Staying Healthy During Cold & Flu Season
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1 Staying Healthy During Cold & Flu Season Life Extension Webinar Series Michael A. Smith, MD Senior Health Scientist
2 Life Extension s Dedication Why Is Flu Risk Higher in the Winter? Report LE Magazine Feb 2007
3 Influenza RNA virus that infects birds and mammals (Orthomyxoviridae) A and B strains Airborne and close contact Influenza Surrounding Mucosal Cell
4 Influenza Influenza Attaching to Respiratory Epithelial Cell
5 Influenza Infection Illness Medically Attended Hospitalizations Deaths 82 million 65 million 30 million 200,000 36,000 CDC 2007 Update
6 Natural Cold & Flu Fighters ACT FAST!
7 ❶ Cimetidine Reduces T-suppressor cells Activates Immune Response Effective for Several Viruses Influenza (classic flu virus) Rhinovirus (cold virus) Rotavirus (gastrointestinal virus) 800 mg/day Eur J. Dematol Sep-Oct; (5):445-8
8 ❷ Garlic Extract Activates Antigen Presenting Cells Direct Viral Killing Effects Up-regulates TH-1 Cells Up-regulates CD8-Cells Up-regulates NK-cells 5000 to 9000 mg/day Adv Ther Jul-Aug;18(4):189-93
9 ❸ DHEA Multiple Immune Effects Monocytes APC B-cells Antibodies T-cells Managers NK-cells Killers IL-2 Cytokine 200 to 400mg/day 35% Monocytes 29% B-cell number 62% B-cell action 25% T-cell number 40% T-cell action 22% NK-cell number 45% NK-cell action 50% IL-2 (cytokine) J Immunol Feb 15;168(4):
10 ❹ Lactoferrin Up-regulates NK-cells Sequesters Iron from Blood Starves Viruses from Energy Supply Activates Antigen Presenting Cells 1200 mg/day Virology Mar 15;333(2)284-92
11 ❺ Zinc Lozenges Up-regulates Antibody Production Inhibits Rhinovirus from Attaching 24 mg twice per day (only for 1 week) Adjust dose if taking a multivitamin No more than 90 mg/day Am Pharm Assoc (Wash DC) Sep-Oct;44(5):
12 ❻ Melatonin Induces a Powerful Immune Response Immune Modulation via IL-10 Up-regulates antigen presenting cells Up-regulates TH1-cells Up-regulates B-cell antibody production 10 to 50 mg at Bedtime Only J Pineal Res Mar;36(2):73-9
13 ❼ Vitamin D Regulates Immune Response Cytokine production and control B & T-cell Numbers & Activity Antigen Presenting Cell Activity Crucial Role in Controlling H1N1 Severity Cytokine storm 5000 IU/day (or higher) Am. J of Clinical Nutrition 2008
14 Viruses Hate Bitter Herbs!
15 ❶ Andrographis Paniculata King of Bitters Produces Andrographolides Up-regulates TH1-cells Increases IL-2 Increases TNF 300 mg/day (5% standardized) Planta Medica 2004 Apr;70(4):293-8.
