Regeneration Bone Grafting & Soft Tissue Management

Transcription

1 Regeneration Bone Grafting & Soft Tissue Management 1 Regeneration Bone Grafting & Soft Tissue Management

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3 Table of contents Bone Graft Material OSTEON II OSTEON OSTEON II Collagen OSTEON Collagen Membrane Collagen Membrane HA Collagen Membrane Bone Material Products 14 16

4 Dentium Regeneration Products information

5 Regeneration Bone Grafting & Soft Tissue Management 5 Bone Graft Material OSTEON II OSTEON OSTEON II Collagen OSTEON Collagen

6 6 Regeneration Bone Grafting & Soft Tissue Management Application of OSTEON II Sinus Lift Ridge Augmentation Extraction Socket Grafting Cystic Cavities Periodontal Defect Composition of OSTEON II Osteoconductive biphasic calcium phosphate with higher β-tcp OSTEON II = HA 30% + β-tcp 70% Characteristics of OSTEON II Highly resorbable due to higher β-tcp content Convenient handling Excellent wettability Osteoconductive synthetic bone graft Pore Size : 250 μm Porosity : 70% Cell Adhesion Test In Vitro Dissolution Test Microsturcure 500 μm 100 μm X 1000 Osteoblasts attached & spreaded well Animal Test 12-weeks follow up in rabbit calvaria model OSTEON OSTEON II

7 Regeneration Bone Grafting & Soft Tissue Management 7 Application of OSTEON Sinus Lift Ridge Augmentation Extraction Socket Grafting Cystic Cavities Periodontal Defect Composition of OSTEON 100% Synthetic bone graft : HA scaffold coated with β-tcp OSTEON = HA 70% + β-tcp 30% Characteristics of OSTEON 100% synthetic bone graft Interconnected porous structure similar to that of human cancellous bone Osteoconductive material as a bone growth scaffold Pore Size : 300~500 μm Porosity : 77% OSTEON Human bone Cell Adhesion Test Human ostelblast cell OSTEON X 1000 X 1000 X 5000 Osteoblast cell was well attached and spreaded on OSTEON surface. Human Histology OSTEON New bone OSTEON OSTEON New bone New bone 0.5mm 0.25mm 1.0mm 1.5mm 0.5mm 0.25mm 6.5 months after sinus graft surgery OSTEON area = 1.24mm2 (17.1%) New bone area = 1.63mm2 (22.7%) 10 months after sinus graft surgery OSTEON area = 3.04mm2 (35.5%) New bone area = 2.38mm2 (27.7%) 21 months after sinus graft surgery OSTEON area = 6.30mm2 (40.4%) New bone area = 5.12mm2 (33.0%)

8 8 Regeneration Bone Grafting & Soft Tissue Management Syringe Size Product OSTEON Sinus OSTEON II Sinus OSTEON Lifting OSTEON II Lifting Syringe outer diameter Syringe inner diameter Ø7.0mm Ø5.0mm Ø5.0mm Ø3.4mm Application of OSTEON ① Slightly retract the plunger and gently tap to loosen particles. Gently push plunger back into place. ② Place syringe into a sterile dappen dish and retract plunger to draw liquid into the syringe. ③ To optimize delivery, OSTEON should be wetted and loosened sufficiently. ④ Expel excess liquid by applying very gentle pressure on the plunger. ⑤ When sufficiently hydrated, OSTEON will expel with ease from the syringe. Before injecting OSTEON, remove the cap from the syringe. ⑥ Deliver OSTEON directly into the surgical site with the syringe.

9 Regeneration Bone Grafting & Soft Tissue Management 9 Application of OSTEON II Collagen Simple Grafting Ridge Augmentation Extraction Socket Grafting Cystic Cavities Periodontal Defect Characteristics of OSTEON II Collagen Composed of synthetic bone graft material (OSTEON II) and natural Type I Collagen Moldable property to accommodate any shape or form Significantly reduce chairtime due to excellent handling and delivery Collagen content becomes resorbed over several weeks after the initial shaping OSTEON II is highly resorbable due to higher β-tcp content (HA:β-TCP=30:70) Microstructure In Vitro Dissolution Test of OSTEON II Animal Test Animal: New Zealand White Rabbit Implantation Area : Femur Period : 6 Weeks Visual: CT Image

