CURRICULUM VITAE Wei-Chuan Tsai, M.D. 蔡惟全

Transcription

1 CURRICULUM VITAE Wei-Chuan Tsai, M.D. 蔡惟全 Current Position: Associate Professor, Division of Cardiology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Attending Physician, Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital Director, Echocardiography Laboratory, Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital Current Address: Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan 704, Taiwan. Telephone: ext 2388 Fax: Date and Place of Birth: April 2, 1964, Taichun, Taiwan Education: BS. National Taiwan University, Taipei, Taiwan MD. National Cheng Kung University, Tainan, Taiwan Clinical Training: Internship, National Cheng Kung University Hospital Resident in Internal Medicine, Department of Internal Medicine, National Cheng Kung University Hospital Chief Resident, Department of Internal Medicine, National Cheng Kung University Hospital Fellow, Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital Visiting Physician, Victoria Heart Center, Melbourne, Australia Professional Appointment: 1996-Now Attending Physician, Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital.

2 Clinical Assistant Professor, Department of Internal Medicine, College of Medicine, National Cheng Kung University Assistant Professor, Department of Internal Medicine, College of Medicine, National Cheng Kung University Visiting Assistant Professor, Cardiovascular Medicine, Stanford University Director, Department of Internal Medicine, National Cheng Kung University Hospital Dou-Liou Branch Senior Attending Physician, Department of Internal Medicine, National Cheng Kung University Hospital Dou-Liou Branch Board Certification: 1991 Registered Physician-Taiwan 1995 Board of Internal Medicine-Taiwan 1997 Board of Cardiology-Taiwan 1997 Board of Critical Care Medicine-Taiwan Membership in National Societies: Since 1996 Member of Formosan Medical Association-Taiwan Since 1995 Member of Society of Internal Medicine-Taiwan Since 1995 Member of Society of Cardiology-Taiwan Since 1994 Member of Society of Ultrasound in Medicine-Taiwan Since 1994 Member of Society of Critical Care and Emergency Medicine -Taiwan Since 1997 Member of American Society of Echocardiography-USA Since 2009 Member of European association of Echocardiography-EU Honors: 2001 Medical Research Award, Taiwan Society of Critical Care and Emergency Medicine 2005 Medical Research Award, Department of Internal Medicine, NCKUH 2008 Medical Research Award, Department of Internal Medicine, NCKUH 2011 Award of best full-text paper, Society of Ultrasound in Medicine, Taiwan Journal Reviewers: Editorial board of World Journal of Cardiology, World Journal of Hypertension Invited reviewer for Atherosclerosis, American Journal of Cardiology, American Journal of Hypertension, European Journal of Echocardiography,

3 Journal of the American Society of Echocardiography, Journal of Hypertension Represented publications (total >90): 1. Tsai WC, Tsai LM, Teng JK, Li YH, Lin LJ, Chen JH. Prognostic value of Doppler-derived mitral deceleration time in postinfarction patients with left ventricular ejection fraction of 35% or more. J Formos Med Assoc 1999;98: Tsai WC, Li YH, Tsai LM, Chao TH, Lin LJ, Chen TY, Chen JH. Correlation of homocysteine levels with the extent of coronary atherosclerosis in patients with low cardiovascular risk profiles. Am J Cardiol 2000;85: Tsai WC, Li YH, Sheu BS, Tsai LM, Chao TH, Lin LJ, Chen JH. Association of elevation of anti-helicobacter pylori antibody with ischemic events in coronary artery disease. Am J Cardiol 2001;87: Tsai WC, Li YH, Chao TH, Chen JH. Relation between antibody against oxidized low-density lipoprotein and extent of coronary atherosclerosis. J Formos Med Assoc 2002;101: Tsai WC, Li YH, Lin CC, Chao TH, Chen JH. Effects of oxidative stress on endothelial function after a high-fat meal. Clin Sci 2004;106: Tsai WC (correspondence), Li YH, Huang YY, Lin CC, Chao TH, Chen JH. Plasma Vascular Endothelial Growth Factor as a Marker for Early Vascular Damage in Hypertension. Clin Sci 2005;109: Tsai WC, Chen JY, Wang MC, Wu HT, Chi CK, Chen YK, Chen JH, Lin LJ. Association of Risk Factors with Increased Pulse Wave Velocity Detected by a Novel Method Using Dual-channel Photoplethysmography. Am J Hypertens 2005;18: Chen JY, Tsai WC (correspondence), Lin CC, Huang YY, Hsu CH, Liu PY, Chen JY. Stiffness index derived from digital volume pulse as a marker in target organ damage of untreated hypertension. Blood Pressure 2005;14: Hsu CH, Tsai WC (correspondence), Tsai LM, Lin CC, Chen JY, Huang YY, Chao TH, Liu PY, Chen JH. The effects of left ventricular hypertrophy on the respiratory changes in transmitral Doppler flow patterns of hypertension patients. Clin Physiol Funct Imaging 2005;25: Lee CH, Tsai WC (correspondence), Hsu CH, Liu PY, Lin LJ, Chen JH. Predictive factors of a fulminant course in acute myocarditis. Int J Cardiol 2006;109: Chen JY, Tsai WC (correspondence), Wu MS, Hsu CH, Lin CC, Wu HT, Lin LJ, Chen JH. Novel compliance index derived from digital volume pulse associated with risk factors and exercise capacity in patients undergoing treadmill exercise tests. J Hypertens 2007; 25: Tsai WC (correspondence), Lin CC, Huang YY, Chen JY, Chen JH. Association on increased arterial stiffness and inflammation with proteinuria and left ventricular hypertrophy in non-diabetic hypertensive patients. Blood Pressure 2007;16: Lin CC, Tsai WC (correspondence), Chen JY, Li YH, Lin JL, Chen JH. Supplements of L-arginine attenuate the effects of high fat meal on endothelial function and oxidative stress. Int J Cardiol 2008; 127: Tsai WC (correspondence), Lin CC, Chen JY, Huang YY, Lee CH, Li WT, Weng CM, Chen JH. Association of Adiponectin with Procollagen Type I Carboxyterminal Propeptide in Non-diabetic Essential Hypertension. Blood Pressure 2008; 17: Tsai WC (correspondence), Huang YY, Lin CC, Li WT, Lee CH, Chen JY, Chen JH. Uric acid is an independent predictor of arterial stiffness in hypertensive patients.

