Vaccination and Control of PRRS
|
|
- Alyson Thomas
- 5 years ago
- Views:
Transcription
1 Vaccination and Control of PRRS
2 Key Contributors Univ of Minnesota RP Mulupuri Zhengguo Xiao Craig Johnson Juan Li Sally Robinson Scott Dee Pipestone Vet Clinic Jeff Zimmerman Iowa State Paul Yeske Swine Vet Center Eric Nelson South Dakota State Mike Roof Boehringer Ingelheim Eric Vaughn Sponsors USDA CAP USDA NRI National Pork Board Minnesota Pork Board Boehringer Ingelheim Vetmedica University of Minnesota NIH NIDA Schulze Diabetes Institute Competing interests Patents
3 There are Two General Types of PRRSV Type 1 (European) Type 2 (North American) ORF5 Dendrogram The virulent viruses of Asia
4 There are Two General Types of PRRSV Feature Peak viral load Virulence respiratory Virulence reproductive Innate interferon induction Growth in MARC 145 Global distribution (wt virus) Global distribution (Live vaccines) Evolution rate Type 1 PRRSV Medium Low Medium No Very poor Europe, Korea, US Europe, Korea High Type 2 PRRSV High High High Yes Medium Asia, N and S America All continents High Type 2 PRRSV is the Key Problem in Asia
5 How Does PRRSV Move? Pigs Semen Transport People Needles Air
6 Routes of PRRS Infection PRRSV? PRRSV? Gilts PRRSV? Boar Stud Infected Animal Grow-Finish Semen Sow Herd Infected Pig Market PRRSV? Infected Piglet in Utero or After Birth Nurseries PRRSV? Standard USA production system. Multi-site, All in-all out, Unidirectional flow PRRSV goes where pigs go.
7 Disease Goes Where Pigs Go Interstate pig movements in the U.S.A. in 2001 Disease goes where pigs go.
8 Methods and Tools for PRRSV Control Negative Animals Negative Semen Biosecurity Clean Transport Herd Closure Air Filtration Health Management Vaccination
9 Clean and Disinfect Transport Vehicles Paul Yeske Swine Vet Center
10 Biosecurity Down Time UMN and Purdue work showing just have to change clothes and boots and wash hands to avoid spread Paul Yeske Swine Vet Center
11 Preventing Disease: People Remove shoes in the initial entryway while sitting on the bench Without touching socks to the floor, swing feet over the bench to the other side Paul Yeske Swine Vet Center
12 Getting Rid of PRRSV Herd Closure: Mass vaccinate or inoculate entire herd to PRRSV and close to animal entry for >250 days. 15 multiplication herds were preloaded with gilts and closed for an average of 260 days. After closure, all farms tested negative for PRRSV by PCR and have remained negative for 4 years. Torremorrell, Moore, Christianson Establishment of a herd negative for porcine reproductive and respiratory syndrome virus (PRRSV) from PRRSV-positive sources. J Swine Health Prod. 10: Schaefer and Morrison Effect on total pigs weaned of herd closure for elimination of PRRSV. J Swine Health Prod. 15: Herd Closure Gets Rid of PRRS
13 Biosecurity with Air Filtration Field experience includes 21 boar studs, 8 sow farms, 1 finisher, 1 research farm (Swine Vet Clinic). Air filtration prevented PRRS transmission during demonstrated episodes of local area spread. Also, no mycoplasma breaks, and 2 SIV breaks in 3 years field experience. Spronk G, Otake S, Dee S Prevention of PRRSV infection in large breeding herds using air filtration. Vet Rec. 166: Photo: Paul Yeske Air Filtration Keeps PRRS Out
14 Why Do we Care So Much? PRRS outbreaks are really expensive!
15 Pathogenesis News: Recent Isolates are Really Virulent Reproductive PRRS Acute Outbreak Nov 2007, 2,000 naïve sow herd Sow death loss >60% Pre-weaning mortality 100% Direct losses ~$750,000 or >5 million RMB
16 The Role of Vaccination in Control of PRRS PRRSV? Gilts Sow Herd Vaccine Protects against Severe Clinical Signs at All Stages of Production PRRSV? Grow-Finish Market PRRSV? Nurseries PRRSV? Standard USA production system. Multi-site, All in-all out, Unidirectional flow PRRSV goes where pigs go.
17 The Role of Vaccination in Control of PRRS Gilts Sow Herd Protects Naïve Pigs going into a Positive Herd or a Pig-Dense Region PRRSV? Grow-Finish Market PRRSV? Nurseries PRRSV? Standard USA production system. Multi-site, All in-all out, Unidirectional flow PRRSV goes where pigs go.
18 The Role of Vaccination in Control of PRRS Gilts PRRSV? Sow Herd Reduces Disease Losses in an Outbreak Grow-Finish Market PRRSV? Nurseries PRRSV? Standard USA production system. Multi-site, All in-all out, Unidirectional flow PRRSV goes where pigs go.
19 Attenuated Live PRRSV Cross-Protects Against Heterologous Challenge Opriessnig et al J. Swine Hlth. Prod. 13: Gross and microscopic lung lesions induced by PRRSV in vaccinated and unvaccinated groups at 14 days post PRRSV inoculation. Group % Gross lesions Microscopic lesions (mean±standard 0-6 scale error) (mean±standard err or ) 1 - Vaccinated + SDSU73 4.2±0.8 A,B 1.8±0.2 A 2 - Vaccinated + VR ±2.5 A,D 1.6±0.2 A 3 - Vaccinated + Mn-01-A1 3.6±1.4 A,B 2.2±0.2 A 4 - Unvaccinated + SDSU ±7.5 C 5.1±0.2 B 5 - Unvaccinated + VR ±3.5 D 4.1±0.2 C 6 - Unvaccinated + Mn-01-A1 49.2±4.9 C 4.8±0.3 B,C 7 - Unvaccinated/Unchallenged 0.1±0.1 B 0.0±0.2 D 8 - Vaccinated control 0.3±0.3 A,B 1.3±0.3 A,D Different superscripts within each column indicate significantly different values (p<0.001).
