Characterization of retinal nerve fiber layer thickness changes associated with Leber's hereditary optic neuropathy by optical coherence tomography
|
|
- Magdalen McKinney
- 5 years ago
- Views:
Transcription
1 EXPERIMENTAL AND THERAPEUTIC MEDICINE 7: , 2014 Characterization of retinal nerve fiber layer thickness changes associated with Leber's hereditary optic neuropathy by optical coherence tomography YIXIN ZHANG *, HOUBIN HUANG *, SHIHUI WEI, HUAIYU QIU, YAN GONG, HONGYANG LI, YANLI DAI, ZHAOCAI JIANG and ZIHAO LIU Department of Ophthalmology, Chinese PLA General Hospital, Beijing , P.R. China Received July 12, 2013; Accepted November 12, 2013 DOI: /etm Abstract. In the present study, the changes in the retinal nerve fiber layer (RNFL) thickness associated with Leber's hereditary optic neuropathy (LHON) were examined by Cirrus high definition-optical coherence tomography (OCT), and the correlation between the RNFL thickness and the best corrected visual acuity (BCVA) was evaluated. A cross-sectional study was performed. Sixty eight eyes from patients with LHON and 30 eyes from healthy individuals were scanned. Affected eyes were divided into 5 groups according to disease duration: Group 1, 3 months; group 2, 4 6 months; group 3, 7 9 months; group 4, months; and group 5, >12 months. The RNFL thickness of the temporal, superior, nasal and inferior quadrants and the 360 average were compared between the LHON groups and the control group. The eyes in groups 1 and 2 were observed to have a thicker RNFL in the superior, nasal and inferior quadrants and a higher 360 -average RNFL thickness compared with those of the control group (P<0.05), the RNFL was observed to be thinner in the temporal quadrant in groups 1 and 2. The eyes in groups 3 and 4 showed a thinner RNFL in the temporal (P=0.001), superior and inferior (both P<0.05) quadrants, and a lower 360 -average RNFL thickness as compared with controls (P=0.001). No significant correlation was identified between BCVA and RNFL thickness. RNFL thickness was observed to undergo a unique process from thickening to thinning in the patients with LHON. Changes in different quadrants occurred at different time periods and the BCVA was not found to be correlated with RNFL thickness. Correspondence to: Dr Shihui Wei, Department of Ophthalmology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing , P.R. China sihuiwei12@163.com * Contributed equally Key words: Leber's hereditary optic neuropathy, optical coherence tomography, retinal nerve fiber layer Introduction Leber's hereditary optic neuropathy (LHON) is a maternally inherited disease characterized by acute or subacute bilateral visual loss in young adulthood, particularly in males, with a median age of onset of 24 years (1,2). A study identified that >95% of LHON cases were caused by three point mutations of mitochondrial DNA (mtdna): G11778A, T14484C and G3460A (3). However, the incomplete penetrance implicates that the mtdna mutations are necessary but do not determine LHON, and additional genetic or environmental factors are required to trigger the pathological processes (4). Histopathological descriptions of molecularly characterized patients with LHON have demonstrated a marked loss of retinal ganglion cells and their axons (5,6). The small caliber fibers of the papillomacular bundle (PMB) are selectively lost at a very early stage of the pathological process, which eventually extends to the rest of the nerve, resulting in optic atrophy (7). According to disease duration, LHON may be divided into three stages: The preclinical stage, the acute/subacute stage (defined as 'early' within 6 months from onset; E-LHON) and the atrophic phase (>6 months; A-LHON), with 6 months being the mean time for the development of optic atrophy (8). A follow-up study showed evident optic atrophy and a stable visual acuity remaining at the lowest level after 6 months (9). Optical coherence tomography (OCT) is a novel noninvasive, noncontact diagnostic technology, which is capable of performing high-resolution imaging of the transverse section of the retina in vivo and in real time (10). OCT has been used extensively to measure the retinal nerve fiber layer (RNFL) thickness and the macula lutea in patients with optic nerve and retinal diseases. Since the RNFL thickness begins to change prior to disease onset, analyzing only the changes in RNFL thickness following disease onset may not be sufficient. Thus far, to the best of our knowledge, no previous studies have identified the changes of RNFL thickness that are associated with a cycling period in patients with LHON. In the present study, the changes in RNFL thickness in each quadrant were examined in patients with LHON at different disease durations, and the correlation between RNFL thickness and the best corrected visual acuity (BCVA) was investigated.
2 484 ZHANG et al: RETINAL NERVE FIBER LAYER THICKNESS IN LEBER'S HEREDITARY OPTIC NEUROPATHY Table I. Demographic information of the patients in each group. Demographics Group 1 Group 2 Group 3 Group 4 Group 5 Control Gender Male Female Age, years (range) 15.4 (4-29) 19 (12-34) 21.5 (7-45) 17.7 (7-28) 28.9 (15-45) 24.9 (7-43) Onset age, years (range) 15.1 (4-29) 18.8 (12-33) 20.7 (6-44) 17.1 (6-28) 17.6 (12-36) - ADV, months (range) 1.3 (0.3-3) 4.3 (3.3-5) 7.2 (6-9) 10.5 (9-12) (14-360) - LogMAR BCVA score 1.5 ( ) 1.6 ( ) 1.6 ( ) 1.6 ( ) 1.8 ( ) - ADV, average duration of disease; Logmar, logarithm of the minimal angle of resolution; BCVA, best corrected visual acuity; group 1, disease duration 3 months; group 2, disease duration 4 6 months; group 3, disease duration 7 9 months; group 4, disease duration months; group 5, disease duration >12 months. Patients and methods Ethical considerations. This study was approved by the ethics committee of the Chinese PLA General Hospital (Beijing, China). The ethics committee approved the screening, inspection and data collection of these patients, and all patients provided written informed consent. All experiments followed the provisions of the Declaration of Helsinki. Patients. All patients with LHON diagnosed by mtdna analysis in the Chinese PLA General Hospital (Haidian, China) between September 1, 2011 and March 31, 2013 were recruited. These patients were evaluated prospectively by ophthalmic tests, comprising BCVA, non-contact intraocular pressure measurements, slit lamp microscopy, ophthalmoscopy and OCT. Patients were excluded according to the following criteria: Patients with retinal diseases and/or optic nerve diseases other than LHON; patients who were unable to accept OCT examination; patients with nystagmus whose OCT images were not stable; and patients with an OCT signal intensity of <6. The recruited patients with LHON were divided into 5 diagnostic groups according to the duration of eye symptoms: Group 1, 3 months; group 2, 4 6 months; group 3, 7 9 months; group 4, months; and group 5, >12 months. Age- and gender-matched control individuals were recruited following the routine visual acuity testing of volunteers at the hospital. The control individuals underwent the same tests as those used to evaluate the patients with LHON. Based on OCT results, the eye with the better OCT signal was selected in each individual. OCT analysis. OCT scanning was performed by Cirrus high definition-oct (software version 3.0, model 4000; Carl