GRANULOLYSIS IN A CELLS OF ENDOCRINE PANCREAS AND EXPERIMENTAL DIABETES IN ANIMALS
|
|
- Shona Rich
- 5 years ago
- Views:
Transcription
1 Published Online: 1 August, 1968 Supp Info: Downloaded from jcb.rupress.org on December 25, 2018 GRANULOLYSIS IN A CELLS OF ENDOCRINE PANCREAS IN SPONTANEOUS AND EXPERIMENTAL DIABETES IN ANIMALS L. ORCI, A. JUNOD, R. PICTET, A. E. RENOLD, and C. ROUILLER. From Institut d'histologie and Institut de Biochimie Clinique, Universit6 de Gentve, Gen6ve, Switzerland By comparison with the B cell of the endocrine pancreas, the A cell has been little studied both in the normal and in pathologic states. Recently, however, several publications have been devoted to A-cell morphology and secretory cycle (1), and to the still controversial distinction between several A-cell types (2). Furthermore, with the availability of the immunoassay procedures for glucagon (3), dynamic studies of glucagon secretion have become possible. The suggestion has been made that glucagon not only opposes insulin action but also favors it through stimulation of insulin release (4). This double relationship proposed between the two major types of endocrine pancreatic cells prompts us to report on a striking increase in A-cell lysosomes which we have observed in two types of diabetes in animals: the spontaneous diabetes of spiny mice (Acomys cahirinus) and the experimental diabetes resulting from the injection of streptozotocin in rats. In both instances, the increased A-cell lysosomes were associated with evidence for lysis of alpha granules. Acomys cahirinus is a small rodent living in semidesertic regions of the southeastern Mediterranean region. All specimens which we have examined exhibited marked congenital hyperplasia of the islets of Langerhans (5). Diabetes occurred spontaneously in approximately 15% and was either intermittent or, in most instances, persistent. It was characterized by hyperglycemia, decreased levels of immunoreactive insulin in 462 B R I E F N O T E S
2 FIGURE 1 Adult diabetic spiny miouse. In the center part of all A cell, where lysosomes of several types may be seel; some contain secretory granules (sg) still recognizable at different stages of degradation (lb); others contain heterogenous material. G, Golgi complex; n, nucleus; B, parts of B cells, filled with glycogen. Fixation in 2% osmium tetroxide in 0.13 M phosphate buffer. Epon embedding. Lead stain. X 26,
3 FIGURE 2 A cell from diabetic rat, 3 months after the intravenous injection of 45 mg/kg streptozotocin. Secretory granules are recognizable within several Iytic bodies (lb). C, capillary. m, mitochondria. n, nucleus. G, Golgi complex of an exocrine cell. Perfusion with glutaraldehyde and postfixation in 2% osmium tetroxide. Epon embedding. Lead stain. X 20,000. FIGURES 3 and 4 Diabetic rat, 3 wk after the intravenous injection of 55 mg/kg streptozotocin. Lytic bodies contain up to five secretory granules. Fixation in 2 % osmium tetroxide buffered with s-collidine. Epon embedding. Lead stain. Fig. 3, X 38,000; Fig. 4, X 47,000. FIGURE 5 Diabetic rat, 3 wk after the intravenous injection of 55 mg/kg streptozotocin. Residual body. Fixation in 2% osmium tetroxide buffered with s-collidine. Epon embedding. Lead stain. X 45, B R I E F N T E S
4 plasma and pancreas, and finally by ketonuria. 1 Streptozotocin is a N-nitroso derivative of glucosamine and has antibiotic and antitumoral properties. It is a potent diabetogenic agent (6) as a result of rapid, irreversible, and specific cytotoxicity limited to the B cells of the pancreas (7). Intravenous injection of a single dose of mg/kg streptozotocin is followed after 24 hr by a permanent diabetic state, characterized by hyperglycemia and reduction of the pancreatic insulin content to 5-10% of normal (7). Granulolysis in A cells was noticed as early as 3 wk after the appearance of diabetes and was still present after 9 months of untreated diabetes. In both types of diabetic animals, electron microscopic study of the endocrine pancreatic A cells revealed the frequent occurrence of cytoplasmic bodies containing granules easily identifiable as alpha granules by their shape, size, and density (Figs. 1-4). The number of granules within these bodies varied from one to five. These granules appeared to undergo gradual degradation, with different stages being simultaneously detectable within any one cell and even the same body. The final product of granular degradation was bodies filled with very fine granulations of varying densities. We suggest that these bodies are to be considered as lysosomes, with sequestration of granules occurring in dense bodies and subsequent evolution through autolysosomes to residual bodies (Fig. 5) (8). On the other hand, autophagic vacuoles containing other cellular organelles such as mitochondria or ribosomes were not seen. Nor were there clear-cut signs of increased protein synthesis. A-cell lysosomes have also been observed in metabolically normal rats and mice. However, they were much less numerous and did not, as a rule, show evidence of granulolysis. It would seem likely, therefore, that the formation of granulolytic lysosomes in endocrine A cells of the pancreas is somehow enhanced by the endocrine and metabolic derangements