20 Cross-Protection is Reproducible Ingelvac PRRS MLV ATP Challenge Isolate Difference Vac Non-Vac Reduction VR2332 0% NADC 6% % % SDSU73 11% SDSU73 11% SDSU73 11% FI % MN % MN % MN % MN % MN % FI % SDSU73 10% SDSU73 10% SDSU73 10% VR % FI % FI % MN % Amy Patterson and Jose Angulo Boehringer Ingelhiem Vetmedica
21 1. All Experiments Show Protection (Reduction in Lesions) 2. Average Effect is the Same Regardless of Genetic Difference 0 Scatterplot of Lung L Red vs Het -10 Lung Lesion Reduction Lung L Red ,00 0,02 0,04 0,06 0,08 0,10 0,12 Het Percent Genetic Difference versus Challenge Virus 0,14 Amy Patterson and Jose Angulo Boehringer Ingelhiem Vetmedica
22 Immune Intervention as Treatment in a Nursery Philips et al International PRRS Symposium
23 Preventive/Therapeutic Vaccination: Nursery PRRS Positive Vaccinated Nurseries Before Vaccination Total # Out % Mortality After Vaccination 2005 Closeout Data: Immune Intervention Equals PRRS-Negative Production PRRS Negative Non-vaccinated Nurseries In Wt. Out Wt. ADG FE 331, % , % Waddell, J Pig vaccination as an essential part of a comprehensive PRRS control program. AASV meeting. San Diego, USA. Conclusion: Live Virus Vaccination Controls PRRS
24 Vaccines against PRRSV Name Description Introduction Manufacturer Comments Efficacy Citations * Ingelvac MLV Cell-culture attenuated 1994 Boehringer Ingelheim Also known as ResPRRS, 2 4 form of strain VR Vetmedica ResPRRS Rep r o Ingelvac PRRS KV Inactivated form of strain Boeringer Ingelheim PRIMEPAC PRR S VR-2332 Cell-culture attenuated form of a Nebraska field strain Vetmedica 1996 Schering Ploug h Discontinued in 2000 due to patent infringemen t Ingelvac ATP Cell-culture attenuated form of strain JJ Boehringer Ingelheim Vetmedica 2 Suvaxyn PRRS? Fort Dodge Animal Health Discontinued? AmervacPRRS? Laboratories Hipr a 1 Porcilis PRRS? Intervet 8 Pyrsvac-183 SYVA Laboratorie s 1 Inactivated cell culture Bayer lysate Progressis Inactivated vaccine Meria l Only in Europ e 13??? PRRomiSe Inactivated vaccine Intervet? 0 Autogenous Inactivated field isolate s Newport Laboratories 20% of market in 2000, low 3 vaccines and other s today MJPRR S MJ Biologics In combination with a live vaccine or virus inoculatio n 0 PRRSV RS AAV-GP5/6 vectored vaccine 2009 Sirrah Bios 0 BSL-PS 100 MLV No information availab l e Bestar Laboratories Pte Ltd. Singapore BSL-PS 100 Killed vaccin e No information availab l e Bestar Laboratories Pte Ltd. Singapore SuiShot PRRS Killed vaccin e s No information availab l e ChoongAng Vaccine Laboratories Co. Ltd South Korea Suivac PRRS-I N Killed vaccin e VD-E1, VD-E2, VD-A1 Dyntec spol. S.r. o. Czech Republ i c Suivac PRRS-I n e Killed vaccin e VD-E1, VD-E2 Dyntec spol. S.r. o. Czech Republ i c Suipravac Killed vaccin e 5710 ( adapted ) Hipra Spain/Singapore Amervac PRRS MLV VP046 BIS Hipra Spain/Singapore?? MLV No information availab l e Kaketsuken Japan PRRS vaccine Killed vaccin e NVDC-JXA1 PRRS Vaccine, Live (R98 Strain) Lan Yi Ling Qilu Animal Health Products Factory China MLV R98 strai n? China 1
25 Vaccines against PRRSV Name Description Introduction Manufacturer Comments Efficacy Citations * Ingelvac MLV Cell-culture attenuated 1994 Boehringer Ingelheim Also known as ResPRRS, 2 4 form of strain VR Vetmedica ResPRRS Rep r o Ingelvac PRRS KV Inactivated form of strain Boeringer Ingelheim PRIMEPAC PRR S VR-2332 Cell-culture attenuated form of a Nebraska field strain Vetmedica 1996 Schering Ploug h Discontinued in 2000 due to patent infringemen t Ingelvac ATP Cell-culture attenuated form of strain JJ Boehringer Ingelheim Vetmedica 2 Suvaxyn MANY PRRS? OF Fort Dodge THESE Animal Discontinued? Health AmervacPRRS? Laboratories Hipr a 1 Porcilis PRRS? Intervet 8 Pyrsvac-183 SYVA Laboratorie s 1 Inactivated cell culture Bayer lysate Progressis Inactivated vaccine Meria l Only in Europ e 13??? VACCINES PRRomiSe Inactivated vaccine ARE Intervet? NO 0 Autogenous Inactivated field isolate s Newport Laboratories 20% of market in 2000, low 3 vaccines and other s today MJPRR S MJ Biologics In combination with a live 0 vaccine or virus inoculatio n PRRSV RS AAV-GP5/6 vectored 2009 Sirrah Bios 0 vaccine Bestar Laboratories Pte BSL-PS 100 MLV No information availab l e Singapore Ltd. GOOD Bestar Laboratories Pte BSL-PS 100 Killed vaccin e No information availab l e Singapore Ltd. ChoongAng Vaccine SuiShot PRRS Killed vaccin e s No information availab l e South Korea Laboratories Co. Ltd Suivac PRRS-I N Killed vaccin e VD-E1, VD-E2, VD-A1 Dyntec spol. S.r. o. Czech Republ i c Suivac PRRS-I n e Killed vaccin e VD-E1, VD-E2 Dyntec spol. S.r. o. Czech Republ i c Suipravac Killed vaccin e 5710 ( adapted ) Hipra Spain/Singapore Amervac PRRS MLV VP046 BIS Hipra Spain/Singapore?? MLV No information availab l e Kaketsuken Japan PRRS vaccine Killed vaccin e NVDC-JXA1 Qilu Animal Health Products Factory China PRRS Vaccine, Live (R98 Strain) Lan Yi Ling MLV R98 strai n? China 1
26 Qualities of a Good PRRS Vaccine Attenuated (modified) live virus (MLV) Killed and subunit products do not protect Attenuated (modified) should be safe Field isolates are virulent Good technical support Timing and use of PRRS vaccines takes skill
27 Scortti et al Failure of an inactivated vaccine against porcine reproductive and respiratory syndrome to protect gilts against a heterologous challenge with PRRSV. Vet Record 161, Killed Vaccines do not Protect Against PRRSV
28 Killed Vaccine Does Not Reduce PRRS Infection +/ VR2385 PRRSV KV /63 Days of Treatment Examine I No Treatment II KV PRRomiSe d III VR2385 d 0 IV VR2385 d 0, KV d V VR2385 d 0, KV d 7+21 Conclusion: Live, replicating virus is required for protective immunity.
