- Our patients with iliofemoral DVT - Effective thrombus removal with purely mechanical thrombectomy can lead to better outcomes
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1 - Our patients with iliofemoral DVT - Effective thrombus removal with purely mechanical thrombectomy can lead to better outcomes Michael K. W. Lichtenberg, FESC
2 Conflict of Interest - Disclosure Within the past 12 months, I or my spouse/partner have had a financial interest/arrangement or affiliation with the organization(s) listed below. Affiliation/Financial Relationship Company 1. Honoraria for lectures: CR Bard, Veniti, AB Medica, Volcano, Optimed GmbH, Straub Medical, Terumo, Biotronik, Veryan 2. Honoraria for advisory board activities: Veniti, Optimed GmbH, Straub Medical, Biotronik, Veryan, Boston Scientific 3. Participation in clinical trials: Biotronik, CR Bard, Veryan, Straub Medical, Veniti, TVA Medical, Boston Scientific, LimFlow 4. Research funding: Biotronik, Boston Scientific, Veryan, Veniti, AB Medica
3 PTS after DVT Frequent, but underestimated chronic complication after DVT > 25% at risk for developing PTS following an acute DVT 5-10% severe PTS (iliofemoral DVT) Kahn S. et al. Determinants of health-related quality of life during the 2 years following deep vein thrombosis. Journal of Thrombosis and Haemostasis 2009, 6: Kahn S. et al. The postthrombotic syndrome: evidence-based prevention, diagnosis, and treatment strategies. Circulation.2014;130: Kearon Chest 2008, Kahn Br J Haematol 2006
4 Recurrent DVT Rate Clinical course of DVT after the first episode of symptomatic deep venous thrombosis following traditional systemic anticoagulant therapy. Study Design: Prospective Study of 355 Patients with First Episode of DVT Follow-up Period Recurrent DVT Rate 2 years 17.5% 5 years 24.6% 8 years 30.3% Prandoni P, Lensing AW, Cogo A, et al. The long-term clinical course of acute deep venous thrombosis. Ann Intern Med. 1996;125(1):1-7.
5 Acute DVT Treatment Goal is to Reduce DVT Recurrence and Postthrombotic Syndrome Treatment window = two weeks Venous stenting in conjunction with thrombus removal is safe and effective and has low incidence of PTS Foegh P, Jensen LP. Factors associated with long-term outcome in 191 patients with ilio-femoral DVT treated with catheter-directed thrombolysis. Eur J Vasc Endovasc Surg. 2017;53(3): Engelberger RP, Fahrni J, Willenberg T, et al. Fixed low-dose ultrasound-assisted catheter-directed thrombolysis followed by routine stenting of residual stenosis for acute iliofemoral deep-vein thrombosis. Thromb Haemost. 2014;111(6): ten Cate-Hoek AJ, Henke PK. The post thrombotic syndrome: Ignore it and it will come back to bite you. Blood Rev. 2016;30(2):131-7.
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7 21 y, female, descending DVT in May Thurner syndrome. Transpopliteal access, 10 F Aspirex 8 F: blood volume aspiration up to 75 ml/min 10 F: blood volume aspiration up to 130 ml/min
8 ATTRACT trial Outcome (24 mo) PCDT (n=336) no PCDT (n=335) P value Any PTS 46,7 % 48,2% 0.56 Recurrent VTE 12,5% 8,5% 0.09 Generic QOL (SF-36 PCS) 11,8 10, VENOUS QOL (VEINES) 27,7 23, Moderate or Severe PTS 17,9% 23,7% MS-PTS IFDVT 18,4% 28,2% MS-PTS FPDVT 17,1% 18,1% Major bleed 1,7% 0,3% Any bleed 4,5% 1,7% PTCD less effective in patients 65 years (p = 0.038) SIR, Washington
9 Catheter-Directed Thrombolysis (CDT) Endovascular placement of infusion catheter into affected area Thrombolytic drug migrates into clot Advantages Technologically simple Minimally invasive Resolves thrombus Low equipment expense Limitations Extensive exposure to thrombolytics Extended ICU stay Post-treatment care can be complicated Logistically challenging (ICU, Labs, Nursing) Requires specialized skills Multiple visits to the procedure lab Postthrombotic Syndrome; Patricia E. Thorpe, MD, FSIR; October 2007; Endovascular Today
10 Venous Thrombus Treatment Options: Proactive Endovascular Treatment
