MICHAEL ANNE GRATTON, Ph.D.

Transcription

1 MICHAEL ANNE GRATTON, Ph.D. EDUCATION Postgraduate Cochlear Anatomy, Department of Otolaryngology Fellowship University of Texas Southwestern Medical Center at Dallas Ph.D Hearing Science State University of New York at Buffalo M.A Audiology University of Denver B.S Speech Pathology University of Wisconsin-Milwaukee cum laude Deaf Education-minor General Science-minor APPOINTMENTS February, 2009 Professor: Department of Otolaryngology, Head & Neck Surgery; Department of present Pharmacology & Physiology, School of Medicine, Saint Louis University, 6FDT, 3635 Vista Ave., St. Louis, MO July, 2003 to Acting Director, Auditory Research Lab: Department of Otorhinolaryngology, Head- December, 2004 Neck Surgery, School of Medicine, University of Pennsylvania, Philadelphia, PA July, 2001 to February, 2009 July 1997 to June, 2001 December 1990 to July 1997 Research Assistant Professor: Department of Otorhinolaryngology,Head-Neck Surgery,School of Medicine, University of Pennsylvania, Philadelphia, PA Senior Research Associate, Research Department, Genetics Division Boys Town National Research Hospital, Omaha, NE Assistant Professor: Otolaryngology & Communicative Science Department Medical University of South Carolina, Charleston, South Carolina January 1989 Post-Doctoral Research Fellow: Department of Otolaryngology to January 1991 University of Texas Southwestern Medical Center at Dallas November 1989 Research Scientist: Communication Disorders Program, to January 1991 Callier Center for Communication Disorders, School of Human Development, University of Texas at Dallas January 1989 to Lecturer: Communication Disorders Program, November 1989 Callier Center for Communication Disorders, School of Human Development, 1

2 University of Texas at Dallas September 1987 Graduate Research Assistant: Hearing Research Labs, to January 1989 Communication Disorders and Sciences Department, State University of New York at Buffalo July 1984 to Graduate Research/Teaching Assistant: Communication Disorders Program, September 1987 Callier Center for Communication Disorders, School of Human Development, University of Texas at Dallas September 1982 Lecturer/Hearing Clinic Coordinator: Communicative Disorders Program, to July 1984 Division of Special Education and Rehabilitation, School of Education, Syracuse University February 1980 to Senior Staff Audiologist: Communication Disorder Unit, September 1982 State University of New York Upstate Medical Center January 1982 to June 1982 Lecturer: Department of Speech Pathology and Audiology, State University of New York College at Cortland October 1978 Audiologist: Audiology and Speech Pathology Service, to January 1980 VA Chicago Westside Medical Center October 1976 Audiologist: Audiology Service, to October 1978 VA Marion Indiana Medical Center September 1974 Speech Therapist: P.S. District 131 Elementary Schools to June 1975 Aurora, Illinois AFFILIATIONS HONORS Acoustical Society of America American Society of Matrix Biology Association for Research in Otolaryngology Society for Neuroscience Institute on Aging, University of Pennsylvania Center of Excellence in Neuroloscience, Saint Louis University Dean's Academic Honor's List, University of Wisconsin Graduate Assistantship, University of Texas at Dallas Visiting Scientist, Marine Biology Laboratory, Wood s Hole, MA CERTIFICATION Certificate of Clinical Competence in Audiology: American Speech-Language-Hearing Association New York State License - Audiology #496, inactive Texas State License - Audiology #50578, inactive 2

3 SERVICE UNIVERSITY Member, Search Committee, Communicative Disorders Program, Syracuse University Alternate Representative, Communication Disorders Program, Graduate Student Council, University of Texas at Dallas Member, Review Committee, Summer Health Professional Research Fellowship Program, Medical University of South Carolina Member, Research Committee, Department of Otorhinolaryngology-HNS, University of Pennsylvania Member, Resident Review Committee, Department of Otorhinolaryngology-HNS, University of Pennsylvania Member, Ad Hoc Committee for Revision of Research Track, School of Medicine, University of Pennsylvania Member, Senior Scientist Search Committee, Department of Otorhinolaryngology- HNS, University of Pennsylvania Member, Training in the Neurobiology of Otorhinolaryngology: Executive Committee, Department of Otorhinolaryngology-HNS, University of Pennsylvania TEACHING Occupational Hearing Conservation Program, Hearing and Vision Consultants, Syracuse, New York Audiology for Medical Students, Upstate Medical Center Rehabilitative Audiology, State Univ New York, College at Cortland Seminar in Clinical Audiology, Syracuse University Introduction to Speech and Hearing Science, University of Texas at Dallas Seminar in Cochlear Anatomy and Dissection, University of Texas at Dallas Embryological Development of the Auditory System, University of Texas at Dallas Occupational Hearing Programs/Noise-Induced Hearing Loss, Univ Texas at Dallas Noise-Induced Hearing Loss, Lecture Series for ENT Residents, University of Texas Southwest Medical Center Peripheral and Central Anatomy of the Auditory & Vestibular Systems, Lecture Series for ENT Residents, Medical University of South Carolina Supervisor, Clinical Fellows in Audiology, SUNY Upstate Medical Center Supervisor, Audiology Practicum, Master's Candidates in Communication Disorders, Syracuse University Supervisor, Anatomy and Evoked Potential Laboratories, SUNY - Buffalo Consultant, Parallel Curriculum Program. College of Medicine, Med Univ So Carolina Mentor, Daniel Vincent, M.D., ENT Clinical Fellow, Medical Univ of South Carolina Mentor, Summer Undergraduate Research Program, College of Graduate Studies, Medical University of South Carolina Mentor, South Carolina Alliance for Minority Participation, College of Charleston and Medical University of South Carolina Mentor, Summer Science Intern Program, Boys Town National Research Hospital Lecturer, Neurobiology of Hearing, Neuroscience Graduate Group, University of Pennsylvania Mentor, D. Michael Patterson, Year-out Medical Student, University of Pennsylvania Mentor, Senior Undergraduate Project. William Lavery, University of Pennsylvania Mentor, Independent Study, Joseph F. Cannuscio, Undergraduate, Temple 3