29 Protection from PRRS: GP5 Vaccine Enhanced Disease Prieto et al Immunisation of pigs with a major envelope protein sub-unit vaccine against porcine reproductive and respiratory syndrome virus (PRRSV) results in enhanced clinical disease following experimental challenge. Vet J. [Epub ahead of print] Subunit Vaccine Did Not Protect; It Made Disease Worse
30 Protection from PRRS: Subunit and Vectored Vaccines give Little Protection or Increase Disease Percent of Sows/Piglets Total Number of Days No challenge control No vaccine control Subunit (MJ) Vectored (Sirrah) Modified live (ATP) Sows PCR+ at 8 days Sows Days off feed Piglets Failure to wean 0 Darwin Reicks, 2010 Leman Conference Conclusion: Live, replicating virus is required for immunity
31 Limitations of a Good PRRS Vaccine IT ONLY WORKS AGAINST PRRS DIAGNOSTICS ARE IMPORTANT IT DOES NOT REPLACE SANITATION, GENETICS, OR GOOD ANIMAL CARE
32 A Few Words about Diagnostics Health +/ Viremia +/ Real time RT-PCR IDEXX ELISA S/P ratio Reproduction +/ PSY, PWSY Growth +/ ADG, FE Financial +/ Not Quantitative $, RMB Quantitative Quantitative Observations Give More Information
33 Advanced Swine Production Practices Multi-site, All-in All-out production with unidirectional flow Artificial insemination with semen from high-health, PRRSV-negative boar stud PRRSV-free replacement gilts. High quality complete biosecurity program. Goal: PRRSV-free production Reasons: Profitability, humane care, responsible management
34 Final Comment What We Can Do to Control PRRS: Use All of the Tools Multi-site, All in-all out, production. High biosecurity and sanitation. Good veterinary practice. Good animal management. Good diagnostics. Effective use of live, safe, attenuated vaccines. Good recordkeeping and financial data.
Patrick L. Graham, DVM, MS
MJ PRRS Vaccine: Field efficacy Patrick L. Graham, DVM, MS Peggy Anne Hawkins, DVM, MS Farm Introduction Fall 2008 4/5 year old sow farm 6400 sows 2 previous PRRSV outbreaks Serum therapy Sows and GDU
More informationMINNESOTA VOLUNTARY PRRS ELIMINATION PROJECT. Pork Lenders Meeting July 29, 2011 Dave Wright, D.V.M.
MINNESOTA VOLUNTARY PRRS ELIMINATION PROJECT Pork Lenders Meeting July 29, 2011 Dave Wright, D.V.M. Coordinator Minnesota Voluntary Regional PRRS Elimination Project N212 Funding USDA APHIS PRRS CAP AASV
More informationPorcine Reproductive and Respiratory Syndrome Virus
Compilation of experimental investigations of PRRS vaccine technologies using modified live vaccines, inactivated vaccines and immunomodulation Michael Roof, PhD, Executive Director of Bio-Research Boehringer
More informationPRRS The Challenge Continues. Cameron Schmitt, DVM, MS Iowa Pork Congress
PRRS The Challenge Continues Cameron Schmitt, DVM, MS Iowa Pork Congress - 2013 My Background 2002 graduate of Iowa State University Completed DVM and MS (Veterinary Microbiology) Joined Pipestone Vet
More informationKeeping disease off the farm.
Keeping disease off the farm. Scott Dee, Andrea Pitkin, Satoshi Otake, Simone Olivera, John Deen, Peter Davies, Gordon Spronk, Darwin Reicks, Paul Ruen Disclosure and Acknowledgements USDA NRI PRRS CAP
More informationSwine Biosecurity Practices
Swine Biosecurity Practices 3rd International Biosafety & Biocontainment Symposium: Bio-risk Management in a One Health World Baltimore, MD February 4, 2015 Dr. Derald Holtkamp, Iowa State University Outline
More informationA Systematic Management Strategy for Breeding Herds Based on PRRS Herd Status
A Systematic Management Strategy for Breeding Herds Based on PRRS Herd Status James F. Lowe, DVM,MS 1,2 and committee members, Neil Debuse, DVM, MS 3, Robert Morrison, DVM, PhD, MBA 4, Montserrat Torremorell,
More informationEconomic Impact of Disease
Economic Impact of Disease Dr. Derald Holtkamp Cartagena, July 16, 2014 Outline Financial impact of disease on the global pork industry Examples in the U.S. PRRS virus - Summary of cost of PRRS study sponsored
More informationPEDV in the US: Overview, history and lessons
PEDV in the US: Overview, history and lessons 3rd International Biosafety & Biocontainment Symposium: Bio-risk Management in a One Health World Baltimore, MD February 4, 2015 Dr. Derald Holtkamp, Iowa
More informationPRRS control and eradication in a production system
PRRS control and eradication in a production system Tara S. Donovan, DVM The Hanor Company of Wisconsin, LLC, Spring Green, Wisconsin Introduction The HANOR Company is a pork production company located
More informationIngelvac CircoFLEX Symposium
Ingelvac CircoFLEX www.bi-vetmedica.com 2007 Boehringer Ingelheim Vetmedica, Inc. Ingelvac is a registered trademark and CircoFLEX is a trademark of Boehringer Ingelheim Vetmedica, GmbH, Ingelheim, Germany.