16 ❷Aronia Extracts Chokeberries Queen of Bitters Increases Activity of NK-Cells Potent Antioxidant (ORAC = 16k) Compounds Mimic Natural Cytokines 500 mg/day (25% standardized) Kalkman, C Rosaceae. In The families and genera of vascular plants. Edited by K. Kubitzki. Springer, Berlin. pp , isbn=
17 ❸Astragulus Membranaceus Native to temperate regions of the Northern Hemisphere Common names include milk-vetch, locoweed and goat's-thorn Increases Circulating Time of CD-4 Cells Increases telomere length May activate SIRT-1 gene (inflammatory control) Increase IL-2 & TNF Phytotherapy Research 11 (6):
18 ❹ Honeysuckle Japenese Honeysuckle Contains Ochnaflavone Antiviral properties Coxsakie B-3 virus Inhibit HIV in mice Contains Salicylic Acid Eases headache pain Eases inflammation Immune Support NK cells APC Natural Antibiotic Resistant TB Strep throat Skin rashes Acne Phytotherapy Research 11 (6):
19 Natural Immune Enhancement
20 ❶ Glutathione Boosters Key Antioxidant that Helps Immune Cells Live Longer Glutamine 1-3 grams/d SAMe 200 mg/d N-acetylcysteine 1200 mg/d Depletion causes down-regulation of immune response. Immune cells use lots of glutamine. Intrinsically related to glutathione synthesis. Important for melatonin production. Precursor to glutathione production. Modulates inflammatory cytokines. Prog Retin Eye Res. 2000;19(2):
21 ❷ Other Antioxidants Immune Boosters Because they Scavenge Free Radicals CoQ mg/d Lipoic Acid 250 mg/d Grape Seeds & Quercetin mg/d Stimulates many parts of the immune system and improves direct viral-killing mechanism. Regenerates certain vitamins (C & E) that are critical to enhanced immune function. Twice as potent as vitamin E and 4 times as potent as vitamin C. Increase NK-killer cells and boost production of IL-2. Drugs Exp Clin Res. 1985;11(8):
22 ❸ Vitamins & Minerals Scavenge Free Radicals Enhancing Number & Function Vitamin C 2000 mg/d Vitamin E 400 IU/d Zinc 25 mg/day Selenium 250 mcg/d Reduces DNA damage in immune cells and helps them live longer. Activates the function of B and T-cells. Modulates inflammatory cytokines and activates B-cell antibody function. Modulates inflammatory cytokines and activates B-cell antibody function. Complementary and Alternative Medicine
23 ❹ Whey Protein & Fiber Amino Acids & Fiber are Used for Communication Amino Acids Lactoglobulin Lactoalbumin Lactoperoidase Lactoferrin Beta-glucans Precursors to glutathione and immune cytokines. Modulate lymphatic responses and have direct effects on B and T-cell function. Reduces the immune toxin hydrogen peroxide and sequesters iron from pathogens. Stimulate antigen presenting cells and NK-cells. Altern Med Rev. 2004;9(2):
24 ❺ Hormones Numerous Immune-enhancing Effects DHEA 15 to 50 mg/d Melatonin 5 to 10 mg/d GH Secretagogues Multiple immune effects at the cellular level: monocytes, T-cells, B-cells, and NK-cells. Multiple effects on inflammatory cytokines AND a good night sleep! Stimulates WBC production in the bone marrow (ariginine, ornithine, glysine, glutamine). Eur Urol Aug 29
25 ❻ Essential Fatty Acids Anti-inflammatory Effects & Lessen Severity of the Flu Omega-6 Fats 1000 mg/d Omega-3 Fats 4000 mg/d Monounsaturated Oils Plant-based sources that regulate inflammatory cytokine production (flax and chi seeds). Marine vegetable and fish sources that promote anti-inflammatory effects (cold water fish). Strong antioxidants that promote antiinflammatory effects (olive oil). Br J Sports Med Aug;34(4):
26 ❼ Tea Extracts Qualitative & Quantitative Immune Support Green Tea 725 mg/d Theaflavins 100 mg/d Modulates the inflammatory response and protects immune cell DNA. Nutrigenomic from black tea that influences the genetic expression of anti-inflammatory cytokines. Free Radic Biol Med. 2004;36(3):359 70
27 Building an Immune Support Regimen The Supplement Pyramid
28 Optimization Prevention Foundation Immune System Supplement Pyramid
29 Foundation Multivitamin (Optimal Dosing) Ubiquinol CoQ10 Essential Fatty Acids (Omega-3) Probiotics
30 Prevention Prevent Immune Dysfunction DHEA Vitamin D Glutathione/NAC Grape Seed Extract
31 Prevention Prevent Attacks Andrographis (Bitter Herbs) Cimetidine Honeysuckle Zinc
32 Optimization Melatonin Oil of Oregano Olive Leaf Extract Bitter Melon
33 Thank You! Health Advisors - Discounts Healthy Talk with Dr. Mike Live Thursdays 3-4 PM ET
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