4 University Mentor, Research Rotation, Rohan Ramakrishna, Medical Student, University of Pennsylvania Mentor, Research Rotation, Vinay Aggarwal, Medical Student, Drexel University College of Medicine (MCP/Hahnemann) Mentor, Senior Undergraduate Project. Charles Askew, University of Pennsylvania Careers in Science, Lourdes High School, Oshkosh, WI Auditory System: Transduction Mechanisms and Central Pathways, Brain and Behavior, School of Medicine, University of Pennsylvania Mentor, Research Rotation, Tejas Patel, Medical Science Graduate Student, Drexel University Mentor, Jeffrey C. Bedrosian, Year-out Medical Student, University of Pennsylvania Mentor, Senior Undergraduate Project. Bryan SukBae Lee, University of Pennsylvania Mentor, Lara Dunn, Year-out Medical Student, University of Pennsylvania Mentor, Kristen Hoffman, Co-op Undergraduate, Northeastern University PROFESSIONAL Ad Hoc Reviewer, Hearing Research Ad Hoc Reviewer, Otolaryngology - Head and Neck Surgery Ad Hoc Reviewer, Anatomical Record Ad Hoc Reviewer, Journal of the Acoustical Society of America (JASA) Ad Hoc Reviewer, Ear and Hearing Ad Hoc Reviewer, The Journal of Histochemistry and Cytochemistry Ad Hoc Reviewer, American Journal of Audiology Ad Hoc Reviewer, Otology and Neurotology Ad Hoc Reviewer, Journal of Pediatric Hematology & Oncology Ad Hoc Reviewer, Journal of the Association for Research in Otolaryngology (JARO) Ad Hoc Reviewer, Annals of Otology, Rhinology and Laryngology Ad Hoc Reviewer, Journal of Clinical Investigation Ad Hoc Reviewer, American Journal of Human Genetics Ad Hoc Reviewer, Philip Morris External Research Program, 2004 Ad Hoc Reviewer, Royal National Institute for Deaf People Research Program, 2005 Member, Working Group on Speech Audiometry, American Speech-Language- Hearing Association, Member, Review Panel R-03 National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 1992 Member, Podium Committee, Association for Research in Otolaryngology Midwinter Meeting, Member, Be a Hero for Life Organ Recovery Campaign, University of Nebraska Medical Center, Member, Scientific Review Board, Deafness Research Foundation, Member, Research Task Force, Deafness Research Foundation, Moderator, Association for Research in Otolaryngology Mid-Winter Meeting, 2002 Member, Eastern Auditory Research Retreat, Organizing Committee, Member, Training in the Neurobiology of Otolaryngology Research Retreat, Organizing Committee, Moderator, Association for Research in Otolaryngology Mid-Winter Meeting,

5 Member, Review Panel R-03, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Member, Animal Research Committee, Association for Research in Otolaryngology, Member, Review Panel P01, National Institute on Aging, National Institutes of Health, 2007 Chair, Animal Research Committee, Association for Research in Otolaryngology Member, Review Panel P01, National Institute on Aging, National Institutes of Health, 2008 GRANT SUPPORT Matrix Otopathology. R01DC , Principal Investigator, National Institutes of Health, National Institute on Deafness and Other Communication Disorders : $2,000,000 Administrative Supplement to Matrix Otopathology. R01DC , Principal Investigator, National Institutes of Health, National Institute on Deafness and Other Communication Disorders : $200,000 Potassium Homeostasis in the Inner Ear. R01 DC Principal Investigator for Subcontract, National Institutes of Health, National Institute on Deafness and Other Communication Disorders. April 1, 2005-March 31, 2010: $158,000 Gene therapy for Usher syndrome 1C. R21 DC Co-Investigator National Institutes of Health, National Institute on Deafness and Other Communication Disorders, July 1, 2007-June 30, 2009: $250,000 Assessment of metabolic energy substrate in the cochlea. Principal Investigator, Pennsylvania Lions Hearing Research Foundation, , 40,000 The Aged Middle Ear. Principal investigator, The Pennsylvania Lions Hearing Research Foundation, : $40,000 Training in the Neurobiology of Otorhinolaryngology,T35, Executive Committee, Trainer, National Institutes of Health, National Institute on Deafness and Other Communication Disorders. July 1, June 30, 2008: $1,359,957. Measures of Hypoxia in the Cochlea. Principal Investigator, National Organization for Hearing Research, 2003: $10,000 The Aged Middle Ear. 1 R03 AG Small Grant Program, Principal Investigator, National Institutes of Health, National Institute on Aging : $50,000. Recovery of tegmentum vasculosum homeostasis. Principal investigator, The Pennsylvania Lions Hearing Research Foundation, : $60,000 5