More informationPRRS Regional Elimination
PRRS Regional Elimination Authors Cesar A. Corzo, DVM, MS, University of Minnesota Montserrat Torremorell, DVM, PhD, University of Minnesota Robert B. Morrison DVM, MBA, PhD, University of Minnesota Reviewer
More informationSponsors. Production Assistant Janice Storebo. Formatting Tina Smith. CD-ROM David Brown
Sponsors University of Minnesota College of Veterinary Medicine College of Food, Agricultural and Natural Resource Sciences Extension Service Swine Center Thank you to IDEXX Laboratories for their financial
More informationNEW CONCEPTS FOR THE CONTROL OF PRRS: WITHIN PIG STRATEGIES
NEW CONCEPTS FOR THE CONTROL OF PRRS: WITHIN PIG STRATEGIES Monte B. McCaw Department of Population Health and Pathobiology North Carolina State University Past problems PRRS is the most demoralizing swine
More informationPRRSV: Comparison of commercial vaccines in their ability to induce protection against current PRRSV strains of high virulence
PRRSV: Comparison of commercial vaccines in their ability to induce protection against current PRRSV strains of high virulence Osorio 1, F.A., MS, DVM, PhD.; Zuckermann 2, F.; Wills 1 R.; Meier 2, W.;
More informationM. hyo. M. hyo. M. hyo. Single injection. Double protection. Ready-to-use protection against both PCV2 and M. hyo. It s easy. It works.
M. hyo P C V 2 P C V 2 M. hyo M. hyo P C V 2 Single injection. Double protection. Single injection. Double protection. Ready-to-use protection against both PCV2 and M. hyo. PCV M Hyo It s easy. It works.
More informationCUSTOMIZED CONTROL. Because every herd is unique
TM CUSTOMIZED CONTROL Because every herd is unique The FLEX Family of swine vaccines puts you in control CUSTOMIZED CONTROL FOR MANAGING MAJOR RESPIRATORY DISEASES IN YOUR SWINE HERD Porcine Circovirus
More informationSWINE HEALTH INFORMATION CENTER FINAL RESEARCH GRANT REPORT FORMAT
SWINE HEALTH INFORMATION CENTER FINAL RESEARCH GRANT REPORT FORMAT Project Title and Project identification number Description of biosecurity aspects of herds with low or high PRRS incidence and comparison
More informationProgress in biosecurity and risk assessment of swine diseases
Progress in biosecurity and risk assessment of swine diseases Iowa Swine Day Ames, Iowa June 29, 2017 Dr. Derald Holtkamp, Iowa State University Outline PRRS Outbreak Investigation Program Evaluation of
More informationPauline Berton 1*, Valérie Normand 1, Guy-Pierre Martineau 2, Franck Bouchet 1, Arnaud Lebret 1 and Agnès Waret-Szkuta 2
Berton et al. Porcine Health Management (2017) 3:11 DOI 10.1186/s40813-017-0058-1 CASE STUDY Open Access Evaluation of porcine reproductive and respiratory syndrome stabilization protocols in 23 French
More informationPCVAD A PRODUCER S GUIDE TO MANAGING. Porcine Circovirus Associated Diseases
A PRODUCER S GUIDE TO MANAGING PCVAD Porcine Circovirus Associated Diseases National Pork Board 1776 NW 114th St Des Moines, IA 50325 Tel: 515-223-2600; fax: 515-223-2646 E-mail: pork@pork.org www.pork.org
More informationDrew Robert Magstadt Iowa State University. Iowa State University Capstones, Theses and Dissertations. Graduate Theses and Dissertations
Graduate Theses and Dissertations Iowa State University Capstones, Theses and Dissertations 2015 Cross-protection in Fostera PRRS vaccinated nursery swine against contemporary, heterologous porcine reproductive
More informationResponding to PEDV Lessons Learned
Responding to PEDV Lessons Learned Paul Thomas, DVM AMVC Management Services ISU Swine Medicine Education Center Responding to PEDV. Mistakes we made Paul Thomas, DVM AMVC Management Services ISU Swine
More informationNow with even more combinations, it s easier to find the best match for your operation.
January - February 2004 AASV Industry Support Council advertising Click a thumbnail to view the advertisement Now with even more combinations, it s easier to find the best match for your operation. Only
More informationEconomic Analysis of PRRS Virus Elimination from a Herd
Animal Industry Report AS 658 ASL R2678 2012 Economic Analysis of PRRS Virus Elimination from a Herd Derald J. Holtkamp Iowa State University James B. Kliebenstein Iowa State University Jeffrey J. Zimmerman
More informationHow does Air Filtration fit into Porcine Reproductive and Respiratory Virus Regional Control and Eradication Strategies?
