Cover Page. The handle holds various files of this Leiden University dissertation.

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1 Cover Page The handle holds various files of this Leiden University dissertation. Author: Nicolaie, Mioara Alina Title: Dynamic aspects of competing risks with application to medical data Issue Date:

2 List of Publications 1. A. Nicolaie. A sufficient condition for the convergence of a finite Markov chain, Math. Rep.(Bucur.), 10(60), 2008, A. Nicolaie. On the asymptotic behaviour of finite Markov chains, Carpathian J. Math. 24(2008), 2, A. Nicolaie. A generalization of a result concerning the asymptotic behavior of finite Markov chains, Statistics and Probability Letters 18(78), 2008, M. N. Pascu, A. Nicolaie. On a discret version of the Laugesen-Morpurgo conjecture, Statistics and Probability Letters 6(79), 2009, M.A. Nicolaie, Hans van Houwelingen and Hein Putter. Vertical modeling: a pattern mixture approach for competing risks data, Statistics in Medicine, 2010, 29 (11), M.A. Nicolaie. Competing risks as purged Markov chains, Bulletin of the Transilvania University of Braşov, Vol 3(52) , Series III: Mathematics, Informatics, Physics, M.A. Nicolaie. Hans van Houwelingen and Hein Putter. Vertical modeling: analysis of competing risks data with missing causes of failure. Statistical Methods in Medical Research (2011). DOI: / M.A. Nicolaie. Analysis of missing causes of failure in competing risks in the context of the Larson and Dinse approach. In Mathematical Modelling of Environmental and Life Sciences Problems, 2010, MatrixRom. ISBN: M.A. Nicolaie, Hans van Houwelingen, T.M de Witte, Hein Putter. Dynamic prediction in competing risks by landmarking. Statistics in Medicine 32 (12), , M.A. Nicolaie, Hans van Houwelingen and Hein Putter. Dynamic pseudoobservations: a robust approach to dynamic prediction in competing risks. Biometrics. DOI: /biom

3 160 LIST OF PUBLICATIONS 11. M.A. Nicolaie, Hans van Houwelingen and Hein Putter. Comparison of dynamic prediction models. Submitted. 12. M.A. Nicolaie, Catherine Legrand. Vertical modeling: analysis of competing risks data with a cured fraction. Submitted. 13. M.A. Nicolaie, Catherine Legrand. Vertical modeling: analysis of multistate data with a cured fraction. Working paper.

4 Curriculum vitae Mioara Alina Nicolaie was born on the 20th of November 1977, în Braşov, Romania. After finishing her secondary education at Liceul de Ştiinţe ale Naturii C. D. Neniţescu, Braşov, she studied Mathematics at the Faculty of Sciences of Transilvania University of Braşov, where she graduated as B.Sc. in 2000 at the top of her class and as M.Sc on an extreme value theory thesis in Between 2002 and 2007 she was PhD student at the Faculty of Mathematics. Besides, she jointed several research projects in the field of probability theory. She got her first PhD title on December 14, 2012 with a thesis entitled Convergence and Monotony Theorems for Finite Markov Chains under the supervision of Prof.dr. Gabriel V. Orman. In 2008, she started her second PhD studies at the Department of Medical Statistics and Bioinformatics, Leiden University Medical Center. She worked in the project entitled Prognostic Modeling and Dynamic Prediction for Competing Risks and Multi-State Models under the supervision of Prof.dr. Hein Putter and Em. Prof.dr. Hans van Houwelingen. Her work was focused on the development of new analysis strategies for competing risks. The results of this research are presented in this thesis. Since 2012, she works as post-doctoral fellow at the Institute of Statistics, Biostatistics and Actuarial Sciences at the Catholic University of Louvain, Belgium. She develops new statistical methodology for multi-state models with a cured fraction. 161

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6 Acknowledgments The research presented in this thesis is the result of my work in the Department of Medical Statistics and Bioinformatics of Leiden University Medical Center. The first thoughts of gratitude I have are for my supervisors Prof. Hans van Houwelingen and Prof. Hein Putter. Prof. Hans van Houwelingen is the father of biostatistics in the Netherlands. He created a new school of thought in medical statistics by translating results from theoretical statistics to applications in medical research. His innovations are characterized by usefulness, deepness, elegance and wideness and they have greatly influenced the international community of (clinical) biostatisticians. Prof. Hein Putter, having given me the opportunity to pursue this PhD, helped me to improve my research skills, to gain a technical writing style and he inspired me on how to tackle a long list of scientific challenges concerning the passage from the theoretical field of research of Markov chains to the more applied one of competing risks. My supervisors will always be for me reference models as researchers, professors and human beings. Leiden University Medical Center is a great establishment which has acquired genuine researchers from all over the world. Many thanks go to my colleagues from whom I benefited a lot: Marta, Rosa, Roula, Liesbeth, Wendim, Andrea, Bruna, Lies, Henk Jan, Watze, Erik, Jelle, Ron, Ronald, Bart, Saskia, Theo, Anika, Jeanine, Hae Won, Tekla, Stefan, Oksana, Fabrice, Cristian, Leila, Aldo and Livio. Romanians complete the list: Dana, Irina, Cristina, Cristina, Crina, Dana, Andrei, Răzvan and Sandrin. My best friend Olivia helped me a lot with her unceasing presence when needed, her devoted and kind heart. My Belgian parents, Father Ioan and Presbytera Christina genuinely inspired me through their living example of how great human values can be preserved in the context of an extremely diverse culture and far away from home. I am grateful to my family. Mămucă, îţi mulţumesc pentru devotamentul şi dragostea ta. Iulia and Emi, I hope you will share my joy on the defense day. Tătucă şi Ucu, sper că acolo unde v-aţi dus, vă bucuraţi de această zi din viaţa mea. Alina Nicolaie Genval, Belgium 163