Zeiss Meditec, Inc. Dublin, CA, USA). Real-time image scans (27,000 A-scans/sec) were performed, an axial resolution of 5 microns was adopted and data were restructured as a 3-dimensional cube. RNFL thickness measurements were acquired using the optic disk cube 200x200 protocol and were analyzed the using optic nerve head (ONH) and RNFL oculus utro (OU) analysis protocols. BCVA examinations were performed using the logmar visual testing chart (11). All OCT scanning was performed in a darkroom by the same technician. Patients with a pupil diameter of <2 mm underwent mydriasis. In these patients, internal fixation was used whenever possible. If the patient was not able to see the internal fixation, they were asked to observe the external fixation using the fellow eye. If the method described above was infeasible for a patient, they were asked to move their eyes laterally during the scan acquisition until the image of the optic disc appeared on the screen of the operator. Each eye was rescanned until a good quality was obtained and an image was recorded for each eye. Statistical analyses were performed for the 360 average RNFL thickness and the RNFL thickness in the temporal, superior, nasal and inferior quadrants. Statistical analysis. Statistical analysis was performed with SPSS software, version 19.0 (SPSS Inc., Chicago, IL, USA). Quantitative data were analyzed by the method of variance analysis with least significant difference multiple comparisons post hoc test. Linear correlation analysis was used for comparisons between the RNFL thickness and the BCVA. P<0.05 was considered to indicate a statistically significant difference. Results Demographic data of patients. A total of 68 eyes from patients with LHON (males, n=61; females, n=7) and 15 eyes from healthy individuals (males, n=10; females, n=5) were included. Table I presents demographic data of the study cohorts. Patients with a LHON duration of >12 months had a relatively older age and a longer mean duration of the disease; in this group, the longest duration of LHON was 3 years, but the LogMAR evaluation showed no statistically significant difference between disease groups. Fig. 1 demonstrates the OCT scanning visual field report of three typical patients; the degree of the central visual field defect was aggravated gradually to diffuse defects in these three patients. RNFL thickness variation. To compare RNFL thickness by OCT in patients with LHON and the control group, the changes in RNFL thickness were investigated at 3, 6, 9 and
3 EXPERIMENTAL AND THERAPEUTIC MEDICINE 7: , Table II. Mean values of the 360 -average RNFL thickness and the RNFL thickness in the temporal, superior, nasal and inferior quadrants in each group. Group 360 -average (µm) T (µm) S (µm) N (µm) I (µm) ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±17.1 Control 100.5± ± ± ± ±14.0 RNFL, retinal nerve fiber layer; group 1, disease duration 3 months; group 2, disease duration 4 6 months; group 3, disease duration 7 9 months; group4, disease duration months; group 5, disease duration >12 months; T, temporal; S, superior; N, nasal; and I, inferior. A B C D E F Figure 1. OCT scanning visual-field report of three typical patients. The central visual field defect degree aggravated gradually to diffuse defects in these three patients. (A) Patient 1 had a central visual field defect to a lesser degree; (B) 3-dimensional (3D) cube representation of results for patient 1 after processing. (C) Patient 2 showed a serious central visual field defect; (D) 3D cube representation of results for patient 2 after processing. (E) Patient 3 showed a more serious central visual field defect; (F) 3D cube representation of results for patient 3 after processing. OCT, optical coherence tomography. 12 months following onset. The mean RNFL thickness in each group is shown in Table II. The OCT scans show the RNFL to be temporarily relatively thicker in patients with LHON within 3 months from the time of disease onset. After 6 months, the 360 average RNFL thickness and the RNFL in all quadrants (temporal, superior, nasal and inferior) became thinner and
4 486 ZHANG et al: RETINAL NERVE FIBER LAYER THICKNESS IN LEBER'S HEREDITARY OPTIC NEUROPATHY Correlation between RNFL thickness and BCVA. In the present study, logmar values were used as a measure of the BCVA in each group. Following analysis, the RNFL thickness in the four quadrants and the 360 average showed no linear correlation with BCVA (P>0.05; data not shown). Discussion Figure 2. RNFL thickness in the temporal, superior, nasal and inferior quadrants, and the 360 average in each group. RNFL, retinal nerve fiber layer; group 1, disease duration 3 months; group 2, disease duration 4 6 months; group 3, disease duration 7 9 months; group 4, disease duration months; group 5, disease duration >12 months. progressively thinned over 12 months. The changes in RNFL thickness in each quadrant and the 360 averages for the different time course groups are displayed in Fig. 2. Changes in the superior and inferior quadrant and 360 average RNFL thickness. Compared with the control group value, the 360 -average RNFL thickness was significantly higher in group 1 (P=0.026), and lower in groups 3, 4 and 5 (P=0.005, <0.001 and <0.001, respectively). The 360 average RNFL thickness in groups 3, 4 and 5 was significantly increased compared with those in group 1 (P=0.016, and <0.001, respectively) and group 2 (P=0.006, <0.001 and <0.001, respectively). In groups 4 and 5, the 360 -average RNFL thickness was significantly increased compared with that of group 3 (P=0.002 and <0.001, respectively), while the RNFL thickness was not observed to be significantly different between groups 4 and 5. The changes in RNFL thickness in the superior and inferior quadrants were comparable with those in the 360 -average RNFL thickness. Changes in RNFL thickness in the nasal quadrant. The RNFL thickness in the nasal quadrant was significantly increased in groups 1, 2 and 5 compared with that of the control group (P=0.046, and 0.005, respectively). The RNFL thickness of the nasal quadrant was significantly reduced in groups 4 and 5 compared with that in group 1 (P=0.048 and 0.002, respectively), and in groups 3, 4 and 5 compared with that in group 2 (P=0.048, and <0.001, respectively). The RNFL thickness of the nasal quadrant was significantly reduced in group 5 compared with those in group 3 (P=0.01) and group 4 (P=0.013). Changes in RNFL thickness in the temporal quadrant. The RNFL thickness of the temporal quadrant was significantly increased in groups 2, 3, 4 and 5 compared with that in the control group (P=0.005, <0.001, <0.001 and <0.001, respectively). The temporal RNFL thickness was significantly decreased in groups 3, 4 and 5 compared with that in group 1 (P=0.019, and 0.002, respectively), and significantly decreased in groups 4 and 5 compared with that in group 2 (P=0.016 and 0.043, respectively). No other statistically significant differences were identified between the groups. With the development and continuous upgrading of technology, OCT has become one of the most effective technologies with which to study optic nerve and retinal diseases (12,13), particularly regarding the anatomical structure of the retina and RNFL thickness. Recently, OCT has been commonly applied in optic neuropathy research, such as the study