Need for Development of Oriental Medicine-derived Systemic Treatments against Chronic Fatigue-associated Symptoms
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1 30 4 ( ) J Korean Oriental Med 2009;30(4):28-36 Original Article 조정효 손창규 대전대학교한의과대학간장면역학교실 Need for Development of Oriental Medicine-derived Systemic Treatments against Chronic Fatigue-associated Symptoms Jung-Hyo Cho Chang-Gue Son Internal Department of Oriental Medicine College Daejeon University Objectives: Fatigue is a prevalent symptom encompassing both acute and chronic manifestations Most fatigue symptoms can be cured by taking a rest or removing underlying causes However chronic fatigue is frequently problematic due to its duration and effect on quality of life There are no particularly effective therapies for chronic fatigue of unknown causes and patients in Korea usually visit an Oriental clinic This study aimed to analyze the current status of treatments and patients with chronic fatigue and then map out of a strategy for development of generalized-treatments for chronic fatigue in Oriental Medicine Methods: Clinical information related to chronic fatigue was selected from various different databases such as PubMed KoreaMed KStudy DBPIA OIM and KOMS Also to understand current tendency of medical examination and treatment related with chronic fatigue we requested Health Insurance Review & Assessment Service for clinical datum from 2003 to 2007 Results: The medical fees of National Health Insurance related with fatigue show an explosive year-on-year increase On the other hand it has been decreasing annually in the western medical fields To take charge of clinical fields related with chronic fatigue by Oriental Medicine we should make a unified diagnostic system Then we should also make standard evaluation tools and develop herbal drugs according to this unified diagnostic system Conclusions: Fatigue-related symptoms will be a main target of Oriental medicine in the future We expect that various studies related with chronic fatigue will be undertaken hereafter Key Words : Chronic fatigue Oriental medicine herbal drug 서론 (chief complaint) 6 45) 275% 1-3) 10-40% 6 Received:16 January 2009 Revised:6 May 2009 Accepted:19 May 2009 Correspondence to: 손창규 (Chang-Gue Son) ( ) 대전시중구대흥동 22-5 번지대전대학교부속한방병원간장면역학교실 Tel: Fax: ckson@djuackr 28
2 1 : (485) 6) 7) (peripheral fatigue) (central fatigue) 2 자료수집방법 Pubmed ( nihgov/sites/entrez?db=pubmed) Koreamed (http: //koreamedorg) ( kstudycom) DBPIA ( 89) ) 1112) R53 G933 B104 ( - ) B105 ( - ) B4301 ( - ) B4302 ( - ) C222 ( - ) E02315 ( - ) E03109 ( - ) E15 ( - ) E1615A ( - ) E17701 ( - ) E22307 ( - ) F42 ( - ) I163 ( - ) I16301 ( - ) L29 ( - ) 본론및고찰 1 피로에대한동서의학적병태에대한개괄 연구방법 1 연구설계 1314) 29
3 (486) 30 4 ( ) 7) ) ) ( (idiopathic chronic fatigue) pituitary-adrenal axis (chronic fatigue syndrome) 16) hypothalamic ) 2324) (sexual abuse) 2021) (Fig 1) adrenal axis hypothalamic-pituitary- 22) 2 한국에서만성피로의유병율분석 급성피로 지연피로 만성피로 원인이있는피로 원인불명의피로 정신적원인피로 만성피로증후군 육체적원인피로 특발성만성피로 Fig 1 30
4 1 : (487) Table 1 Prevalence (%) Study Prolonged fatigue Chronic fatigue Chronic fatigue syndrome Included subjects 오미경등 30) 검진자중질환자는제외 (510명) 김영복등 31) 1996 남자 : 207 여자 : 근로자대상의통계 (10927 명 ) 지종대등 32) 차의료기관건강검진자 (416명) 윤방부등 33) 차의료기관방문객 (12152 명 ) 김철환등 34) 차의료기관방문객 (988명) 김철환등 35) 차의료기관방문객 (1648명) 10-25% 5-15% 05-25% 25-28) 20% 80% ( vs 3 : 4) 35) 042% % 42% 29) ) 30-35) (Table 1) % 84% 06% 3637) 3 피로환자들의한ㆍ양방적진료경향분석 ( 건 (1000) 양방 피로관련건강보험청구건수 한방 Fig 2 31
5 (488) 30 4 ( ) 원 ( 억 ) 양방 피로관련건강보험청구건수 한방 Fig 3 ) R53 ( ) G933 ( ) B104 ( - ) B4302 ( - ) 14 4 만성피로에대한한의학의적극적연구필요성 (Fig 2 3) ) ) 38-41) 32
6 1 : (489) 12) 30) 162% (diagnostic criteria) 5 만성피로에대한한방치료법의체계화및 활성화를위한제안 3 162% ) 33
7 (490) 30 4 ( ) 결론 10% 감사의글 2007 ( ) (No R ) (B080043) 참고문헌 1 Jorgensen R Chronic fatigue: an evolutionary concept analysis J Adv Nurs 2008;63(2): Wessely S Chalder T Hirsch S Wallace P Wright D The prevalence and morbidity of chronic fatigue and chronic fatigue syndrome: a prospective primary care study American Journal of Public Health 1997;87(9): Ricci JA Chee E Lorandeau AL Berger J Fatigue in the US workforce: prevalence and implications for lost productive work time Journal of Occupational and Environmental Medicine 2007;49(1): Shin HC Choi HC Song SW Choi HS Patients with fatigue in family practice J Korean Acad Fam Med 1993;14(12): Available from URL: plan/?fn=v&no=9503&cid = & pg=1 6 Sekiya N Shimada Y Shintani T Tahara E Kouta K Shibahara N et al Reduction of perception of chronic fatigue in an observational study of patients receiving 12 weeks of Kampo therapy Journal of Alternative and Complementary Medicine 2005;11(5): Glacken M Coates V Kernohan G Hegarty J The experience