11 Clinical follow-up study with the ASPIREX S Endovascular System to investigate safety and effectiveness in treatment of iliofemoral DVT patients - ARNSBERG ASPIREX REGISTRY - Responsible principal investigator (PI): M. Lichtenberg, R. de Graaf Study sponsored by Vascular Clinical Research Department, Arnsberg
12 Rotational thrombectomy (Aspirex ) Archimedisches Wirkprinzip Förderantrieb U/min Magnetkopplung 1,5 ml/s mit 8 F System 0,66 ml/s mit 6 F System 6 10 French M. Lichtenberg (Hrsg.), C. Tiefenbacher, M. Katoh, P. Minko, E. Minar, C. Wissgott, A. Storck, B. Hailer: Thrombektomie: medikamentös, mechnisch, operativ. Uni-med Verlag, 2013
13 Patient Demographics Retro-ASPIREX Total N (%) 56 (100 %) Age Mean (Median [Range]) in years 52 (51 [17-89]) Female N (%) 37 (66 %) Male N (%) 19 (34 %) General Medical History N (%) Smoking status (valid observations) 55 (100 %) Current 9 (16 %) Former 4 (7 %) Hypertension 56 (100%) Yes 28 (50 %) Immobilisation (valid observations) 55 (100 %) Yes 4 (7 %) Malignancy 56 (100 %) Current active 4 (7 %) Condition post 5 (5 %) Oral contraceptive 56 (100 %) Yes 21 (38 %) No 35 (62%) Study is sponsored by Klinikum Arnsberg
14 Diagnostic details (contd.) N (%) Type of occlusion 56 (100 %) Acute (< 14 days) 40 (71 %) Subacute (> 14 days) 13 (23 %) Chronic 2 (4 %) Acute / Chronic 1 (2 %) N (%) Location of occlusion (vessel) 56 (100 %) Left complete pelvic veins including com. femoral vein, left sup. femoral vein (may also include profunda femoral vein and 42 (75 %) distal part of IVC) Left common iliac vein only 7 (13 %) Left common iliac vein / Left external iliac vein without com. femoral vein 3 (5 %) Right complete pelvic veins 4 (7 %) Length of occlusion [mm] N=56 (100 %) Statistics Mean (SD) (72.0) Median (Range) (60 410) Study is sponsored by Klinikum Arnsberg
15 Aspirex treatment (contd.) N (%) Heparin [IU] 56 (100) 5, (89 %) 10,000 3 (5 %) 7,000 OR 7,500 OR 9,000 (1 patient each) 3 (5 %) Thrombolysis 56 (100 %) No 52 (93 %) Yes 4 (7%) Technical success Yes 56 (100 %) Stent rate 100 % Mean (SD) 1.9 (1.2) Median (Range) 2 (0 6) Treatment duration [min] N=34 Mean (SD) 94.2 (44.8) Median (Range) 81.5 ( ) Study is sponsored by Klinikum Arnsberg
16 Patency analysis: DUS with restenosis < 50% N (%) Patency on FU month 1 (valid observations) 47 (100 %) Yes 44 (94 %) Patency on FU month 6 (valid observations) 37 (100 %) Yes 35 (95 %) Patency on FU month 12 (valid observations) 26 (100 %) Yes 24 (92 %) Patency rate including scondary patency rate after 12 months 92 % Study is sponsored by Klinikum Arnsberg
17 Outcome: Post thrombotic syndrome N (%) Post-thrombotic syndrome 53 (100 %) low PTS (CEAP Score < 3, rvcss Score < 3) 34 (64 %) moderate/severe PTS (CEAP Score > 3, rvcss Score > 3) 19 (36 %) Prevention of moderate and severe PTS in 64 % of patients Study is sponsored by Klinikum Arnsberg
18 CaVenT ATTRACT Arnsberg N Control group without treatment YES YES No Age, years Symptom duration, days <21 <14 < - 4 weeks Ascending femoropopliteal DVT 52 % 43% 25% Descending iliofemoral DVT 48% 57% 75% Mean tpa dose, mg 55 (variable) 21 (max 35 mg) 0 Major bleeding 9.0% 1.7% 0 Definition of criteria for stenting NO NO Yes ( stenosis > 50%) IVUS % Dedicated venous stents NO NO YES Stenting rate 17% 30% 100% Overall PTS mts 41% 47% 36% Patency rate 75% (2y) Not evaluated 92%
19 The ATTRACT failures Inclusion of femoropopliteal DVT (43%) No definition of criteria for stenting No IVUS No dedicated venous stents (59%) Outcome 24 months PCDT (n=336) No-PCDT (n=355) P Value Recurrent DVT 12.5% 8.5% Placebo around 10% recurrent DVT ASA 6% recurrent DVT NOACS 1% recurrent DVT
20 THANK YOU FOR YOUR ATTENTION
21 - Our patients with iliofemoral DVT - Effective thrombus removal with purely mechanical thrombectomy can lead to better outcomes Michael K. W. Lichtenberg, FESC
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