ME/CFS RESEARCH TREND ~ PubMed & March 2017 CC-Zero

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1 ME/CFS RESEARCH TREND ~ PubMed & March 2017 CC-Zero

2 ME/CFS Articles Published Per Year Data mining PubMed-NLM-NIH ~ esearch -db pubmed -query "myalgic encephalomyelitis" \ efetch -format xml \ xtract -pattern PubmedArticle -block PubDate -element Year MedlineDate \ cut -c -4 \ sort-uniq-count-rank \ sort -n -t $'\t' -k 2 > xl.txt ME/CFS Research Articles

3 ME/CFS Research Articles Per Year What happened between 1984 and 1991?

4 Definition Crisis ME = CFS? Correspondence on defining ME and CSF for disability pension criteria. Conflict of Interests Link:

5 Two Camps: Genes vs Psychosocial Data mining ME/CFS Psychosocial ~ esearch -db pubmed -query "(myalgic encephalomyelitis) AND (cognitive OR behaviour OR graded exercise therapy OR adaptive pacing therapy) AND (\"1951/01/01\"[PDAT] : \"2016/12/31\"[PDAT])" \ efetch -format xml \ xtract -pattern PubmedArticle -block PubDate -element Year \ sort-uniq-count-rank \ sort -n -t $'\t' -k 2 > xla.txt Data mining ME/CFS Genes ~ esearch -db pubmed -query "(myalgic encephalomyelitis) AND (gene OR cell) AND (\"1951/01/01\"[PDAT] : \"2016/12/31\"[PDAT])" \ efetch -format xml \ xtract -pattern PubmedArticle -block PubDate -element Year \ sort-uniq-count-rank \ sort -n -t $'\t' -k 2 > xlb.txt

6 ME/CFS Genes vs Psychosocial Research Output Genes Psychosocial TOTAL Articles Genes: 1015 Psychosocial: 1750

7 Top ME/CFS Authors Data mining ME/CFS Top Authors ~ esearch -db pubmed -query "(myalgic encephalomyelitis) AND (\"1951/01/01\"[PDAT] : \"2017/03/24\"[PDAT])" \ efetch -format xml \ xtract -pattern Author -sep " " -element LastName,Initials \ sort-uniq-count-rank Psychosocial Authors Output Genes Authors Output Top Authors Output Chalder T 84 Maes M 28 Bleijenberg G 132 Bleijenberg G 81 Komaroff AL 21 Wessely S 132 Wessely S 50 Vernon SD 19 Jason LA 121 Knoop H 41 Ablashi DV 17 Chalder T 116 van der Meer JW 36 Staines D 15 Natelson BH 112 Natelson BH 33 Brenu EW 14 Buchwald D 81 White PD 33 de Meirleir K 14 Komaroff AL 79 Jason LA 32 Kerr JR 14 White PD 77 Sharpe M 28 Marshall-Gradisnik S 14 Nijs J 75 Nijs J 27 Staines DR 14 van der Meer JW 74

8 Top ME/CFS Grants Psychosocial ME/CFS Grants Grants Genes ME/CFS Grants Grants NIAID NIH HHS 168 NIAID NIH HHS 143 Medical Research Council 80 NCI NIH HHS 88 NIMH NIH HHS 54 NHLBI NIH HHS 39 NCRR NIH HHS 49 Medical Research Council 32 NIAMS NIH HHS 40 NCRR NIH HHS 28 Department of Health 36 NIAMS NIH HHS 27 NINDS NIH HHS 33 NIDDK NIH HHS 26 NIA NIH HHS 32 NINDS NIH HHS 25 NIDDK NIH HHS 26 NIMH NIH HHS 23 PHS HHS 23 Intramural NIH HHS 20 Wellcome Trust 23 Wellcome Trust 16 NCATS NIH HHS 18 PHS HHS 15

9 Top ME/CFS Research Institutions Psychosocial ME/CFS Research Output Genes ME/CFS Research Output DePaul University, USA 29 Dept. of Oncology & Medical Physics Haukeland Uni. Hospital, Norway Dept. of Paediatric & Adolescent Medicine Mayo Clinic, Rochester, MN, USA Chronic Illness Team: School of Psychology University of East London, UK Dept. of Neurological & Movement Science University of Verona, Verona, Italy School of Social & Community Medicine University of Bristol, Bristol, UK War Related Illness & Injury Study Center Veterans Affairs Med. Center, Was. DC, USA Dept. of Health Toxicology, China Second Military Med. University, Shanghai Dept. of Physiology, Osaka, Japan Osaka City Uni. Grad. School of Medicine 14 Institute for Medical Immunology University Medicine Berlin, Germany 8 National Centre for Neuroimmunology Griffith University, QLD, Australia 8 Dept. of Neurological & Move Science University of Verona, Verona, Italy 8 Griffith Health Institute Griffith University, QLD, Australia 8 NIH Undiagnosed Diseases Program Officer of the Director, NIH, USA 7 University of Utah, Salt Lake City. USA 7 Molecular Inflammation Research Pusan National University, Korea

10 MK ULTRA?? ME/CFS research output: 7459 articles per 66 years. Of those, 1750 articles: ~ 1 in 5 articles on psychosocial ME/CFS research. That s NOT a lot. Why is the military investigating? Fatigue Altering information processing in this region can increase or decrease fatigue responses in a human subject. This leads them to either increased endurance, or Myalgic encephalomyelitis (ME)/ Chronic Fatigue Syndrome (CFS) which effectively disables a human subject

11 DISCLAIMER The data mining techniques used is this analysis isn t precise. For accuracy, each article needs to be scoped individually and multiple databases needs to be sourced. This normally takes months to years. The data hasn t been cleaned or assessed qualitatively and may not be accurate. These figures give a rough estimate of ME/CSF research trends. It doesn t take into consideration divergent views and interventions within ME/CSF research. Further precise analysis may yield a completely different research trend. Search terms are verified MeSH terms and not key words. for full codes and full data extracts.

12 APPENDIX Source code for ME/CFS PMID Title Abstract Year Authors Affiliation ~ esearch -db pubmed -query "(myalgic encephalomyelitis) AND (\"1951/01/01\"[PDAT] : \"2017/03/25\"[PDAT])" \ efetch -format xml \ xtract -pattern PubmedArticle -element MedlineCitation/PMID -element ArticleTitle -element Title -element Abstract -block PubDate -element Year - block Author -tab " " -sep "," -element LastName,Initials,Affiliation \ sort -n -t $'\t' -k 2 > xl.txt For clinical trials substitute the first line as ~ esearch -db pubmed - query "myalgic encephalomyelitis AND clinicaltrials.gov[si]" \ -datetype PDAT -mindate 1951/01/01 -maxdate 2017/03/25 \ All codes were written by author: Sonia March 2017 CC-Zero