hospial seing a Clinica de la Luz Virginia Marson, ND

4 Our Researchers and Clinicians Paricia Kane, PhD Millville, NJ Edward Kane Millville, NJ Krisine Gedroic, MD Morrisown, NJ Meinrad Milz, MD Germany Carolyn Mazinger, MD Las Vegas, NV Shideh Pouria, MD Unied Kingdom Thomas Wnorowski, PhD Millville, NJ Sheryl Levenhal, MD Valley College, NY Virginia Marson, MD Galeana, Mexico Damien Downing, MD Unied Kingdom Annee Caraxo, MD Morrisown, NJ Neal Speigh, MD Charloe, NC John McLaren-Howard, PhD Unied Kingdom Carrie Loughran, RD, LD Porland, OR Karin Bieber, MD Germany

5 Normalizaion of Phospholipid Membrane wih Oral Phosphaidylcholine Five year old female wih an undiagnosed neuromuscular disorder presened wih a gross disorion of her phospholipid archiecure wih abnormal lipid binding in June Afer 4 monhs (Oc 2010) of oral phosphaidylcholine imaging of her lipid membrane shows marked improvemen along wih normalizaion of her miochondria (an immune viral complex was isolaed on he miochondria). Paien is now able o walk wih assisance, marked improvemen in coordinaion and muscle one, and increased growh and developmen. Normalizaion of Phospholipid Membrane wih IV Phosphaidylcholine Male paien, age 82, wih a hisory of prosae cancer. Iniial picures reveal gross oxidaive damage o he cell membrane surface, phospholipid membrane and miochondria afer invasive radiaion herapy. PSA levels spiked and paien was in exreme spinal pain. Paien received inravenous IV PK Proocol (Phenylbuyrae, Esseniale, Gluahione) and high dose oral lipids for 2 monhs prior o visiing oncologis Meinrad Milz in Germany. Pain was diminished 50% and paien was able o comforably ravel o Germany for hyperhermia and IV PK Proocol herapy for 2 weeks. Pain was compleely eradicaed on he firs visi in May 2011 and PSA normalized. Paien coninued IV and Oral PK Proocol herapy a home and reurned for a check up in Germany December Paien s condiion is sable and he is enjoying his renewed life.