associated with the diabetic state. A direct action of streptozotocin appears unlikely, since the increase in A-cell lysosomes occurs weeks after the administration of the drug and, most significantly, since it is also seen in spontaneous diabetes in spiny mice, without any preceding or concomitant therapy whatever. As to the function of these granulolytic autolyso- 'Junod, A. Unpublished observations. somes, we can only speculate, of course. However, it would seem reasonable to mention three possible hypotheses within the wider framework of the probable functions of autolysosomes in general, as recently reviewed by de Duve and Wattiaux (8). Firstly, lysosomal granulolysis could favor cellular dedifferentiation, either preceding and leading to cellular destruction or returning the cell to a potentially more versatile state. A similar mechanism has been invoked as an explanation of the appearance of "mixed" or "intermediate" endocrine-exocrine cells in both normal and diabetic spiny mice (9) and in rats with chronic streptozotocin-induced diabetes. 2 Secondly, lysosomal granulolysis might represent solubilization of stored hormone prior to its secretion, as in the case of the mobilization of thyroglobulin from thyroidal colloid. However, evidence for such a release mechanism has never been reported for either pancreatic A or B cells and it would seem unlikely that chronic systemic hyperglycemia represents a major stimulus to the secretion of pancreatic glucagon (10). Also, increased lysosomal granulolysis was not associated with morphological evidence for increased protein secretion in A cells. Thirdly, in our present view, the most attractive hypothesis would assign to the granulolytic lysosomes the function of participating in the destruction of an unneeded secretory product, as might be true for glucagon in the presence of chronic hyperglycemia and lack of pancreatic insulin. While atrophy of A cells and decreased glucagon secretion are not generally accepted concomitants of spontaneous or experimental diabetes, a few recent reports on alloxanized rats (11) and diabetic Chinese hamsters (12) lend some support to this hypothesis. That lysosomes may play an important role in the involution of no longer stimulated secretory cells has been clearly demonstrated for pituitary MT cells after cessation of lactation (13). This work was supported by Fonds National Suisse de la Recherche Scientifique, grants No and Receivedfor publication 19 February REFERENCES 1. MUNGER, B Lab. Invest. 11: HELLERSTROM, C., and B. HELLMAN Proc. 2 Orci, L., and R. Pictet. Unpublished observations. B R E F N O T E S 465
5 Intern. Congr. Diabetes Federation 2 Ied. Hyg. 4th Genrve UNGER, R. H., A. M. EISENTRAUT, S. S. MCCALL, and L. L. MADISON J. Clin. Invest. 40: SAMOLS, E., J. TYLER, and V. MARKS Lancet. 2: GONET, A. E., W. STAUFFACHER, R. PICTET, and A. E. RENOLD Diabetologia. 1: RAKIETEN, N., M. L. RAKIETEN, and M. NAD KARNI Cancer Chemotherapy Rep. 29: JUNOD, A., A. E. LAMBERT, L. ORCI, R. PICTET, and A. E. RENOLD Proc. Soc. Exptl. Biol. Med. 126: DE DUVE, C., and R. WATTIAUX Ann. Rev. Physiol PICTET, R., L. ORCI, A. E. GONET, C. ROUILLER, and A. E. RENOLD Diabetologia. 3: UNGER, R. H., A. OANEDA, I. VALVERDE, A. M. EISENTRAUI, and J. EXTON J. Clin. Invest. 47: HELLMAN, B., and B. PETERSON Endocrinology. 72: CARPENTER, A. M., G. C. GERRITSEN, W. E. DULIN, and A. LAZAROW Diabetologia. 3: SMITH, R. E., and M. G. FARQUHAR J. Cell Biol. 31: B R I E F N 0 T E S
THE JOURNAL OF CELL BIOLOGY. VOLUME 60, pages
Published Online: 1 March, 1974 Supp Info: http://doi.org/10.1083/jcb.60.3.685 Downloaded from jcb.rupress.org on July 1, 2018 MONOLAYER CULTURES DERIVED FROM NEONATAL HAMSTER PANCREAS Light and Electron
More informationMorphological Characterization of Membrane Systems in A- and B-Cells of the Chinese Hamster*
Diabetologia 10, 529--539 (1974) 9 by Springer-Verlag 1974 Morphological Characterization of Membrane Systems in A- and B-Cells of the Chinese Hamster* L. 0rci, M. Amherdt, F. MMMsse-Lagae, A. Perrelet,
More informationEffect of glucose on beta cell proliferation and population size in organ culture of foetal and neonatal rat pancreases
J. Embryol. exp. Morph. 74, 303-312 (1983) 3Q3 Printed in Great Britain The Company of Biologists Limited 1983 Effect of glucose on beta cell proliferation and population size in organ culture of foetal
More informationBIOCHEMISTRY ondmolecular BIOLOGY INTERNATIONAL Poges
Vol. 40, No. 3, October 1996 BIOCHEMISTRY ondmolecular BIOLOGY INTERNATIONAL Poges 515-520 ATTENUATION BY NICOTINAMIDE OF THE STREPTOZOCIN INDUCED EARLY HYPERGLYCAEMIA IN FASTING RATS Kai K. Wong Department
More informationStrain Differences in the Diabetogenic Activity of Streptozotocin in Mice
1110 Biol. Pharm. Bull. 29(6) 1110 1119 (2006) Vol. 29, No. 6 Strain Differences in the Diabetogenic Activity of Streptozotocin in Mice Koji HAYASHI, Rhyoji KOJIMA, and Mikio ITO* Laboratory of Analytical
More informationDiabetogenic action of streptozotocin: relationship of dose to metabolic response
Diabetogenic action of streptozotocin: relationship of dose to metabolic response Alain Junod,, Werner Stauffacher, Albert E. Renold J Clin Invest. 1969;48(11):2129-2139. https://doi.org/1.1172/jci1618.