10 10 Regeneration Bone Grafting & Soft Tissue Management Application of OSTEON Collagen Sinus Lift Ridge Augmentation Extraction Socket Grafting Cystic Cavities Periodontal Defect Description OSTEONTM Collagen is a bone void filler composed of synthetic bone(osteon ), and natural type I collagen. Characteristics of OSTEON Collagen Composed of synthetic bone graft material (OSTEON ) and natural Type I Collagen Moldable property to accommodate any shape or form Significantly reduce chairtime due to excellent handling and delivery Collagen content becomes resorbed over several weeks after the initial shaping Excellent new bone formation and space maintenance function Cell Adhesion Test X 1000 X 5000 Osteoblasts cultured and permeated well on the OSTEON Collagen surface Animal Test Animals: new zealand white rabbit Implantation area: calvaria Period: 8 weeks Staining method: goldner trichrome

11 Regeneration Bone Grafting & Soft Tissue Management 11 Membrane Material Collagen Membrane HA Collagen Membrane

12 12 Regeneration Bone Grafting & Soft Tissue Management Application of Collagen Membrane Periodontal / Infrabony Defects Ridge Augmentation Extraction Socket Grafting Guided Bone Regeneration(GBR) Sinus Lift Characteristics of Collagen Membrane Biodegradable barrier membrane for guided bone and tissue regeneration Highly pure Type I Collagen derived from bovine tendon sourced in New Zealand Thin membrane (300µm) with multiple layers for easy manipulation and high mechanical strength in surgery Resorption period of 6 months to provide enough time for stabilizing graft material and supporting bone growth In Vitro Dissolution Test Microstructure X 1000 Animal Test X weeks follow-up in Rabbit Calvaria model

13 Regeneration Bone Grafting & Soft Tissue Management 13 Application of HA Collagen Membrane Periodontal / Infrabony Defects Ridge Augmentation Extraction Socket Grafting Guided Bone Regeneration (GBR) Sinus Lift Characteristics of HA Collagen Membrane Resorbable collagen membrane containing hydroxyapatite (HA) particles Highly pure Type I Collagen derived from bovine tendon sourced in New Zealand Highly osteoconductive due to the HA particles New bone formation through the membrane Cell Adhesion Test Microstructure X 500 X 1000 MC3T3 / E1 (Osteoblast cell) Animal Test 12 weeks follow-up in Rabbit Calvaria Model X 70000

14 14 Regeneration Bone Grafting & Soft Tissue Management Bone Material Products OSTEON II Type OSTEON II (Vial type) OSTEON II Sinus (Syringe type) REF Size (mm) Volume (cc) DT7G DT7G /0.25/0.5 DT7G ~ /2.0 DT7G DT7G DT7G DT7G /0.25/0.5 DT7G ~ /2.0 DT7G DT7G DT7G DT7G /0.25/0.5 DT7G ~ /2.0 DT7G DT7G DT7G SS DT7G SS 0.5~ ~ ~ ~2.0 OSTEON II Lifting (Syringe type) DT7G LS DT7G LS 0.2~ ~ OSTEON Type OSTEON (Vial type) OSTEON Sinus (Syringe type) REF Size (mm) Volume (cc) GBG GBG / ~0.5 GBG / 2.0 GBG GBG GBG / ~1.0 GBG / 2.0 GBG GBG GBG / ~2.0 GBG / 2.0 GBG GBG0510SS 0.5~ GBG1020SS 1.0~2.0 OSTEON Lifting (Syringe type) GBG0305LS GBG0510LS 0.3~ ~

15 Regeneration Bone Grafting & Soft Tissue Management 15 OSTEON TM Collagen Type REF Size (mm) Volume (cc) OtSTEON TM Collagen Cylinder GOCC0605 GOCC0610 Ø6.0 x 5.0 Ø6.0 x ~ 1.0 OSTEON TM II Collagen Type REF Size (mm) Volume (cc) OSTEON TM II Collagen Cylinder OTCC0605M OTCC0610M Ø6.0 x 5.0 Ø6.0 x ~1.0 Collagen Membrane Type Collagen Membrane REF Size (cc) Thickness (mm) GCM1020 GCM1520 GCM X X X HA Collagen Membrane Type HA Collagen Membrane REF Size (cc) Thickness (mm) GCHM 1020 GCHM 1520 GCHM X X X

16 16 Regeneration Bone Grafting & Soft Tissue Management The All-round Products in Bone Related Cases Dentium s regeneration products are covering all round of the bone related clinical cases. Each of OSTEON TM series has characteristic and own materials it made for. Dentium s regeneration products are applicable to a variety of surgical parts. Series of regeneration products will take big role in the treatment area of GBR and considering expanding to practitioners and patients. β-tcp content Convenient Operability Extraction socket with intact socket Soft tissue regeneration Sinus elevation Extraction socket with defective socket Peri-implantitis Major bone augmentation Minor bone augmentation Periodontal defects

