Use of EKOS Catheter in the management of Venous Mr. Manoj Niverthi, Mr. Sarang Pujari, and Ms. Nupur Dandavate, The GTF Group

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1 Use of EKOS Catheter in the management of Venous Mr. Manoj Niverthi, Mr. Sarang Pujari, and Ms. Nupur Dandavate, The GTF Group Introduction Georgia Thrombosis Forum (GTF, is an affiliate of North American Thrombosis Forum (NATF, GTF is dedicated to the advocacy of thrombosis in the community and conducting research in the area of various aspects of management of thrombosis. GTF is also focused on training the next generation of leaders, and encourages youth volunteers as a medium for action in the community. This latest research project is on the EKOS Catheter, an innovative technique for the management of thrombosis. In this report, GTF will be discussing some general facts about the EKOS Catheter, and delving into some specifics on what it is, how it is used, what are the results (both efficacy and safety). 1. What is EKOS Catheter? EKOS Catheter uses ultrasound pressure and acoustic streaming along with physician specified fluids, including thrombolytic agents to dissolve the thrombus.

2 EKOS Catheter set up

3 A. Ultrasound core B. EKOS Catheter A schematic representation of EKOS Catheter. This demonstrates the guide wire crossing the occlusion prior to the placement of the EKOS Catheter

4 2. Who developed the EKOS Catheter? The EKOS Catheter was created in 2005 as part of an acoustic movement to treat thrombotic conditions. It is made by the EKOS Corporation, and is used by many endovascular physicians, including cardiologists, radiologists and surgeons. 3. How does EKOS Catheter work? The EKOS EkoSonic Endovascular System generates ultrasonic energy waves which emit high frequency, low power ultrasound at the treatment zone. The ultrasound emanates radially into and through blood, thrombus, or tissue surrounding the treatment zone, within the patient s vasculature. The EKOS system is available for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), and peripheral arterial occlusions. EKOS makes the clot become permeable. Ultrasound pressure drives the physician specified thrombolytic agent through the permeated thrombus. EKOS Catheter is different from other catheters because it is able to deliver drugs effectively to the source of the clot. The acoustic pressure generated thus allows the physician recommended thrombolytic agent to remain embedded at the local site of the thrombus for a longer period of time, increasing the efficiency. 4. Insertion of the EKOS Catheter / technology The EKOS Catheter is inserted through the thrombus. The ultrasonic wire is advanced through the Catheter and secured in place. Infusion of the physician specified thrombolytic agent is then started. The ultrasound component of the EKOS technology is then engaged, thus allowing for the generation of the acoustic streaming which allows the clot to be more effectively dissolved. 5. Risks of the EKOS Catheter / technology As with any endovascular procedure, there is a risk of infection or allergic reaction during skin penetration. Damage to the blood vessel, bruising or bleeding at the puncture site, and infection: none of these is unique to the EKOS catheter. Whenever any thrombolytic agent is used, there is an inherent risk that bleeding could occur.

5 There is also a risk of damage to the kidneys, especially with those have pre-existing kidney disease due to the contrast medium used during the procedure. 6. Role played by EKOS Catheter in the management of VTE Compared to many other treatments, EKOS is relatively new. Many endovascular physicians use EKOS Catheter exclusively as the first line of treatment. Some physicians use EKOS Catheter after traditional therapy has been used. GTF is a volunteer group dedicated to the advocacy of thrombosis in the community and doing research in the area of the treatment and prevention of thrombosis. This latest research project conducted by GTF is on the EKOS Catheter, an innovative treatment for patients with thrombosis.

6 The authors selected a series of three articles which give a detailed description of the application of EKOS Catheter in multi-center trials for the treatment of venous thromboembolism (VTE). Through these articles, we hope to assess the role of the EKOS Catheter in its management of VTE, as well as the pros and cons of its usage. End point: Reduction in RV Strain in all 3 trials The ULTIMA Trial

7 This multicenter randomized, controlled trial investigated whether UltraSound-Assisted catheter-directed Thrombolysis (USAT) is superior to anticoagulation alone in the reversal of RV dilatation in intermediate-risk patients. Fifty-nine patients (63±14 years) with acute main or lower lobe pulmonary embolism were randomized in 2 groups Group 1: Received unfractionated heparin alone (n=29). Group 2: Ultrasound-Assisted catheter-directed thrombolysis (USAT) group. This consisted of infusion of 10 to 20 mg recombinant tissue plasminogen activator over 15 hours (n=30) Primary outcomes Efficacy outcome: The difference in the RV/LV ratio from baseline to 24 hours. Safety outcome: Death, major and minor bleeding, and recurrent venous thromboembolism at 90 days. Results 1. The USAT group: 1.1. The mean RV/LV ratio improved significantly from 1.28±0.19 at baseline to 0.99±0.17 at 24 hours (P<0.001) The reduction in RV / LV ratio was significantly greater (than that in the control group) at 24 h and improved at 90 days 2. The heparin group 2.1. Mean RV/LV ratios were 1.20±0.14 and 1.17±0.20, respectively (P=0.31). 3. At 90 days, there were no deaths in the USAT group, and 1 death in the heparin group 4. There was no major bleeding in either of the 2 groups

8 5. There were 3 minor bleeding events in the USAT group and 1 in the heparin group (P=0.61). 6. There was no recurrent venous thromboembolism in any of the 2 groups. Conclusion In patients with pulmonary embolism, a standardized USAT regimen was superior to anticoagulation with heparin alone in reversing RV dilatation at 24 hours, without an increase in bleeding complications.