of glaucoma, optic neuritis and multiple sclerosis (14,15). However, studies of LHON are limited in the literature. A previous study of LHON by OCT showed that unaffected carriers demonstrated thicker RNFL in the temporal and inferior quadrants than the control (16). The RNFL thickness in patients with E-LHON and A-LHON also differs. In a cross sectional study, eyes with E-LHON showed a thicker RNFL in the temporal quadrant compared with that of the healthy control group, and no significant changes were detected in other quadrants, whereas eyes with A-LHON demonstrated a thinner RNFL in all measurements (17). Furthermore, a cohort study of four patients with molecularly defined LHON by Barboni et al (18), demonstrated that the temporal and inferior quadrants showed a statistically significant increase of RNFL thickness between the presymptomatic stage and disease onset. With the exception of the temporal quadrant, the RNFL thickness showed a statistically significant increase between the presymptomatic stage and the 3-month follow-up. A significant reduction of RNFL thickness was detected in all but the nasal quadrant between the presymptomatic stage and the 9 month follow up (18). A previous study showed that the RNFL thickness increased significantly in the temporal quadrant and marginally increased in the inferior quadrant of non-invasive carriers (16). Combined with the findings of the present study, this suggests that RNFL in the temporal and inferior quadrants thickens prior to the occurrence of the disease, but swelling in the temporal quadrant recovers gradually within 3 months following disease onset. In the pathological process, small caliber fibers of the PMB are selectively lost at a very early stage and this loss is then extended to the other nerve fibers, resulting in diffused optic atrophy (7,19). As the RNFL in the temporal quadrant is mainly composed of the PMB, its thickness was altered earlier than that of the other quadrants. Between 4 6 months, RNFL in the temporal quadrant was significantly reduced, suggesting that the RNFL in the temporal quadrant started to atrophy and the swelling of RNFL in other quadrants began to subside. Between 7 and 9 months, the RNFL in the superior, nasal and inferior quadrants had started to shrink with the reduction in the superior and inferior quadrants being apparent while the nasal quadrant only showed a tendency to thin. The results of the present study are consistent with the findings of Barboni et al (18). The mean values of RNFL thickness in the nasal quadrant decreased at months, which indicated that the RNFL in the nasal quadrant was thinning continuously. After 12 months, all measurements of RNFL showed
5 EXPERIMENTAL AND THERAPEUTIC MEDICINE 7: , significant thinning, and significant atrophy of RNFL in the nasal quadrant was observed. Furthermore, no significant differences were identified in the BCVA between groups in the present study, and no linear correlation between the BCVA and RNFL thickness was observed. These results are consistent with the clinical observations of patients with LHON, since their visual acuity remained stable at the lowest level 6 months following disease onset (9,20). Certain patients even showed visual recovery to a certain degree while their RNFLs continued to shrink. In five patients with a disease duration of >20 years, the 360 average RNFL thickness was relatively low, but not the lowest among all the study participants, indicating that the RNFL thickness varied in patients with LHON according to the time sequence recorded. A larger sample size may further elucidate this phenomenon. In conclusion, the present study demonstrates the unique features of changes in RNFL thickness from the onset of LHON to 18 months and provided noteworthy information. References 1. Nikoskelainen EK, Huoponen K, Juvonen V, Lamminen T, Nummelin K and Savontaus ML: Ophthalmologic findings in Leber hereditary optic neuropathy, with special reference to mtdna mutations. Ophthalmology 103: , Leo-Kottler B and Wissinger B: Leber's hereditary optic neuropathy. Ophthalmologe 108: , 2011 (In German). 3. Mao YJ, Qu J and Guan MX: The influence of mitochondrial haplogroup on Leber's hereditary optic neuropathy. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25: 45-49, 2008 (In Chinese). 4. Carelli V, Giordano C and d'amati G: Pathogenic expression of homoplasmic mtdna mutations needs a complex nuclear mitochondrial interaction. Trends Gene 19: , Sadun AA, Kashima Y, Wurdeman AE, Dao J, Heller K and Sherman J: Morphological findings in the visual system in a case of Leber's hereditary optic neuropathy. Clini Neurosci 2: , Kerrison JB, Howell N, Miller NR, Hirst L and Green WR: Leber hereditary optic neuropathy. Electron microscopy and molecular genetic analysis of a case. Ophthalmology 102: , Sadun AA, Win PH, Ross-Cisneros F, Walker SO and Carelli V: Leber's hereditary optic neuropathy differentially affects smaller axons in the optic nerve. Trans Am Ophthalmol Soc 98: , Nikoskelainen E, Hoyt WF, Nummelin K and Schatz H: Fundus findings in Leber's hereditary optic neuroretinopathy. III. Fluorescein angiographic studies. Arch Ophthalmol 102: , Riordan-Eva P, Sanders MD, Govan GG, Sweeney MG, Da Costa J and Harding AE: The clinical features of Leber's hereditary optic neuropathy defined by the presence of a pathogenic mitochondrial DNA mutation. Brain 118: , Huang D, Swanson EA, Lin CP, et al: Optical coherence tomography. Science 254: , Laidlaw DA, Tailor V, Shah N, Atamian S and Harcourt C: Validation of a computerised logmar visual acuity measurement system (COMPlog): comparison with ETDRS and the electronic ETDRS testing algorithm in adults and amblyopic children. Br J Ophthalmol 92: , Aydin A, Wollstein G, Price LL, Fujimoto JG and Schuman JS: Optical coherence tomography assessment of retinal nerve fiber layer thickness changes after glaucoma surgery. Ophthalmology 110: , Garcia-Martin E, Pinilla I, Sancho E, et al: Optical coherence tomography in retinitis pigmentosa: reproducibility and capacity to detect macular and retinal nerve fiber layer thickness alterations. Retina 32: , Garcia-Martin E, Pinilla I, Sancho E, et al: Optical coherence tomography in retinitis pigmentosa: reproducibility and capacity to detect macular and retinal nerve fiber layer thickness alterations. Retina 32: , He XF, Liu YT, Peng C, Zhang F, Zhuang S and Zhang JS: Optical coherence tomography assessed retinal nerve fiber layer thickness in patients with Alzheimer's disease: a meta-analysis. Int J Ophthalmol 5: , Savini G, Barboni P, Valentino ML, et al: Retinal nerve fiber layer evaluation by optical coherence tomography in unaffected carriers with Leber's hereditary optic neuropathy mutations. Ophthalmology 112: , Barboni P, Savini G, Valentino ML, et al: Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy. Ophthalmology 112: , Barboni P, Carbonelli M, Savini G, et al: Natural history of Leber's hereditary optic neuropathy: longitudinal analysis of the retinal nerve fiber layer by optical coherence tomography. Ophthalmology 117: , Barcella V, Rocca MA, Bianchi-Marzoli S, et al: Evidence for retrochiasmatic tissue loss in Leber's hereditary optic neuropathy. Hum Brain Mapp 31: , Smith KH, Johns DR, Heher KL and Miller NR: Heteroplasmy in Leber's hereditary optic neuropathy. Arch Ophthalmol 111: , 1993.