More informationThe Endocrine System Pituitary
The Endocrine System Pituitary Look at your slide of the human pituitary with your naked eye. You should see a cellular region and a more fibrous region. Then view each region with your microscope under
More informationHistology of the Thyroid Gland
Histology of the Thyroid Gland A Introduction The thyroid hormone is derived The thyroid gland is responsible for the secretion of the from the amino acid tyrosine thyroid hormone that controls the basal
More informationNew aspect of hepatic nuclear glycogenosis
J. clin. Path. (1968), 21, 19 New aspect of hepatic nuclear glycogenosis in diabetes1 F. CARAMIA, F. G. GHERGO, C. BRANCIARI, AND G. MENGHINI From the Institute of General Pathology, University of Rome,
More informationHormonal Regulations Of Glucose Metabolism & DM
Hormonal Regulations Of Glucose Metabolism & DM What Hormones Regulate Metabolism? What Hormones Regulate Metabolism? Insulin Glucagon Thyroid hormones Cortisol Epinephrine Most regulation occurs in order
More informationInsulin, Not C-Peptide (Proinsulin), Is Crinophagic Bodies of the Pancreatic B-Cell
Published Online: 1 January, 1984 Supp Info: http://doi.org/10.1083/jcb.98.1.222 Downloaded from jcb.rupress.org on November 18, 2018 Insulin, Not C-Peptide (Proinsulin), Is Present in Crinophagic Bodies
More informationMedical School Histology Basics Introduction to Microscopy. VIBS 289 lab
Medical School Histology Basics Introduction to Microscopy VIBS 289 lab Larry Johnson Texas A&M University Objectives Learn the difference in magnification and resolution Learn about different types of
More informationControl of Glucose Metabolism
Glucose Metabolism Control of Glucose Metabolism The pancreas is both an exocrine and endocrine gland. It secretes digestive enzymes into the duodenum (exocrine) and 3 specific hormones into the bloodstream
More informationDURING the past ten years it has been suggested that the classical form
163 The Golgi Apparatus and Lipoidal Bodies in Exocrine and Endocrine Cells in the Pancreas of Man By DENNIS LACY (From the Department of Zoology and Comparative Anatomy, St. Bartholomew's Medical College)
More informationExperiments were carried out then with the object of producing complete disappearance of the A
Relation of Glucagon to A Cells of the Pancreas*. (22339) SERGIO A. BENCOSME AND J. FREI. (Introduced by J.S.L. Browne Departament of pathology, Queen`s University, Kingston, Ontario, Canada. In spite
More informationHormonal regulation of. Physiology Department Medical School, University of Sumatera Utara
Hormonal regulation of nutrient metabolism Physiology Department Medical School, University of Sumatera Utara Homeostasis & Controls Successful compensation Homeostasis reestablished Failure to compensate
More informationArticle. Reference. Effect of insulin on glucose- and arginine-stimulated somatostatin secretion from the isolated perfused rat pancreas
Article Effect of insulin on glucose- and arginine-stimulated somatostatin secretion from the isolated perfused rat pancreas GERBER, Pietro, et al. Abstract The effects of exogenous insulin on somatostatin
More informationRELATIONS BETWEEN INSULIN AND PITUITARY HORMONES IN AMINO ACID METABOLISM
RELATIONS BETWEEN INSULIN AND PITUITARY HORMONES IN AMINO ACID METABOLISM BY WILLIAM D. LOTSPEICH* WITH THE TECHNICAL ASSISTANCE OF JOAN B. SHELTON (From the Department of Physiology, Syracuse University
More informationUltrastructural Study of Human Natural Killer CNK) Cell*)
Hiroshima Journal of Medical Sciences Vol. 31, No. 1, March, 1982 HJIM 31-6 31 Ultrastructural Study of Human Natural Killer CNK) Cell*) Yoshinori KAWAGUCHI, Eishi KITTAKA, Yoshito TANAKA, Takeo TANAKA
More information6. The diagram below represents an interaction between parts of an organism.
Endocrine Review 1. Base your answer to the following question on the diagram below and on your knowledge of biology. Each arrow in the diagram represents a different hormone released by the pituitary
More informationSTUDIES OF THE HUMAN UNFERTILIZED TUBAL OVUM*t
FERTILITY AND STERILITY Copyright @ 1973 by The Williams & Wilkins Co. Vol. 24, No.8, August 1973 Printed in U.S.A. STUDIES OF THE HUMAN UNFERTILIZED TUBAL OVUM*t C. NORIEGA, M.D., AND C. OBERTI, M.D.