6 Cytokines and strial dysfunction. Co-investigator & Sponsor, The Deafness Research Foundation Otological Research Fellowship, : $15,000 Cytokines and strial dysfunction. Principal Investigator, National Organization for Hearing Research, 2002: $10,000 Cell-specific mechanisms regulating cochlear vasomotion and homeostasis: An in vitro model. Principal Investigator, The Deafness Research Foundation, : $60,000. Interactive cultures from the cochlear lateral wall. Principal Investigator, National Organization for Hearing Research, : $5,000. Development of cochlear cell cultures. R03 Small Grant Program, Principal Investigator, National Institutes of Health, National Institute on Deafness and Other Communication Disorders : $72,000. Experimental and clinical studies of presbyacusis. Program Project Grant, John H. Mills, Program Director. Principal Investigator, Core D, Co-Investigator, Projects 1 & 3, National Institutes of Health, National Institute on Deafness and Other Communication Disorders : $4,062,242. Evaluation of environmental noise exposure in pediatric patients receiving cisplatin chemotherapy. Principal Investigator, New Investigator Award, American Speech-Language-Hearing Foundation, Rockville Pike, Rockville, MD, 1989: $1,000. Interaction of noise and cisplatinum: Effects on hearing. Co-Investigator, Deafness Research Foundation, 366 Madison Avenue, New York, NY, 1988: $15,000. Cisplatin/noise interaction: Auditory effects. Principal Investigator, Mark Diamond Research Fund, SUNY at Buffalo, Buffalo, NY, 1988: $675. Ultrastructural effects of cisplatinum on inner ear tissues. Co-Investigator, American Cancer Society Institutional grant to the University of Texas Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX, :$6,000. PUBLICATIONS MANUSCRIPTS Boettcher, F.A., Henderson, D., Gratton, M.A., Danielson, R.W. and Byrne, C.D. (1987) Synergistic effects of noise and other ototraumatic agents. Ear and Hearing. 8(4): Gratton, M.A., Henderson, D. and Salvi, R.J. (1988) Interaction of cisplatinum and noise. Quadreni di Audiologica. 4: Arehole, S., Salvi, R.J., Saunders, S.S. and Gratton, M.A. (1989) Evoked-response forward-masking functions in chinchillas with noise-induced permanent hearing loss. Audiology. 28(2): Boettcher, F.A., Henderson, D., Gratton, M.A., Byrne, C. and Bancroft, B. (1989) Recent advances in the understanding of noise interactions. Archives of Complex Environmental Studies. 1(1):

7 Fiorino, F., Gratton, M.A., Subbana, M., Bianchi. L. and Henderson, D., (1989) Physiological mechanism underlying the progressive resistance to noise induced hearing loss. Il Valsalva. 54 (Suppl 1): Gratton, M.A., Salvi, R.J., Kamen, B.A. and Saunders, S.S. (1990) Interaction of cisplatin and noise in the peripheral auditory system. Hearing Research. 50: Salvi, R.J., Saunders, S.S., Gratton, M.A., Arehole, S. and Powers, N. (1990) Enhanced evoked response amplitudes in the inferior colliculus of the chinchilla following acoustic trauma. Hearing Research. 50: Gratton, M.A. and Kamen, B.A. (1990) Potentiation of cisplatin ototoxicity by noise. Journal of Clinical Oncology. 8(12): Henderson, D., Subramanian, M., Gratton, M.A. and Saunders., S.S. (1991) Impact noise: The importance of level, duration and repetition rate. Journal of the Acoustical Society of America. 89(3): Danielson, R., Henderson, D., Gratton, M.A., Bianchi, L. and Salvi, R.J. (1991) The importance of "temporal pattern' in traumatic impulse noise exposures. Journal of the Acoustical Society of America. 90(1): Gratton, M.A. and Wright C.G. (1992) Hyperpigmentation of chinchilla stria vascularis following acoustic trauma. Pigment Cell Research. 5: Gratton, M.A. and Wright, C.G. (1992) Alterations of inner ear morphology in experimental hypercholesterolemia. Hearing Research. 61: Gratton, M.A. and Schulte, B.A. (1995) Alterations in microvasculature are associated with atrophy of the stria vascularis in quiet-aged gerbils. Hearing Research. 82: Gratton, M.A., Smyth, B.J., Schulte, B.A. and Vincent, D.A., Jr. (1995) Na,K-ATPase activity decreases in the cochlear lateral wall of quiet-aged gerbils. Hearing Research. 83: Vincent, D.A., Jr., Gratton, M.A., Smyth, B.J. and Schulte, B.A. (1995) Effect of postmortem autolysis on Na,K-ATPase activity and antigenicity in the gerbil cochlea. Hearing Research. 89: Nakazawa, K., Spicer, S.S., Gratton, M.A. and Schulte, B.A. (1996) Localization of actin in basal cells of stria vascularis. Hearing Research. 96: Gratton, M.A., Schulte, B.A. and Hazen-Martin, D.J. (1996) Development and characterization of an inner ear type I fibrocyte cell culture. Hearing Research. 99: Gratton, M.A., Schmiedt, R.A. and Schulte, B.A. (1996) Age-related decreases in endocochlear potential are associated with vascular abnormalities in the stria vascularis. Hearing Research. 102: Gratton, M.A., Smyth, B.J., Lam, C.F., Schmiedt, R.A. and Boettcher, F.A. (1997) Decline of the 7