6 MEMBRANE MEDICINE NeuroLipid r e s e a r c h f o u n d a i o n MEMBRANE MEDICINE: NEUROMETABOLIC CELLULAR STABILIZATION WITH LIPID THERAPY FOR TREATMENT OF NEUROLOGICAL DISEASE Paricia Kane, PhD - Direcor NeuroLipid Research Foundaion, 501(c)3 non-profi 45 Reese Road, Millville, NJ USA Ph: Fax: Sheryl L. Levenhal, MD Annee L. Caraxo, MD Mark O Neal Speigh, MD Damien Downing, MD Shideh Pouria, MD Krisine Gedroic, MD Ralph Holsworh, DO Karin Bieber, MD John McLaren-Howard, PhD Meinrad Milz, MD Absrac Mainaining he appropriae balance and conen of lipids in cellular membranes is criical for normal neural processes. Accumulaing evidence suggess ha even suble perurbaions in he lipid conen of neurons and myelin can disrup heir funcion. The membrane and organelles wihin he cell are he primary focus of elecrical discharge wihin he cenral nervous sysem and can be sabilized wih phospholipid herapy and a Phospholipase A2 (PLA2) suppressive die which is a argeed phospholipid, nurien-dense, membrane sabilizing die. The brain is 60% lipid, conaining phospholipids, which comprise he plasma and organelle membranes, along wih cardiolipin, locaed exclusively in he inner lipid membrane of miochondria and myelin, and is a arge for oxic exposure. Sabilizaion of cardiolipin is a primary herapeuic arge in neurooxic disorders brain on fire which may be addressed using lipid herapy. Recen research has revealed ha in he brain myelin acs as one enormous miochondrion. Examinaion of red cell lipids a Johns Hopkins Peroxisomal Diseases Laboraory in subjecs wih encephalopahy, psychiaric syndromes, seizure disorders, super-refracory saus epilepicus, rare diseases, Auism, Alzheimer s, Pos Sroke, neurolyme, Chronic Faigue Syndrome, neurofungal oxiciy, Muliple Sclerosis, Moor Neuron and Parkinson s Disease over he pas 15 years in 9000 analyses has revealed a characerisic accumulaion of very long chain fay acids (VLCFAs), which comprise lipid rafs, or ceramides, depiced as cell membrane derangemen per disurbance in peroxisomal respiraion, which has a vial role in cell membrane inegriy and funcion. Membrane phospholipid abnormaliies wih elevaion of VLCFAs may be indicaive of exposure o neurooxins resuling in suppressed peroxisomal bea oxidaion of VLCFAs. Paiens wih psychiaric syndromes presen wih a very low oal lipid conen and ofen overmyelinaion indicaive of miochondrial lipid disurbance and an increase in sphingomyelin wih a marked decrease in phosphaidylcholine in he ouer membrane leafle of heir cell membranes. Idenificaion of nuclear and miochondrial DNA adducs (oxins) has revealed a link beween oxic exposure and he developmen of cell membrane derangemen / dysfuncion linking epigeneics o hese neuromeabolic syndromes. In our curren sudies we have capured visual images of disored phospholipid membranes and have linked he impac of he DNA adducs (oxins) alering gene expression o aberraions in lipid meabolism, cellular dysfuncion and aleraion of he srucure of phospholipids in he cell membrane characerisic o he presening diagnosis and sympoms. Our reamen proocol includes an oral argeed lipid herapy wih and a membrane sabilizing die wih supplemenal proocol (phospholipids and SR3 oil), and in some cases an inravenous infusion of phenylbuyrae, phosphaidylcholine/esseniale, leucovorin, and gluahione o clear bioaccumulaion of oxins impacing gene