How does Air Filtration fit into Porcine Reproductive and Respiratory Virus Regional Control and Eradication Strategies? Laura Batista, Françis Pouliot, Valerie Dufour and Michel Morin Centre de développement
More informationThe FIRST intradermal M Hyo vaccine
The FIRST intradermal M Hyo vaccine Effective, safe and animal friendly in a single dose Porcilis M Hyo ID Once Take the leap forward with easy-to-use needle free vaccinations Porcilis M Hyo ID Once One
More informationWisconsin Show Pig Assn. Symposium. Tammy Vaassen, WI Pork Association
Wisconsin Show Pig Assn. Symposium Tammy Vaassen, WI Pork Association Who we are Board Jim Magolski, President Jonathan Wyttenbach, VP Brian Klubertanz, Sec. Mike Salter, Treas. Nathan Brickl Ray Ibeling
More informationHealth Protection Concepts. Health Protection Concepts. Health Protection Concepts. Health Protection Concepts. Health Protection Concepts
Managing PCVAD and other Health Issues R.B. Baker, DVM, MS Senior Clinician Food Supply Veterinary Service High Health Status through exclusion Economically important diseases loss of productivity Unacceptable
More informationWhat it feels like to have PRRS on your farm Dr. Carlo Lasagna. Martini S.p.A. Italy
What it feels like to have PRRS on your farm Dr. Carlo Lasagna Martini S.p.A. Italy Agenda Introduction: the battlefield, the pigs, the viruses Disease impact: from psychology to economy passing through
More informationFRA Swine Bioscwin Leman China Swine Conference
FRA Swine 2016 Bioscwin Leman China Swine Conference Content 1. Welcome: Challenge Question 2. The origin of FRA C12 Dry 3. What is FRA C12 Dry 4. PRRS in Swine Industry 5. FRA C12 versus PRRS 6. Summary:
More informationEffect of various stocking methods and extra-label PRRS vaccination on average daily gain
ORIGINAL RESEARCH Sornsen SA, Zimmerman JJ, Roof MB. Effect of various stocking methods and extra-label PRRS vaccination on average daily gain. Swine Health and Production. 1998;6(1):7 11. Effect of various
More informationThe PRRS vaccine for the entire herd. H appy to. be healthy. Licensed. in breeding pigs and piglets. from weeks of age
The PRRS vaccine for the entire herd H appy to be healthy Licensed in breeding pigs and piglets 2 from weeks of age P orcine Reproductive and Respiratory Syndrome, endemic in most pig producing countries,
More informationPORCINE EPIDEMIC DIARRHEA : A Canadian perspective
PORCINE EPIDEMIC DIARRHEA : A Canadian perspective Julie Ménard, Agr., D.V.M. F. Ménard inc., Québec, Canada SIPAS MEETING Parma, Italy October 9, 2015 My personal background Swine practitioner in Canada
More informationThis article is the result of review
Peer reviewed Diagnostic notes Porcine reproductive and respiratory syndrome (PRRS) diagnostics: Interpretation and limitations Jane Christopher-Hennings, DVM, MS; Kay S. Faaberg, PhD; Michael P. Murtaugh,
More informationThe 5 th Leman China Swine Conference October 16-18, 2016, Nanjing, China Draft Program. Sunday ( October 16)
The 5 th Leman Swine Conference October 16-18, 2016, Nanjing, Draft Program 8:00am-5:00pm 1:30pm-4:30pm Exhibition open Registration open Poster set up Pre-conference: Sunday ( October 16) 1. Swine nutrition
More informationThe 5 th Leman China Swine Conference October 16-18, 2016, Nanjing, China
The 5 th Leman Swine Conference October 16-18, 2016, Nanjing, Program 8:00am-5:00pm 9:00am -9:30am Exhibition open Registration open Poster set up Sunday ( October 16) 2016 Exhibition Opening Ceremony
More informationCASE REPORT. Using vaccination and unidirectional pig flow to control PRRSV transmission. Summary. Materials and methods.
CASE REPORT Using vaccination and unidirectional pig flow to control PRRSV transmission Scott A Dee, DVM, PhD, Dipl; ACVM; Reid Philips, DVM Dee S, Philips R. Using vaccination and unidirectional pig flow
More informationReducing effects of PRRS in Wean-to-finish production
Reducing effects of PRRS in Wean-to-finish production Amber Stricker, DVM, MS Suidae Health & Production Algona, Iowa Suidae Health & Production Hartington, Nebraska Full service, swine consulting practice
More informationLocke Karriker, 2008 Iowa Pork Regional Conferences 1
Case Studies of Swine Viral Diseases February 18-19, 5-7 008 Ainsworth, Oelwein, Sioux Center, Carroll, Dows IA Dr. Locke Karriker, DVM, MS, DACVPM Veterinary Diagnostic and Production Animal Medicine
More informationThe Basics of Grow-Finish Biosecurity
The Basics of Grow-Finish Biosecurity PorkBridge Alex Ramirez, DVM, MPH Iowa State University Veterinary Diagnostic and Production Animal Medicine August 3, 2006 Goals Discuss the foundations for biosecurity
More informationEnhancing Our Preparedness
Enhancing Our Preparedness Dr. Paul Sundberg, Executive Director Swine Health Information Center psundberg@swinehealth.org www.swinehealth.org 1. Preparedness for a FAD (regulatory disease) 2. Preparedness
More informationMethods for Inactivating PEDV in Hog Trailers
Animal Industry Report AS 661 ASL R3028 2015 Methods for Inactivating PEDV in Hog Trailers Paul R. Thomas Iowa State University, prthomas@iastate.edu Alejandro Ramirez Iowa State University, ramireza@iastate.edu
More informationStarting with Healthy Pigs E /06
E-418 10/06 how pigs can bring many disease organisms into a farm and spread them to other swine. However, there are things you can do to prevent yours from contracting and spreading diseases. These are
More informationExtension Swine Husbandry. Biosecurity Guidelines for Pork Producers
Extension Swine Husbandry ANS 02-818S Biosecurity Guidelines for Pork Producers W.E. Morgan Morrow Department of Animal Science North Carolina State University John Roberts College of Veterinary Medicine
More informationFostera PCV MH: Efficacy of Single-Dose Vaccination in Swine Subsequently Challenged with PCV2 and/or Mycoplasma hyopneu moniae
October 213 Technical Update Fostera PCV MH: Efficacy of Single-Dose Vaccination in Swine Subsequently Challenged with PCV2 and/or Mycoplasma hyopneu moniae Darrell Neuberger, DVM Greg Nitzel, MS Zoetis
More informationPorcine Epidemic Diarrhea virus (PEDv), Delta corona and variants
Porcine Epidemic Diarrhea virus (PEDv), Delta corona and variants April 22 nd 2014 2014 Heartland Animal Manure Management Workshop Something new coronaviruses from Asia PEDv entered the US in April, source
More informationUpdate on PEDV. Lisa Becton, DVM, MS National Pork Board
Update on PEDV Lisa Becton, DVM, MS National Pork Board Porcine Epidemic Diarrhea Virus (PEDV) Overview of the disease Current US status Actions to manage PEDV American Association of Swine Veterinarians
More informationAn Overview of PRRS Elimination Best Practices in Breeding Herds
An Overview of PRRS Elimination Best Practices in Breeding Herds Rodney B. Baker, DVM, MS, Senior Clinician College of Veterinary Medicine, Iowa State University, Ames, IA Introduction Since 1987, porcine
More informationEvaluación económica de programas de control vs erradicación de enfermedades porcinas.
