biomaterials Product Catalog botiss soft tissue education hard tissue Dental bone and tissue regeneration dental bone & tissue regeneration
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1 dental bone & tissue regeneration botiss biomaterials Product Catalog Dental bone and tissue regeneration biomaterials soft tissue education hard tissue 1
2 botiss regeneration system maxresorb flexbone* collacone.. max* synthetic + native collagen Augmentation Preservation hard tissue 6-9 months 3-4 months soft tissue maxgraft maxgraft bonering maxgraft bonebuilder maxresorb inject maxresorb synthetic human 4-6 months Resorption 4-6 months 4-6 months Regeneration 3-4 months Biological Potential Biomimetic Composites Controlled Degradation Healing 2-4 weeks 2-3 months Barrier 3-6 months native collagen Jason fleece collacone... collprotect membrane Jason membrane cerabone bovine 6-9 months 6-9 months mucoderm Integration High Quality Learning Integration botiss academy SCIENCE EDUCATION CLINIC bone & tissue days cerabone maxresorb maxresorb inject maxgraft bonebuilder maxgraft bonering maxgraft Natural bovine bone graft Synthetic biphasic calcium phosphate Synthetic injectable bone paste Patient matched allogenic bone implant Processed allogenic bone ring Processed allogenic bone graft collacone max* maxresorb flexbone* Jason fleece / collacone... collprotect membrane Jason membrane mucoderm Cone (CaP / Collagen composite) Flexible blocks (CaP / Collagen composite) Collagenic hemostypt (Sponge / Cone) Native collagen membrane Native pericardium GBR / GTR membrane 3D-stable soft tissue (Collagen) graft 2 * Coming soon
3 dental bone & tissue regeneration botiss biomaterials The botiss regeneration system: Innovation, Safety, Reliability, and Esthetics botiss biomaterials offers you a unique systematic BTR approach, the complete regenerative biomaterial portfolio for Implantology, Oral and CMF Surgery and Periodontology out of one hand. We all know no single bone graft or soft tissue biomaterial is able to suit all medical needs, biological situations and indications. A variety of factors (indication, age, hygiene, biotype, bone height, treatment plan) require a sophisticated approach with different, coordinated products. To achieve optimal, predictable results, we offer you the botiss regeneration system. It includes all long-term proven biological materials (bovine, synthetic, allografts, collagen, granules, blocks, membranes, soft tissue matrices), to be used in various combinations for each specific indication. The products are manufactured with the highest quality standards and all products are strictly biological (e.g. no chemical cross-linking). Patient safety, ease of use, reliable and predictable treatment results these are your and our first priorities. The products of botiss regeneration system have proven their success (safety, efficacy, reliability) in a multitude of preclinical and clinical studies, and even more importantly in the daily clinical work with hundreds of thousands of patients world-wide. and education with the botiss academy, and our international bone & tissue days are the results of our partnerships with world-wide renowned academic research institutes, global opinion leaders, and practitioners in their daily clinical environment. botiss biomaterials, already No. 2 in Europe for dental BTR with a growing global market share, provides the botiss regeneration system via a global network of distribution partners in over 80 countries world-wide. Our distribution partners and staff are dedicated specialists in dental surgery and implantology. botiss is an innovative, clinically oriented biotech company headquartered in Berlin, with R&D and production sites in Germany, Austria and Great Britain. We are 100% focused on dental regeneration. We proudly welcome you to the botiss regeneration system community. We invite you to share your experiences and suggestions with us, for improvements or new product concepts. We invest substantially in research and education. The unique innovations and new clinical solutions of mucoderm, maxgraft bonebuilder and maxresorb flexbone, the concept of high quality learning Dr. Drazen Tadic dt@botiss.com Oliver Bielenstein ob@botiss.com 3
4 bone regeneration cerabone maxresorb maxresorb inject perossal maxgraft maxgraft bonering maxgraft bonebuilder 4
