* 2 Third Department of Internal Medicine, Kyorin University School of Medicine
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1 Diabetes Mellitus and Metabolic Bone Disorder Kiyoshi Suzuki * 1, Makoto Takizawa * 2, Eij i Itagaki * 2 and Hitoshi Ishida * 2 * 1 Shimada Municipal Hospital ; * 2 Third Department of Internal Medicine, Kyorin University School of Medicine
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7 Vol. 57 No. 3 1) Seino, Y. and Ishida, H.: Diabetic osteopenia-pathophysiology and clinical aspect, Diabetes Metab. Rev., 11, 21 `35 (1995) 3) Ishida, H., Seino, Y., Matsukura, S., Ikeda, M., Yawata, M., Yamashita, G., Ishizuka, S. and Imura, H.: Diabetic osteopenia and circulating levels of vitamin D metabolites in type 2 (non-insulin dependent) diabetes, Metabolism, 34, 797 `801 (1985) 4) De Leeuw, I. and Abs, R.: Bone mass and bone density in maturity-type diabetics measured by the 125I photon-absorption technic, Diabetes, 26, (1977) 5) Krakauer, J. C., Mckenna, M. J., Buderer, N. F., Rao, D. S., Whitehouse, F. W. and Parfitt, A. H.: Bone loss and bone turnover in diabetes, Diabetes, 44, 775 `782 (1995) 6) Suzuki, K., Ishida, H., Kikuyama, M., Togawa, H., Taguchi, Y., Sugimoto, C., Kasahara, H. and Seino, Y.: A comparative study on the bone mineral density in diabetic osteopenia using CXD and DXA method. Preferential decrease of mineral content in cortical bone, Osteoporosis Int., 7 (Suppl 2), S83 (1997) 7) Ross, P., Huang, C., Davis, J., Imose, K., Yates, J., Vogel, J. and Wasnich, R.:
8 Predicting vertebral deformity using bone densitometry at various skeletal sites and calcaneus ultrasound, Bone, 16, 325 `332 (1995 8) Mazess, R. B., Barden, H. S., Bisek, J. P. and Hanson, J.: Dual-energy X-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition, Am. J. Clin. Nutr., 51, 1106 `1112 (1990) 9) McNair, P., Madsbad, S., Christensen, M. S., Faber, 0. K., Transbol, I. and Binder, C. Osteopenia in insulin-treated diabetes mellitus. Its relation to age at onset, sex and duration of disease, Diabetrogia, 15, 87 `90 (1978) 10) McNair, P., Madsbad, S., Christensen, M. S., Christiansen, C., Faber, 0. K., Binder, C. and Transbol, I.: Bone mineral loss in insulin-treated diabetes mellitus : Studies on pathogenesis, Acta Endocrinol. (Copenh), 90, 463 `472 (1979) 12) McNair, P., Fough-Anderson, N., Madsbad, S. and Christensen, M. S.: Decreased serum concentration of ionized calcium in insulin-dependent human diabetes mellitus, Eur. J. Clin. Invest., 13, 267 `270 (1983) 13) Saggese, G., Federico, G., Bertelloni, S., Baroncelli, G. I. and Calisti, L.: Hypomagnesemia and the parathyroid hormone-vitamin D endocrine system in children with insulin-dependent diabetes mellitus : effects of magnesium administration, J. Pediatr., 118, 220 `225 (1991) 14) Ishida, H., Suzuki, K., Someya, Y., Nishimura, M., Sugimoto, C., Goto, M., Taguchi, Y., Kasahara, H., Kadowaki, S., Imura, H. and Seino, Y.: Possible compensatory role of parathyroid hormone-related peptide on maintenance of calcium homeostasis in patients with non-insulin-dependent diabetes mellitus, Acta Endocrinol., 129, 519 `524 (1993) 15) Gregorio, F., Cristallini, S., Santeusanio, F., Filipponi, P. and Fumelli, P. Osteopenia associated with non-insulin-dependent diabetes mellitus : what are the : caus es?, Diabetes Res. Clin. Pract., 23, 43 `54 (1994) 16) Wu, K., Schbeck, K. E., Frost, H. M. and Villanueva, A.: Harversian bone formation rates determined by a new method in a mastodon, and in human diabetes mellitus and osteoporosis, Calcif. Tissue Res., 6, 204 `219 (1970) 17) Hough, S., Avioli, L. V., Bergfell, M. A., Fallon, M. D., Slatopolsky, E. and Teitelbaum, S. L.: Correction of abnormal bone and mineral metabolism in chronic streptozotocin-induced diabetes mellitus in the rat by insulin therapy, Endocrinology, 108, 2228 `2234 (1981) 18) Takeshita, N., Ishida, H., Yamamoto, T., Koh, G., Kurose, T., Tsuji, K., Okamoto, Y., Ikeda, H, and Seino, Y.: Circulating levels and bone contents of bone r -carboxy