Characterization of macular thickness changes in Leber s hereditary optic neuropathy by optical coherence tomography
Zhang et al. BMC Ophthalmology 2014, 14:105 RESEARCH ARTICLE Open Access Characterization of macular thickness changes in Leber s hereditary optic neuropathy by optical coherence tomography Yixin Zhang
More informationMacular thickness changes in a patient with Leber s hereditary optic neuropathy
Mizoguchi et al. BMC Ophthalmology DOI 10.1186/s12886-015-0015-1 CASE REPORT Open Access Macular thickness changes in a patient with Leber s hereditary optic neuropathy Ayako Mizoguchi 1, Yuki Hashimoto
More informationRETINAL NERVE FIBER LAYER
CLINICAL SCIENCES The Effect of Scan Diameter on Retinal Nerve Fiber Layer Thickness Measurement Using Stratus Optic Coherence Tomography Giacomo Savini, MD; Piero Barboni, MD; Michele Carbonelli, MD;
More informationRetinal nerve fiber layer thickness variability in Leber hereditary optic neuropathy carriers
Studio Oculistico d Azeglio, Bologna - Italy Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL - USA Department of Ophthalmology, Federal
More informationA retrospective analysis of characteristics of visual field damage in patients with Leber s hereditary optic neuropathy
DOI 10.1186/s40064-016-2540-7 RESEARCH Open Access A retrospective analysis of characteristics of visual field damage in patients with Leber s hereditary optic neuropathy Ruijin Ran 1,2, Shuo Yang 1, Heng
More informationLeber s hereditary optic neuropathy A B Figure 1. Fundus photographs of the right (A) and left (B) eyes showing bilateral optic disc hyperemia and mar
LEBER S HEREDITARY OPTIC NEUROPATHY: A CASE REPORT Chi-Wu Chang, Chi-Huang Chang, and Mei-Lin Peng Department of Ophthalmology, Chung Shan Medical University, Taichung, Taiwan. Leber s hereditary optic
More informationRetinal nerve fiber layer thickness in Indian eyes with optical coherence tomography
Original articles in Indian eyes with optical coherence tomography Malik A, Singh M, Arya SK, Sood S, Ichhpujani P Department of Ophthalmology Government Medical College and Hospital, Sector 32, Chandigarh,
More informationReports. Macular Thickness as a Potential Biomarker of Mild Alzheimer s Disease
Reports Macular Thickness as a Potential Biomarker of Mild Alzheimer s Disease Although several postmortem findings in the retina of patients with Alzheimer s disease (AD) are available, 1 new biomarkers
More informationComparative evaluation of time domain and spectral domain optical coherence tomography in retinal nerve fiber layer thickness measurements
Original article Comparative evaluation of time domain and spectral domain optical coherence tomography in retinal nerve fiber layer thickness measurements Dewang Angmo, 1 Shibal Bhartiya, 1 Sanjay K Mishra,
More informationRetinal Nerve Fiber Layer Measurements in Myopia Using Optical Coherence Tomography
Original Article Philippine Journal of OPHTHALMOLOGY Retinal Nerve Fiber Layer Measurements in Myopia Using Optical Coherence Tomography Dennis L. del Rosario, MD and Mario M. Yatco, MD University of Santo
More informationMethod for comparing visual field defects to local RNFL and RGC damage seen on frequency domain OCT in patients with glaucoma.
Method for comparing visual field defects to local RNFL and RGC damage seen on frequency domain OCT in patients with glaucoma. Donald C. Hood 1,2,* and Ali S. Raza 1 1 Department of Psychology, Columbia
More informationCLINICAL CASE. Vision Recovery Despite Retinal Ganglion Cell Loss in Leber s Hereditary Optic Neuropathy. Ann L. Webber*
1040-5488/16/9312-0000/0 VOL. 93, NO. 12, PP. 00Y00 OPTOMETRY AND VISION SCIENCE Copyright * 2016 American Academy of Optometry CLINICAL CASE Vision Recovery Despite Retinal Ganglion Cell Loss in Leber
More informationJong Chul Han, Da Ye Choi, and Changwon Kee. 1. Introduction
Ophthalmology Volume 2015, Article ID 641204, 7 pages http://dx.doi.org/10.1155/2015/641204 Clinical Study The Different Characteristics of Cirrus Optical Coherence Tomography between Superior Segmental
More informationEthambutol (EMB), the first-line drug used to treat mycobacterium
Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology Ganglion Cell Layer and Inner Plexiform Layer as Predictors of Vision Recovery in Ethambutol-Induced Optic Neuropathy: A Longitudinal OCT Analysis
More informationReproducibility of Nerve Fiber Layer Thickness Measurements by Use of Optical Coherence Tomography
Reproducibility of Nerve Fiber Layer Thickness Measurements by Use of Optical Coherence Tomography Eytan Z. Blumenthal, MD, 1 Julia M. Williams, BS, 1 Robert N. Weinreb, MD, 1 Christopher A. Girkin, MD,
More informationMacular Ganglion Cell Complex Measurement Using Spectral Domain Optical Coherence Tomography in Glaucoma
Med. J. Cairo Univ., Vol. 83, No. 2, September: 67-72, 2015 www.medicaljournalofcairouniversity.net Macular Ganglion Cell Complex Measurement Using Spectral Domain Optical Coherence Tomography in Glaucoma
More informationOtticaFisiopatologica
Anno quindicesimo dicembre 2010 How to assess the retinal nerve fiber layer thickness Antonio Ferreras Miguel Servet University Hospital, Zaragoza. Aragón Health Sciences Institute University of Zaragoza
More informationAndrew J. Barkmeier, MD; Benjamin P. Nicholson, MA; Levent Akduman, MD
c l i n i c a l s c i e n c e Effectiveness of Laser Photocoagulation in Clinically Significant Macular Edema With Focal Versus Diffuse Parafoveal Thickening on Optical Coherence Tomography Andrew J. Barkmeier,
More informationStudy of clinical significance of optical coherence tomography in diagnosis & management of diabetic macular edema
Original Research Article Study of clinical significance of optical coherence tomography in diagnosis & management of diabetic macular edema Neha Kantilal Desai 1,*, Somesh Vedprakash Aggarwal 2, Sonali
More informationGanglion cell complex scan in the early prediction of glaucoma
Original article in the early prediction of glaucoma Ganekal S Nayana Super Specialty Eye Hospital and Research Center, Davangere, Karnataka, India Abstract Objective: To compare the macular ganglion cell
More informationPRIMUS 200 from ZEISS The essential OCT
PRIMUS 200 from ZEISS The essential OCT Seeing beyond the surface. ZEISS PRIMUS 200 // INNOVATION MADE BY ZEISS Clear Visualization. Advanced Technology. Reliability. Essential elements of your first OCT.