5 cerabone Natural bovine bone graft SEM: cerabone microporosity; perfect surface roughness for accelerated cell attachment SEM: cerabone macro- and micropores resembling human bone Bovine bone grafting material is due to its reliability and treatment predictability the material of choice for the majority of dentists. cerabone is a highly reliable, dimensionally stable, safe bone graft. It is derived from the mineral phase of bovine bone, which shows strong resemblance to human bone (surface, porosity and chemical composition). Due to the pronounced hydrophilicity of the cerabone surface, mixing with blood or physiological saline solution provides a suitable stickiness for optimal moldability. The three-dimensional porous network allows fast deposition and penetration of blood serum and proteins, and serves as a reservoir for proteins and growth factors. The unique manufacturing process based on high-temperature heating removes all proteins and other organic components, and eliminates potential immunological reactions. cerabone is the leading natural bovine bone grafting material of German origin, as evidenced by clinical and scientific success. Histology of cerabone six months after sinus lift: Optimal integration and bone healing with cerabone Indications: Implantology, Periodontology and Oral and CMF Surgery - Sinus lift - Horizontal and vertical augmentation - Intraosseous defects - Peri-implant defects - Extraction sockets - Furcation defects cerabone excellent biofunctionality; superior hydrophilicity and blood uptake... Product Specifications cerabone granules Properties - Natural bovine bone grafting material - Fast integration by new bone formation - Long-term three-dimensional graft stability - No foreign body or inflammatory reaction - Rough surface, optimal cell adhesion and blood absorption - Interconnective porosity - Safe and sterile - Easy handling Art.-No. Particle Size Content mm 1 x 0.5 ml mm 1 x 1.0 ml mm 1 x 2.0 ml mm 1 x 5.0 ml mm 1 x 0.5 ml mm 1 x 1.0 ml mm 1 x 2.0 ml mm 1 x 5.0 ml cerabone block Art.-No. Dimension Content x 20 x 10 mm 1 x block cerabone block... 5
6 maxresorb Synthetic biphasic calcium phosphate maxresorb is an innovative, safe, reliable and fully synthetic bone graft substitute with improved controlled resorption properties and outstanding handling characteristics. The homogenous composition of 60% hydroxyapatite (HA) and 40% beta-tricalcium phosphate (β-tcp) results in two active mineral phases: it supports the formation of new vital bone and maintains the volume and mechanical stability over a long-time period. ingrowth and efficiently promotes the regeneration of vital bone. The high microporosity and surface roughness of maxresorb facilitates diffusion of biological fluids and cell attachment. maxresorb is manufactured ensuring a completely homogenous distribution of the two calcium phosphate phases; resulting in a graft material equally The osteoconductivity of maxresorb is achieved by a matrix of interconnecting pores ranging from 200 to 800μm, and a very high porosity of approx. 80%. The high macroporosity of maxresorb is ideal for osteogenic cell reliable to bovine bone. The unique maxresorb production process leads to a highly nano-structured, bioactive rough surface for improved cell adherence and hydrophilicity. Histology of maxresorb six months after sinus lift: Optimal integration and bone healing with maxresorb Perfect hydrophilicity of maxresorb granules provides excellent handling characteristics in contact with blood... Properties - Synthetic, resorbable and safe - Volume and mechanical graft stability - Unique multistep production process - 60% HA/40% β TCP - Osteoconductive - Ultra-high interconnected porosity - Micropores from ~1-10μm SEM: Structured surface and porosity Product Specifications maxresorb granules Art.-No. Particle Size Content mm (S) 1 x 0.5 ml mm (S) 1 x 1.0 ml mm (L) 1 x 0.5 ml mm (L) 1 x 2.0 ml maxresorb cylinder SEM: maxresorb particle Indications: Implantology, Periodontology and Oral and CMF Surgery - Sinus lift - Ridge augmentation - Intraosseous defects - Extraction sockets - Osseous defects - Furcation defects Art.-No. Dimension Content Ø 7.5 mm; height 15 mm 1 x cylinder Ø 6.0 mm; height 15 mm 1 x cylinder maxresorb blocks 6 Art.-No. Dimension Content x 10 x 10 mm 1 x block x 20 x 10 mm 1 x block
7 maxresorb inject Synthetic injectable bone paste maxresorb inject is a unique and highly innovative, injectable bone graft paste, with improved resorption properties. The unique four-phasic homogenous composition of gel, active hydroxyapatite (HA) and granules of 60% HA and 40% β-tcp supports the formation of new vital bone, maintains volume and mechanical graft stability, and is gradually replaced by mature new bone. The highly viscous maxresorb inject paste allows perfect shaping, molding, fitting and complete bone bonding to the surrounding bone surface of the defect. maxresorb inject is a non-hardening synthetic bone paste. Histology of maxresorb inject six months after sinus lift: Optimal integration and bone healing with maxresorb inject maxresorb inject paste Unique Regenerative Four-Phases Activity water/gel carrier guided vascularization active HA cell activation, bioactive regeneration biphasic Ca/P balanced resorption and bone formation, volume stability maxresorb inject unique, injectable, synthetic bone graft maxresorb inject perfect blood adherence Properties Indications: - Injectable and easy handling - Non-hardening bone graft paste - Synthetic, resorbable and safe - Viscous and moldable Implantology, Periodontology and Oral and CMF Surgery - Active hydroxyapatite gel - 60% HA/40% β-tcp granules SEM: maxresorb inject surface structure - Sinus lift - Osteoconductive - Intraosseous defects - Ultra-high interconnected porosity - Extraction sockets Product Specifications maxresorb inject - Osseous defects - Furcation defects Art.-No. Unit Content x syringe 1 x0.5 ml x syringe 1 x1.0 ml x syringe 1 x2.5 ml maxresorb inject - Easy handling and good moldability 7
