NEWSYOU CANUSE. PRO VITALITY NUTRITION: The Evidence Continues to Build. NEWSYOU CANUSE Issue 4/2008 Page 1

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1 NEWSYOU CANUSE Issue 4/8 PRO VITALITY NUTRITION: The Evidence Coninues o Build Scienific evidence reinforcing he imporance of key wholefood nuriens in maximising healh, vialiy and longeviy, coninues o moun. The nuriens conained in fruis, vegeables, whole grains and fish are so srongly conneced o preserving healh and wellness, ha auhoriies worldwide urge us o increase our consumpion of hese foods as he primary ool in he bale agains chronic disease. Here are hree recen sudies from major research cenres published in leading peer-reviewed scienific journals ha affirm his message: Too much of he wrong foods ses a course for disease A sudy published in he Augus 15, 27 issue of he Journal of he American Medical Associaion (JAMA) calls aenion o he severe healh risks associaed wih our Wesern die, grossly deficien in wholefood nuriens from fruis, vegeables, grains and fish, bu excessive in processed fas, carbohydraes and calories. While evaluaing colorecal cancer recurrence, researchers from he Dana- Farber Cancer Insiue in Boson demonsraed ha 8% of all colorecal cancer cases were boh direcly or indirecly aribuable o he Wesern indusrialised-eaing habi and prevenable wih dieary change. Their recommendaions for reducing his risk: a pruden die rich in fruis, vegeables, poulry and fish. 1 Geing an abundance of he righ foods is he pah o long-erm healh! Published in he July 27 issue of he American Journal of Clinical Nuriion, researchers from Monash Universiy and he Cancer Council of Vicoria, The Universiy of Melbourne, he Universiy of Cambridge and S. Vincen s Hospial Melbourne repor ha, This combinaion [of frui, vegeable, and omega-3 dieary conen] is believed o have anioxidan, ani-inflammaory and ani-hromboic properies ha reduce he risk of cardiovascular disease by 3%. These nuriens have also been shown o lower he rae of incidence for obesiy and various cancers. 2 Evidence demonsraing he healh benefis associaed wih hese foods was also described by a sudy conduced a he Harvard School of Public Healh in 27 suggesing ha higher inakes of anioxidan and ani-inflammaory micronuriens are associaed wih lower repors of cough, respiraory infecions and less severe ashma-relaed sympoms. 3 Much is los o indusrialised growing and processing! According o a research from Wageningen Universiy in Holland published in he November 25 issue of he Journal of Food Chemisry, nearly every phase of processing from farm-o-fork reduced he level of he healhy phyonuriens in fruis and vegeables. 4 Daa presened by researchers from he Deparmen of Soil Sciences a he Universiy of Wisconsin Madison confirms ha while grea advances in crop yield have occurred in he las 5 years, nurien conen has been under siege and declining. 5 A similar review of daa published by he USDA s ARS Nurien Daa Laboraory (char 1) shows a sharp decline in he minerals in foods since he las comprehensive survey [nearly 2 years ago]. Char 1 - Decline in Minerals Conen of Foods milligrams/1 grams A = Beans, snap, green B = Broccoli, raw C = Carros, raw D = Peaches, raw E = Tomaoes, red A B C D E A B C D E Calcium Magnesium A B C D E Poassium MODERN INDUSTRIALISED DIETS ARE DIRECTLY LINKED TO DISEASE The die ha has dominaed he indusrial world for he las few decades is direcly relaed o he epidemic of chronic disease. 6 Foods consumed by he average human oday are no only energy-dense and nurien-deficien, bu also lack he nuriional diversiy fundamenal o healhy human biochemisry. Overflowing wih processed fas, carbohydraes and chemicals alien o he human food chain, he modern-day die leaves us overfed, under-nourished and needlessly exposed o vialiy-robbing healh problems. WHOLEFOOD SUPPLEMENTATION: A STRATEGY THAT WORKS Changing our dies is no an easy or convenien ransiion for someone living in he quick pace of he modern indusrialised world. Bu we know ha nuriional supplemenaion ha is well-formulaed and derived from wholefood sources acually found in he human food chain can fill in he gaps lef by he modern indusrialised die. I suppors our body in producing energy, and promoing vialiy and long life. NEWSYOU CANUSE Issue 4/28 Page 1