of fatigue for people living with hepatitis C Journal of Clinical Nursing 2003;12 (2): Jones DE Bhala N Burt J Goldblatt J Prince M Newton JL Four-year follow up of fatigue in a geographically defined primary biliary cirrhosis patient cohort Gut 2006;55(4): Kralik D Telford K Price K Koch T Women s experiences of fatigue in chronic illness Journal of Advanced Nursing 2005;52(4): Kim CH Shin HC Clinic for chronic fatigue J Korean Acad Fam Med 1998;19(8): Yoo SR Son CG Survey Analysis of 101 Subjects Using Herbal Medicine with Deer Antler J Korean Oriental Med 2008;29(2): Kim SH Lee JH Lee SB Choi MY Kim YC Woo HJ Speculation of the Correlationship between Public Health Practice Consumption and Fatigue in Patients who Complain Fatigue 34
8 1 : (491) Korean J Orient Int Med 2008:29(1) Sharpe M Wilks D Fatigue BMJ 2002;325 (7362): Clarke JN James S The radicalized self: the impact on the self of the contested nature of the diagnosis of chronic fatigue syndrome Social Science & Medicine 2003;57: Holmes GP Kaplan JE Gantz NM Komaroff AL Schonberger LB Straus SE et al Chronic fatigue syndrome: a working case definition Ann Intern Med 1988;108: Fukuda K Straus SE Hickie I Sharpe MC Dobbins JG Komaroff A International chronic fatigue syndrome study group The chronic fatigue syndrome: a comprehensive approach to its definition and study Ann Intern Med 1994;121: Hickie I Kirk K Martin N Unique genetic and environmental determinants of prolonged fatigue: a twin study Psychol Med 1999;29(2): Klimas NG Salvato FR Morgan R Fletcher MA Immunologic abnormalities in chronic fatigue syndromej Clin Microbiol 1990;28(6): Staines DR Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis Clin Dev Immunol 2006;13(1): Visser MRM Smets EMA Fatigue depression and quality of life in cancer patients: how are they related? Supportive Care in Cancer 1998; 6: Kato K Sullivan PF Evengard B Pedersen NL Premorbid predictors of chronic fatigue Archives of General Psychiatry 2006;63: Yi JH Lee JH Park SM Kim YC Lee JH Woo HJ Clinical investigation and follow-up monitering of fatigue patients visiting the Oriental medical hospital J Korean Oriental Med 2002; 21(4): Oh TH Jung SG Rhee HK Review of literature on languor and fatigue Korean J Orient Int Med 1990;11(2): Jeon SB Oh TH Jung SG Rhee HK Review of literature on languor and fatigue Korean J Orient Int Med 1991;12(1) Lloyd AR Hickie I Boughton CR Spencer O Wakefield D Prevalence of chronic fatigue syndrome in an Australian population Med J Aust 1990;153: Bates D Schmitt W Buchwald D Ware NC Lee J Thoyer E et al Prevalence of fatigue and chronic fatigue syndrome in a primary care practice Arch Intern Med 1993;153: Kroenke K Wood DR Mangelsdorff AD Meier NJ Powell JB Chronic fatigue in primary care; prevalence patient characteristics and outcome JAMA 1988; 260: Hickie IB Hooker AW Hadzi-Pavlovic D Bennett BK Wilson AJ Lloyd AR Fatigue in selected primary care settings: sociodemographic and psychiatric correlates Med J Aust 1996;164 : Jason LA Richman JA Rademaker AW Jordan KM Plioplys AV Taylor RR et al A communitybased study of chronic fatigue syndrome Arch Intern Med 1999;159(18): Oh MK Evaluation of the chronic fatigue of periodic health examination visitors J Korean Acad Fam Med 1990;11(4): Kim YB Kim BW A statistical study on the causative factors of chronic fatigue among workers Chonnam medical journal 1996;23(4) Ji JD Choi SJ Lee YH Song GG Incidence and clinical manifestations of chronic fatigue in Korea KJIM 1999;56(6): Youn BB Lee KS Kang HC Shin KK An analysis of fatigue among outpatients J Korean Acad Fam Med 1999;20: Kim CH Shin HC Park YW The prevalence of chronic fatigue and CFS-a hospital based 35
9 (492) 30 4 ( ) study J Korean Acad Fam Med 2000;21: Kim CH Shin HC Won CW Prevalence of chronic fatigue and chronic fatigue syndrome in Korea: community-based primary care study J Korean Med Sci 2005 Aug;20(4): Kim SG Lee YJ Oh MK Youn BB Evaluation of chronic fatigue of periodic health examination J Korean Acad Fam Med 1990;11(12): Kim CH Shin HC Clinical characterization of chronic fatigue and chronic fatigue syndrome in Korea J Korean Acad Fam Med 1998;19(12): Cho JH Yoo SR Cho JK Son CG Analytic Study for Syndrome-differentiation and Sasangconstitution in 72 Adults with Chronic Fatigue J Korean Oriental Med 2007;28(4): Lee DE The effect of Dangguibohyultang and Ssanbohwan on the muscle-fatigue recovery in rats J Korean Oriental Med 1996;17(1): Kim SW Du HK Experimental study on the effects of Palmiwon Korean J Orient Int Med 1989:10(1): Na CS Youn DH Choi DH Kim JS Jang KS The effect of Bambusaw caulis in liquamen J Korean Oriental Med 2001;22(4):
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