8 perossal Unique nanocrystalline calcium phosphate matrix perossal is a unique, synthetic, osteoconductive and resorbable bone graft substitute. perossal is a composite of nanocrystalline hydroxyapatite (HA) and calcium sulfate. SEM: perossal cone surface The nanocrystalline hydroxyapatite gives perossal a very high specific surface which allows proteins and growth factors to bind directly onto the surface and results in controlled osteostimulation of the surrounding tissue. The nano- and microporous network of perossal offers the possibility to load the bone graft substitute individually with liquids (e.g. antibiotics) and provides the property of a controlled prolonged release. perossal ensures guided bone regeneration together with stabilization of the extraction socket. Properties - Volume and mechanical stability - Synthetic, resorbable and safe - Nano- and micropores - Nano HA/calcium sulfate composite - Osteostimulative - Individual liquid antibiotics loading - Controlled prolonged release i.e. of liquid and/or antibiotics Histology of perossal biopsy taken four months after surgery: Optimal integration and bone healing with perossal Indications: Implantology and Oral and CMF Surgery - Osseous defects - Extraction sockets - In combination with antibiotics in infected/ contaminated bone areas SEM: perossal nano and microporosity perossal controlled release and bone regeneration Time Bone Regeneration Controlled Prolonged Release Product Specifications perossal synthetic cones Art.-No Dimension Content Volume Ø 6 mm; 6 mm height 1 x 6 cones 1.2 ml Ø 6 mm; 6 mm height 2 x 6 cones 2.4 ml perossal 8
9 maxgraft Processed human allograft maxgraft is a sterile, high-safety allograft product, derived from human donor bone, processed by the Cells + Tissue Bank Austria (C + TBA). C + TBA, a high-quality bone bank, is regulated, audited and certified by the Austrian Ministry of Health and fulfills the highest EU safety standards. Histology of maxgraft five months after implantation: Optimal integration and bone remodelling with maxgraft Structure of maxgraft block For experienced oral and maxillofacial surgeons, allograft bone blocks for block augmentation are the only real alternative to harvesting the patient s own autologous bone, preventing well known risks as donor-site morbidity, infection, postoperative pain and loss in bone stability. The excellent biological regeneration capability of maxgraft results in a predictable clinical outcome. Properties Indications: - Preserved biomechanical properties - Sterile without antigenic effects - Storable at room temperature for five years - Osteoconductive properties supporting natural Implantology, Periodontology and Oral and CMF Surgery and controlled tissue remodelling SEM: maxgraft particle SEM: maxgraft mineralized collagen fibers Mixability with blood maxgraft granules: - Localized augmentation of the ridge for future implant placement - Ridge augmentation Product Specifications - Osseo defects - Extraction sockets maxgraft cancellous granules - Elevation of maxillary sinus Art.-No. Particle Size Content mm 1 x 0.5 ml mm 1 x 1.0 ml mm 1 x 2.0 ml mm 1 x 4.0 ml floor - Repair of intrabony periodontal defects maxgraft cortico-cancellous granules mm 1 x 0.5 ml mm 1 x 1.0 ml mm 1 x 2.0 ml mm 1 x 4.0 ml maxgraft blocks uni-cortical 1 x block 10 x 10 x 10 mm uni-cortical 1 x block 20 x 10 x 10 mm cancellous 1 x block 10 x 10 x 10 mm cancellous 1 x block 20 x 10 x 10 mm maxgraft blocks: - A predictable and highly effective alternative to traditional block grafting - Ridge augmentation 9
10 maxgraft bonering Processed allogenic bone ring The maxgraft bonering technique maxgraft bonering is a pre-fabricated ring of processed allogenic donor bone, which is placed press-fit into a trephine drill-prepared ring bed. At the same time, an implant is inserted into the ring. The bony integration of both maxgraft bonering, and the implant, occurs via the surrounding vital bone. Preparation of ring bed Indications: After determination of the position of the implant by the pilot drill, the ring bed is prepared with the trephine. Subsequently, the planator allows an even paving of the local bone for optimal contact with maxgraft bonering and in addition, removes the cortical layer for improved graft revascularization. For starters it can be of advantage to begin with the planator. Thereby, the position of the implant can be manually adjusted before its final position is assigned by the pilot