More informationAdvances in OCT Murray Fingeret, OD
Disclosures Advances in OCT Murray Fingeret, OD Consultant Alcon, Allergan, Bausch & Lomb, Carl Zeiss Meditec, Diopsys, Heidelberg Engineering, Reichert, Topcon Currently Approved OCT Devices OCT Devices
More informationAssessment of Retinal Nerve Fiber Layer Changes by Cirrus High-definition Optical Coherence Tomography in Myopia
Divya Singh et al Original REASEARCH 10.5005/jp-journals-10028-1223 Assessment of Retinal Nerve Fiber Layer Changes by Cirrus High-definition Optical Coherence Tomography in Myopia 1 Divya Singh, 2 Sanjay
More informationEye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology
Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthaology Scanning Laser Polarimetry, but Not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Nonarteritic Anterior Ischemic
More informationThe Effect of Pupil Dilation on Scanning Laser Polarimetry With Variable Corneal Compensation
C L I N I C A L S C I E N C E The Effect of Pupil Dilation on Scanning Laser Polarimetry With Variable Corneal Compensation Amjad Horani, MD; Shahar Frenkel, MD, PhD; Eytan Z. Blumenthal, MD BACKGROUND
More informationGanglion cell analysis by optical coherence tomography (OCT) Jonathan A. Micieli, MD Valérie Biousse, MD
Ganglion cell analysis by optical coherence tomography (OCT) Jonathan A. Micieli, MD Valérie Biousse, MD Figure 1. Normal OCT of the macula (cross section through the line indicated on the fundus photo)
More informationPRIMUS 200 from ZEISS The essential OCT
EN 00_00I The contents of the brochure may differ from the current status of approval of the product in your country. Please contact your regional representative for more information. Subject to change
More informationClinical Study Choroidal Thickness in Eyes with Unilateral Ocular Ischemic Syndrome
Hindawi Publishing Corporation Journal of Ophthalmology Volume 215, Article ID 62372, 5 pages http://dx.doi.org/1.1155/215/62372 Clinical Study Choroidal Thickness in Eyes with Unilateral Ocular Ischemic
More informationNon-arteritic anterior ischemic optic neuropathy (NAION) with segmental optic disc edema. Jonathan A. Micieli, MD Valérie Biousse, MD
Non-arteritic anterior ischemic optic neuropathy (NAION) with segmental optic disc edema Jonathan A. Micieli, MD Valérie Biousse, MD A 75 year old white woman lost vision in the inferior part of her visual
More informationOphthalmology Department, Lozano Blesa University Hospital, c/ San Juan Bosco 15, Zaragoza, Spain 2
Ophthalmology Volume 2012, Article ID 107053, 6 pages doi:10.1155/2012/107053 Clinical Study Comparison of Retinal Nerve Fiber Layer Thickness Measurements in Healthy Subjects Using Fourier and Time Domain
More informationDifferences between Non-arteritic Anterior Ischemic Optic Neuropathy and Open Angle Glaucoma with Altitudinal Visual Field Defect
pissn: 1011-8942 eissn: 2092-9382 Korean J Ophthalmol 2015;29(6):418-423 http://dx.doi.org/10.3341/kjo.2015.29.6.418 Original Article Differences between Non-arteritic Anterior Ischemic Optic Neuropathy
More informationLongitudinal Changes of Retinal Thicknesses in Branch Retinal Artery Occlusion: Spectral-Domain Optical Coherence Tomography Study METHODS.
Retina Longitudinal Changes of Retinal Thicknesses in Branch Retinal Artery Occlusion: Spectral-Domain Optical Coherence Tomography Study Min-Su Kim, 1 Kyeung-Min Kim, 1 Hyung-Bin Lim, 1,2 Young-Joon Jo,
More informationEXPERIMENTAL AND THERAPEUTIC MEDICINE 6: , 2013
268 Comparison of optic nerve morphology in eyes with glaucoma and eyes with non-arteritic anterior ischemic optic neuropathy by Fourier domain optical coherence tomography YUXIN YANG 1, HAITAO ZHANG 1,
More informationCirrus TM HD-OCT. Details define your decisions
Cirrus TM HD-OCT Details define your decisions 2 With high-definition OCT Carl Zeiss Meditec takes you beyond standard spectral domain Built on 10 years experience at the vanguard of innovation, Carl Zeiss
More informationIl contributo dell'angio-oct: valutazione integrata della componente nervosa e vascolare della malattia glaucomatosa
SIMPOSIO G.O.A.L. - LE NUOVE FRONTIERE DIAGNOSTICHE E LE LINEE DI INDIRIZZO AMBULATORIALI DEL GLAUCOMA Coordinatore e moderatore: D. Mazzacane Presidente: L. Rossetti Il contributo dell'angio-oct: valutazione
More informationNIH Public Access Author Manuscript Br J Ophthalmol. Author manuscript; available in PMC 2010 April 29.
NIH Public Access Author Manuscript Published in final edited form as: Br J Ophthalmol. 2009 August ; 93(8): 1057 1063. doi:10.1136/bjo.2009.157875. Retinal nerve fibre layer thickness measurement reproducibility
More informationOptical coherence tomography of the retinal nerve fibre layer in mild papilloedema and pseudopapilloedema
294 SCIENTIFIC REPORT Optical coherence tomography of the retinal nerve fibre layer in mild papilloedema and pseudopapilloedema E Z Karam, T R Hedges... Aims: To determine the degree to which optical coherence
More informationJuvenile open-angle Glaucoma associated with Leber s hereditary optic neuropathy: a case report and literature review
Lin et al. BMC Ophthalmology (2018) 18:323 https://doi.org/10.1186/s12886-018-0980-2 CASE REPORT Open Access Juvenile open-angle Glaucoma associated with Leber s hereditary optic neuropathy: a case report
More informationOptical Coherence Tomograpic Features in Idiopathic Retinitis, Vasculitis, Aneurysms and Neuroretinitis (IRVAN)
Columbia International Publishing Journal of Ophthalmic Research (2014) Research Article Optical Coherence Tomograpic Features in Idiopathic Retinitis, Vasculitis, Aneurysms and Neuroretinitis (IRVAN)
More informationCHAPTER 13 CLINICAL CASES INTRODUCTION
2 CHAPTER 3 CLINICAL CASES INTRODUCTION The previous chapters of this book have systematically presented various aspects of visual field testing and is now put into a clinical context. In this chapter,
More informationEye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology
Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Retinal Ganglion Cell Dysfunction in Asymptomatic G11778A: Leber Hereditary Optic Neuropathy John Guy, William J. Feuer, Vittorio Porciatti,
More informationComparison of Retinal Nerve Fiber Layer Thickness between Stratus and Spectralis OCT
pissn: 1011-8942 eissn: 2092-9382 Korean J Ophthalmol 2011;25(3):166-173 DOI: 10.3341/kjo.2011.25.3.166 Original Article Comparison of Retinal Nerve Fiber Layer Thickness between Stratus and Spectralis
More informationOptical coherence tomography (OCT) is a relatively new noninvasive. The Use of Optical Coherence Tomography in Neurology DIAGNOSTIC UPDATE
DIAGNOSTIC UPDATE The Use of Optical Coherence Tomography in Neurology Cédric Lamirel, MD,* Nancy Newman, MD,* Valérie Biousse, MD* Departments of *Ophthalmology, Neurology, and Neurological Surgery, Emory
More informationAnalysis of Peripapillary Atrophy Using Spectral Domain Optical Coherence Tomography
Analysis of Peripapillary Atrophy Using Spectral Domain Optical Coherence Tomography The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters.