2 Tre-en-en Grain Concenraes Feed your cells Background: We firs discovered he imporan role lipids play as building blocks for our cell membranes in By he 195 s researchers realised ha he cell membrane no only served as a mechanism o separae he inside of he cell from he ouside, bu also funcioned as a highly selecive filer ha faciliaed ranspor sysems conrolling nurien enry and wase removal. 14 From ha poin, we began o recognise he imporance of specific lipids in membrane funcion, energy producion and meabolie secreion (biochemicals manufacured in cells; i.e.; hormones, enzymes). 15 GNLD Research: In he mid-195s, a group of Souhern California docors invesigaing he possible causes of paien-repored chronic faigue drew a connecion beween he absence of whole grain dieary lipids and reduced cellular energy producion. This research led o he concep of lipid supplemenaion made from whole grain whea, rice and soy, as a soluion o chronic faigue. This gave rise o GNLD s Tre-en-en Grain Concenraes. In he years ha followed, Tre-en-en s beneficial effecs on cell membrane srucure and funcion were furher confirmed. The mos compelling demonsraion of he posiive effecs of he lipids and serols in Treen-en Grain Concenraes was in a sudy conduced a Texas A & M Universiy in This sudy compared he effecs of Tre-en-en use in he es group o a conrol group. The resuls (see chars 2-4) were dramaic. 16 Char 2 - Cardiovascular Developmen Weigh in Grams Wihou Char 3 - Nurien Uilisaion Efficiency Raio growh and developmen o nuriens consumed Wihou Char 4 - Overall Growh Developmen Weigh in Grams Wihou Wih Wih Wih Laes Findings: The significance of he key role whole grain lipids and serols play in cellular srucure and funcion, and in human healh overall, coninues o be suppored by even more recen scienific publicaions and governmen-funded awareness campaigns. A 1998 sudy of 34, women showed whole grain nuriion had a srong cardio-proecive effec. 17 A componen of he 1999 Nurse s Healh Sudy (a survey of 75, nurses) showed regular whole grain consumpion lowered he risk of hear disease by 25% and sroke by 36%. 18 Anoher sudy from 2 published in he Journal of he American Medical Associaion showed nearly a 5% reducion in ischemic sroke risk for people who normally consumed whole grain producs. 19 Whole grain nuriens and he imporance of lipids and serols coninue o be a srong focus poin for nuriional research. 2 Here are a few more examples: A May 25 aricle in Human Nuriion & Meabolism idenified whole grain oils, now nearly devoid from he average die, as anicancer dieary componens. 21 Two sudies conduced in 25 22,23 demonsraed he unique benefis of rice bran oil in choleserol reducion. A 27 mea-analysis sudy (a sudy of an accumulaion of evidence) 24 concluded ha he need for whole grain nuriion is so acue in he populaion ha governmen effors o promoe awareness should be doubled. The researchers furher concluded ha he process of refining grains removed many biologically acive agens, including fibre, viamins, minerals, lipids, serols and oher compounds. These biological agens influence cardiovascular risk hrough effecs on glucose meabolism, lipids, lipoproeins, endohelial funcion, and oher mechanisms, poenially accouning for much of he observed benefi of high inake of whole grains wroe lead auhor Phillip Mellen of Wake Fores Universiy. Page 2 NEWSYOUCANUSE Issue 4/28