drill. Implantology - Vertical augmentation (in combination with horizontal augmentation) - Single tooth gap - Edentolous space - Sinus lift The maxgraft bonering technique allows bone augmentation and implantation in a one-stage procedure. The technique is applicable for almost all indications, including sinus lift with limited maxillary bone height. The height of maxgraft bonering is adjustable to the defect Compared to the classic, two-stage augmentation with bone blocks, this technique reduces the entire treatment period by several months and saves the re-entry. The maxgraft bonering technique enables vertical bone augmentation and direct implant insertion... Immediate implant insertion through maxgraft bonering ensures primary stability of implant and graft The maxgraft bonering allows vertical and horizontal augmentation and new bone formation, therefore simplifying the surgical treatment. Advantages - Simultaneous implant placement and bone augmentation - No second surgical procedure Significant reduction of treatment time
11 One-stage bone augmentation and implant placement Sharp edges should be smoothened to avoid soft tissue perforation and to support accelerated wound healing. Moreover, maxgraft bonering should be covered with a slowly resorbable bone regeneration material (e.g. cerabone, maxresorb ) to fill the residual defect volume and to avoid potential adaption resorption of the graft. Soft tissue management After covering of the graft with a collagen membrane (Jason membrane, collprotect membrane) a tension-free suturing of the operation site must be assured to avoid tissue perforation and graft exposure maxgraft bonering surgical kit With this surgical kit, botiss biomaterials provides all necessary instruments to apply the maxgraft bonering technique. The kit includes two convenient sizes of trephines, which precisely fit together with the two maxgraft bonering diameters. The planator allows paving of the local bone to create a congruent and fresh contact surface of the implant area. Trephines and planator are perfectly adjusted to the pilot drill. The diamond disc and the diamond ball mill serve to manipulate the maxgraft bonering for excellent adjustment to the local bone and for improved soft tissue healing. Altogether, these instruments allow optimal preconditions for the bony ingrowth of maxgraft bonering. All instruments are made of high quality surgical steel. Product Specifications maxgraft bonering Art.-No. Dimension Content height 10 mm 1 x cancellous ring Ø 6 mm/3.5 mm (outer/inner diameter) height 10 mm 1 x cancellous ring Ø 7 mm/3.5 mm (outer/inner diameter) maxgraft bonering surgical kit 1 set planator 6 mm 1 x bonering fix 1 x pilot drill 2 mm trephine 7 mm trephine 6 mm planator 7 mm diamond disc 22 mm diamond ball mill 5 mm planator 6 mm 11
12 maxgraft bonebuilder Patient matched allogenic bone implant maxgraft bonebuilder provides an allogenic bone implant, which is individually adjusted to the patient s bone defect. With maxgraft bonebuilder, harvesting of autologous bone and manual adjustment of the obtained transplant is no longer required. Donor-site morbidity, operation time and costs may be significantly reduced. The CT/DVT-data of the bone defect is transfered into a 3D model The maxgraft bonebuilder technology In-house planning botiss biomaterials virtually designs the patient matched allogenic bone implant based on the CT/DVT-scan of the bone defect. The design of the bone implant undergoes a final inspection by the clinical user and is, by individual order, released for production. The botiss biomaterials partner Cells + Tissuebank Austria (C + TBA) receives a *.stl milling file and the patient matched allogenic bone implant is produced under cleanroom conditions. The resulting allogenic bone implant is ready for insertion into the defect with only minor adjustments. Indications - Extensive bone defects - Atrophic maxilla/mandibula - Horizontal and vertical augmentation Advantages - Individualized allogenic bone implant - Significantly reduced operation time - Improved wound healing Based on this model botiss designs a virtual block, which matches the surface structure of the defect and allows stable implant insertion after augmentation After placement, the maxgraft bonebuilder block is fixed with osteosynthesis screws. Residual defect volume should be filled with bone regeneration material and the augmentation site should be covered with a collagen membrane. The strong capillary action of the three-dimensional, porous trabecular bone network enables fast and efficient penetration of fluids, nutrients and blood, resulting in excellent handling, reliability and predictability in the daily clinical use. The patient matched maxgraft bonebuilder block allows optimal horizontal and vertical reconstruction of the atrophic ridge 12
