Supplemental tables/figures

Transcription

1 Supplemental tables/figures Table S:Baseline variables included in calculation of QRISK and Framingham scores Ethnicity (European, Indian Pakistani, Bangladeshi, Black African, Black Caribbean) QRISK Age, years Sex Smoking: Current or nonsmoker (includes ex-smoker) Systolic blood pressure Total cholesterol: high density lipoprotein ratio Type diabetes Body mass index Treated hypertension Townsend deprivation score (output area level census data) Family history of CHD in first degree relative under 6. Available only from survivors at year follow-up: history of CHD in parents diagnosed at <6years) Rheumatoid arthritis. Not available. Chronic renal disease. Not available. Atrial fibrillation. Available only in subset. Left ventricular hypertrophy. Available only in subset. Sensitivity analyses only. Otherwise null values assumed. Null values assumed Null values assumed Null values assumed. Framingham For South Asian men score is multiplied by. Sensitivity analyses only. (multiply score by. if any positive family history) Otherwise null values assumed. Sensitivity analyses only. Otherwise null values assumed.

2 Table S. Baseline characteristics of those lost to follow-up or excluded from analyses due to missing baseline data (means±sd, geometric means(9% CIs) Men European Indian Asian African Caribbean N 8 6 Age.±7..±7..±.9 SBP, mm Hg ±7 7±8 ±9 HDL cholesterol.(.7,.).(.,.8).(.7,.) Cholesterol: HDL ratio.9(.77,.).(.7,.).8(.6,.8) Body mass index 6.±.8.9±. 6.±. Smoking: Never Ex (%) 76(%) 6(66%) (8%) 67(7%) (%) Current 6(%) 6(%) 6(%) Diabetes (%) 99(9%) 9(%) Treated hypertension (%) (6%) 8(9%) Townsend score.(.,.8).(.8,.).(.9,.7) Women N Age.6±6..±7.8.9±.6 SBP, mm Hg ±7 9± ±6 HDL cholesterol.(.6,.6).(.,.6).6(.,.7) Cholesterol: HDL ratio.86(.6,.).(.8,.9).(.8,.6) Body mass index 6.±. 6.±. 9.6±.9 Smoking: Never Ex (8%) (%) 6(96%) 8(8%) (%) Current (%) (%) 6(6%) Diabetes 7(6%) 9(8%) 6(6%) Treated hypertension (%) 8(6%) (%) Townsend score.(.9,.9).6(.,.).(.7,.8)

3 Supplemental Table S: Comparison of QRISK and Framingham scores in classification into low and high year of cardiovascular events and observed and predicted QRISK Total MEN Framingham score (with South Low (<%) High (>=%) Asian ethnicity adjustment): low (<=%) Number of men 77 6 (.%) 87 Number of events ( year 9(8.(7., 9.8)) 7(.(7.6, 9.6)) 6(8.7(7.,.)) (9%) QRISK: geometric means(9% 7.(6.9, 7.).(.7,.9) 7.(7., 7.) 9.(9., 9.) 6.7(.9, 7.) 9.(9., 9.7) means(9% Framingham (with South Asian ethnicity adjustment): high (>%) Number of men (8.%) 7 9 Number of events( year 8(6.6(., 7(.(7., (.(.8, 8.)) (9%).9)).)) QRISK: geometric means(9%.(.8,.6) 9.(8.7,.).8(.,.).9(.,.).(.,.) 9.9(9.,.) means(9% WOMEN Framingham score: low (<=%) Number of women 87 (.7%) 8 Number of events( year 8(6.9(., 8.8)) 8(6.9(., 8.8)) (9%) QRISK: geometric means(9%.(.,.6).8(.,.).(.,.8).(.8,.).(., 8.).(.9,.) means(9% Framingham): high (>%) Number of women 9 (6.%) 8 Number of events( year 7(.(.,.) (6.(6., (.6(7.,.6)) (9%)%).) QRISK: geometric means(9% 6.(., 7.) 8.(6.,.).(.6,.87) means(9%.(.6,.) 8.7(6.9,.6) 6.(., 7.7)

4 Figure S: Follow-up of SABRE cohort: Those without CVD at baseline Baseline Europeans Indian Asians African Caribbeans N=6 CVD N=7 CVD N=8 at baseline at baseline N=6 N=8 CVD at baseline N=9 Traced at follow-up 8- N=8 (.6% embarked,.6% no address) N=9 N=9 (.% embarked, % no address) N= N=76 (.7% embarked,.6% no address) N=6 Follow-up data available to years after baseline N=866(9% of traced) N=77 (9% of traced) N=78 (9% of traced) Follow-up data available to years + complete baseline factor data N=8 (88% of traced, 8% of total) N=7 (86% of traced, 8% of total) N= (86% of traced, 7% of total)

5 Ratio of predicted to observed Ratio of predicted to observed Ratio of predicted to observed Figure S) : Plots of year predicted vs observed ratios (9% CIs), by tenths of predicted, for QRISK and Framingham (with South Asian male ethnicity adjustment) scores a)men i)qrisk Europeans ii)framingham South Asians African Caribbeans Deciles of predicted Deciles of predicted

6 Ratio of predicted to observed Ratio of predicted to observed Ratio of predicted to observed Figure S(continued) b)women i)qrisk Europeans ii) Framingham South Asians African Caribbeans Deciles of predicted Deciles of predicted