Cover Page. The handle holds various files of this Leiden University dissertation.

Transcription

1 Cover Page The handle holds various files of this Leiden University dissertation. Author: Raeven, R.H.M. Title: Systems vaccinology : molecular signatures of immunity to Bordetella pertussis Issue Date:

2 Curriculum vitae Curriculum vitae René Raeven was born on August 18, 1982 in Geleen, The Netherlands. After graduating from the Mavo St. Anna in Geleen in 1998 he obtained a dual MBO Chemistry degree at the Leeuwenborgh College, Sittard (Netherlands) and Rheinwestfalische Technische Hochschule (RWTH), Aachen (Germany) in In 2004 he obtained a Bachelor degree in Biochemistry at the Hogeschool Zuyd in Heerlen, The Netherlands. During this study he performed an internship at the Arkansas State University in Jonesboro, USA on the effects of phytoestrogens in the reproductive tract of sheep. In 2005 he continued for a Master Degree Nutrition and Health at the Wageningen University, The Netherlands which he obtained in During this study he performed two internships. The first was at the Nutrigenomics Department at the Wageningen University where he investigated the role of transcription factor PPARα in obesitas-induced inflammation in hepatic and adipose tissue. His second internship was at the Nanyang Technological University in Singapore where he performed research on the role of FIAF/Angptl4 in the development and regeneration of villi in small intestine of mice. Subsequently, he worked as a researcher at DSM Dyneema and the Netherlands Vaccine Institute (NVI). In September 2011 he started his PhD project on systems vaccinology and the molecular signatures of immunity to Bordetella pertussis at the Institute of Translational Vaccinology (Intravacc) and Leiden University under the supervision of Prof. Dr. Gideon Kersten, Prof. Dr. Wim Jiskoot and Dr. Bernard Metz, which resulted in this thesis. In January 2016 he started working as a scientist at Intravacc continuing his work on systems vaccinology. Curriculum vitae 295

3 296 Appendices

4 List of publications List of publications Raeven RHM, Brummelman J, Pennings JLA, Nijst OEM, Kuipers B, Blok LER, Helm K, van Riet E, Jiskoot W, van Els CACM, Han WGH, Kersten GFA, Metz B. Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection. PLoS One, (8): p. e Raeven RHM, van der Maas L, Tilstra W, Uittenbogaard JP, Bindels THE, Kuipers B, van der Ark A, Pennings JLA, van Riet E, Jiskoot W, Kersten GFA, Metz B. Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity. J Proteome Res (7): Brummelman J, Raeven RHM, Helm K, Pennings JLA, Metz B, van Eden W, van Els CACM, Han WGH. Transcriptome signature for dampened Th2 dominance in acellular pertussis vaccineinduced CD4(+) T-cell responses through TLR4 ligation. Sci Rep : Raeven RHM, Brummelman J, van der Maas L, Tilstra W, Pennings JLA, Han WGH, van Els CACM, van Riet E, Kersten GFA, Metz B. Immunological signatures after Bordetella pertussis infection demonstrate importance of pulmonary innate immune cells. Manuscript submitted Raeven RHM, Brummelman J, Pennings JLA, van der Maas L, Tilstra W, Helm K, van Riet E, Jiskoot W, van Els CACM, Han WGH, Kersten GFA, Metz B. Bordetella pertussis outer membrane vesicle vaccine confers equal efficacy in mice with a lower inflammatory response compared to a classic whole-cell vaccine. Manuscript submitted Raeven RHM, Brummelman J, Pennings JLA, van der Maas L, Helm K, Tilstra W,van der Ark A, Sloots A, van der Ley P, van Eden W, Jiskoot W, van Riet E, van Els CACM, Kersten GFA, Han WGH, Metz B. Systems vaccinology reveals superior protection after pulmonary compared to subcutaneous administration of an outer membrane vesicle pertussis vaccine associated with local and systemic immune signatures in mice. Manuscript submitted Raeven RHM, Pennings JLA, van Riet E, Kersten GFA, Metz B. Meta-analysis of pulmonary transcriptomes from differently primed mice identifies molecular signatures to differentiate immune responses following Bordetella pertussis challenge. Manuscript submitted List of publications 297

5 René Raeven 2016