Evaluación económica de programas de control vs erradicación de enfermedades porcinas. Evaluation of the Control vs Eradication of Endemic Diseases of Swine Daniel Hurnik University of Prince Edward Island
More informationPorcine reproductive and respiratory syndrome virus (PRRSV): Immunization strategies, virulence of various isolates, and efficacy of DNA vaccination
Graduate Theses and Dissertations Graduate College 2009 Porcine reproductive and respiratory syndrome virus (PRRSV): Immunization strategies, virulence of various isolates, and efficacy of DNA vaccination
More informationPCV2 and Mycoplasma Vaccine Comparison in a Midwest Commercial Swine Herd
PCV2 and Mycoplasma Vaccine Comparison in a Midwest Commercial Swine Herd STUDY BULLETIN Merck Animal Health Swine Technical Services Introduction In this report, a swine veterinarian investigated the
More informationAllen D. Leman Swine Conference
Allen D. Leman Swine Conference Volume 39 2012 Published by: Veterinary Continuing Education Sponsors We thank the following sponsors: Platinum Bayer Animal Health Pfizer Animal Health Gold Novartis Animal
More informationHealth Interventions in Light of New Antibiotic Regulations Chris Rademacher, DVM
Health Interventions in Light of New Antibiotic Regulations Chris Rademacher, DVM Clinical Associate Professor ISU Swine Extension Veterinarian Iowa State University Agenda Effects of new regulations on
More informationBiosecurity Panel: Where Are You Headed?
Biosecurity Panel: Where Are You Headed? Dr. Mitch Christensen, Norsvin USA Pat Albright, Albright Swine Farms Dr. Jim Kober, Four Star Veterinary Service Dr. Mike Brumm, Brumm Swine Consultancy, Inc.
More informationTHE DANISH SPF SYSTEM & DIFFERENT DISEASE ELIMINATION PROCEDURES
Poul Baekbo DVM, PhD, Dipl. ECPHM SEGES, Danish Pig Research Centre THE DANISH SPF SYSTEM & DIFFERENT DISEASE ELIMINATION PROCEDURES Canada 26th of October 2018 2.. 32 million pigs produced per year in
More informationDiagnostic Center for Population and Animal Health
Diagnostic Center for Population and Animal Health Trends of Swine Diseases in the USA Dr. med. vet. Matti Kiupel, BS, MS, PhD, DACVP Diagnostic Center for Population and Animal Health College of Veterinary
More informationPRRS Control Practitioner s View. John Hayden BVSc MRCVS Integra Veterinary Services
PRRS Control Practitioner s View John Hayden BVSc MRCVS Integra Veterinary Services PRRS diagnoses trend and seasonality (data for Q3 and 2015 incomplete) Viruses PRRS and swine flu predominant PCV2 associated
More informationHIGHLY PATHOGENIC PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS
HIGHLY PATHOGENIC PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS Prepared for the Swine Health Information Center By the Center for Food Security and Public Health, College of Veterinary Medicine,
More informationHaemophilus parasuis is normally
Peer reviewed Original research Evaluation of Haemophilus parasuis control in the nursery using vaccination and controlled exposure Simone Oliveira, DVM, MS, PhD; Carlos Pijoan, DVM, MS, PhD; Robert Morrison,
More informationSponsors. Production Assistant Janice Storebo. Formatting Tina Smith. CD-ROM David Brown
Sponsors University of Minnesota College of Veterinary Medicine College of Food, Agricultural and Natural Resource Sciences Extension Service Swine Center Thank you to IDEXX Laboratories for their financial
More informationSponsors. We thank the following sponsors: Formatting Tina Smith Graphics CD-ROM David Brown
Sponsors We thank the following sponsors: Gold Boehringer-Ingelheim Vetmedica, Inc. Pfizer Animal Health Bronze Alpharma Animal Health Bayer Animal Health Intervet/Schering Plough Animal Health National
More informationExperiences on Mycoplasma Hyopneumoniae Elimination on Farrow-to-Wean Farms. Bill Minton DVM. Four Star Veterinary Service LLC.
Experiences on Mycoplasma Hyopneumoniae Elimination on Farrow-to-Wean Farms Bill Minton DVM. Four Star Veterinary Service LLC. Chickasaw, OH Applications of Disease Eliminations WHY? Unwanted Guests PRRS
More informationPorcilis PRRS and Porcilis M Hyo
Porcilis PRRS and Porcilis M Hyo can now be mixed Protect against two top respiratory pathogens with one less injection Two important respiratory vaccines can now be mixed Porcilis PRRS and can now be
More informationHerd Health for Small-Scale Swine Farms Ines Rodriguez, M.S., V.M.D.