8 endocochlear potential correlates with decreasing Na,K-ATPase activity in the lateral wall of aged Mongolian gerbils. Hearing Research. 108:9-16. Gratton, M.A., Schulte, B.A. and Smythe, N.M. (1997) Quantification of stria vascularis and strial capillary areas in quiet-reared young and aged gerbils. Hearing Research. 114:1-9. Thomopoulos, G.N., Spicer, S.S., Gratton, M.A. and Schulte, B.A. (1997) Age-related thickening of basement membrane in stria vascularis capillaries. Hearing Research. 111: Spicer, S.S., Schulte, B.A. and Gratton, M.A. (1997) Expression patterns of ion-transport enzymes in spiral ligament fibrocytes change in relation to strial atrophy in the aged gerbil cochlea. Hearing Research. 111: White, D.R., Boettcher, F.A., Miles, L.R. and Gratton, M.A. (1998) Effectiveness of intermittent and continuous acoustic stimulation in preventing noise-induced hearing and hair cell loss. Journal of the Acoustical Society of America 103: Wangemann, P., Cohn, E.S., Gruber, D.D. and Gratton, M.A. (1998) Ca 2+ -dependence and nifedipine-sensitivity of vascular tone and contractility in the isolated superfused spiral modiolar artery in vitro. Hearing Research 118: Boettcher, F.A., Caldwell, R.K., Gratton, M.A., White, D.R. and Miles, L.R. (1998) Effects of nimodipine on noise-induced hearing loss. Hearing Research 121: Gratton, M.A., Meehan, D.T., Smyth, B.J. and Cosgrove, D.E. (2002) Strial marginal cells play a role in basement membrane homeostasis: In vitro and in vivo evidence. Hearing Research 163: Gratton, M.A., and Vázquez, A.E. (2003) Age-Related Hearing Loss: Current Research. Curr Opin in Otolaryngol & HNS, 11: Gratton, M.A., Veldi, H.R., Meehan, D.T., Askew, C. and Cosgrove, D. (2005) Matrix metalloproteinase dysregulation in the stria vascularis of mice with Alport syndrome: implications for capillary basement membrane pathology. American Journal of Pathology 166: Nie, L., Feng, W., Diaz, R., Gratton, M.A., Doyle, K.J. and Yamoah, E.N. (2005) Functional Consequences of Inhibition of Polyamine Synthesis by DFMO: Cellular Mechanisms for DFMOmediated Ototoxicity. Journal of Biological Chemistry 280: Nie, L., Gratton, M.A., Mu, K.J., Dinglasan, J.N., Feng, W., and Yamoah, E.N. (2005) Expression and Functional Phenotype of Mouse ether-a-go-go-related gene K + Channels in the Cochlea: Potential role in K + Regulation in the Inner Ear. Journal of Neuroscience 25: Rao, V., Meehan, D., Delimont, D., Nakajima, M., Wada. T., Gratton, M.A.and Cosgrove, D. (2006) Role for Macrophage Metalloelastase in Glomerular Basement Membrane Damage Associated with Alport Syndrome. American Journal of Pathology 169: Bedrosian, J.C., Gratton, M.A., Brigande, J.V., Tang, W., Landau, J., Bennett, J. (2006) In vivo delivery of recombinant viruses to the fetal murine cochlea: Transduction characteristics and longterm effects on auditory function. Molecular Therapy. 14:

9 Gratton, M.A., Bateman, K.M., Cannuscio, J.F. and Saunders, J.C. (2008) Middle ear contribution to presbycusis in the Brown-Norway rat. Audiology and Neurotology 13:37-52 Nie, L., Zhu, J., Gratton, M.A., Liao, A., Mu, K.J., Nonner, W., and Yamoah, E.N. (2008) Molecular Identity and Functional Properties of a Novel Cav3.1 Channel in Sensory Epithelia of Inner Ear, Journal of Neurophysiology 100(4): Bleier BS, Gratton MA, Leibowitz JM, Palmer JN, Newman JG, Cohen NA. (2008) Laser-welded endoscopic endoluminal repair of iatrogenic esophageal perforation: An animal model. Otolaryngology Head and Neck Surgery. 139(5):713-7 Bleier BS, Palmer JN, Gratton MA, and Cohen NA (2008) Laser Tissue Welding in the Rabbit Maxillary Sinus. American Journal of Rhinology. 22(6): Wang, X, Levic, S, Gratton, MA, Doyle, KJ, Yamoah, EN and Pegg,AE, (2009) Spermine synthase deficiency leads to deafness and a profound sensitivity to -difluoromethylornithine. Journal of Biological Chemistry. 284:930-7 Gratton, MA, Eleftheriadou, A., Garcia, J., Verduzco, E., Martin, G.K., Lonsbury-Martin, B.L. and Vazquez, A.E., (In Review) Noise-induced changes in gene expression in the cochleae of mice differing in their susceptibility to noise-damage. Journal of the Association for Resesarch in Otolaryngology. Davis, R.R., Murphy, W.J., Krieg, E.F. and Gratton, MA. (In Review) Hearing loss in the Chinchilla from impact noise exposure: Effect of peak pressure, interstimulus interval and impact spectrum. Hearing Research Bhattacharya, G., Meehan, D. Rao, V. Delimont, D, Gratton, MA., Chang, B., Hawes, N. Kalluri, R., Kimberling, W., Birch, D., and Cosgrove, D. (In Review) Usherin/integrin interactions mediate retinal pigment epoithelial cell adhesion and homeostasis. Journal of Cell Biology Zallocchi, M., Garrige, S., Meehan, D.T., Gratton, MA, Askew, C., Fields, R.R., Rothermund C., and Cosgrove, D. (Submitted) Localization and expression of Clarin-1, the USH3 gene product, in auditory hair cells and photoreceptors. Journal of the Association for Research in Otolaryngology. Furman A.C., Bateman, K.M., Saunders, J.C. and Gratton, MA. (Submitted) Decline and Recovery of EP post-acoustic overstimulation in the chick is age dependent. Journal of the Association for Research in Otolaryngology. Askew, C.C., Bateman, K., Saunders, J.C. & Gratton,MA (In Preparation) Ultrastructural Analysis of the Tegmentum Vasculosum After Intense Sound. Journal of the Association for Research in Otolaryngology. Lee, S.B., Askew, C., Cosgrove, D and Gratton,.A. (In Preparation) Site-specific changes occur in the cochlear basement membrane of Alport mice. Hearing Research Davis, JD* Banks, C.A.*, Antunes, M., Woodworth, B.A., Tamashiro, E., Gratton, MA* and Cohen, N.A* (In Preparation) Respiratory ciliary beat frequency in a mouse model of Alport's 9