3 Caroenoid Complex Proec your cells Background: Caroenoids firs ook cenre-sage as proecor nuriens in he mid 197 s when researchers a he US Deparmen of Healh and Human Services and he Ceners for Disease Conrol and Prevenion (CDC) idenified heir role in reducing he risk of disease. 25 Naional Cancer Insiue researcher Regina Ziegler wen on o reveal is connecion o lung cancer prevenion in 1986, 26 and hen showed a lower risk of cancer in hose wih he highes dieary inake of frui and vegeable-derived caroenoids. 27,28 The Naional Healh and Nuriion Examinaion Survey (NHANES) and oher sudies a he ime found caroenoids also funcioned in hear healh and reduced he risk of hear disease. 29,3 Proof of benefi soon expanded o include eye healh and visual acuiy 31 and immune funcion. 32 GNLD Research: Research conduced on GNLD s Caroenoid Complex has spanned more han 15 years. I sared wih he firs ever proof of bioavailabiliy of wholefood derived caroenoids. 33,34 USDA researchers wen on o reaffirm is bioavailabiliy and hen demonsraed is cardio-proecive 35,36 (see char 6) and cellular proecive powers. 37 This was followed by wo more sudies conduced by he USDA researchers showing Caroenoid Complex s beneficial effecs (see char 5) on immune capaciy. 38,39 In 21, GNLD researchers reaffirmed bioavailabiliy across an even broader specrum of dieary caroenoids. 4 Char 5 - Caroenoid-Flavonoid Immune Response in Women Baseline TBar Values (um) Char 6 - Caroenoid Complex: Lipid Peroxidaion Suscepibiliy Naural Killer Cell Proliferaion Lymphocye Proliferaive Responsiveness Caroenoid-Deficien Die Baseline Baseline Depleion Bea-Caroene Only Day Day 6 Day 1 Day Day on Bea Caroene only Day 71 Day 92 Day 99 Serum Sample Days GNLD s Caroenoid Complex 7 Days on Caroenoid Complex Laes Findings: Evidence supporing he imporance of caroenoid inake for healh benefis coninues o moun. Concern by leading healh auhoriies over insufficien caroenoid consumpion has resuled in campaigns o increase awareness for higher levels of caroenoid inake. 41,42 Hear and cardiovascular healh: A 24 sudy conduced by a eam a he Harvard Medical School found ha men in he op quinile wih higher levels of serum caroenoids (including alphacaroene, bea-caroene, lycopene, luein, and bea-crypoxanhin) had a 4% decreased risk of ischemic sroke han hose wih he lowes serum levels. 43 Similarly, a 28 sudy of 559 men showed ha increased inake of alpha and bea caroene from carros equaed o a 17% reducion in risk of cardiovascular (CVD) deah. 44 Swedish researchers in 26 correlaed consisenly lower levels of he caroenoids luein, zeaxanhin, and bea crypoxanhin wih coronary arery disease occurrence. The healhy conrols had significanly higher levels of hese caroenoids in heir blood. 45 Prosae healh: Since he early nineies, scienific research has repored a connecion beween he caroenoid Lycopene and prosae cancer risk reducion. One sudy showed ha Lycopene (from omaoes) presen in he die 4 o 5 imes per week, aribued o a 25% reducion in prosae cancer risk. The 2-year sudy found ha an 82% increase in blood Lycopene levels corresponded wih a 42% decrease in prosae-specific anigen (PSA) levels. 46 Immune healh: Swedish researchers in 21 observed higher levels of naural killer cells (NK cells) in people wih higher levels of hese caroenoids, confirming he relaionship beween dieary caroenoid inake, immune capaciy and healh. Vision healh: In a 48-week inervenion rial, researchers esed Luein supplemenaion for vision proecive-funcion in paiens wih reiniis pigmenosa (RP). They concluded: Comparing he developmen of vision measures agains he naural loss expeced o occur over he course of he 48 weeks, mos measures showed reduced decline, and hese reducions were significan for normal illuminaion. 47 Menal performance: A 27 French sudy 48 showed a connecion beween caroenoids and cogniive performance in a healhy elderly populaion. Sudy auhor Tasnime Akbaraly saes In his sudy, low levels of specific plasma caroenoids (lycopene and zeaxanhin) were associaed o poor cogniive funcioning in a highly educaed, communiy-dwelling elderly populaion. Inflammaory healh: A 25 UK sudy by Cambridge Universiy 49 researchers showed ha sudy subjecs wih he highes (op one hird) daily inake of bea-crypoxanhin had only abou one-half he risk of developing polyarhriis han hose in he boom one-hird. Researchers commened ha even modes increases in beacrypoxanhin inake were associaed wih a significanly reduced risk of developing inflammaory disorders such as rheumaoid arhriis. DATA SOURCE: EFFECTS OF A CAROTENE DEFICIENT DIET ON MEASURES OF OXIDATIVE SUSCEPTIBILITY AND SUPEROXIDE DISMUTASE ACTIVITY IN ADULT WOMEN; Free Radical Biology in Medicine, Vol. 17, No. 6, pp , Page 3 NEWSYOUCANUSE Issue 4/28