More informationAdrenal gland And Pancreas
Adrenal gland And Pancreas Structure Cortex Glucocorticoids Effects Control of secretion Mineralocorticoids Effects Control of secretion Sex steroids Medulla Catecholamines Adrenal cortex 80% of an adrenal
More informationAge Related Histomorphological and Transmission Electron Microscopic Studies of the Pancreatic Islets in Goats
IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS) e-issn: 2319-2380, p-issn: 2319-2372. Volume 8, Issue 11 Ver. II (Nov. 2015), PP 37-45 www.iosrjournals.org Age Related Histomorphological
More informationEffect of Cobalt Chloride on Blood Glucose, Plasma Insulin and Lipids in Rabbits.
Effect of Cobalt Chloride on Blood Glucose, Plasma Insulin and Lipids in Rabbits. Masayoshi Ohmichi, Hiroyuki Morita, Yoko Onuma and Shigeo Koike Department of Hygiene, School of Medicine, Showa University,
More informationStudies of streptozotocin-induced insulitis and diabetes
Proc. NatI. Acad. Sci. USA Vol. 7, No. 6, pp. 285-289, June 1977 Cell Biology "I ",.-" I-,- -i,' Studies of streptozotocin-induced insulitis and diabetes (pancreatic beta cells/islets of Langerhans/alloxan
More informationEssentials of Anatomy and Physiology, 9e (Marieb) Chapter 3 Cells and Tissues. Short Answer. Figure 3.1
Essentials of Anatomy and Physiology, 9e (Marieb) Chapter 3 Cells and Tissues Short Answer Figure 3.1 Using Figure 3.1, match the following: 1) The illustration of simple cuboidal epithelium is. Answer:
More informationInsulin and glucagon release from the isolated pancreas of foetal and newborn mice
/. Embryol. exp. Morph. Vol. 28, 3, pp. 607-614, 1972 607 Printed in Great Britain Insulin and glucagon release from the isolated pancreas of foetal and newborn mice ByAKE LERNMARK 1 AND BRITT INGER WENNGREN
More informationEndocrine System. Regulating Blood Sugar. Thursday, December 14, 17
Endocrine System Regulating Blood Sugar Stress results in nervous and hormonal responses. The adrenal glands are located above each kidney. Involved in stress response. Stress Upsets Homeostasis Stress
More informationUsing the Ch6diak-Higashi Marker
A Study of the Origin of Pulmonary Macrophages Using the Ch6diak-Higashi Marker Kent J. Johnson, MD, Peter A. Ward, MD, Gary Striker, MD, and Robin Kunkel, MS Using bone marrow reconstitution techniques
More informationReports. Ocular vascular and epithelial barriers to
Reports Ocular vascular and epithelial barriers to microperoxidase. RICHARD S. SMITH AND LINDA A. RUDT. Microperoxida.se (MP) is an ultrastructural tracer of small molecular weight (1,900) derived from
More informationThe Endocrine System Part II
The Endocrine System Part II Thyroid gland Parathyroid glands Regulation of blood Calcium level Adrenal gland Exocrine part of pancreas (Islets of Langerhans) Thyroid Gland Located in the anterior neck
More informationPANCREATIC BETA CELLS PRODUCE AND SECRETE
15 March, 2018 PANCREATIC BETA CELLS PRODUCE AND SECRETE Document Filetype: PDF 374.06 KB 0 PANCREATIC BETA CELLS PRODUCE AND SECRETE Among the oldest and cheapest drugs for diabetes are the drugs that
More information:1c.c :& Preliminary and Short Report GRANULE FORMATION IN THE LANGERHANS CELL* structure with rounded ends and a striated lamella
THE JOURNAL OF INVESTIGATIVE DERMATOLOGY Copyright 1566 by The Williams & Wilkins Co. Vol. 7, No. 5 Printed in U.S.A. Preliminary and Short Report GRANULE FORMATION IN THE LANGERHANS CELL* ALVIN S. ZELICKSON,
More informationPituitary growth hormone secretory granules in streptozotocin-induced diabetic rats
Histol Histopath (1 988) 3: 263-268 Histology and Histo pathology Pituitary growth hormone secretory granules in streptozotocin-induced diabetic rats Masataka Shiino and Toshiko lshibashi Department of
More informationAcid phosphatase activity in the neutral red granules of mouse exocrine pancreas cells
343 Acid phosphatase activity in the neutral red granules of mouse exocrine pancreas cells By JENNIFER M. BYRNE (From the Cytological Laboratory, Department of Zoology, University Museum, Oxford) With
More informationEndocrine System Objectives
Component 3-Terminology in Healthcare and Public Health Settings Unit 7- Endocrine System Lecture 7a-Overview of the Endocrine System, Adrenal Glands and Pancreas This material was developed by The University
More informationChapter 2 Cell. Zhou Li Prof. Dept. of Histology and Embryology
