ACUTE AND CHRONIC NEUROPATHIES
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1 ACUTE AND CHRONIC NEUROPATHIES American College of Osteopathic Internists Internal Medicine Board Review Course 2018 April 25-29, 2018 Marriott Chicago Downtown Chicago, Illinois Scott Spradlin D.O.,FACP,FACOI I have no relevant financial or nonfinancial relationships in the products or services described, reviewed, evaluated or compared in this presentation.
2 Mononeuropathy one nerve with one point of impingement Mononeuropathy multiplex one nerve with multiple points impingement Polyneuropathy multiple nerves and multiple points impingement
3 Board Exam Sample 72-year-old man presents to your outpatient clinic with the complaint of recurrent spells of hand numbness. On exam he has weakness of finger spreading. He also has sensory loss in the last two fingers splitting the ring finger. The most likely etiology for his symptoms is A. Recurrent transient ischemic attacks (TIAs) B. C6 radiculopathy C. C7 radiculopathy D. Ulnar neuropathy
4 Board Exam Sample 72-year-old man presents to your outpatient clinic with the complaint of recurrent spells of hand numbness. On exam he has weakness of finger spreading. He also has sensory loss in the last two fingers splitting the ring finger. The most likely etiology for his symptoms is A. Recurrent transient ischemic attacks (TIAs) B. C6 radiculopathy C. C7 radiculopathy D. Ulnar neuropathy Answer: Ulnar Neuropathy(D)
5 Clinical Workup: Personal/Family History Glucose Sedimentation rate Creatinine Thyroxine Complete Blood Count Pertinent Radiographic films EMG-NCV
6 Focal Compressive Radiculopathies: Localized peripheral nerve Usually from compression Must differentiate from multiplex Examples: Radial neuropathy Carpal tunnel syndrome Ulnar neuropathy Sciatic nerve Peroneal nerve compression Brachial neuritis
7 Mononeuropathy Multiplex Diabetic Neuropathy- MOST COMMON Alcoholic Neuropathy- Bell s Palsy- Multiple Sclerosis (MS)-
8 Polyneuropathies Landry-Guillain-Barre- most common autoimmune Diabetic Peripheral Neuropathy- most common overall Hereditary Motor and Sensory Neuropathy Chronic Inflammatory Demyelinating Polyneuropathy (CIDS) - steroids make it better Other HIV Toxicity- usually sensory- (Thallium, Organophosphates,Lead) Nutritional- Thiamine,B6,B12 Deficiencies Paraneoplastic Rheumatologic
9 Hereditary Motor and Sensory Neuropathy Also known as Charcot-Marie-Tooth Most common inherited polyneuropathy Two main types: Type I and Type II Autosomal recessive or autosomal dominant Slow onset- gradual onset over years Foot drop/weakness Sensory loss in a stocking distribution
10 Landry-Guillain-Barre Most common inflammatory polyneuropathy Ascending paralysis/weakness limbs Areflexia Causes: Preceding infectious illness (2/3) CMV EBV VARICELLA Campylobacter Swine influenza Rabies CSF: elevated protein and slight increase cell count Treatment: Plasmaphoresis IVIG Steroids of no use
11 Case 1 A 52-year-old man presents with 2 years of gradual progressive burning, stinging, and tingling in the feet To a lesser extent he has tingling in the fingertips bilaterally. Shoes, socks, and even the light touch of bed sheets are very irritating and limit his ability to rest. When walking the pain becomes more severe like an electrical shock pain in the feet. The examination shows: Decreased sensation in a stocking-glove pattern which is symmetric. Muscle strength is normal. The muscle stretch reflexes are absent at the ankles otherwise normal
12 Diagnosis: Chronic Progressive Sensory Neuropathy Metabolic: Diabetes, HIV, Sarcoidosis, Myeloma, or Porphyria Alcohol Nutritional Vascular Toxic Rheumatologic
13 Diagnostics Glucose, Creatinine, Liver profile ESR T4 CBC CXR SPEP,HIV,ANA,ACE, B12, B1
14 Treatment of neuropathic pain Trigeminal neuralgia (sharp stabbing face pain) Carbamazepine/Oxcarbazepine Gabapentin Lamotrigine Baclofen Limb neuralgia (sharp, stabbing, zinging, lightning, bee-sting pain) Gabapentin Lyrica (only diabetic/zoster) Duloxetine (only diabetic) Lamotrigine Topomax Lidocaine/Capsaicin Continuous burning dysesthesias and supersensitivity (as in a diabetic) Pregabalin Gabapentin SSRI Tricyclic Antidepressants such as Nortriptyline and Amitriptyline Topical Lidocaine Lamotrigine Topomax Tramadol Opioid Analgesics
15 Case 2 A 24-year-old man presents with 5 days of progressive burning, stinging, and tingling in the feet, gradually ascending up the legs Creeping into the hands symmetrically. On the day of admission he has difficulty walking because of the development of bilateral foreleg weakness with foot drop. A few days before the onset of his sensory symptoms he had a severe 24-hour gastrointestinal syndrome The examination shows distal sensory loss in a stocking-glove pattern, muscle stretch reflexes are absent, and foot drop bilaterally Hands are shown in picture
16 Answer: Heavy Metal Poisoning- probably Arsenic or Thallium
17 Case 3 29-year-old man presents after waking up with intense aching pain in the right jaw and ear. He has sagging of the right side of the face. Examination shows: Face at rest, smiling, raised eyebrows with deficit otherwise normal exam Sensation is mildly increased The examination of the ear is normal. What is the diagnosis? How much work-up is appropriate?