9 Vol. 57 No. 3 glutamic acid-containing protein in rats models of non-insulin-dependent diabetes mellitus, Acta Endocrinol., 128, 69 `73 (1993) 19) Ishida, H., Seino, Y., Taminato, T., Usami, M., Takeshita, N., Seino, Y., Tsutsumi, C., Moriuchi, S., Akiyama, Y., Hara, K. and Imura, H.: Circulating levels and bone contents of bone r -carboxyglutamic acid-containing protein are decreased in streptozotocin-induced diabetes : possible marker for diabetic osteopenia, Diabetes, 37, 702 `706 (1988) 20) Suzuki, K., Taguchi, Y., Ishida, H. and Seino, Y.: The evidence for uncoupling between bone formation and resorption in NIDDM patients, Diabetologia, 40 (Suppl 1), A581 (1997) 21) Russell, R. G. G.: The assesment of bone metabolism in vivo using biochemical approaches, Horm. Metab. Res., 29, 138 `144 (1997) 22) Katayama, Y., Akatsu, T., Yamamoto, M., Kugai, N. and Nagata, N.: Role of nonenzymatic glycosylation of type I collagen in diabetic osteopenia, J. Bone Miner. Res., 11, 931 `937 (1996) 23) Ebeling, P. R., Peterson, J. M, and Riggs, B. L.: Utility of type I propeptide assays for assessing abnormalities in metabolic bone diseases, J. Bone Miner. Res., 7, 1243 `1250 (1992) 24) Parfitt, A. M., Simons, L. S., Villanueva, A. R. and Krane, S. M.: Procollagen type I carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone. correlation with iliac bone formation rates and comparison with total alkaline phosphatase, J. Bone Miner. Res., 2, 427 `436 (1987) 26) Inaba, M., Terada, M., Koyama, H., Yoshida, O., Ishimura, E., Kawagishi, T., Okuno, Y., Nishizawa, Y., Otani, S. and Morii, H.: Influence of high glucose on 1,25 dihydroxyvitamin D3-induced effect on human osteoblast-like MG-63 cells, J. Bone Miner. Res., 10, 1050 `1056 (1995) 27) Williams, J. P., Blair, H. C., McDonald, J. M., Mckenna, M. A., Jordan, S. E., Willitora, J. and Hardy, R. W.: Regulation of osteoclastic bone resorption by glucose, Biochem. Biophys. Res. Comm., 235, 646 `651 (1997) 28) Suzuki, K., Ishida, H., Takeshita, N., Taguchi, Y., Sugimoto, C., Nosaka, K. and Seino, Y.: Circulating levels of tartrate-resistant acid phosphatase in rat models of non-insulin dependent diabetes mellitus, J. Diab. Comp., 12, 176 `180 (1998) 29) Risteli, J., Elomaa, I., Niemi, S. Novamo, A. and Risteli, L.: Radioimmunoassay for pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen : New serum marker of bone collagen degradation, Clin. Chem., 39, 635 `640 (1993)
10 30) Eriksen, E. F., Charles, P., Mosekilde, L., Risteli, L. and Risteli, J.: Serum markers of type I collagen for mation and degradation in metabolic bone diseases : correlation with bone histomo rphometry, J. Bone Miner. Res., 8, 127 `132 (1993) 31) Eyre, D. R.: New biomarkers of bone resorption, J. Gun. Endocrinol. Metab., 74, 470A `472A (1992) 32) Garnero, P., Gineyts, E., Riou, J. P. and Delmas, P. D.: Assesment of bone resorption with a new marker of collagen degradation in patients with metabolic bone disease, J. Gun. Endocrinol. Metab., 79, 780 `785 (1994) 33) Imura, H., Seino, Y. and Ishida, H.: Osteopenia and circulating levels of vitamin D metabolites in diabetes mellitus, J. Nutr. Sci. Vitaminol., 31 (Suppl. ), 527 `32 (1985) 34) Fraser, W. D., Durham, B. H., Berry, J. L. and Mawer, E. B.: Measurement of plasma 1,25 dihydroxyvitamin D using a novel immunoextraction technique and immunoassay with iodine labelled vitamin D tracer, Ann. Clin. Biochem., 34, 632 `637 (1997) 35) Ishida, H., Cunningham, N. S., Henry, H. L, and Normen, A. W.: The number of 1,25- dihydroxyvitamin D 3 receptors is decreased in both intestine and kidney of genetically db/db mice, Endodrinology, 122, 2436 `2443 (1988) 36) Weiss, R. E. and Reddi, A. H.: Influence of experimental diabetes and insulin on matrix-induced cartilage and bone differentiation, Am. J. Physiol., 238 (Endocrinol Metab 1), E200 (1980) 37) Wettenhall, R. E. H., Schwartz, P. L. and Bornstein, J.: Actions of insulin and growth hormone on collagen chondroitin sulfate synthesis in bone organ cultures, Diabetes, 18, (1969) 38) Ishida, H., Seino, Y., Takeshita, N., Kurose, T., Tsuji, K. Imura, H. and Nozawa, M. Effects of pancreas transplantation of decreased levels of circulating bone r -carbox : yglutamic acid-containing protein and osteopenia in rats with streptozotocin-induced diabetes, Acta Endocrinol., 127, 81 `89 (1992)
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