Chapter 2 Cell Zhou Li Prof. Dept. of Histology and Embryology The inner life of the cell Ⅰ. Plasma membrane (Plasmalemma) 1.1 The structure Unit membrane: inner layer 3-layered structure outer layer mediat
More informationCell Overview. Hanan Jafar BDS.MSc.PhD
Cell Overview Hanan Jafar BDS.MSc.PhD THE CELL is made of: 1- Nucleus 2- Cell Membrane 3- Cytoplasm THE CELL Formed of: 1. Nuclear envelope 2. Chromatin 3. Nucleolus 4. Nucleoplasm (nuclear matrix) NUCLEUS
More informationSilver-Impregnation of the Golgi Complex in Epididymal Epithelial Cells of Mice
CELL STRUCTURE AND FUNCTION 8, 339-346 (1984) C by Japan Society for Cell Biology Silver-Impregnation of the Golgi Complex in Epididymal Epithelial Cells of Mice Ikuo Yamaoka, Sumie Katsuta and Yoshimi
More informationEndocrine System. Organs and Tissues: Pituitary Adrenals Pancreas Thyroid Parathyroids
Endocrine System Organs and Tissues: Pituitary Adrenals Pancreas Thyroid Parathyroids Bruce A. Fenderson, Ph.D. Pathology, Anatomy & Cell Biology Sidney Kimmel Medical College Bruce.Fenderson@Jefferson.edu
More informationExocrine vs. Endocrine Glands. Dr. Sami Zaqout IUG
Exocrine vs. Endocrine Glands Hypophysis (Pituitary Gland) It lies in a cavity of the sphenoid bone the sella turcica Weighs about 0.5 g, and its normal dimensions in humans are about 10 x 13 x 6 mm.
More informationLab Activity 21. Endocrine System Glucometer. Portland Community College BI 232
Lab Activity 21 Endocrine System Glucometer Portland Community College BI 232 2 Hormone Functions ACTH (adrenocorticotropic hormone) Regulates the activity of the cortex of the adrenal gland TSH (thyroid
More informationChapter 13 worksheet
Name: Chapter 13 worksheet The Endocrine System Please label the: hypothalamus pineal gland pituitary gland thyroid gland parathyroid gland thymus heart stomach liver adrenal glands kidneys pancreas small
More informationROBERT E. SMITH and MARILYN
LYSOSOME FUNCTION IN THE REGULATION OF THE SECRETORY PROCESS IN CELLS OF THE ANTERIOR PITUITARY GLAND ROBERT E. SMITH and MARILYN G. FARQUHAR From the Department of Pathology, University of California
More information8. Ultrastructural examination of the liver of the rainbow trout
Józef Szarek, Izabella Babińska, Beata Szynaka, Anna Andrzejewska, Emilia Strzyżewska, Joanna Wojtacka, Krzysztof Wąsowicz, Anna Wiśniewska, Magdalena Szweda, Krystyna Dublan 8. Ultrastructural examination
More informationChapter 21. Human Endocrine System
Chapter 21 Human Endocrine System Endocrine System Consist of endocrine glands that secrete hormones which regulate a wide range of activities in humans Hormones- are secreted by glands and diffuse directly
More informationChapter 12 The Digestive Glands
Chapter 12 The Digestive Glands Lyu Zhengmei Department of Histology and Embryology, Anhui Medical University Components of digestive glands large salivary glands, pancreas, liver, gallbladder. These organs
More informationMITOSIS IN DEVELOPING CARDIAC MUSCLE. FRANCIS J. MANASEK. From the Department of Anatomy, Harvard Medical School, Boston, Massachusetts 02115
Published Online: 1 April, 1968 Supp Info: http://doi.org/10.1083/jcb.37.1.191 Downloaded from jcb.rupress.org on June 30, 2018 MITOSIS IN DEVELOPING CARDIAC MUSCLE FRANCIS J. MANASEK. From the Department
More informationFORMATION OF CELL COAT MATERIAL FOR THE WHOLE SURFACE OF COLUMNAR CELLS IN THE RAT SMALL INTESTINE, AS VISUALIZED BY RADIOAUTOGRAPHY WITH L-FUCOSE 3H
Published Online: 1 August, 1970 Supp Info: http://doi.org/10.1083/jcb.46.2.409 Downloaded from jcb.rupress.org on December 25, 2018 FORMATION OF CELL COAT MATERIAL FOR THE WHOLE SURFACE OF COLUMNAR CELLS
More informationON THE PRESENCE OF A CILIATED COLUMNAR EPITHELIAL CELL TYPE WITHIN THE BOVINE CERVICAL MUCOSA 1
ON THE PRESENCE OF A CILIATED COLUMNAR EPITHELIAL CELL TYPE WITHIN THE BOVINE CERVICAL MUCOSA 1 R. I. Wordinger, 2 J. B. Ramsey, I. F. Dickey and I. R. Hill, Jr. Clemson University, Clemson, South Carolina
More informationChapter 16: The Endocrine System
Chapter 16: The Endocrine System Objectives Define the terms endocrine and exocrine. Describe the physiology of hormones including the different types and the mechanisms of their actions. Compare endocrine
More informationChapter 9. The Endocrine System. Lecture Presentation by Patty Bostwick-Taylor Florence-Darlington Technical College Pearson Education, Inc.
