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5 187 " 15 Downloaded from journal.bums.ac.ir at 1:12 IRST on Monday March 11th /0 &/ Wj6 '! 2$P 5!A 2+=F M.+ =K u M 'A! "C M >! :;! dh K4F *l) d$ -! 0 :'i M: 02M) 2 % > =MF 0(.'+ 2! D 2!G :;! ' G :1*2 1- Mandell G, Bennet J, Dolin R. Principles and practice of infectious disease. St.Louis: Churchill Livingstone; 2005; Sadr Hosseini SM, Saedi B. Petergopalatine fossa: s key area in rhinocerebral mucormycosis extension. J Tehran Faculty Med. 200; 61 (6): [Persian] - Nateghian AR, Karimi A. Report of 6 cases with rhinocerebral Mucormycosis. Feyz, Kashan Univ Med Sci Health Services. 2004; 0 (8): [Persian] 4- Javadi M, Daneshi A, Poosti SB, Mohammadi Sh. Rhinocerebral Mucormycosis, report on three cases at Hazrat Rasol Akram Hospital. J Mazandaran Univ Med Sci. 2002; 12 (6): [Persian] 5- Raziei SMB. Rhinocerebral Mucormycosis: Report of cases. Iranian J Otorhinolaryngol.1998; 22 (10): 5-8. [Persian] 6- Galleta SL, Wule AF, Goldberg HI, Nichols CW, Glaser JS. Rinocereberal mucormycosis: mamagment and survival after carotid occluslon. Ann Neural. 1990; 28 (1): Ferguson AD. Rinocerebral Mucormycosis acquired after course of prednisone therapy. JAM Osteopath Assoc. 2007; 107 (11): Auluck A. Maxillary necrosis by mucormycosis. a case report and literature review. Med Oral Patol Oral Cir Bucal. 2007; 12 (5): Bernhard L. Zygomycosis. in: Feigin's textbook of pediatric infectious diseases. 5 th ed. Philadelphia: Saunders; 1998; Carrillo-Esper R, Elizondo-Argueta S, Vicuna-Gonzalez RM, Gonzalez-Trueba EF. Isolated renal mucormicosis. Gac Med Mex. 2006; 142 (6): Yeung CK, Cheng VC, Lie AK, Yuen KY. Invasive disease due to mucorales: a case report and review of literature. Hong Kong Med J. 2001; 7 (2):
6 7 8 59: 84;5 12" "4 " 5 6" -0 Downloaded from journal.bums.ac.ir at 1:12 IRST on Monday March 11th 2019 Title: A case report of rhinocerebral mucormycosis Authors: Z. Azarkar 1, SH. Golboeei Mousavi 2, M. Zardast Abstract Mucormycosis is the most fatal systemic fungal disease which is precipitated by diabetes or immunodeficiency state. The most common form of the disease is the rhinocerebral involvement. The disease has a high rate of mortality if not diagnosed in time and treated properly. This article presents Mucormycosis in a diabetic. The case was a 26 year old young male with diabetes mellitus being treated with insulin; who was presented with fever, facial and right eye swelling, general bad condition, having a year history of heroin (crystal) addiction, and referred with initial diagnosis of cellulites. On examination, it was found that the case had right eye proptosis and ecchymossis, unilateral bloody discharge of nose and dispnea. Moreover, black necrotic lesion was found in nasal mucosa. Biopsy of necrotic tissue was done and staining with PAS was performed, which proved the existence of rhinocerebral mucormycosis. The patient was taken to ICU and was Administered broad spectrum antibiotic treatment and 1mg/kg amphotericin B. But the next day, in spite of the treatment, the patient got dementia and deceased three days later. Key Words: Mucormycosis; Diabetes; Rhinocerebral 1 Corresponding Author; Assistant Professor, Department of Infectious Diseases; Faculty of Medicine, Birjand University of Medical Sciences. Birjand, Iran drz.azarkar@yahoo.com 2 Assistant Professor, Department of ENT, Faculty of Medicine, Birjand University of Medical Sciences. Birjand, Iran Assistant Professor, Department of Pathology, Faculty of Medicine, Birjand University of Medical Sciences. Birjand, Iran 108
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