Herd Health for Small-Scale Swine Farms Ines Rodriguez, M.S., V.M.D. Currently in the United States, about 110 million hogs are raised and slaughtered on an annual basis. Of that number, roughly 5% are
More informationBiosecurity: Understanding its importance when working on livestock farms
Biosecurity: Understanding its importance when working on livestock farms Kevin Janni, Extension Engineer Abby Neu, Extension Educator 1 2017 Regents of the University of Minnesota. All rights reserved.
More informationFIELD STUDY. Comparison of techniques for controlling the spread of PRRSV in a large swine herd. Summary. Materials and methods.
FIELD STUDY Comparison of techniques for controlling the spread of PRRSV in a large swine herd Gonzalo Bruna, DVM,MS; Salvador Cabeza de Vaca, DVM,MS; HanSoo Joo, DVM,PhD; Carlos Pijoan, DVM,PhD Summary
More informationPathogen survival in swine environments - putting it in context - Jeff Zimmerman DVM PhD Iowa State University
Pathogen survival in swine environments - putting it in context - Jeff Zimmerman DVM PhD Iowa State University Topic A general review of the issues involved in the persistence of infectious pathogens in
More informationSwine Day 2017 Rowland Lab Research Update
Swine Day 2017 Rowland Lab Research Update Raymond (Bob) Rowland K-State Swine Day Progress Report November 17, 2016 Manhattan North American PRRS Symposium on PRRS, Emerging and Foreign Animal Diseases
More informationMSD Animal Health THERE S ONLY ONE THING THAT DRIVES US. Updated Brand Video The Science of Healthier Animals TM
MSD Animal Health THERE S ONLY ONE THING THAT DRIVES US Updated Brand Video The Science of Healthier Animals TM MSD Animal Health Breeding Herd and Progeny Vaccination Now and the Future APV Conference
More informationPEDV Update and Lessons Learned. Lisa Becton, DVM, MS, DACVPM Dir. Swine Health Information & Research National Pork Board
PEDV Update and Lessons Learned Lisa Becton, DVM, MS, DACVPM Dir. Swine Health Information & Research National Pork Board Porcine Epidemic Diarrhea virus On May 17 th, 2015 the US reached the 2-year mark
More informationProduction results from piglets vaccinated in a field study in Spain with a Type 1 Porcine Respiratory and Reproductive virus modified live vaccine
Cano et al. Porcine Health Management (2016) 2:22 DOI 10.1186/s40813-016-0038-x RESEARCH Open Access Production results from piglets vaccinated in a field study in Spain with a Type 1 Porcine Respiratory
More informationWe are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,500 108,000 1.7 M Open access books available International authors and editors Downloads Our
More informationUse of an Experimental Model To Test the Efficacy of Planned Exposure to Live Porcine Reproductive and Respiratory Syndrome Virus
CLINICAL AND VACCINE IMMUNOLOGY, Dec. 2007, p. 1572 1577 Vol. 14, No. 12 1556-6811/07/$08.00 0 doi:10.1128/cvi.00332-07 Copyright 2007, American Society for Microbiology. All Rights Reserved. Use of an
More informationFLEX Symposium & PCVAD Research Award Winners Presentation
FLEX Symposium & PCVAD Research Award Winners Presentation St. Paul, Minnesota Ingelvac CircoFLEX Ingelvac MycoFLEX Ingelvac CircoFLEX-MycoFLEX Table of Contents FLEX Symposium September 20, 2008 Performance
More informationAsst. Prof. Dusit Laohasinnarong, D.V.M., Grad. Dip. (IT), Ph.D. Department of Clinical Sciences and Public Health, Faculty of Veterinary Science
Asst. Prof. Dusit Laohasinnarong, D.V.M., Grad. Dip. (IT), Ph.D. Department of Clinical Sciences and Public Health, Faculty of Veterinary Science Conference Place 4/12/58 International Pig Conference Digest
More informationDerald J. Holtkamp Iowa State University, Hui Lin Iowa State University. Chong Wang Iowa State University,
Veterinary Diagnostic and Production Animal Medicine Publications Veterinary Diagnostic and Production Animal Medicine 2013 Development and Validation of an Objective Risk Scoring System for Assessing
More informationBIOSECURITY FACTSHEETS Dewey CE, Richardson KL
BIOSECURITY FACTS DISINFECTANTS DISEASES APP FLU ILEITIS MYCO PED BIOSECURITY FACTSHEETS Dewey CE, Richardson KL PRRS SALMONELLA STREP SWINE DYSENTERY TGE A project supported by the American Association
More informationOFFLU Technical Meeting Coordinating world-wide surveillance for influenza in swine. OIE headquarters, Paris, France March 27-28, 2012
OFFLU Technical Meeting Coordinating world-wide surveillance for influenza in swine OIE headquarters, Paris, France March 27-28, 2012 Brazil update Janice Reis Ciacci Zanella Brazilian Agricultural Research
More informationEconomic Impacts of Porcine Reproductive and Respiratory Syndrome (PRRS) Outbreak in Vietnam Pig Production
Tropical Agricultural Research Vol. 23 (2): 152 159 (2012) Economic Impacts of Porcine Reproductive and Respiratory Syndrome (PRRS) Outbreak in Vietnam Pig Production H. Zhang * and H. Kono 1 Department
More informationPERSISTENCE OF EUROPEAN AND AMERICAN TYPE PRRSV STRAINS WITHIN LITHUANIAN PIG HERD
Bull Vet Inst Pulawy 52, 319-323, 2008 PERSISTENCE OF EUROPEAN AND AMERICAN TYPE PRRSV STRAINS WITHIN LITHUANIAN PIG HERD ARUNAS STANKEVICIUS, RYTIS CEPULIS, HENRIKAS ZILINSKAS, TOMASZ STADEJEK 1, AND
More informationEvaluation of contact exposure as a method for acclimatizing growing pigs to porcine reproductive and respiratory syndrome virus
JAVMA 07-08-0418 Vashisht 3fig 1tab VLS KJM Evaluation of contact exposure as a method for acclimatizing growing pigs to porcine reproductive and respiratory syndrome virus Kapil Vashisht, bvsc & ah, phd;
More informationInanimate objects (fomites), such as
Peer reviewed Original research Transmission of porcine reproductive and respiratory syndrome virus by fomites (boots and coveralls) Satoshi Otake, DVM; Scott A. Dee, DVM, PhD, Diplomate ACVM; Kurt D.