10 disease. Journal of Membrane Biology TEXT CHAPTERS Salvi, R.J., Saunders, S.S., Powers, N.L. and Gratton, M.A. (1988) Acoustic trauma can 'enhance' evoked response amplitudes in the chinchilla. In: Berglund, B., Berglund, U., Karlsson, J. and Lindvall, T. (eds.) Noise as a Public Health Problem, Vol 2, Hearing, Communication and Nonauditory Physiological Effects. Swedish Council for Building Research. Stockholm, Sweden, pp Gratton, M.A., Salvi, R.J., Kamen, B.A., Henderson, D., and Poon, M. (1988) Combined effects of noise and cisplatin. In: Manninen O. (ed.) Recent Advances in Researches in the Combined Effects of Environmental Factors. International Society of Complex Environmental Studies, Tamperii, Finland, pp Boettcher, F.A., Bancroft, B., Gratton, M.A. and Spongr, V. (1992) Interaction of noise and other ototraumatic agents: Recent advances. In: Dancer, A., Henderson, D., Salvi, R.J. and Hamernik, R.P. (eds.) Noise-Induced Hearing Loss. Mosby-Year Books, St. Louis. pp Boettcher, F.A., Gratton, M.A. and Schmiedt, R.A. (1995) Effects of noise and age on the suditory system. In: Dunn, D. and Morata, T. (eds.) Occupational Medicine - State of the Art Reviews 10(4): Henley and Belfuss, Philadelphia, PA, pp: Henderson, D., M c Fadden, S.L., Gratton, M.A. and Spongr, V.P. (1995) Similarities and differences between noise-induced and age-related hearing loss. In: Rossi, G. (ed.) : Man and environmental noise twenty years after. Edizioni Minerva Medica, Torino Italy, pp Gratton, M.A. and Smyth, B.J. (2004) Platinum compounds. In: Roland, P. & Rutka, J. (eds.) Ototoxicity. BC Decker Inc., Hamilton, Ontario, pp Cosgrove, D., and Gratton, M.A..(2005) Extracellular matrix in inner ear development and function. In Miner, J.H. (ed.) Extracellular Matrices and Development: Advances in Developmental Biology, Vol 15. Elsevier, New York, pp ABSTRACTS AND PRESENTATIONS Gratton, M.A. (1981) Drugs and ototoxicity: A review. American Speech-Language-Hearing Association Annual Convention Gratton, M.A. (1982) Ototoxic monitoring: Do we know what we're doing? New York State Speech and Hearing Association Annual Convention. Gratton, M.A. and Henderson, D. (1987) Interaction of cisplatinum and noise. American Speech- Language and Hearing Association Annual Convention. Saunders. S.S., Salvi, R.J., Gratton, M.A. and Arehole, S. (1988) Growth of evoked response amplitude with stimulus level in noise exposed chinchillas. Abstracts of the Association for Research in Otolaryngology. 11:

11 Gratton, M.A., Salvi, R.J. and Kamen, B.A. (1988) Interaction of cisplatinum and noise. Abstracts of the Association for Research in Otolaryngology. 11:255. Salvi, R.J., Saunders, S.S., Powers, N.L. and Gratton, M.A. (1988) "Enhanced" evoked response amplitudes in the chinchilla following acoustic trauma. Journal of the Acoustical Society of America. 83, Suppl 1:S116. Salvi, R.J., Saunders, S.S., Powers, N.L. and Gratton, M.A. (1988) Acoustic trauma can "enhance" evoked response amplitudes in the chinchilla. Proceedings of the 5th International Congress on Noise as a Public Health Hazard. Gratton, M.A., Salvi, R.J., Kamen, B.A., Henderson, D. and Poon, M. (1988) Combined effects of noise and cisplatin. Proceedings of the 3rd International Conference in the Combined Effects of Environmental Factors. Bianchi, L.M., Gratton, M.A., Henderson, D., Danielson, R.W. and Salvi, R.J. (1988) Impulse noise and the equal energy hypothesis: Relationship to hair cell loss. American Speech-Language-Hearing Association Annual Convention. Fiorino, F., Gratton, M.A., Subbana, M., Bianchi, L. and Henderson, D. (1989) Physiological mechanism underlying the progressive resistance to noise-induced hearing loss. Proceedings of the 2nd International Symposium on Cochlear Mechanics and Echoes. Boettcher, F.A., Bancroft, B., Gratton, M.A. and Spongr, V. (1990) Interaction of noise and other ototraumatic agents: Recent advances. IVth International Conference on Effects of Noise on the Auditory System. Gratton, M.A. and Wright, C.G. (1991) Morphological alterations of the inner ear in experimental hypercholesterolemia. Abstracts of the Association for Research in Otolaryngology. 14:16. Gratton, M.A. and Schulte, B.A. (1992) Assessment of age-related changes in strial vascular patterns via computer-assisted image analysis. Abstracts of the Association for Research in Otolaryngology 15:48. Gratton, M.A., Smyth, B.J. and Schulte, B.A. (1993) Quantification of Na,K-ATPase activity in lateral wall tissues of Mongolian gerbils. Abstracts of the Association for Research in Otolaryngology. 16:106. Vincent, D.A., Jr. Smyth, B.J., Winston, D., Gratton, M.A. and Schulte, B.A. (1993) Effect of postmortem autolysis on protein structure and Na,K-ATPase activity of lateral wall and organ of Corti from individual cochleas. Abstracts of the Association for Research in Otolaryngology. 16:137. Boettcher, F.A. and Gratton, M.A. (1993) Resistance to noise induced hearing loss in the Mongolian gerbil. Abstracts of the Society for Neuroscience Annual Meeting. 23(2):1421. Gratton, M.A. and Schulte, B.A. (1994) Strial vasculature and ion transport in the aged Fisher rat. Abstracts of the Association for Research in Otolaryngology. 17:135. Gratton, M.A. and Hazen-Martin, D.J. (1995) Long-term secondary cultures from specialized lateral wall cells. Abstracts of the Association for Research in Otolaryngology. 18:27. 11