13 The Process Flow 1. Upload of CT/DVT-data on After registration, CT/DVT-data of the patient s defect can be uploaded on the botiss biomaterials server. All radiological data have to be single sliced, unlinked images (single-frame data images). The only data type suitable for 3D planning is DICOM (*.dcm). Please find further information on the correct data format on our website. 2. Design of the customized allogenic bone block botiss biomaterials creates a three-dimensional model of the radiological images and designs a virtual patient matched bone implant in consultation with the clinical user. Alternatively, the clinical user can design the bone block by himself and upload the final *.stl file of the designed implant on The maxgraft bonebuilder technology allows complex reconstruction in cases of extensive jaw atrophy Each block is designed individually according to the patient s defect and the desired dimension of the augmentation 3. Design quality check The clinical user receives a 3D PDF file containing the virtually constructed maxgraft bonebuilder block and has to confirm its design. Alternatively, the virtual bone block can be adjusted according to specific requirements. 4. Individual order The production of the block starts after the clinical user fills in the patient based order form for the bone block to the attention of C + TBA, the responsible tissue bank. 5. Production of the individual bone block At C + TBA the *.stl data of the design is imported into a milling machine and a block of maximally 23 x 13 x 13 mm is produced. Product Specifications maxgraft bonebuilder Art.-No. Content... PMIa Individual planning and production of a bone transplant max. dimensions 23 x 13 x 13 mm 13
14 soft tissue regeneration Jason membrane collprotect membrane mucoderm Jason fleece collacone 14
15 Jason membrane Native pericardium GBR/GTR membrane Jason membrane is a native collagen membrane of porcine pericardium, developed and manufactured for dental tissue regeneration. SEM: Jason membrane Due to the unique patented production process, the superior properties of the native pericardium are preserved. The inherent structure of the membrane provides a long-lasting barrier function for 12 to 28 weeks. Easy handling, tear resistance, slow resorption and SEM: Jason membrane threedimensional structure... therapeutic safety are the essential characteristics of the Jason membrane. The Jason membrane has a smooth side with a denser structure (marked with G) and a rough side to be placed towards the bone as a guide for cell and blood vessel ingrowth. Indications: Implantology, Periodontology and Oral and CMF Surgery - Implant dehiscence - Sinus lift - Protection of Schneiderian membrane - Fenestration defects - Extraction sockets - Ridge preservation - Horizontal and vertical augmentation - Alveolar ridge reconstruction - Intraosseous defects (1-3 walls) - Furcation defects (class I-II) Good handling of Jason membrane after rehydration Histology of Jason membrane 24 weeks after implantation shows perfect integration without inflammatory reaction Properties - Long-lasting barrier function for ~12 to 28 weeks - Native structure of low thickness - Easy manipulation, may be applied dry or wet - No stickiness after rehydration - Fast vascularization due to three-dimensional structure - Multidirectional strength and tear resistance Product Specifications Jason membrane Art.-No Size Content x 20 mm 1 membrane x 30 mm 1 membrane x 40 mm 1 membrane titan pin set 1 set titan pins 3 mm 10 pieces 15
16 collprotect membrane Native collagen membrane The collprotect membrane is a natural collagen membrane, which due to its rough and porous three-dimensional structure achieves optimal treatment results by ensuring controlled wound healing along with guided bone and tissue regeneration. During the regeneration process the collprotect membrane offers the necessary barrier function balanced with a controlled resorption time without inflammatory soft tissue reaction. The soft tissue around the collprotect membrane usually heals without complications, also in cases of postoperative dehiscence. The pore size of the collprotect membrane prevents rapid ingrowth of soft tissue whilst allowing blood vessel and nutrient penetration, leading to quick integration into the surrounding tissue. This unique biological function provides a perfect basis for hard and soft tissue healing. SEM: collprotect membrane Indications: SEM: collprotect membrane Implantology, Periodontology and Oral and CMF Surgery - Protection or covering of minor perforations of the Schneiderian Membrane - Sinus lift - Socket preservation - Horizontal and vertical ridge augmentation - GBR/GTR simultaneous use with bone substitutes - Fenestration and dehiscence defects Properties - Three-dimensional natural collagen matrix - Controlled wound healing and blood clot support - Optimal barrier function in GBR/GTR procedures - Resorption time approx. eight to 12 weeks - Easy application and handling in dry or wet status - Rough and porous structure for cell guidance - Natural collagen structure Product Specifications collprotect membrane Art.-No Size Content x 20 mm 1 membrane x 30 mm 1 membrane x 40 mm 1 membrane titan pin set 1 set titan pins 3 mm 10 pieces Histology six weeks after implantation of collprotect membrane: Blood vessels have penetrated the porous structure; Collagen fibres are visible and the resorption proceeds without any inflammatory tissue response... 16