4 Salmon Oil Plus Balance & Regulae your cells Background: No only are omega-3 fay acids in general direcly ied o hear healh, bu heir individual abiliies o lower riglycerides, increase HDL (good choleserol), inhibi plaque formaion, sabilise hear rhyhm and mainain healhy veins and areries have highlighed he huge imporance of having all eigh members of he omega-3 fay acid family. 5 Researchers were aware of he benefis of omega- 3 fay acids before hey were even publicised in he 197s. In 1936, an epidemiologis sudying he Inui in Greenland observed a zero rae of incidence of hear disease in he populaion, and firs drew connecions beween hear healh and he presence of hese fay acids in he Inui die. 51,52 In 198, Danish researchers documened he exen of he healh proecing powers of omega-3 fay acids by comparing he incidence of several diseases in Danish versus Greenland Inui populaions. 53 They showed he Danish populaion had 1 imes more cases of hear aacks, 2 imes more cases of Psoriasis, 25 imes more cases of ashma, and 9 imes more cases of diabees han he Inui. GNLD Research: GNLD inroduced Salmon Oil, derived from pure, naural Salmon, as he mos biocompaible, wholefood, human food chain source of omega-3 fay acids. Throughou he 198 s and 9 s he SAB followed scienific and echnological developmens in omega-3 supplemenaion. In he early 2 s hey direced he developmen of a unique echnology called molecular differeniaion which, for he firs ime, allowed consisen idenificaion, quanificaion and delivery of all eigh members of he omega-3 fay acids family in a wholefood supplemen. Inroduced in 26, Omega-III Salmon Oil Plus se a new sandard for excellence in omega-3 supplemenaion. Human clinical rials conduced under he direcion of SAB member Dr. Arianna Carughi and presened a he Annual meeing of he Federaion of American Socieies for Experimenal Biology, April 28, 54 and a he annual meeing of he American College of Nuriion in Ocober 28, 55 displayed powerful performance across a wide range of benefis, including: 56 Rapid bioavailabiliy and assimilaion; resuling in increased ani-inflammaory balance in cell membranes. Triglyceride reducion; on average, 17% in jus 8 weeks. Improved omega-3 o omega-6 raio; lowering indicaors of hear disease risk. Improved omega-3 index; a 38% increase in his cardio-proecive measure. Lowered he inflammaory index by 68%; reducing he endency oward inflammaion and inflammaory condiions. Char 7 - Increased Cardio Proecion - Decreased Cardio Risk Laes Findings: As more is being discovered abou heir imporance o healh, many scieniss and researchers have coined he erm maser molecules o describe he power of omega-3 fay acids. They are fundamenal o human biochemisry, and have been proven o have an imporan role in healh, vialiy and longeviy. Cardiovascular healh: In 25, daily supplemenaion of omega-3 fay acids was shown o reduce risk of faal hear failures in high risk paiens. 57 In 26 researchers looked a daa from more han 34, paricipans and repored a 35% reducion in he risk of cardiac deah, and a 45% reducion in he risk of sudden deah for hose who consumed 85 mg of dieary omega-3 s each day. 58 A 27 sudy from Japan repored ha daily supplemenaion resuled in a 24% reducion in angina (hear pain) and a 19% reducion in nonfaal coronary evens. 59 Tha same year researchers from he Universiy of Ahens repored ha high dieary omega-3 saus equaed o healhier more sable hear rhyhm. 6 Cogniive healh: In 25 researchers a Louisiana Sae Universiy (LSU) showed ha fish derived omega-3 fay acid are no only vial o brain issue building bu exers a proecive effec agains neurodegeneraion and brain funcion decline associaed wih Alzheimer s. 61 In 27 researchers published daa ha showed ha elderly wih he highes dieary omega-3 inake had significanly less cogniive decline han hose wih he lowes. 