12 Gratton, M.A., Hazen-Martin, D.J. and Re, G.G. (1995) Identification of Ca-ATPase in cultured type I fibrocytes. The Molecular Biology of Hearing and Deafness. 2:161. Henderson, D., M c Fadden, S.L., Gratton, M.A. and Spongr, V.P. (1995) Similarities and differences between noise-induced and age-related hearing loss. Proceedings of the International Advanced Research Workshop. Gratton, M.A. and Spicer, S.S. (1996) Immunohistochemical changes in the lateral wall of the quietaged gerbil. Abstracts of the Association for Research in Otolaryngology. 19:636. Mills, J.H., Boettcher, F.A., Dubno, J.R., Gratton, M.A., Schmiedt, R.A. and Schulte, B.A. (1996) Evidence for age-related hearing loss in the auditory periphery. Abstracts of the Association for Research in Otolaryngology. 19:642. Schulte, B.A., Gratton, M.A. and Smythe, N. (1996) Morphometric analysis of spiral ganglion neurons in young and old gerbils raised in quiet. Abstracts of the Association for Research in Otolaryngology. 19:640. Smyth, B.J., Lam, C.F. and Gratton, M.A. (1996) Decline in the endocochlear potential corresponds with decreasing Na,K-ATPase activity in the lateral wall of quiet-aged gerbils. Abstracts of the Association for Research in Otolaryngology. 19:635. Spicer, S.S., Gratton, M.A. and Schulte, B.A. (1996) Age-related changes in fine structure of lateral wall cells in the gerbil cochlea. Abstracts of the Association for Research in Otolaryngology. 19:637. Thomopoulos, G., Spicer, S.S., Gratton, M.A. and Schulte, B.A. (1996) Ultrastructural changes in the stria vascularis of quiet-aged gerbils. Abstracts of the Association for Research in Otolaryngology. 19:639. Dubno, J.R., Boettcher, F.A., Gratton, M.A., Schmiedt, R.A., Schulte, B.A. and Mills, J.H. (1996) Evidence for age-related hearing loss in the auditory periphery. American Speech-Language and Hearing Association Annual Convention. White, D.R., Miles, L.R., Gratton, M.A. and Boettcher, F.A. (1997) Effects of intermittent and continuous acoustic stimulation on threshold shift, otoacoustic emission and outer hair cell loss. Abstracts of the Association for Research in Otolaryngology. 20:806. Gratton, M.A., Lee, F.S. and Schmiedt, R.A. ( 1997) Correlation of hearing loss with cochlear pathology in aged gerbils. Abstracts of the Association for Research in Otolaryngology. 20:413. Mills, J.H., Boettcher, F.A., Dubno, J.R., Gratton, M.A., Schmiedt, R.A., and Schulte, B.A. (1997) Evidence for age-related hearing loss in the auditory periphery. American Academy of Audiology Annual Convention Wangemann, P., Cohn, E.S., Gruber, D.D. and Gratton, M.A. (1998) Ca 2+ -dependence and nifedipine-sensitivity of tone and contractility in the isolated in vitro superfused spiral modiolar artery. Abstracts of the Association for Research in Otolaryngology. 21:

13 Gratton, M.A., Liu, J. Wangemann, P. (1998) Osmotic water permeability of isolated strial capillaries. Abstracts of the Association for Research in Otolaryngology. 21: 192 Wangemann, P., Cohn, E.S., Gruber, D.D. and Gratton, M.A. (1998) Ca-dependence and nifedipinesensitivity of tone and contractility in the isolated in vitro superfused spiral modiolar artery. Experimental Biology, Gratton, M.A. (1998) Cultured pericytes derived from stria vascularis capillaries. The Molecular Biology of Hearing and Deafness. 3:151. Warr, W.B., Gratton, M.A. and Boche, J.E.B. (1999) Fine structure of labeled lateral efferent axons in the rat cochlea. Abstracts of the Association for Research in Otolaryngology. 22:840. Gratton, M.A. and Cosgrove, D. (2000) The strial cell line SV-k1 as a model system for the study of strial capillary basement membrane pathology. Abstracts of the Association for Research in Otolaryngology.23:669. Walsh, E., Cranfill, C., Gouthro, M., Gratton, M.A., and McGee, J. (2000) Distortion product otoacoustic emissions in Tshr mutant mice. Abstracts of the Association for Research in Otolaryngology.23:664. Gratton, M.A. and Cosgrove, D. (2001) Modulation of metalloproteinases and their inhibitors in cultured strial marginal cells. Abstracts of the Association for Research in Otolaryngology 24:476. Gratton, M.A., Rao, V.H., Rodgers, K.D. and Cosgrove, D. (2001) Modulation of basement membrane proteins in Alport Syndrome. The Molecular Biology of Hearing and Deafness. 4: 33. Gratton, M.A., Cosgrove, D., Smyth B.J. and Ruckenstein, M.J. (2002) Alport Syndrome mice exhibit sensitivity to acoustic overstimulation. Abstracts of the Association for Research in Otolaryngology. 25:251. Gratton, M.A.,, Ruckenstein, M.J., and Cosgrove, D.E. (2003) Alport Syndrome" Mice Exhibit Lateral Wall Dysfunction Following Acoustic Overstimulation. Abstracts of the Association for Research in Otolaryngology. 26: 72. Patterson, D.M., Ruckenstein, M.J. and Gratton, M.A. (2003) Pro-Inflammatory Cytokine Receptors in the Lateral Wall of the MRL-Fas lpr mouse. Abstracts of the Association for Research in Otolaryngology. 26: 73. Gratton, M.A.,, and Cosgrove, D.E. (2003) Quantifying Cochlear Basement Membrane Width in Alport Mice Reveals Site-Specific Changes. Abstracts of the Association for Research in Otolaryngology. 26: 490. Patterson, D,M, Snyder, W.N., Ruckenstein, M.J. and Gratton, M.A. (2004) Serum Levels of Pro- Inflammatory Cytokines and Hearing Loss in the MRL-Fas lpr mouse. Abstracts of the Association for Research in Otolaryngology. 27:173. Gratton, M. A., Lonsbury-Martin, B. L., Martin, G. K. and Vázquez, A.E. (2004) Noise-induced changes in gene expression in mice strains susceptible to and resistant to noise damage. Abstracts of 13