17 mucoderm 3D-stable soft tissue (Collagen) graft mucoderm is a collagen tissue matrix derived from porcine dermis that passes through a multi-stage cleaning process, which removes all potential immunogenic components from the dermis. The remaining matrix is a membrane consisting of collagen and elastin. SEM: mucoderm mucoderm supports revascularization and fast soft tissue integration and is a valid alternative to the patient s own connective tissue. After placement, the patient s blood infiltrates the mucoderm graft through the three-dimensional soft tissue network, bringing host cells to the soft tissue graft surface and starting the revascularization process. Significant revascularization may begin after implantation depending on the health condition of the patient. mucoderm offers a safe alternative to autologous connective tissue for many soft tissue grafting indications. Easy handling properties of mucoderm after rehydration with sterile saline... Properties - Rapid revascularization and integration - Soft tissue replacement without palatal autograft harvesting - Complete remodeling into patient s own tissue - Resorption time approx. six to nine months - May be easily applied and fixed - May be cut to shape for specific procedures After rehydration mucoderm may be cut to shape... Indications: Immunohistology three months after implantation - excellent vascularization of the mucoderm matrix Product Specifications mucoderm Implantology, Periodontology and Oral and CMF Surgery - Root coverage - Soft tissue grafting in combination with GBR/GTR - Broadening of attached gingiva Art.-No Size Content x 20 mm 1 matrix x 30 mm 1 matrix x 40 mm 1 matrix 17
18 Jason fleece Collagenic hemostypt (Sponge) Jason fleece is a ph-neutral, wet-stable hemostypt made of native collagen. The quick hemostatic effect of collagen is well-known and induced by the adhesion of platelets to the collagen fibrils. As a consequence, platelets aggregate and release coagulation factors by degranulation. This initiates the coagulation cascade resulting in hemostasis. The Jason fleece is designed for use in extraction sockets or coverage procedures. The collagen wound dressing protects the bone graft material and induces blood clot formation and stabilization of the wound. Jason fleece is also available preloaded with Gentamycin (Jason G). SEM: fleece SEM: Jason fleece 3D structure Properties - Highly effective hemostypt - Fast resorption by enzymatic degradation - Easy application - Maintains integrity in the presence of blood and during application - Wound protection and support of wound healing... Jason fleece wet-stable and fast uptake of blood Indications: 18 Implantology, Periodontology and Oral and CMF Surgery - Minor oral wounds - Closure of grafted sites - Protection of Schneiderian Membrane - Extraction sites - Mucosal flaps - Biopsy sites - Periodontal bone defects Clinical use of Jason fleece Product Specifications Jason fleece Art.-No. Size Content x 20 mm 12 pieces x 50 mm 10 pieces Jason G Gentamycin preloaded collagen fleece Art.-No. Size Content x 25 mm 12 pieces (single sterile units) Jason fleece in blister pack
19 collacone Collagenic hemostypt (Cone) collacone is both a resorbable native collagen cone intended to assist the wound healing process, and a natural matrix providing SEM: collacone the structure for new bone formation. The healing of an extraction socket following tooth removal is characterized by the formation and maturation of a blood clot, followed by infiltration of fibroblasts to replace the coagulum, and finally establishment of a provisional matrix that allows new bone tissue Indications: Implantology, Periodontology and CMF Surgery formation within the extraction socket. 1 SEM: collacone collagen fibers three-dimensional network... collacone wet-stable, fast uptake of blood and stabilization of the blood coagulum... Properties - Resorption within ~two to four weeks - Stabilization of blood clot and efficient local hemostasis - Maintains integrity in the presence of blood and during application - Wound protection - Three-dimensional matrix for tissue ingrowth - Controlled wound healing process - Native collagen cone - Hemostatic reactivity - Closure of extraction sites - Biopsy sites - Minor oral wounds - Control and stop of bleeding in extraction sockets or biopsy sites - Internal sinus lift Clinical use of collacone 1 G. Cardaropoli et al. J Clin Periodontol 2003; 30: Product Specifications collacone Art.-No Shape Dimension Content ~16 mm height, 12 pieces width on top ~11 mm, (single sterile bottom width ~7 mm units) 19