More informationPublished March 3, 2017
Published March 3, 2017 Effect of a major quantitative trait locus for porcine reproductive and respiratory syndrome (PRRS) resistance on response to coinfection with PRRS virus and porcine circovirus
More informationABCD. The Research and Development of Enterisol Ileitis. The European Licensure of Enterisol Ileitis. Mike Roof. Jeremy Kroll
European Enterisol Ileitis Symposium October 13 15, 2005 Barcelona Mike Roof The Research and Development of Enterisol Ileitis Jeremy Kroll The European Licensure of Enterisol Ileitis Mike Roof Phd Jeremy
More informationTechnical Bulletin. Pfizer Animal Health
LIN617 Pfizer Animal Health Technical Bulletin June 26 Clinical and economic effects of lincomycin in-feed ( ) and/or a porcine proliferative enteropathy (ileitis) vaccine ( Ileitis) in pigs challenged
More informationCONTROL STRATEGIES OF SRRP IN NEW CONTAMINATED FARMS
CONTROL STRATEGIES OF SRRP IN NEW CONTAMINATED FARMS S. BARAITAREANU, M.V. CAMPEANU, MIHAELA BEZMAN, S.D. MARINACHE, SINZIANA RADULESCU, GABRIELA BAGRINOVSCHI, D. COBZARIU, DOINA DANES Faculty of Veterinary
More informationOIE Reference Laboratory Reports Activities
OIE Reference Laboratory Reports Activities Activities in 2015 This report has been submitted : 2016-03-08 23:26:29 Name of disease (or topic) for which you are a designated OIE Reference Laboratory: Transmissible
More informationunderstood as achieving highest possible efficiency (combined pigs produced per sow per
Bio-markers measuring health status and management tools to improve productive performance and animal health on swine commercial farms CARLOS PIÑEIRO NOGUERA Current swine production is led by competitiveness
More information! "# $% % &! % % ' ( #! )*!%( #!$! ' # %!% #&! #! %$ # # %%!! +! & # #$ % $ % ,-#%.#!$ #$ &#"/ #! %0 ' ! $!$ $" "!&#! 0 &!&,%. % !
! "# $% % &! % % ' ( #! )*!%( #!$! ' # %!% #&! #! %$ # # %%!! +! & # #$ % $ %,-#%.#!$ #$ &#"/ #! %0 '! $!$ $" "!&#! 0 &!&,%. %!% / "##-#% " % 1 & %!! 2 #! # $&!%$% % 34!2 %(# $ %!.&! %!/, #& &%%#%& #&
More informationControlling Emerging Swine Health Challenges
Controlling Emerging Swine Health Challenges Iowa Pork Congress 2016 Dr. Paul Sundberg, Executive Director Swine Health Information Center psundberg@swinehealth.org www.swinehealth.org Starting Up! Swine
More informationGROW/FINISH VARIATION: COST AND CONTROL STRATEGIES
GROW/FINISH VARIATION: COST AND CONTROL STRATEGIES Cate Dewey, Angel de Grau, Bob Friendship Department of Population Medicine, Ontario Veterinary College University of Guelph Variation in growth rate
More informationPorcine Reproductive and Respiratory Syndrome Virus: Diagnostic update and search for novel modified live vaccines
Graduate Theses and Dissertations Iowa State University Capstones, Theses and Dissertations 2013 Porcine Reproductive and Respiratory Syndrome Virus: Diagnostic update and search for novel modified live
More informationOriginal Paper Veterinarni Medicina, 51, 2006 (8):
Restriction fragment length polymorphism of ORF6 and ORF7 genes of porcine reproductive and respiratory syndrome virus (PRRSV) vaccine strains registered in the Czech Republic E. KOSINOVA, I. PSIKAL Veterinary
More informationStudies on transmission of porcine circovirus type 2 (PCV2)
Graduate Theses and Dissertations Graduate College 2011 Studies on transmission of porcine circovirus type 2 (PCV2) Michelle Grabosch Iowa State University Follow this and additional works at: http://lib.dr.iastate.edu/etd
More informationSponsors. Editors W. Christopher Scruton Stephen Claas. Layout David Brown
Sponsors University of Minnesota College of Veterinary Medicine College of Agricultural, Food and Environmental Sciences Extension Service Swine Center Editors W. Christopher Scruton Stephen Claas Layout
More informationPEDV s Emergence in US Status Report, Diagnostics, & Observations Iowa Pork Congress 1/22/2014
PEDV s Emergence in US Status Report, Diagnostics, & Observations Iowa Pork Congress 1/22/2014 Department of Veterinary Diagnostic and Production Animal Medicine, Veterinary Diagnostic Lab,, Ames, IA 50011
More informationPrevention of heterologous Porcine Reproductive and Respiratory Syndrome Virus (PRRSv) infection using an antibody-virus complex vaccine
Graduate Theses and Dissertations Iowa State University Capstones, Theses and Dissertations 2014 Prevention of heterologous Porcine Reproductive and Respiratory Syndrome Virus (PRRSv) infection using an
More informationHealthy Animals. Figure One Healthy Animals
This publication contains suggested vaccinations and health practices for pork producers in Oregon regardless of whether it is a commercial herd, small part time operation or a youth project. The old saying
More informationTatjana Sattler 1,2*, Jutta Pikalo 2, Eveline Wodak 2 and Friedrich Schmoll 2
Sattler et al. BMC Veterinary Research (2016) 12:259 DOI 10.1186/s12917-016-0888-0 RESEARCH ARTICLE Ability of ELISAs to detect antibodies against porcine respiratory and reproductive syndrome virus in
More information