17 Regeneration Bone Grafting & Soft Tissue Management 17 Socket preservation OSTEON II Collagen OTCC0605M Pre-op Extraction OSTEON ll Collagen Post-op Provisional restoration OSTEON II Collagen OTCC0605M x 2ea OSTEON ll Collagen After bone graft Post-op Healing 3months Provisional restoration Follow up 2 years 4 months Follow up 3 years

18 18 Regeneration Bone Grafting & Soft Tissue Management Immediate implantation OSTEON ll DT7G cc Collagen Membrane GCM1020 Pre-op Implantation SuperLine 4012 OSTEON ll Collagen Membrane Post-op Healing 2 months, 2 nd surgery OSTEON II DT7G cc Collagen Membrane GCM1020 Pre-op Extraction & Flap reflection Implantation #26 SuperLine 5010 #27 SuperLine 6012 Autogenous bone OSTEON ll Collagen Membrane Healing 3 months, 2 nd surgery

19 Regeneration Bone Grafting & Soft Tissue Management 19 OSTEON ll DT7G cc x 2ea HA Collagen Membrane GCHM1520 x 2ea Flap reflection Extraction Implantation #11 SuperLine 4012 #12 SuperLine 3612 OSTEON ll, HA Collagen Membrane After 3 months OSTEON II DT7G cc Pre-op Extraction Implant guide OSTEON ll Implantium ll 3810 Post-operative Healing 2 months

20 20 Regeneration Bone Grafting & Soft Tissue Management Ridge preservation for delayed implant placment OSTEON II Collagen OTCC0605M Extraction socket OSTEON ll Collagen, Post-op Healing 2 months 1 week Flap reflection Implantation SuperLine 4508 OSTEON II Collagen OTCC0605M x 2ea Extraction OSTEON ll Collagen Post-op Healing 2 months Implantation NR Line 3611S, OSTEON ll Collagen Healing 3 months 2 nd surgery

21 Regeneration Bone Grafting & Soft Tissue Management 21 OSTEON II Collagen OTCC0610M OTCC0605M Flap reflection OSTEON ll Collagen Healing 3 months Implantation SuperLine 4010 OSTEON ll Collagen Follow up 1 year 4 months OSTEON II Collagen OTCC0610M Extraction OSTEON ll Collagen Post-op Healing 1 year Implantation SuperLine 5010 Post-op Healing 2 weeks Provisional restoration

22 22 Regeneration Bone Grafting & Soft Tissue Management Ridge preservation for delayed implant placment OSTEON II DT7G cc Collagen Membrane GCM1020 Pre-op Implantation SuperLine 5008 Autogenous bone OSTEON ll Collagen Membrane OSTEON II DT7G cc Collagen Membrane GCM1520 Pre-op Flap reflection Decotification Implantation SuperLine 4508, Implantium 3810 OSTEON ll, Collagen Membrane Healing 4 month Flap reflection 2 nd Surgery

23 Regeneration Bone Grafting & Soft Tissue Management 23 OSTEON II DT7G cc OSTEON II Collagen OTCC0605M Pre-op Implantation SimpleLine ll S OSTEON ll Collagen Healing 2 weeks Follow up 11 months OSTEON II DT7G cc Collagen Membrane GCM1020 x 2ea Using spreader drill Implantation #23 SuperLine 4010 #24 SuperLine 4510 Autogenous bone graft OSTEON ll, Collagen Membrane Collagen Membrane Healing 5 months 2 nd Surgery Follow up 6months

24 DENTIUM LONG-TERM CLINICAL DATA Pre-op Post-op

25 YEARS years years OVER A DECADE OF COMMITMENT TO THE BEST PRODUCTS FOR DENTISTS AND PATIENTS

26 Regeneration Specifications are subject to change without prior notice. Some products to be launched in the market after necessary approvals are also listed in this catalog. HEAD OFFICE 504 Gyeonggi R&DB Center, 105 Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, Korea [ ] T F biz_mail@dentium.com / RECO-1504 [REV.1] MANUFACTURER 1F, Gyeonggi R&DB Center / 226, 2F, GSBC, 105 Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, Korea 1F, 31, Deogyeong-daero 1499beon-gil, Yeongtong-gu, Suwon-si, Gyeonggi-do, Korea T F