20 Innovation. Regeneration. Aesthetics. dental bone & tissue regeneration botiss biomaterials Education. Welcome to education Welcome to science, welcome to innovation, welcome to regeneration, welcome to fun. botiss invests substantially into research and education. Live Webinars Interact with our world renowned dental professionals and experts to get Live C.E. Credits On-Demand Courses Watch fantastic On- Demand Courses whenever you want From the Lab Comment on Clinical Articles and leave your thoughts 20
21 Among other things these topics and speakers are available Henriette Lerner Soft and hard tissue surgery with mucoderm Jan Kielhorn Cortical struts and computer aided bone augmentation Adrian Kasaj Recession coverage new regenerative materials Fabian Hirsch Modernes Wundmanagement der Einsatz körpereigener Wachstumsfaktoren im zahnärztlichen Alltag Peter Randelzhofer Immediate and early implant placement: Decision criteria and techniques for achieving long term success Bernhard Giesenhagen The bone ring technique - new perspectives in augmentation Marius Steigmann Soft tissue management for bone augmentation Markus Schlee Customized allogenic bone blocks - an innovative augmentation technique Daniel Rothamel Sinus lift procedures in the daily practice 21
22 Clinical Cases Implantology, Periodontology, Oral and CMF Surgery Sinus lift: cerabone ; Jason membrane Dr. Alessandro Rossi, Milan Clinical view of the sinus lift area Preparation of the lateral sinus window Filling of the sinus cavity with cerabone mm particle size Covering the lateral sinus area with Jason membrane 20 x 30 mm size Sinus lift and lateral augmentation: maxresorb ; Jason membrane PD Dr. Dr. Daniel Rothamel, Cologne Preparation of a lateral sinus window Sinus lift and additional lateral augmentation with maxresorb mm Covering of the augmentation area with Jason membrane Bony regeneration six months after implant insertion Sinus lift and ridge augmentation with simultaneous implantation: cerabone ; Jason membrane Dr. Derk Siebers, Berlin Filling of sinus cavity with cerabone 1-2 mm Immediate implantation Clinical view after augmentation with cerabone and implant insertion Final prosthetic restoration Sinus lift: cerabone ; collprotect membrane; Jason fleece Dr. Viktor Kalenchuk, Chernivtsi Filling of subantral cavity with cerabone mm Covering of the augmentation site with collprotect membrane Soft tissue defect coverage with Jason fleece and wound closure Soft tissue situation after six months healing time 22
23 Clinical Cases Implantology, Periodontology, Oral and CMF Surgery Immediate implantation: maxresorb inject; Jason membrane Dr. Damir Jelušić, Opatija Immediate implantation into extraction socket Placement of Jason membrane at the buccal bone wall maxresorb inject placed at buccal wall and protected by Jason membrane Clinical view at control one year after surgery Circular bone splitting: maxresorb ; collprotect membrane PD Dr. Jörg Neugebauer, Landsberg Deep bone splitting with oscillating saw in region 15 to 25 Lateral deposition of maxresorb to prevent resorption of the vestibular wall Covering of the augmentation site with the initially inserted collprotect membrane Soft tissue situation after healing with inserted abutments Implant dehiscence: cerabone ; Jason membrane Dr. Marius Steigmann, Neckargemünd Clinical situation after implant insertion Augmentation of the vestibular wall with cerabone mm particle size Covering of the augmentation site with Jason membrane Final prosthetic restoration Ridge augmentation: maxgraft cancellous block; cerabone ; Jason membrane Dr. Damir Jelušić, Opatija Athrophic maxillary ridge after flap preparation and perforation of cortical bone Fixation of adjusted maxgraft blocks Filling of residual gaps with cerabone and covering with Jason membrane Regenerated ridge three months postoperative after insertion of implants and healing abutments 23
24 Clinical Cases Implantology, Periodontology, Oral and CMF Surgery Ridge augmentation: maxgraft bonebuilder; Jason membrane Dr. Markus Schlee, Forchheim Clinical situation before maxgraft bonebuilder augmentation maxgraft bonebuilder block fixation, perfect bone to block surface contact Complete maxgraft bonebuilder block coverage with Jason membrane 20 x 30 mm size Wound closure and suturing Ridge augmentation: cerabone ; maxgraft ; Jason fleece; PRF Dr. Reda Benkiran, Cannes Clinical situation after implant placement Vertical and horizontal augmentation with cerabone and maxgraft particles (mix ratio 1:1) Covering of the augmentation area with Jason fleece soaked with PRF Covering with patient s own PRF matrix Ridge augmentation with simultaneous implantation: maxresorb inject; Jason membrane Dr. Dr. Andres Stricker, Konstanz Situation before implantation and augmentation Implantation and augmentation with maxresorb inject Covering of the augmentation site with Jason membrane Situation four months postoperative after healing Filling of biopsy harvesting site: Jason fleece Dr. Roland Török, Nuremberg Clinical situation Jason fleece placed in biopsy harvesting site Closure of biopsy site Recession coverage with gingival soft tissue graft 24