More informationRelationship between the GDx VCC and Stratus OCT in Primary Open Angle Glaucoma
Relationship between the GDx VCC and Stratus OCT in Primary Open Angle Glaucoma Reza Zarei, MD 1 Mohammad Soleimani, MD 2 Sasan Moghimi, MD 3 Mohammad Yaser Kiarudi, MD 2 Mahmoud Jabbarvand, MD 1 Yadollah
More informationOCT in the Diagnosis and Follow-up of Glaucoma
OCT in the Diagnosis and Follow-up of Glaucoma Karim A Raafat MD. Professor Of Ophthalmology Cairo University Hmmmm! Do I have Glaucoma or not?! 1 Visual Function 100% - N Gl Structure : - 5000 axon /
More informationPearls, Pitfalls and Advances in Neuro-Ophthalmology
Pearls, Pitfalls and Advances in Neuro-Ophthalmology Nancy J. Newman, MD Emory University Atlanta, GA Consultant for Gensight Biologics, Santhera Data Safety Monitoring Board for Quark AION Study Medical-legal
More informationUniversity Hospital Basel. Optical Coherence Tomography Emerging Role in the Assessment of MS PD Dr. Konstantin Gugleta
University Hospital Basel Optical Coherence Tomography Emerging Role in the Assessment of MS PD Dr. Konstantin Gugleta 15th State of the Art SMSS, Lucerne January 2013 Retinal Nerve Fiber Layer 1.200.000
More informationCLINICAL SCIENCES. Repeatability and Reproducibility of Fast Macular Thickness Mapping With Stratus Optical Coherence Tomography
CLINICAL SCIENCES Repeatability and Reproducibility of Fast Macular Thickness Mapping With Stratus Optical Coherence Tomography Antonio Polito, MD; Michele Del Borrello, MD; Miriam Isola, MHS; Nicola Zemella,
More informationCirrus TM HD-OCT. Details defi ne your decisions
Cirrus TM HD-OCT Details defi ne your decisions 2 With high-defi nition OCT Carl Zeiss Meditec takes you beyond standard spectral domain Built on 10 years experience at the vanguard of innovation, Carl
More informationFigure 1. Illustration of the progression of visual acuity in RESCUE
Press Release GenSight Biologics reports topline results at Week 48 of the RESCUE Phase III clinical trial of GS010 in subjects within six months of visual loss onset due to Leber Hereditary Optic Neuropathy
More informationThickness Changes in the Fovea and Peripapillary Retinal Nerve Fiber Layer Depend on the Degree of Myopia
Thickness Changes in the Fovea and Peripapillary Retinal Nerve Fiber Layer Depend on the Degree of Myopia Sung-Won Choi, MD, Seok-Joon Lee, MD Department of Ophthalmology, Wonju Christian Hospital. Yonsei
More informationSTRUCTURE & FUNCTION An Integrated Approach for the Detection and Follow-up of Glaucoma. Module 3a GDx
STRUCTURE & FUNCTION An Integrated Approach for the Detection and Follow-up of Glaucoma Module 3a GDx Educational Slide Deck Carl Zeiss Meditec, Inc. November 2005 1 Structure & Function Modules Module
More informationSOUTH-EAST EUROPEAN JOURNAL of OPHTHALMOLOGY 2015; 1 (1) 34 40
Review article SOUTH-EAST EUROPEAN JOURNAL of OPHTHALMOLOGY 2015; 1 (1) 34 40 Retinal nerve fiber layer versus peripapillary capillary density assessment A powerful tool for detecting optic nerve head
More informationA pedigree of Leber s hereditary optic neuropathy with visual loss in childhood, primarily in girls
Graefe s Arch Clin Exp Ophthalmol (1999) 237:714 719 Springer-Verlag 1999 CLINICAL INVESTIGATION Hagen Thieme Bernd Wissinger Claudia Jandeck Margot Christ-Adler Hannelore Kraus Ulrich Kellner Michael
More informationEye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology
Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology Retinal Ganglion Cell Layer Thinning Within One Month of Presentation for Non-Arteritic Anterior Ischemic Optic Neuropathy Mark J. Kupersmith,
More informationMacular Thickness and Amblyopia
Original Article Macular Thickness and Amblyopia Zhale Rajavi 1, MD; Hossein Moghadasifar 1, MD; Mohadese Feizi 1, MD; Narges Haftabadi 1, MS Reza Hadavand 1, BS; Mehdi Yaseri 2,3, PhD; Kourosh Sheibani
More informationSUBCLINICAL CARRIERS AND CONVERSIONS IN LEBER HEREDITARY OPTIC NEUROPATHY: A PROSPECTIVE PSYCHOPHYSICAL STUDY
SUBCLINICAL CARRIERS AND CONVERSIONS IN LEBER HEREDITARY OPTIC NEUROPATHY: A PROSPECTIVE PSYCHOPHYSICAL STUDY BY Alfredo A. Sadun MD, PhD,* Solange R. Salomao PhD, Adriana Berezovsky PhD, Federico Sadun
More informationNoel de Jesus Atienza, MD, MSc and Joseph Anthony Tumbocon, MD
Original Article Philippine Journal of OPHTHALMOLOGY Diagnostic Accuracy of the Optical Coherence Tomography in Assessing Glaucoma Among Filipinos. Part 1: Categorical Outcomes Based on a Normative Database
More informationChanges in Peripapillary Retinal Nerve Fiber Layer Thickness after Pattern Scanning Laser Photocoagulation in Patients with Diabetic Retinopathy
pissn: 1011-8942 eissn: 2092-9382 Korean J Ophthalmol 2014;28(3):220-225 http://dx.doi.org/10.3341/kjo.2014.28.3.220 Original Article Changes in Peripapillary Retinal Nerve Fiber Layer Thickness after
More informationOptical coherence tomography in diabetic macular edema: patterns and related risk factors
Original article Optical coherence tomography in diabetic macular edema: patterns and related risk factors Mohammadreza Ahmadpour-Baghdadabad Masoudreza Manaviat Ahmad Shojaoddiny-Ardekani Yazd Diabetes