Chapter 9 The Endocrine System Lecture Presentation by Patty Bostwick-Taylor Florence-Darlington Technical College Intro to the Endocrine System Chief Complaint:8-year-old girl with excessive thirst, frequent
More informationHORMONES AND CELL SIGNALLING
HORMONES AND CELL SIGNALLING TYPES OF CELL JUNCTIONS CHEMICAL SIGNALS AND MODES OF ACTION Endocrine system produces chemical messages = hormones that are transported from endocrine gland to target cell
More informationUltrastructure of Connective Tissue Cells of Giant African Snails Achatina fulica (Bowdich)
Kasetsart J. (Nat. Sci.) 36 : 285-290 (2002) Ultrastructure of Connective Tissue Cells of Giant African Snails Achatina fulica (Bowdich) Viyada Seehabutr ABSTRACT The connective tissue sheath of cerebral
More informationDiabetologia 9 Springer-Verlag 1984
Diabetologia (1984) 26:203 207 Diabetologia 9 Springer-Verlag 1984 How does glucose regulate the human pancreatic A cell in vivo? C. M. Asplin*, P. M. Hollander** and J. P. Palmer Diabetes Research Center
More informationARANEUS SERICATUS CHANGES IN FINE STRUCTURE DURING SILK PROTEIN PRODUCTION IN THE AMPULLATE GLAND OF THE SPIDER. ALLEN L. BELL and DAVID B.
Published Online: 1 July, 1969 Supp Info: http://doi.org/10.1083/jcb.42.1.284 Downloaded from jcb.rupress.org on September 18, 2018 CHANGES IN FINE STRUCTURE DURING SILK PROTEIN PRODUCTION IN THE AMPULLATE
More informationEndocrine Histology Lab GUIDE TO MICROSCOPES IN LAB
Endocrine Histology Lab GUIDE TO MICROSCOPES IN LAB The micrographs that appear on this review page are typical views of the tissues seen in the laboratory. The descriptions that accompany them are designed
More informationInsulin and the brain. Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD
Insulin and the brain Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD 1921 Banting & Macleod Nobel Prize 1923 White, M. F. (2003) Science Berg, J. M., Tymoczko, J. L. and Stryer, L. (2007) Biochemistry
More informationThe Endocrine Pancreas (Chapter 10) *
OpenStax-CNX module: m62118 1 The Endocrine Pancreas (Chapter 10) * Ildar Yakhin Based on The Endocrine Pancreas by OpenStax This work is produced by OpenStax-CNX and licensed under the Creative Commons
More informationPANCREATIC PATHOLOGY IN DASYURID MARSUPIALS
PANCREATIC PATHOLOGY IN DASYURID MARSUPIALS Authors: H. D. ATTWOOD, and P. A. WOOLLEY Source: Journal of Wildlife Diseases, 16(2) : 245-25 Published By: Wildlife Disease Association URL: https://doi.org/1.7589/9-558-16.2.245
More informationENHANCEMENT OF THE GRANULATION OF ADRFNERGIC STORAGE VESICLES IN DRUG-FREE SOLUTION
ENHANCEMENT OF THE GRANULATION OF ADRFNERGIC STORAGE VESICLES IN DRUG-FREE SOLUTION TAKASHI IWAYAMA and J. B. FURNESS. From the Department of Zoology, University of Melbourne, Victoria, Australia. Dr.
More informationMonday, 7 th of July 2008 ( ) University of Buea MED30. (GENERAL ENDOCRINOLOGY) Exam ( )
.. Monday, 7 th of July 2008 (8 30-11. 30 ) Faculty of Health Sciences University of Buea MED30 304 Programme in Medicine (GENERAL ENDOCRINOLOGY) Exam (2007-2008).. Multiple Choice Identify the letter
More informationEndocrine System. Chapter 9
Endocrine System Chapter 9 Endocrine Organs Hormones Chemical messengers that are released from one tissue and transported through blood to a target tissue. Chemical classification: amino acids, steroids,
More informationDiabetologia 9 Springer-Verlag 1983
Diabetologia (1983) 25: 51-55 Diabetologia 9 Springer-Verlag 1983 Experimental Hypothalamic or Genetic Obesity in the Non-Insulin-Dependent Diabetic Rat B. Portha 1, R. Goursot t, M. H. Giroix 1, S. Nicola'fdis
More informationChapter 20. Endocrine System Chemical signals coordinate body functions Chemical signals coordinate body functions. !