25 Clinical Cases Implantology, Periodontology, Oral and CMF Surgery Augmentation of attached gingiva; mucoderm instead of free mucosal graft Dr. Dr. Andres Stricker, Konstanz Clinical situation before surgery Preparation of mucosal flap, mucoderm rehydrated and cut to shape mucoderm sutured to periosteum and left exposed for open healing Situation four months after surgery Root coverage by tunnel technique : mucoderm Dr. Ziv Mazor, Ra anana Clinical situation before surgery mucoderm placement by tunnel technique Repositioning of flap over tooth roots and mucoderm Clinical situation at three years follow-up Recession coverage: mucoderm PD Dr. Stefan Hägewald, Berlin Clinical situation of the root recession before mucoderm placement mucoderm placement over the tooth root Recession coverage: mucoderm PD Dr. Adrian Kasaj, Mainz Gingival tissue coronally repositioned, covering the mucoderm and the roots of teeth, and sutured in place Two-year postoperative view: The previously recessed roots of the teeth are covered with attached pink, keratinized gingival tissue Recession before mucoderm application Split flap and placement of mucoderm over tooth Coronal repositioning, covering of root and mucoderm Six weeks postoperative, coverage of roots and thickening of marginal soft tissue 25
26 Clinical Cases Implantology, Periodontology, Oral and CMF Surgery Extraction socket: collacone Dr. Fernando Rojas-Vizcaya, Castellón and Chapel Hill Clinical situation after extraction Insertion of collacone in the extraction socket Suturing and open healing Clinical situation after healing and implantation Socket preservation: cerabone PD Dr. Adrian Kasaj, Mainz After tooth extraction, a large-volume socket is visible cerabone mm particle size is inserted Covering with a soft tissue punch and suturing Clinical situation after four weeks healing time Ridge preservation: maxresorb inject Dr. Minas Leventis, Athens After surgical extraction a large bone defect is visible Filling of the defect with maxresorb inject Bone grafting material in place Wound closure Socket preservation: maxgraft ; mucoderm Dr. Algirdas Puisys, Vilnius Clinical situation after extraction mucoderm placed vestibularly and filling of socket with Bony regeneration at time of re-entry Final prosthetic restoration maxgraft 26
27 Product Portfolio Product Codes bone regeneration cerabone granules Art.-No. Particle Size Content mm 1 x 0.5 ml mm 1 x 1.0 ml mm 1 x 2.0 ml mm 1 x 5.0 ml mm 1 x 0.5 ml mm 1 x 1.0 ml mm 1 x 2.0 ml mm 1 x 5.0 ml cerabone block Art.-No. Dimension Content x 20 x 10 mm 1 x block maxresorb granules Art.-No. Particle Size Content mm (S) 1 x 0.5 ml mm (S) 1 x 1.0 ml mm (L) 1 x 0.5 ml mm (L) 1 x 2.0 ml maxresorb cylinder Art.-No. Dimension Content Ø 7.5 mm; height 15 mm 1 x cylinder Ø 6.0 mm; height 15 mm 1 x cylinder maxresorb blocks maxresorb inject Art.-No. Unit Content x syringe 1 x 0.5 ml x syringe 1 x 1.0 ml x syringe 1 x 2.5 ml Art.-No. Dimension Content x 10 x 10 mm 1 x block x 20 x 10 mm 1 x block maxgraft cancellous granules maxgraft blocks maxgraft bonering maxgraft bonebuilder Art.-No. Particle Size Content mm 1 x 0.5 ml mm 1 x 1.0 ml mm 1 x 2.0 ml mm 1 x 4.0 ml maxgraft cortical-cancellous granules Art.-No. Particle Size Content mm 1 x 0,5 ml mm 1 x 1.0 ml mm 1 x 2.0 ml mm 1 x 4.0 ml Art.-No. Particle Size Content uni-cortical 1 x block 10 x 10 x 10 mm uni-cortical 1 x block 20 x 10 x 10 mm cancellous 1 x block 10 x 10 x 10 mm cancellous 1 x block 20 x 10 x 10 mm Art.-No. Dimension Content height 10 mm, 1 x cancellous ring Ø 6 mm/3.5 mm (outer/inner diameter) height 10 mm, 1 x cancellous ring Ø 7 mm/3.5 mm (outer/inner diameter) maxgraft bonering surgical kit 1 set planator 6 mm 1 x bonering fix 1 x Art.-No. Content PMIa Individual planning and production of a bone implant from a 23 x 13 x 13 mm cancellous block soft tissue regeneration Jason membrane Art.-No Size Content x 20mm 1 membrane x 30mm 1 membrane x 40mm 1 membrane collprotect membrane Art.-No Size Content x 20mm 1 membrane x 30mm 1 membrane x 40mm 1 membrane Jason fleece Art.-No. Size Content x 20 mm 12 pieces x 50 mm 10 pieces Jason G Art.-No. Size Content x 25 mm 12 pieces mucoderm Art.-No Size Content x 20 mm 1 matrix x 30 mm 1 matrix x 40 mm 1 matrix collacone titan pin set Art.-No Content titan pin set 1 set titan pins 3 mm 10 pieces Art.-No Shape Dimension Content ~16 mm height, 12 pieces width on top ~11 mm, (single sterile bottom width ~7 mm units) 27
28 dental bone & tissue regeneration botiss biomaterials Innovation. Regeneration. Aesthetics. soft tissue education hard tissue botiss dental GmbH Uhlandstraße Berlin / Germany Fon Fax contact@botiss.com Rev.: PKen-03/
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