7 Mehods Applying he Advanced Membrane Sabilizing proocol adul and pediaric paiens are given weekly one o wo muli gram bolus infusions of phosphaidylcholine, followed by Growh Facors, Leucovorin (folinic acid) and rgsh Fas Push. In addiion, Sodium Phenylbuyrae as 3 o 5 grams is adminisered in an IV drip wice weekly. Oral herapy includes unsauraed lower order fay acids as SR3 4:1 omega-6 o omega-3 oil, Evening Primrose oil, EPA, inac phospholipids, Fay Alcohols, Ca/Mg Buyrae or Na Phenylbuyrae, Phosphaidylcholine (PC), coenzyme and mehylaion suppor-folinic acid, 5-MTHF, erahydrobioperin, riboflavin, NADH and mehylcobalamin (by injecion). Targeed reamen proocols are uilized afer red cell lipid analysis has been compleed. 1) Phenylbuyrae per oral and IV o simulae he peroxisomal bea oxidaion and simulae resolvins 2) Bolus inravenous Phosphaidylcholine as Liposabil or Esseniale N 3) Mehylaion facors -folinic acid, riboflavin, mehylcobalamin, 5-MTHF, erahydrobioperin 4) Sulfaion suppor - IV Gluahione and oral free form amino acids 5) Miochondrial respiraion suppor - Oral Phosphaidylehanolamine & Cardiolipin (Linoleic acid) 6) Growh facors per IV applicaion wih phospholipids 7) Elecrolye and race mineral and viamin co-facors per oral supplemenaion 8) Uilizaion of a nurien dense, carbohydrae limied die wih bioacive lipids o conrol Phospholipase A2 9) Targeed EFA/bioacive lipid inake per red cell fay acid es resuls Resuls The use of oral and IV lipids has faciliaed sabilizaion of phospholipids in cellular membranes hereby addressing cell membrane inegriy of our paien populaions along wih clearance of oxins from he nuclear and miochondrial DNA, cardiolipin, proeins (enzymes, meallohionein) and normalized cellular funcion. The addiion of inravenous phenylburae addresses neuroinflammaion by increasing he bea oxidaion of VLCFAs and simulaing for formaion of resolvins and proecins. Growh facors simulae neuroregeneraion. Disurbances in mehylaion due o oxic exposure may desabilize he membrane phospholipid srucure and aler DNA expression hus mehyl co-facors are inegral o herapy. We have noed he clearance of he bioaccumulaion of oxins on he DNA adducs and sabilizaion of membrane funcion in our paiens afer iniiaing clinical reamen four o six monhs afer onse of lipid herapy. The use of he membrane sabilizing inravenous lipid proocol, clears ~ 70% of he inracellular oxins, paricularly hose on he DNA adducs afer 20 bolus lipid infusions. Inensive oral nurien herapy is also simulaneously uilized. We have noed marked and susained clinical improvemen wihin he firs few weeks afer iniiaion of reamen in our combined paien populaion of 500 subjecs using Acumen cellular funcion analysis for verificaion and clinical observaion of paien s saus, especially in regard o neuroinflammaion. Expansion of he Advanced Membrane Sabilizing proocol wih bolus PC dosing, IV Phenylbuyrae, growh facors has yielded furher improvemen in paien response. Conclusion Applicaion of bolus Phospholipid herapy wih Phosphaidylcholine (Esseniale N), Growh Facors, Leucovorin, Phenylbuyrae, Co-Enzymes, Mehyl facors and Gluahione have been successfully uilized in clinical seings hroughou he US and abroad. These resuls demonsrae ha lipid herapy may reverse prevalen sympoms and sabilize aberran membrane archiecure and disurbed neurochemisry in paiens wih neurological disease, and should be considered for more formal sudies. Furher clinical sudies are in progress in preparaion for universiy based rials. The adminisraion of our lipid-based proocol may offer a new herapeuic sraegy for neurological and oher diseases involving oxic exposure. We have documened significan clinical neurological improvemen in our paiens, along wih marked normalizaion of cellular funcion (via laboraory analysis) following hree monhs of an oral and inravenous lipid regime. Recenly we have had he opporuniy o rea acue cases in a hospial seing successfully, coma following encephalopahy, a suicide aemp and synheic marijuana inoxicaion. The adminisraion of our phospholipid herapy as Membrane Medicine may offer a new herapeuic sraegy for paiens wih neurological disorders arising from infecious and oxic exposures.

8 Conference Locaion Hampon Inn Conference Cener 3245 S. Rose Parkway Henderson, NV Clinical Sessions Locaion (All Day Thursday All Day Sunday) Mazinger Insiue of Healing 3031 Wes Horizon Ridge Parkway Henderson, NV Accommodaions Hampon Inn & Suies 3245 S. Rose Parkway Henderson, NV Tel: Regiser Now For Symposium and Clinical Sessions Membrane Medicine Biomedical Symposium Academic - Friday, Ocober 7h Saurday, Ocober 8h, 2016 LOCATION: Hampon Inn Conference Cener. q Membrane Medicine Academic 2-Day Symposium: $ early bird price $ Afer Sepember 15h, 2016 Clinical Sessions - Thursday, Ocober 6h & Sunday, Ocober 9h, 2016 LOCATION: Mazinger Insiue of Healing 3031 Wes Horizon Ridge Parkway Henderson, NV q Thursday Ocober 6h - Clinical Microbiome wih Biomedical Colonic: $ early bird price $ Afer Sepember 15h, 2016 q Sunday Ocober 9h - Clinical Membrane Sabilizing IV Therapy: $ Limied Regisraions No refunds for cancellaions made afer Sep. 15h, SIGNED NON-DISCLOSURE IS REQUIRED Mail or fax your regisraion oday wih paymen o: Open o licensed MD, DO, ND (RN wih MD) Name Degree Address Ciy Sae Zip Counry Telephone ( ) Fax ( ) Aendee s Cell ( ) Circle One Neurolipid Research Foundaion / BodyBio 45 Reese Road Millville, NJ FAX: Please make checks payable o BodyBio CONFERENCE REGISTRATION CLOSED Name on Card Credi Card # Exp. Dae CCV Signaure