26.1 Chemical signals coordinate body functions Chapter 20 Endocrine System! Hormones Chemical signals Secreted by endocrine glands Usually carried in the blood Cause specific changes in target cells Secretory
More informationQUESTIONSHEET 1. The diagram shows some of the cell structures involved in the secretion of an extracellular enzyme. C D
QUESTIONSHEET 1 The diagram shows some of the cell structures involved in the secretion of an extracellular enzyme. C D A (a) Identify A,, C, and D. A:... :... C:... D:... [4] (b) Outline the role of each
More informationEpithelia will be discussed according to the following scheme: Type Number of layers Shape Line drawing. Squamous Cuboidal Columnar
Epithelia Epithelia will be discussed according to the following scheme: Type Number of layers Shape Line drawing Simple Squamous Cuboidal Columnar Covering and Lining epithelium Pseudostratified Stratified
More informationChapter 20 Endocrine System
Chapter 20 Endocrine System The endocrine system consists of glands and tissues that secrete Hormones are chemicals that affect other glands or tissues, many times far away from the site of hormone production
More informationCh. 39 Endocrine System
Ch. 39 Endocrine System The Endocrine System The endocrine system is made up of glands that release their products into the bloodstream These products deliver messages throughout the body Hormones Hormones
More informationUNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DIVISION OF BASIC MEDICAL SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
1 UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DIVISION OF BASIC MEDICAL SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY GLUCOSE HOMEOSTASIS An Overview WHAT IS HOMEOSTASIS? Homeostasis
More informationInfluence of Experimental Diabetes Mellitus on Secretary Granules in ß-Cells in the Dog Pancreatic Islet
Influence of Experimental Diabetes Mellitus on Secretary Granules in ß-Cells in the Dog Pancreatic Islet Author(s: Yuji Asai, Hiroyuki Morimoto, Yoshio Mabuchi1, Eisuke Sakuma, Nobuyuki Shirasawa, Ikuo
More informationChapter 18: Endocrine Glands
Chapter 18: Endocrine Glands I. Functions of the Endocrine System A. List and describe the eight major functions of the endocrine system: 1. 2. 3. 4. 5. 6. 7. 8. Page 1 of 19 C II. Pituitary Gland and
More informationWhat systems are involved in homeostatic regulation (give an example)?
1 UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DIVISION OF BASIC MEDICAL SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY GLUCOSE HOMEOSTASIS (Diabetes Mellitus Part 1): An Overview
More informationRobert Wadlow and his father
Robert Wadlow and his father 1 Robert Wadlow Wadlow reached 8 ft 11.1 in (2.72 m) in height and weighed 485 lb (220 kg) at his death at age 22. Born in Illinois. His great size and his continued growth
More information(A) Cell membrane (B) Ribosome (C) DNA (D) Nucleus (E) Plasmids. A. Incorrect! Both prokaryotic and eukaryotic cells have cell membranes.
High School Biology - Problem Drill 03: The Cell No. 1 of 10 1. Which of the following is NOT found in prokaryotic cells? #01 (A) Cell membrane (B) Ribosome (C) DNA (D) Nucleus (E) Plasmids Both prokaryotic
More informationDr. Heba Kalbouneh. Dr. Heba Kalbouneh. Dr. Heba Kalbouneh
Dr. Heba Kalbouneh Dr. Heba Kalbouneh Dr. Heba Kalbouneh Basement membrane: What is the basement membrane? - It is a layer of ECM separating the epithelial cells from the underlying connective tissue Basement
More informationA Comparison of Leucine- and Acetoacetate-induced Hypoglycemia in Man *
Journal of Clinical Investigation Vol. 43, No. 1, 1964 A Comparison of Leucine- and Acetoacetate-induced Hypoglycemia in Man * STEFAN S. FAJANS, JOHN C. FLOYD, JR., RALPH F. KNOPF, AND JEROME W. CONN (From
More informationDiabetologia 9 Spfinger-Verlag 1984
Diabetologia (1984) 27:32--37 Diabetologia 9 Spfinger-Verlag 1984 Tubular lesions in streptozotoein-diabetic rats R. Rasch Department of Cell Biology, Institute of Anatomy, University of Aarhus, Aarhus,
More informationDiabetologia 9 Springer-Verlag 1981
Diabetologia (1981) 21 : 476481 Diabetologia 9 Springer-Verlag 1981 Morphological Changes in the Hypothalamic-Hypophyseal-Gonadal Axis of Male Rats After Twelve Months of Streptozotocin-Induced Diabetes
More informationChapter 18, Part 2! Chapter 18, Part 2 Endocrine system! The Endocrine System!
Chapter 18, Part 2! The Endocrine System! SECTION 18-3! The bilobed pituitary gland is an endocrine organ that releases nine peptide hormones! What you need to know for each hormone we cover:! 1. Name
More informationKnow at the level covered in these notes! SECTION 18-3! The bilobed pituitary gland is an endocrine organ that releases nine peptide hormones!
Chapter 18, Part 2! The Endocrine System! Know at the level covered in these notes! SECTION 18-3! The bilobed pituitary gland is an endocrine organ that releases nine peptide hormones! What you need to
More informationPRACTICAL ROADMAP. GLANDS AFFECTING LIFESTYLE WJ van der Spuy & T Tshabalala
PRACTICAL ROADMAP GLANDS AFFECTING LIFESTYLE WJ van der Spuy & T Tshabalala GLANDS AFFECTING LIFESTYLE Submandibular gland (salivary gland) Liver Pancreas Hypophysis (pituitary gland) Thyroid Suprarenal
More informationThe endoplasmic reticulum is a network of folded membranes that form channels through the cytoplasm and sacs called cisternae.