More informationA Formula to Predict Spectral Domain Optical Coherence Tomography (OCT) Retinal Nerve Fiber Layer Measurements Based on Time Domain OCT Measurements
pissn: 1011-8942 eissn: 2092-9382 Korean J Ophthalmol 2012;26(5):369-377 http://dx.doi.org/10.3341/kjo.2012.26.5.369 Original Article A Formula to Predict Spectral Domain Optical Coherence Tomography (OCT)
More informationRetinal Nerve Fiber Layer Measurement Variability with Spectral Domain Optical Coherence Tomography
pissn: 1011-8942 eissn: 2092-9382 Korean J Ophthalmol 2012;26(1):32-38 http://dx.doi.org/10.3341/kjo.2012.26.1.32 Retinal Nerve Fiber Layer Measurement Variability with Spectral Domain Optical Coherence
More informationStudy of Retinal Nerve Fiber Layer Thickness Within Normal Hemivisual Field in Primary Open-Angle Glaucoma and Normal-Tension Glaucoma
Study of Retinal Nerve Fiber Layer Thickness Within Normal Hemivisual Field in Primary Open-Angle Glaucoma and Normal-Tension Glaucoma Chiharu Matsumoto, Shiroaki Shirato, Mai Haneda, Hiroko Yamashiro
More informationRelationship Between Structure
Original Article Relationship Between Structure and Function of the Optic Nerve Head-Glaucoma versus Normal Dr Savita Bhat, Dr Anna Elias, Dr Siddharth Pawar, Dr S.J. Saikumar, Dr Alpesh Rajput, superior,
More informationTranslating data and measurements from stratus to cirrus OCT in glaucoma patients and healthy subjects
Romanian Journal of Ophthalmology, Volume 60, Issue 3, July-September 2016. pp:158-164 GENERAL ARTICLE Translating data and measurements from stratus to cirrus OCT in glaucoma patients and healthy subjects
More informationOptical Coherence Tomography Fast versus Regular Macular Thickness Mapping in Diabetic Retinopathy
Original Paper DOI: 10.1159/000127830 Received: March 18, 2007 Accepted after revision: July 9, 2007 Published online: April 25, 2008 Optical Coherence Tomography Fast versus Regular Macular Thickness
More informationOptical Coherence Tomography-Measured Nerve Fiber Layer and Macular Thickness in Emmetropic, High-Myopic and High-Hyperopic Eyes
Optical Coherence Tomography-Measured Nerve Fiber Layer and Macular Thickness in Emmetropic, High-Myopic and High-Hyperopic Eyes Mohammad-Mehdi Parvaresh, MD 1 Marjan Imani, MD 2 Mohsen Bahmani-Kashkouli,
More informationSequential non-arteritic anterior ischemic optic neuropathy (NAION) Jonathan A. Micieli, MD Valérie Biousse, MD
Sequential non-arteritic anterior ischemic optic neuropathy (NAION) Jonathan A. Micieli, MD Valérie Biousse, MD A 68 year old white woman had a new onset of floaters in her right eye and was found to have
More informationS uperior segmental optic hypoplasia (SSOH), also termed
910 CLINICAL SCIENCE Optical coherence tomography of superior segmental optic hypoplasia K Unoki, N Ohba, W F Hoyt... See end of article for authors affiliations... Correspondence to: Kazuhiko Unoki, MD,
More informationCLINICAL SCIENCES. optic neuropathy characterized
CLINICAL SCIENCES Spectral-Domain Optical Coherence Tomography for Detection of Localized Retinal Nerve Fiber Layer Defects in Patients With Open-Angle Glaucoma Na Rae Kim, MD; Eun Suk Lee, MD, PhD; Gong
More informationResearch Article The Pattern of Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness Changes in Glaucoma
Hindawi Ophthalmology Volume 2017, Article ID 78365, 8 pages https://doi.org/10.1155/2017/78365 Research Article The Pattern of Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer
More informationWhat You Should Know About Acute Macular Neuroretinopathy
What You Should Know About Acute Macular Neuroretinopathy David J. Browning MD, PhD Chong Lee BS Acute macular neuroretinopathy is a condition characterized by the sudden, painless onset of paracentral
More informationOPTOMETRY RESEARCH PAPER
C L I N I C A L A N D E X P E R I M E N T A L OPTOMETRY RESEARCH PAPER Interocular symmetry of retinal nerve fibre layer thickness in healthy eyes: a spectral-domain optical coherence tomographic study
More informationClinical and OCT features of different types and stages of diabetic optic neuropathy
Clinical and OCT features of different types and stages of diabetic optic neuropathy P.A. Bezditko 1, Dr Sc (Med), Prof.; M.A. Karliychuk 2, Cand Sc (Med) 1 Kharkiv National Medical University ; Kharkiv
More information53 year old woman attends your practice for routine exam. She has no past medical history or family history of note.
Case 1 Normal Tension Glaucoma 53 year old woman attends your practice for routine exam. She has no past medical history or family history of note. Table 1. Right Eye Left Eye Visual acuity 6/6 6/6 Ishihara
More informationRates of Abnormal Retinal Nerve Fiber Layer and Ganglion Cell Layer OCT Scans in Healthy Myopic Eyes: Cirrus Versus RTVue
CLINICAL SCIENCE Rates of Abnormal Retinal Nerve Fiber Layer and Ganglion Cell Layer OCT Scans in Healthy Myopic Eyes: Cirrus Versus RTVue Jean-Claude Mwanza, MD, MPH, PhD; Fouad E. Sayyad, MD; Ahmad A.