18 Answer: Bell s Palsy Physical exam only What if a vesicular lesion was found on ear exam? What would the diagnosis be?
19 Case 4 A 25-year-old man presents with 3 days of gradual progressive difficulty walking He is having weakness of his arms He has had subjective heaviness in the legs, and mild tingling in the feet Examination shows: Moderate weakness of proximal and distal muscle groups (shoulders, arms, and legs in symmetric fashion). There is mild decrease in position and vibration sense in the toes. The muscle stretch reflexes are absent in the arms and legs. He describes a mild respiratory illness 3 days before the onset of weakness. What is the diagnosis?
20 Acute and Chronic Neuropathy Answer: Landry-Guillain-Barre
21 Case 6 40-year-old woman presents with 15 years of gradual progressive difficulty with ambulation Tendency to stumble easily; Most recent difficulty with hand function including grip, strength, opening jars, and grasping fine objects. The symptoms are symmetric. There is minimal tingling in the toes but no sensory loss in the hands. The examination shows the presence of atrophy in the foreleg muscles Prominent tibial bones; atrophy of the intrinsic hand muscles and pes cavus. The muscle stretch reflexes are absent There is decreased vibration sense in the toes and fingertips, and slightly decreased pin prick in the toes. There is associated foot drop bilaterally. Proximal strength is normal. Diagnosis?
22 Answer: Charcot-Marie-Tooth Disease
23 Case 7 A 51-year-old man presents with 3 weeks of continuous burning, stinging, and intense discomfort in the side of the leg as shown. He has no other past medical history, takes no medications, and has no back pain or leg weakness, and no recent viral symptoms. Examination shows: Super sensitivity in the circle area whether touched with a pin or with cotton, all stimuli are equally noxious. Strength in the legs is normal as are the muscle stretch reflexes. What is the diagnosis? Treatment?
24 Answer: Lateral femoral cutaneous neuropathy syndrome meralgia paresthetica
25 Case 8 53-year-old woman presents with 5 days of burning pain in the left posterior chest It radiates around her side to the anterior chest in a bandlike pattern. She reports recent malaise, nausea, and vomiting. In the last 24 hours she has developed clusters of vesicles on a red base in the area of burning pain. What is the diagnosis?
26 Answer: Herpes Zoster
27 Amyotrophic Lateral Sclerosis (ALS) -Also known as Lou Gehrigs Disease -Progressive Degenerative with muscle wasting -Sensory and Cognitive changes -Affects men more than women ages 40-60
28 Clinical Manifestations: Musculoskeletal Weakness/fasciculations/spasticity/paresis/hyperreflexia Respiratory Dyspnea/Difficulty clearing airway Nutrition Difficulty chewing/dysphagia Emotion Loss of control/ liability Cognitive Intellect intact
29 Prognosis/Treatment: Diagnosis is with EMG Death is usually resultant of pneumonia/respiratory failure Riluzole (Rilutek) which extends life a few months Supportive nutrition/ventilation/communication/mobility Respiratory compromise within 2-5 years of diagnosis
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