14 the Association for Research in Otolaryngology. 27:382. Ramakrishna, R., Kurian, R., Saunders, J.C. and Gratton, M.A. (2004) Recovery of the Tegmentum Vasculosum in the Noise Exposed Chick. Abstracts of the Association for Research in Otolaryngology. 27:383 Cannuscio, J.F., Saunders, J.C. and Gratton, M.A. (2004) Middle Ear Transfer Function: Altered in Aged Rats. Abstracts of the Association for Research in Otolaryngology. 27:643. Nie, L., Mu, K., Feng, W., Gratton, M.A., Vazquez. A.E.,and Yamoah, E.N. (2004) Molecular Cloning and Functional Identification of Merg1a Potassium Channel in Mouse Cochlea. Abstracts of the Association for Research in Otolaryngology. 27: 697. Nie, L., Feng, W., Diaz, R., Doyle, K.J., Gratton, M.A.and Yamoah, E.N. (2004) DFMO-induced Ototoxicity May be Derived from Drug-mediated Effects on the Inward Rectifier Kir4.1 Channel in the Inner Ear. Abstracts of the Association for Research in Otolaryngology. 27:698. Rao, V. H., D. Meehan., D. E. Cosgrove., and Gratton, M.A. (2004) Expression of 72 kda and 92 kda type IV collagenases (gelatinase A/ MMP-2 and gelatinase B/ MMP-9) in mouse stria; implications for Alport inner ear pathogenesis. Abstracts of the Association for Research in Otolaryngology. 27:963 Bhattacharya, G., Meehan, D., Rao, V., Delimont, D., Walsh, E., McGee, J., Gratton, M.A., and Cosgrove, D. (2004) Usherin function: Clues from a gene Knockout mouse model. The Molecular Biology of Hearing and Deafness. 4: 78. Cosgrove, D., Rao, V., and Gratton, M.A. (2004) Matrix metalloproteinase dysregulation in stria vascularis of Alport mice: implications for capillary basement membrane pathology. The Molecular Biology of Hearing and Deafness. 4: 136. Vázquez, A.., Garcia, J., and Gratton, M.A. (2004). The molecular basis of susceptibility to noise damage. The Molecular Biology of Hearing and Deafness. 4: 198. Bhattacharya, G., Gratton, M.A., Meehan, D., Delimont, D., and Cosgrove, D. (2004) Structural and functional properties of usherin: a novel basement membrane protein implicated in Usher syndrome IIa pathogenesis. American Society for Matrix Biology. 2: 1. Barrett, K.L., Bateman, K.L., Snyder, W.L. and Gratton, M.A., (2005) Hypoxia: A mechanism for the susceptibility of Alport mice to noise. Abstracts of the Association for Research in Otolaryngology. 28:296 Nie, L., Simmons, D.D., Gratton, M. A., and Yamoah, E. N. (2005). Identification of T-type calcium channel currents in sensory cells in the inner ear.. Abstracts of the Association for Research in Otolaryngology. 28:877 Vázquez, A.E., Garcia, J., Yip, H., Patel, T.J., and Gratton, M.A. (2005) The role of metallothioneins in protection from noise damage.. Abstracts of the Association for Research in Otolaryngology. 28:359 Ruckenstein, M.J., Patterson, D.M., Cohen, M. and Gratton, M.A. (2005) Strial pathology in lupus mouse strains.. Abstracts of the Association for Research in Otolaryngology. 28:295 14

15 Bhattacharya, G., Gratton, M.A., Meehan, D., Delimont, D., Walsh, E., McGee, J. and Cosgrove, D. (2005) Usherin binding to integrins mediates both cell adhesion and cell signaling: Usherin interaction with A1B1 integrin is central to Usherin function. Abstracts of the Association for Research in Otolaryngology. 28:299 Gratton, MA, Rao, V., Liao, A, and Cosgrove, D. (2006) The Stria Vascularis from Alport Mice Is a Hypoxic Microenvironment. Abstracts of the Association for Research in Otolaryngology. 29:25. Askew, C., Bateman, K., Saunders, JC and Gratton, MA., (2006) Ultrastructural Analysis of the Tegmentum Vasculosum After Intense Sound. Abstracts of the Association for Research in Otolaryngology. 29:42 Ruckenstein, M., Bedrosian, J., Coffey, L., and Gratton, MA., (2006) Cytokine Mediated Strial Pathology. Abstracts of the Association for Research in Otolaryngology. 29:484. Gratton, MA., Nie, L., Diaz, R., Doyle, KJ, Garcia, J., Askew C., Beerman, F. and Yamoah, EN. (2006) Functional Consequences of a Tyrosinase Promoter for Diptheria Toxin. Abstracts of the Association for Research in Otolaryngology. 29:598 Bedrosian, J., Gratton, MA, Waixing, T., Landau, J., Bennett, J. (2006) Adeno Associated Viral Serotype 2/1 Is a Highly Efficient Vector for in Utero Gene Transfer to Hair Cell Precursors. Abstracts of the Association for Research in Otolaryngology. 29:611. Bedrosian, J., Gratton, MA, Waixing, T., Landau, J., Bennett, J. (2006) Adeno Associated Viral Serotype 2/1 Is a Highly Efficient Vector for in utero Gene Transfer to Hair Cell Precursors. American Society of Gene Therapy. Garcia, J., Verduzco, E., Tinling, S.P., Patel, T., Gratton, M.A., Vazquez, A.E. (2007) Metallothionein I and II Knocked Out Mice of 129 Genetic Background Differ in Their Susceptibility to Noise-Induced Hearing Loss. Abstracts of the Association for Research in Otolaryngology. 30: 337. Nie, L., Liao, A., Gratton, M.A., Zhu J., Yamoah. E.N. (2007), Kir5.1 Channels in the Stria Vascularis of the Mouse Inner Ear. Abstracts of the Association for Research in Otolaryngology. 30: 762. Chung, D., Bedrosian, J., Wei, Z., Gratton, M.A., Lipschutz, J.H. and Bennett, J. (2007) Hybrid adenoassociated virus (AAV)-mediated Transduction of Cells with Primary Cilia: Applications for Retinal, Cochlear, and Renal Disease. Abstracts of the Association for Research in Vision and Ophthalmology. Cosgrove, D, Zallocchi, M., Garige, S., Peng, Y-W., Askew, C.H. & Gratton, M.A.. (2008) Clarin-1 is expressed in auditory hair cells and localizes to the base of the stereocilia. Annual Midwinter Meeting of the Association for Research in Otolaryngology. 31:46 Dunn, L., Cosgrove, D., & Gratton, M.A. (2008) Hypoxic environment created by thickened strial capillary basement membranes involves cytokine upregulation. Annual Midwinter Meeting of the Association for Research in Otolaryngology. 31:624 Gratton, M.A., Eleftheriadou, A., & Vázquez, A.E. (2008) GADD45 Is a Pro-Survival Factor Induced 15

