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1 Supplementary Online Content Chernoff KA, Marghoob AA, Lacouture ME, Deng L, Busam KJ, Myskowski PL. Dermoscopic findings in cutaneous metastases. JAMA Dermatol. Published online January 15, doi: /jamadermatol ereferences. Supplemental References etable 1. Clinical Characteristics etable 2. Summary of Dermoscopic Features in 17 Nonpigmented Lesions etable 3. Summary of Dermoscopic Features in 3 Pigmented Lesions This supplementary material has been provided by the authors to give readers additional information about their work.

2 ereferences. Supplemental References 15. De Giorgi V, Alfaioli B, Massi, D et al. Solitary Cutaneous Metastasis as the First Sign of Relapse of Thyroid Carcinoma: A Clinical, Dermoscopic-Pathologic Case Study. Dermatol Surg 2009;35: Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricala C, Argenziano G. How to diagnosis nonpigmented skin tumors: a review of vascular structures seen with dermoscopy, part II. Nonmelanocytic skin tumors. J Am Acad Dermatol 2010 Sep;63(3): Argenziano G, Zalaudek I, Corona R, et al: Vascular structures in skin tumors: A dermoscopic study. Arch Dermatol 2004;140: Virgili A, Zampino MR, Corazza M. Primary Vulvar Melanoma with Satellite Metastases: Dermoscopic Findings. Dermatology 2004;208: Minagawa A, Koga H, Sakaizawa K, Sano K, Saida T. Dermoscopic and histopathological findings of polymorphous vessels in amelanotic cutaneous metastasis of pigmented cutaneous melanoma. British Journal of Dermatology 2009;160: Braun RP, Rabinovitz H, Tzu JE, Marghoob AA. Dermoscopy Research An Update. Seminars in Cutaneous Medicine and Surgery 2009;28: Azzopardi JG, Eusebi V. Melanocyte colonization and pigmentation of breast carcinoma. Histopathology 1977;1: Wyatt AJ, Agero AL, Delgado R, Busam KJ, Marghoob AA. Cutaneous Metastatic Breast Carcinoma with Melanocyte Colonization: A Clinical and Dermoscopic Mimic of Malignant Melanoma. Dermatol Surg 2006;32:

3 23. Aguilar M, Gaffney EF, Finnerty DP. Prostatic melanosis with involvement of benign and malignant epithelium. J Urol 1982;128: Chumas JC, Lorella CA. Melanotic adenocarcinoma of the anorectum. Am J Surg Pathol19821;5: Thomas KM, Hutt MS, Borstein J. Salivary gland tumors in Malawi. Cancer 1980;46: Chiba H, Kazama T, Takenouchi T, et al. Two cases of vulval pigmented extra-mammary Paget s disease: histochemical and immunochemical studies. Br J Dermatol 2001;142: Matsumoto M, Sonobe H, Takeuchi T, et al. Pigmented squamous cell carcinoma of the scrotum associated with a lentigo. Br J Dermatol 1999;141: Braitman M. Supervision of a pigmented basal-cell carcinoma upon a nevus sebaceus. J Dermaol Surg Oncol 1979;5: Stante M, degiorgi V, Massi D, Chiarugi A, Carli P. Pigmented Bowen s disease mimicking cutaneous melanoma: clinical and dermoscopic aspects. Dermatol Surg 2004;30: Nakanishi Y, Matsuno Y, Shimoda T, et al. Eccrine porocarcinoma with melanocyte colonization. Br J Dermatol 1998; 139: Lee HJ, Jeong SH, Seo EJ, Ha SJ, Kim JW. Melanocyte colonization associated with malignant transformation of eccrine poroma. Br J Dermatol 1999;141: Marcus JN, Dise CA, LiVolsi VA. Melanin production in medullary thyroid carcinoma. Cancer 1982;49: Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 2002;29(suppl. 16):15-8.

4 34. Giovagnorio F, Valentini C, Paonessa A. High-resolution and color Doppler sonography in the evaluation of skin metastases. J Ultrasound Med 2003 Oct;22(10): Wobser M, Siedel C, Schrama D, Bröcker EB, Becker JC, Vetter-Kauczok CS. Expression pattern of the lymphatic and vascular markers VEGFR-3 and CD31 does not predict regional lymph node metastasis in cutaneous melanoma. Arch Dermatol Res 2006;Feb 297(8): Marneros A. Tumor Angiogenesis in Melanoma. Hematol Oncol Clin N Am 2009;23:

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7 etable 2. Summary of Dermoscopic Features in 17 Nonpigmented Lesions Dermoscopic Finding # of cases % of non-pigmented cases Serpentine (linear irregular) vessels Arborizing vessels 9 53 Dotted vessels 4 24 Comma vessels 3 18 Homogenous pink/structureless area 2 12 Blue-gray ovoid nest 1 6

8 etable 3. Summary of Dermoscopic Features in 3 Pigmented Lesions Dermoscopic Finding # of cases % of pigmented cases Pigmented Streaks Globules 2 50 Blue-white veil 1 33 Dotted vessels 1 33