More informationAutosomal dominant optic atrophy (ADOA; MIM ;
Reduction of Inner Retinal Thickness in Patients with Autosomal Dominant Optic Atrophy Associated with OPA1 Mutations Yasuki Ito, 1 Makoto Nakamura, 1 Tomomi Yamakoshi, 1 Jian Lin, 1 Hiroshi Yatsuya, 2
More informationComparison of the Thickness and Volume of the Macula and Fovea in Patients with Anisometropic Amblyopia Prior to and after Occlusion Therapy
pissn: 1011-8942 eissn: 2092-9382 Korean J Ophthalmol 2018;32(1):52-58 https://doi.org/10.3341/kjo.2016.0127 Original Article Comparison of the Thickness and Volume of the Macula and Fovea in Patients
More informationInvestigation of the relationship between central corneal thickness and retinal nerve fiber layer thickness in ocular hypertension
Acta Medica Anatolia Volume 2 Issue 1 2014 Investigation of the relationship between central corneal thickness and retinal nerve fiber layer thickness in ocular hypertension Remzi Mısır 1, Sinan Sarıcaoğlu
More informationStructural examina.on: Imaging
ManaMa: Glaucoma Structural examina.on: Imaging Luís Abegão Pinto, MD, PhD Department of Ophthalmology CHLC Lisbon Faculty of Medicine, Lisbon University 1 11-10- 2013 Structural changes Qualitative changes
More informationReproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography
ORIGINAL STUDY Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography Huijuan Wu, MD, PhD,*w Johannes F. de Boer, PhD,z and Teresa C. Chen,
More informationOCT angiography of ONH blood flow in glaucoma
Hawaiian Eye Meeting 19-25 January 2013 OCT angiography of ONH blood flow in glaucoma David Huang, MD, Weeks Professor of Ophthalmic Research Professor of Ophthalmology & Biomedical Engineering Casey Eye
More informationThe leading causes of blindness. ocular circulation: Macular Degeneration
Taiwan Academy of Ophthalmology Taipei, March 31, 2012 Measurement of Blood Flow in the Retina and Optic Disc with OCT David Huang, MD, Weeks Professor of Ophthalmic Research Professor of Ophthalmology
More informationMeasurement of Choroidal Thickness in Normal Eyes Using 3D OCT-1000 Spectral Domain Optical Coherence Tomography
pissn: 111-8942 eissn: 292-9382 Korean J Ophthalmol 212;26(4):255-259 http://dx.doi.org/1.3341/kjo.212.26.4.255 Original Article Measurement of Choroidal Thickness in Normal Eyes Using 3D OCT-1 Spectral
More informationSpectral- and time-domain optical coherence tomography measurements of macular thickness in young myopic eyes
Liu et al. Diagnostic Pathology 2014, 9:38 RESEARCH Open Access Spectral- and time-domain optical coherence tomography measurements of macular thickness in young myopic eyes Lin Liu, Jun Zou *, Lili Jia,
More informationNIH Public Access Author Manuscript Retin Cases Brief Rep. Author manuscript; available in PMC 2012 January 1.
NIH Public Access Author Manuscript Published in final edited form as: Retin Cases Brief Rep. 2011 ; 5(1): 46 48. doi:10.1097/icb.0b013e3181cafc49. Intact Retinal Tissue and Retinal Pigment Epithelium
More informationGlaucoma: a disease of the macula?
Glaucoma: a disease of the macula? Derek MacDonald, OD, FAAO Waterloo, Ontario, Canada Please silence all mobile devices and remove items from chairs so others can sit. Unauthorized recording of this session
More informationEffect of Media Opacity on Retinal Nerve Fiber Layer Thickness Measurements by Optical Coherence Tomography
Original Article Effect of Media Opacity on Retinal Nerve Fiber Layer Thickness Measurements by Optical Coherence Tomography Dae Woong Lee 1, MD; Joon Mo Kim 1, MD; Ki Ho Park 2, MD Chul Young Choi 1,
More informationConfocal Adaptive Optics Imaging of Peripapillary Nerve Fiber Bundles: Implications for Glaucomatous Damage Seen on Circumpapillary OCT Scans
Article DOI: 10.1167/tvst.4.2.12 Confocal Adaptive Optics Imaging of Peripapillary Nerve Fiber Bundles: Implications for Glaucomatous Damage Seen on Circumpapillary OCT Scans Donald C. Hood 1, Monica F.
More informationNIH Public Access Author Manuscript JAMA Ophthalmol. Author manuscript; available in PMC 2013 September 10.
NIH Public Access Author Manuscript Published in final edited form as: JAMA Ophthalmol. 2013 May ; 131(5): 693 694. doi:10.1001/jamaophthalmol.2013.692. Effect of Intravitreous Anti Vascular Endothelial
More informationResearch Article Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography
Ophthalmology Volume 2015, Article ID 605940, 5 pages http://dx.doi.org/10.1155/2015/605940 Research Article Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence
More informationtracking progression we can better manage our patients. Like any tool, any instrument you ve got to
EIYESS ALBEINUTI, MD 1 As we know OCT has become very instrumental in taking care of glaucoma patients whether we have the ability to objectively image the RNFL and therefore pickup earlier signs of damage
More informationEvaluation of retinal nerve fiber layer thickness parameters in myopic population using scanning laser polarimetry (GDxVCC)
Dada T et al Original article Evaluation of retinal nerve fiber layer thickness parameters in myopic population using scanning laser polarimetry (GDxVCC) Dada T1, Aggarwal A1, Bali SJ2, Sharma A1, Shah
More informationCitation International Ophthalmology, 2012, v. 32 n. 6, p
Title Prospective study on retinal nerve fibre layer changes after an acute episode of phacomorphic angle closure Author(s) Lee, JWY; Lai, JSM; Yick, DWF; Yuen, CYF Citation International Ophthalmology,
More informationMoving forward with a different perspective
Moving forward with a different perspective The Leader In Vision Diagnostics Offers A New Perspective Marco has served the eyecare community by offering exceptional lane products and automated high tech
More informationEvaluation of myopia on retinal nerve fiber layer thickness measured by Spectralis optical coherence tomography
2716 Evaluation of myopia on retinal nerve fiber layer thickness measured by Spectralis optical coherence tomography YI ZHA, JINFEI ZHUANG, DA LIN, WANGQIANG FENG, HAIHUA ZHENG and JIANQIU CAI Ophthalmology
More informationDiagnostic Accuracy of the Optical Coherence Tomography in Assessing Glaucoma Among Filipinos. Part 2: Optic Nerve Head and Retinal
Original Article Philippine Journal of OPHTHALMOLOGY Diagnostic Accuracy of the Optical Coherence Tomography in Assessing Glaucoma Among Filipinos. Part 2: Optic Nerve Head and Retinal Nerve Fiber Layer
More informationOCT Assessment of the Vitreoretinal Relationship in CSME
December 2007 Sonia Rani John et al. - IFIS 375 ORIGINAL ARTICLE OCT Assessment of the Vitreoretinal Relationship in CSME Dr. Manoj S. DNB FRCS, Dr. Unnikrishnan Nair MS DO FRCS, Dr. Gargi Sathish MS Introduction
More informationLeber s hereditary optic neuropathy - case report
Journal of Health Sciences www.jhsci.ba Volume 2, Number 2, September 2012 - case report Mirjana A. Janicijevic-Petrovic 1 *, Tatjana Sarenac Vulovic 1, Nenad Petrovic 1, Suncica Sreckovic 1, Svetlana
More information