62 Tha same year i was shown ha high dieary omega-3 inake equaed o less decline in verbal abiliy amongs he elderly. 63 A 28 sudy from Taiwan showed ha 1.8 grams of supplemenal Omega-3 fay acids may improve general clinical funcion in paiens wih mild or moderae Alzheimer s disease and mild cogniive impairmen. 64 Vision healh: In addiion o he impac of omega-3 fay acids on reducing he risk of Age-relaed Macular Degeneraion (AMD) by 7 per cen, 65 omega-3 fay acids, paricularly DHA, have been shown play an imporan role in he layer of nerve cells in he reina. Pregnancy and lacaion: The imporance of omega-3 dieary inake during pregnancy and lacaion has been shown in several recen sudies. One recen example from Canada repored ha an increased inake of he omega-3 DHA during pregnancy could produce improved moor funcion in he offspring in laer life. 66 Bone and Join healh: Confirming previous sudies ha omega-3 fay acids can reduce and even preven inflammaion. A sudy published in he April 26 issue of he journal Surgical Neurology showed ha omega-3 supplemenaion is effecive agains back and neck pain. 67 In 27, Swedish researchers showed ha young men wih he highes dieary omega-3 fay acid inake in general; and DHA in paricular also amassed he sronges bones. 68 NEWSYOUCANUSE Issue 4/28 Page 4

5 Die and he global healh crisis: WHO knew! In heir 25 landmark repor eniled Chronic Disease: A vial Invesmen, he World Healh Organizaion (WHO) spolighs he dire sae of global healh, and sounds he alarm we are quickly losing his bale. Here is wha hey old us:7 Chronic Disease (hear disease, cancer, sroke, chronic respiraory disease and diabees) kills wice as many people as all infecious disease, including HIV/AIDS, uberculosis, malaria, influenza and pneumonia, combined. This coun is expeced o increase 17% by 215. (Faser han he rae of populaion growh.) Unhealhy eaing is idenified as he #1 cause, followed by physical inaciviy and obacco use. STRATEGY FOR PREVENTION: 1: Fix your die 2: Ge acive 3: If you smoke, qui The firs sep in prevening chronic disease is changing our die. Here is wha he WHO and oher global healh auhoriies have o recommend: Hear disease: Hear disease is he #1 killer, accouning for nearly one-hird of all deahs world-wide. WHO s nuriional sraegy for prevenion: Increase inake of fish, fruis, vegeables, nus and whole grains; mainain a healhy weigh. Likewise he American Hear Associaion s 8 nuriional keys for hear healh: ea more fruis, vegeable, whole grains and fish rich in Omega-3 Fay Acids. Cancer: 2 million people suffered wih cancer in 25. WHO projecs a 5% increase in new cases of cancer in jus 15 years. They found ha dieary facors accouned for abou 3% of cancers cases. To reduce he risk of cancer, WHO along wih The US Ceners for Disease Conrol and Prevenion (CDC) and he US Naional Cancer Insiue (NCI) recommend: Ea more fruis, vegeables and whole grains. And of course, if you smoke, qui. 9 The NCI in paricular draws specific aenion o he phyonurien family of caroenoids, highlighing heir role in cancer prevenion. 1 Diabees: Diabees is quickly becoming a global epidemic ,, people suffered from i in 25. And i is projeced o grow o 366,, by a 114% increase! In fac, many medical researchers now believe ha for every person diagnosed wih diabees, here will be wo more individuals in a sae of pre-diabees, resuling in more han 1,,, diabeic sufferers around he world. The nuriional sraegy for prevenion according o he American Diabees Associaion (ADA) 11 and he US Naional Insiues of Healh (NIH) 12 : reduce he consumpion of fas, convenience and processed foods; ea more fruis, vegeables whole grains and omega-3 rich fish and be more physically acive. DIETARY SOLUTIONS Whole Grains Fruis & Vegeables Fish Wholefood Nuriion for Lifelong Healh and Vialiy... in convenien, on-he-go packes Grain Concenraes Caroenoid Complex Omega-III Salmon Oil Plus Page 5 NEWSYOUCANUSE Issue 4/28

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