Endoplasmic reticulum (ER) The endoplasmic reticulum is a network of folded membranes that form channels through the cytoplasm and sacs called cisternae. Cisternae serve as channels for the transport of
More informationLysosomes. Gr: lysis solution, soma body. Membrane bounded vesicles. Usually round ovoid or irregular electron dense bodies m.
Lysosomes Gr: lysis solution, soma body Membrane bounded vesicles Usually round ovoid or irregular electron dense bodies 0.05 0.5 m. Lysosomes No. varies from a few to several hundred per cell, in different
More informationEndocrine System. Part 2
Endocrine System Part 2 Thyroid Gland Saddle bag shaped gland Largest endocrine gland in the body 3 hormones Throxin Triiodothyronine Calcitonin Thyroid hormone Pineal gland Hypothalamus Pituitary gland
More informationCell morphology. Cell organelles structure and function. Chapter 1: UNIT 1. Dr. Charushila Rukadikar
UNIT 1 Cell morphology Cell organelles structure and function Chapter 1: Dr. Charushila Rukadikar Assistant Professor Department Of Physiology ZMCH, Dahod Physiology The science that is concerned with
More informationBiology 2.4 AS Introduction Cells and cell processes. Introduction Cells and cell processes
Biology 2.4 AS 91156 Demonstrate understanding of life processes at the cellular level Externally assessed 4 credits Copy correctly Up to 3% of a workbook Copying or scanning from ESA workbooks is subject
More informationTHE ENDOCRINE PANCREAS IN THE CHINESE HAMSTER
THE ENDOCRINE PANCREAS IN THE CHINESE HAMSTER STUDIES ON NON-DIABETIC, ALLOXAN-TREATED, ZINC-DEFICIENT, AND SPONTANEOUSLY DIABETIC ANIMALS AKADEMISK AVHANDLING SOM MED VEDERBÖRLIGT TILLSTÅND AV MEDICINSKA
More informationSince, for many months after section of the right vagus in the neck,
THE INFLUENCE OF THE VAGUS ON THE ISLETS OF LANGERHANS. Part II. The effect of cutting the vagus upon sugar tolerance. BY G. A. CLARK. (From the Physiological Laboratory, Sheffield University.) IN Part
More informationINTRODUCTION TO THE LIGHT MICROSCOPE
Name: INTRODUCTION TO THE LIGHT MICROSCOPE Introduction: If you missed the microscope lab we did in class, you will need to make it up by using a "virtual microscope" which can be accessed on the internet.
More informationThe Endocrine System. I. Overview of the Endocrine System. II. Three Families of Hormones. III. Hormone Receptors. IV. Classes of Hormone Receptor
The Endocrine System I. Overview of the Endocrine System A. Regulates long term metabolic processes B. Releases hormones from endocrine cells 1. Hormones are chemicals 2. Alter metabolism of cells 3. Release
More informationAnatomy and Physiology. The Endocrine System
Anatomy and Physiology The Endocrine System The endocrine system includes anything that secretes hormones directly into body fluids. Endocrine glands include: the thyroid, parathyroid, adrenal, kidney,
More information6.6 HORMONES & REPRODUCTION
6.6 HORMONES & REPRODUCTION Endocrine system Produces and releases hormones Hormones travel in the blood to target tissues Long distance communication between cells Endocrine Glands Blood stream Hormone
More informationUNIT 1: Introduction to metabolic regulation
UNIT 1: Introduction to metabolic regulation Prof K Syed Department of Biochemistry & Microbiology University of Zululand Room no. 247 SyedK@unizulu.ac.za Topics Metabolism Metabolism: Categories Important
More informationCaused by Glucose, Glucosamine, and Galactose
Proceedings of the National Academy of Sciences Vol. 68, No. 3, pp. 536-540, March 1971 Kinetics of Insulin Release from the Perfused Rat Pancreas Caused by Glucose, Glucosamine, and Galactose RUDIGER
More informationTexas Health Science Center at San Antonio, San Antonio, Texas USA
Influence of Experimental Diabetes Mellitus on Secretary Granules in ß-Cells in the Dog Pancreatic Islet. II. Relationship between the Spherical Granule and the Cored Vesicle Author(s): Yuji Asai, Hiroyuki
More informationEndocrine System WHO IS IN CONTROL?
Endocrine System WHO IS IN CONTROL? Objectives Explain how the endocrine and nervous system work together to regulate bodily functions Describe the basic anatomy of the endocrine system Describe the functions
More informationCARBOHYDRATE METABOLISM Disorders
CARBOHYDRATE METABOLISM Disorders molecular formula C12H22O11 Major index which describes metabolism of carbohydrates, is a sugar level in blood. In healthy people it is 4,4-6,6 mmol/l (70-110 mg/dl)
More informationHormonal control of carbohydrate metabolism
J. clin. Path., 22, suppl. (Ass. clin. Path.), 2, 2-6 Hormonal control of carbohydrate metabolism K. D. BUCHANAN The work which I have done in this field has been mainly in collaboration with Dr J. E.
More information