9 The SEATTLE II Trial A prospective, single-arm, multicenter trial to evaluate the safety and efficacy of ultrasound-facilitated, Catheter-directed, low-dose fibrinolysis, using the EkoSonic Endovascular System Hypothesis Systemic fibrinolysis for acute pulmonary embolism (PE) reduces cardiovascular collapse but causes hemorrhagic stroke at a rate exceeding 2%. Eligible patients had a proximal PE and a right ventricular (RV)-to-left ventricular (LV) diameter ratio 0.9 on chest computed tomography (CT). The authors included the following 2 groups of patients: 1. Patients with acute massive PE (n = 31) 2. Patients with submassive PE (n = 119) Dosing

10 Tissue-plasminogen activator (t-pa) was administered at a dose of 24 mg either as 1 mg/h for 24 h with a unilateral Catheter, or 1 mg/h/catheter for 12 h with bilateral Catheters. Primary efficacy outcome The change in the chest CT-measured RV/LV diameter ratio within 48 h of procedure initiation. Primary safety outcome Major bleeding within 72 h of procedure initiation. Results The mean RV/LV diameter ratio decreased from baseline to 48 h post-procedure (1.55 vs. 1.13; mean difference, -0.42; p < ). Mean pulmonary artery systolic pressure (51.4 mm Hg vs mm Hg; p < ) decreased post-procedure. One GUSTO (Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries)-defined severe bleed (groin hematoma with transient hypotension) and 16 GUSTO-defined moderate bleeding events occurred in 15 patients (10%). No patient exhibited intracranial hemorrhage. When results from the following 3 major trials were compared, there appears to be a reduction of the risk of intracranial bleeding: ICOPER (Goldhaber et al,1999): 9 / 304 (3 %) PEITHO (Meyer et al, 2014): 10 / 506 (2%) SEATTLE II ((Piazza et al, 2014): 0 / 150 (0%) Conclusion

11 Ultrasound-facilitated, Catheter-directed, low-dose fibrinolysis decreased RV dilation, reduced pulmonary hypertension, decreased anatomic thrombus burden, and minimized intracranial hemorrhage in patients with acute massive and submassive PE. Over the period of time, there appears to be a reduced risk of intracranial bleeding from the 3 studies.

12 The Nykamp et al Trial This was a retrospective review of a single-center, acute massive and submassive PE cases with case matching for controls was conducted. The objective of the review was to evaluate the safety and effectiveness of ultrasound accelerated thrombolysis in patients with acute PE. The patients were divided into 2 groups: 1. Control Group, N=45 with systemic anticoagulation alone 2. Treatment Group, N=45 with Ultrasound-accelerated

13 EKOS catheter access was obtained through a common femoral vein under ultrasound guidance. A guidewire and angiographic Catheter was introduced to cross occlusion. With a guidewire tip within the large lower-lobe segmental branch, the angiographic Catheter was exchanged for EKOS Infusion Catheter. Subsequently, infusions were started, and ultrasound was turned on. Infusion Protocol 1. An average of 30.5 mg rtpa was infused at the rate of 1 mg / h. At the same time, saline coolant 35 ml / h was used during the infusion. 2. rtpa was reduced to 0.5 mg / h after four hours. 3. The average thrombolytic time was 14.2 hours. 4. At the end, EKOS devices were removed. Standardized anticoagulation was administered. Key results 1. Complete resolution of cardiac dysfunction was observed in 64% of patients immediately following the procedure 2. Pulmonary artery pressure showed an average reduction of 40.2% 3. The average length of stay was reduced from 6.7 days in the control group to 3.2 days in the treatment group. 4. When followed for a period of 24 months, the EKOS treated patients showed a significantly higher survival rate. 5. No deaths through 90 days of follow-up and no major periprocedural bleeding events.

14 Conclusion EKOS therapy is an effective PE treatment for reducing pulmonary artery pressures and resolving hemodynamic abnormalities, with excellent mortality and complication rates.

15 Summary and Conclusion The data from these studies shows that the EKOS Catheter, with regard to its applications in localized drug delivery, is a viable treatment option for patients with venous thromboembolism. Since the thrombolytics can be delivered directly to the site of the thrombus, significant improvement in cardiac function is observed rapidly, and the incidence of bleeding is greatly minimized. Acknowledgements We would like to thank the BOD of GTF for giving us the opportunity to take up this project. We would like to thank Dr. Laddu for preparing us for this project. We also want to thank Mr. John Bandera of EKOS Corporation for encouraging the authors to conduct research in this new area, and for his help in getting us the references for review. References 1. Kucher N, Boekstegers P, Müller O, et al. Randomized, Controlled Trial of Ultrasound-Assisted Catheter-Directed Thrombolysis for Acute Intermediate-Risk Pulmonary Embolism, Circulation 2014, 129: Nykamp M, VandenHull A, Remund T, et al, Safety and efficacy of ultrasoundaccelerated Catheter-directed lytic therapy in acute pulmonary embolism with and without hemodynamic instability, J Vasc Surg Venous Lymphat Disord, 2015, 3, Piazza G, Hohlfelder B, Goldhaber SZ, et al, A Prospective, Single-Arm, Multicenter Trial of Ultrasound-Facilitated, Catheter-Directed, Low-Dose Fibrinolysis for Acute Massive and Submassive Pulmonary Embolism, SEATTLE II Investigators, JACC Cardiovasc Interv, 2015, 8, Figures courtesy from John Bandera, EKOS Corporation, and from literature for EKOS This data was presented at the NATF Annual Summit, Boston, September 2017

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