Wearable Artificial Kidney Juan Malvar Biomedical Engineering University of Rhode Island November 10, 2015
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1 Wearable Artificial Kidney Juan Malvar Biomedical Engineering University of Rhode Island November 10, 2015
2 CKD AND ESKD CKD (Chronic Kidney Disease)-presence of kidney damage ESKD (End-Stage Kidney Disease)- critical stage of renal failure and irreversible ESKD patients will require continuous dialysis until they receive a transplant 3.3% increase of CKD and 3.7% increase of ESKD patients (data collected in 2012 and 2013 by USRDS and ANZDATA) Accumulation of solutes for ESKD patients will result to high blood pressure
3 Hemodialysis Blood circulated into external filter called a dialyzer Dialyzer contains a semipermeable membrane Sorbent unit contains electrolyte called dialysate which flows the opposite direction of blood Counter flow helps with maximization of concentration gradient of solutions between blood and dialysate
4 Problem? Solution? ESKD patients require constant hemodialysis treatment until they receive a kidney donor Typically done three times a week and require 120L of dialysate per treatment Patients are tethered to a machine for up to 4 hours of no movement Dr. Victor Gura designed the WAK, which miniaturized hemodialysis machines into a belt 61&w=460&fh=&fw=&ll=&pl=&sq=&r= T165311Z_01_L _RTRUKOP_0_PICTURE0
5 Design WAK (Wearable Artificial Kidney) is powered by a 3-watt Faulhaber DC motor Allows a mechanism to use two metal arms that alternately compress two elastic chambers Two chambers allows for alternating pulsatile flow of both blood and dialysate Battery life is approximately 3 days Gura, V., Macy, A., Beizai, M., Ezon, C., & Golper, T. (2009). Technical Breakthroughs in the Wearable Artificial Kidney (WAK). Clinical Journal of the American Society of Nephrology,
6 Experimented for: effectiveness of pumps the clearance of solutes the effect of dialysate flow and its ph level
7 Effectiveness of WAK Pumps Gura, V., Macy, A., Beizai, M., Ezon, C., & Golper, T. (2009). Technical Breakthroughs in the Wearable Artificial Kidney (WAK). Clinical Journal of the American Society of Nephrology,
8 Conventional Pump Clearance of Solutes AN69 Dialyzer F3 Dialyzer Q b Q d K urea K crea K urea K crea ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± 8.9 WAK Pump AN69 Dialyzer F3 Dialyzer Q b Q d K urea K crea K urea K crea 10.1 ± 10.4 ± 15.7 ± 14.4 ± ± ± ± ± ± ± 0.1 Gura, V., Macy, A., Beizai, M., Ezon, C., & Golper, T. (2009). Technical Breakthroughs in the Wearable Artificial Kidney (WAK). Clinical Journal of the American Society of Nephrology, ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± 6.8
9 Effectiveness of Dialysate ph Gura, V., Macy, A., Beizai, M., Ezon, C., & Golper, T. (2009). Technical Breakthroughs in the Wearable Artificial Kidney (WAK). Clinical Journal of the American Society of Nephrology,
10 Results and Plans The Dr. Gura and collegue s WAK is designed to have dialysate to be reused It is designed to be worn for 24 hours 7 days a week WAK prevents ESKD patients to travel long distances to go to hospitals for hemodialysis treatment, may also reduce the cost for having dialysis treatment Increased mobility for ESKD patients In the middle of clinical safety trials by the FDA main_photo/public/wak-gura%20and%20kundzinssm.jpg?itok=5scqrou8&c=6dd8cc42d009d9d f070515f03
11 ANY QUESTIONS?
12 References [1] Armignacco, P., Lorenzin, A., Neri, M., Nalesso, F., Garzotto, F., & Ronco, C. (2015). Wearable Devices for Blood Purification: Principles, Miniaturization, and Technical Challenges. Semin Dial Seminars in Dialysis, [2] Markovic, M., Rapin, M., Correvon, M., & Perriard, Y. (2013). Design and Optimization of A Blood Pump for A Wearable Artificial Kidney Device. IEEE Transactions on Industry Applications IEEE Trans. On Ind. Applicat., [3] Gura, V., Macy, A., Beizai, M., Ezon, C., & Golper, T. (2009). Technical Breakthroughs in the Wearable Artificial Kidney (WAK). Clinical Journal of the American Society of Nephrology, [4] Armignacco, P., Garzotto, F., Neri, M., Lorenzin, A., & Ronco, C. (2015). Wak Engineering Evolution. Blood Purif Blood Purification,
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