16 by Noise- Overexposure in the Membranous Labyrinth of 129 Mice Highly Resistant to Noise Damage. Annual Midwinter Meeting of the Association for Research in Otolaryngology. 31:708 Askew, C.H. & Gratton, M.A.. (2008) Basement Membrane Pathology Influences Stria Metabolism. Annual Midwinter Meeting of the Association for Research in Otolaryngology. 31:622 Bleier BS, Gratton MA, Leibowitz JM, Palmer JN, Newman JG, Cohen NA (2008) Laser Welded Endoscopic Transluminal Repair of Iatrogenic Esophageal Perforation: An Animal Model. American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting. 112:9197 Dunn, L., Zallocchi, M., Cosgrove, D,. & Gratton, M.A. (2008) Cochlear hypoxia in COL4a3 mice involves cytokine upregulation. American Society for Matrix Biology. Davis, J, Hoffman, K, Ziffer, M, Saunders, JC & Gratton MA (2009) Evidence for structural compromise of the tympanic membrane in the aged Brown Norway rat. Annual Midwinter Meeting of the Association for Research in Otolaryngology. 32:594, February, 2009 INVITED LECTURES Neonatal hearing screening. University of Georgia, Athens, GA.. April, 1982 Strial pathology following exposure to ototraumatic agents. University "La Sapienza" of Rome and University of Verona, Italy. May, 1990 Cisplatin: Early ultrastructural changes in the cochlea and measurements of ototoxicity. Trinity College Dublin and University College at Dublin, Ireland. Sept, Cochlear histopathology in presbycusis. Department of Otolaryngology, Wayne State University, MI, March, Cochlear lateral wall dysfunction in presbycusis. Visiting Scholars Colloquium, Kresge Hearing Research Laboratories, University of Michigan. December, Cochlear Homeostasis, Auditory Neurobiology Course, University of Pennsylvania Neuroscience Graduate Group, March, 2002 Basement Membranes and Strial Function, Genetics Colloquium, Boys Town National Research Hospital, April 2002 Otopathology in Alport Syndrome, Grand Rounds, Department of Otolaryngology, UC-Davis, May 2002 Recovery of the Tegmentum Vasculosum from Acoustic Overstimulation, Pennsylvania Lion s Club Hearing Research Foundation Annual Dinner, August, The Status of Hearing Science, University of Wisconsin-Oshkosh, February, 2004 Auditory Neuroscience, Brain and Behavior Course, University of Pennsylvania Medical School, March,

17 Auditory Physiology Series I. External and Middle Ear; II. Cochlea Organ of Corti; III. Stria Vascularis and Ionic Control; IV. Central Pathways. Department of Otorhinolaryngology Grand Rounds, University of Pennsylvania, April, Cochlear Homeostasis, Neurobiology of Otorhinolaryngology Meeting Place, September, Alport Syndrome, Department of Speech Pathology and Audiology, Graduate School of Allied Health, University of So. Alabama, March 2005 Auditory Neuroscience, Brain and Behavior Course, University of Pennsylvania Medical School, March, 2005 Fighting Hearing Loss, National Organization for Hearing Research Annual Fundraising Dinner, June, 2005 Matrix Otopathology, OTO/HNS Seminar, Department of Otolaryngology, Head & Neck Surgery, Columbia University Medical Center, January, 2006 The Anatomical Organization of the Inner Ear, Neuroscience 581, University of Pennsylvania, February, 2006 Cochlear Ionic Homeostasis, Neuroscience 581, University of Pennsylvania, February, 2006 Ages Susceptible to Hearing Loss, Annual Meeting of the Vice District Governors for the Pennsylvania Lions Hearing Research Foundation, Best Western Lehigh Valley Hotel Conference Center, Bethlehem, PA. August, 2006 Alport and Alport-Like Syndromes, Kidney and Ear: Emerging Parallel Functions Symposium, American Society of Nephrology, San Diego, CA, October, 2006 Matrix Otopathology, OTO/HNS Seminar, Department of Otolaryngology, Head & Neck Surgery, St. Louis University, St. Louis, MO, December, 2006 Basement Membrane Homeostasis, Ion transport in the stria vascularis symposium, 30 th Midwinter Research Meeting, Association for Research in Otolaryngology, Denver, CO, February, 2007 Basement Membrane Homeostasis, School of Audiology, Pennsylvania College of Optometry, Elkins Park, PA, April, 2008 Basement Membranes in the Cochlea. Department of Pharmacology & Physiology, St. Louis University, St. Louis, MO, April, 2008 Animal Models of Outer and Middle-Ear Contributions to Presbycusis, 8th International Conference on Cholesteatoma, Antalya,Turkey, June 2008 Presbycusis: Current Status, Clinical Neurosciences Track, University of Pennsylvania, Luncheon Seminar, Philadelphia, December,