Florida Hospital. Richard Pratley, M.D.

Transcription

1 Florida Hospital Richard Pratley, M.D. Samuel Crockett Chair in Diabetes Research Director, Florida Hospital Diabetes Institute Senior Scientist, Translational Research Institute Professor, Sanford Burnham Medical Research Institute Orlando, Florida Pratley/Endo Fellows/12Nov11

2 Adventist Health System 48 hospitals in 10 states Over 8000 beds Pratley/Endo Fellows/12Nov11

3 Florida Division of Adventist Health System 25 Hospitals Patient Visits 2.3m+ Beds 4,380+ Employees 23,000+ Net Revenue $2.8b+ Pratley/Endo Fellows/12Nov11

4 Florida Hospital Hospital Visits 900,000+ Florida Hospital Orlando The Walt Disney Pavilion at Florida Hospital for Children Emergency Visits 350,000 Admissions 110,000+ Inpatient Beds 2,188+ Physicians 2,000+ Employees 15,000+ Centra Care Visits 300,000+ Primary Care Clinics 250,000+ Net Revenue $1.7b Florida Hospital Altamonte Florida Hospital Kissimmee Florida Hospital Apopka Florida Hospital East Orlando Florida Hospital Celebration Health Winter Park Memorial Hospital 8 hospitals in Seminole, Orange, Osceola Counties

5 Our Mission To improve the lives of people with diabetes, promote a healthy life style, deliver excellence in clinical care and education, and conduct research leading to diabetes prevention and a cure. Our Vision To become a preeminent global leader for diabetes care, education, and research.

6 Patient Education Cooking Demonstrations Florida Hospital TV Diabetes Channel Web-based interactive modules

7 FHDI Education

8 FHDI Education

9 FHDI Education

10 FHDI Education

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12 ORLANDO LAKE NONA

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15 15 TRI Innovate. Discover. Cure. Mission: To extend and improve the quality of lives through the conduct of world-class, innovative translational research that leads to discoveries and ultimately cures for metabolic diseases. Scope: Translational research focused on metabolism, diabetes, and the metabolic origins of cardiovascular diseases

16 Translational Research Basic Knowledge Pre-clinical testing Proof-of- Concept Target validation Is the treatment safe and effective? Implementation of best practices Sanford-Burnham Translational Research Institute Florida Hospital Discovery Research Step 1 Translational Research Step 2 Translational Research Clinical Practice

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18 The Translational Research Institute Facilities Overview 54,000 sq feet of dedicated clinical research space on the FL Hospital campus 18 Floor 1: Clinical, Imaging and Administrative Core Facilities Floor 2: CRU, Metabolism and Energy Expenditure Core, Research Pharmacy, Laboratory-Biorepository Floor 3: Shelled for future growth 650 kw backup power PI Resources Dedicated office and administrative space Shared research staff (coordinators, core experts, stats & database) Privileges to TRI and SBMRI Core Facilities

19 TRI 19 Approaches Disease pathobiology Clinical Trials Experimental medicine Target validation Segmentation/Differentiation Biopsy-based PD / biomarker development and validation Adipose and skeletal muscle Leverage relationship with SBMRI PoC / PoM studies Industry sponsored Co-developed protocols IIT Deep Phenotyping Energy expenditure Indirect calorimetry Doubly labeled water Glucose, fat, and muscle metabolism Emphasis on exercise testing and mitochondrial bioenergetics In-situ biochemistry (MRS) Energy, 31 P Lipid, 1 H Food (energy and macronutrient) intake Body composition Endocrine testing / PK Biomarker Discovery and Development

20 TRI Research / Technology Cores 20 Clinical Operations Research Clinic Research Administration Clinical Research Unit Research Pharmacy Metabolic Kitchen Energy Metabolism Hood and whole-room calorimetry Imaging DXA MRI/MRS Research CTMS, ecrfs, Database and Biostatistics Laboratory Industry Partners 1. Clinical Laboratory (Florida Hospital Lab) 2. Biorepository 3. Biomarker Discovery and Development Laboratory (links to SBMRI)

21 TRI Faculty Scientists Richard Pratley, MD Dwight Towler, MD Magdalena Pasarica, Lauren Sparks, PhD Diabetes Pathobiology and Therapeutics Vascular Biology MD, PhD Obesity Muscle Metabolism Victor Herrera, MD Attila Seyhan, PhD 21 Gut Microbiome in Metabolic Diseases Biomarkers and RNA Metabolism

22 TRI Research Scientists Hui Xie, PhD BioStatistics / BioInformatics Heather Cornnell, PhD MR Physics and Bioengineering Stephanie Parsons, PhD Research Scientist Skeletal Muscle Alok Pachori, PhD Research Scientist Biomarkers Chris Davis, PhD Research Scientist Industry Alliances 22 Adeline Divoux, PhD Postdoctoral Fellow Obesity Rebecca Zuvich, PhD Postdoctoral Fellow Personalized Medicine Zuzana Kovacova, PhD Postdoctoral Fellow Diabetes

23 TRI Operations and Administration Julie Clyatt, ARNP Nurse Practitioner Karen Potter Jones, RN Clinical Operations Manager Penny Carlson, RN Clinical Operations Manager Jennifer McCall, MS Laboratory Manager Sabrina Gmerek-Pettus, ARNP Nurse Practitioner 23 Shelly Crunk, MBA Director of Finance- Research Regina Tan, MBA Grants and Contracts Manager Jan Holladay Pierre, MPH Quality and Audit Compliance Manager

24 Clinical Operations 12 exam rooms Phlebotomy in clinic Bariatric design elements Adjacent to imaging

25 BioImaging Core DEXA (body composition) Proton MRS Muscle and hepatic lipid Cardiac 3T research dedicated MRI / MRS Multi-nuclear: 1 H, 31 P, 13 C Optical spectroscopy (muscle O 2 ) 31 P muscle Echocardiography - planned

26 26 Clinical Research Unit (CRU) Hotel design features Nursing unit 8 rooms (10 beds) for overnight stays 3 Procedure rooms Exercise testing suite Recreation areas including outside patio Research Pharmacy Supports Energy Expenditure and Metabolism Core Initially prn eventually 24-7

27 27 Metabolic Kitchen Supports: CRU Calorimetry Diet intervention studies Equipped for inpatient and outpatient studies Dining room Walk-in cooler and freezer Dry storage

28 Exterior glass wall (east) Resting metabolic rate / pharmacodynamic room 1 Room calorimeters Resting metabolic rate / pharmacodynamic room 2 Instrument room

29 Room Calorimeters Two 30,000L calorimeters push-pull air flow Two 5 o 3kL C - 38 o 5kL calorimeters C temperature Convertible Full digital from datastream bed control (3kL) Best-in-class to small room accuracy format (5kL) Exercise testing (bike) RMR / RQ PK / PD

30 Active Collaborative Studies with S B Scientists Regional differences in adipose gene expression Alt. RNA splicing [muscle] across a range of metabolic phenotypes Developing oxidative and glycolytic cell lines Orexin A as a treatment for obesity BNP as a treatment for obesity and hypertension

31 TRI / TRIMDorg ipad app

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