4 Heart Vessel 2009; 24: Liu YW, Tsai WC (correspondence), Lin CC, Hsu CH, Li WT, Lin LJ, Chen JH. Comparison of real-time three-dimensional echocardiography to two-dimensional transthoracic echocardiography for diagnosis of infective endocarditis. Scand Cardiovasc J 2009; 43: Tsai WC (correspondence), Lee CH, Lin CC, Liu YW, Huang YY, Li WT, Chen JY, Lin LJ. Association of left atrial strain and strain rate assessed by speckle tracking echocardiography with paroxysmal atrial fibrillation. Echocardiography 2009; 26: Liu YW, Tsai WC (correspondence), Su CT, Lin CC, Chen CH. Evidence of left ventricular systolic dysfunction detected by automatic function imaging in patients with heart failure and preserved left ventricular ejection fraction. J Cardiac Failure 2009; 15: Weng CM, Chou CH, Huang YY, Lin CC, Liu YW, Tsai WC (correspondence). Increased C-reactive protein is associated with future development of diabetes mellitus in essential hypertensive patients. Heart Vessel 2010; 25: Chen JY, Chou CH, Lee YL, Tsai WC (correspondence), Lin CC, Huang YY, Chen JH. Association of central aortic pressure indexes with development of diabetes mellitus in essential hypertension. Am J Hypertens 2010; 23: Tsai WC (correspondence), Liu YW, Huang YY, Lin CC, Lee CH, Tsai LM. Diagnostic value of segmental longitudinal strain by automatic function imaging in coronary artery disease without left ventricular dysfunction. J Am Soc Echocardiogr 2010;23: Liu YW, Su CT, Huang YY, Yang CS, Huang JW, Yang MT, Chen JH, Tsai WC (correspondence). Left ventricular systolic strain in chronic kidney disease and hemodialysis patients. Am J Nephrol 2011;33: Wang MC, Wu AB, Cheng MF, Chen JY, Ho CS, Tsai WC (correspondence). Association with arterial stiffness index, determined from digital volume pulse measurement, and cardiovascular risk factors in chronic kidney disease. Am J Hypertens 2011; on line. 24. Liu YW, Su CT, Wang SPH, Yang CS, Huang JW, Hung KY, Chen JH, Tsai WC (correspondence). Application of speckle-tracking echocardiography in detecting coronary artery disease in patients with maintenance hemodialysis. Blood Purif 2011;32: Shih JY, Tsai WC (correspondence), Huang YY, Liu YW, Lin CC, Huang YS, Tsai LM, Lin LJ. Association of decreased left atrial strain and strain rate with stroke in chronic atrial fibrillation. J Am Soc Echocardiogr 2011;24: Tsai WC (correspondence). Treatment options for hypertension in high-risk patients. Vasc Health Risk Manage 2011;7: Tsai WC (correspondence), Liu YW, Huang YY, Tsai LM, Lin LJ. Decreased mechanical function of left atrium assessed by speckle tracking and tissue Doppler echocardiography in patients with congestive heart failure. J Med Ultrasound 2012; online. 28. Liu YW, Chou CC, Su CT, Wang SPH, Yang CS, Huang YY, Tsai LM, Chen JH, Tsai WC (correspondence). Association of subtle left ventricular systolic dysfunction with elevated cardiac troponin T in asymptomatic hemodialysis patients with preserved left ventricular ejection fraction. Acta Cardiol Sin 2011; accepted. 29. Tsai WC (correspondence), Liu YW, Chen JY, Huang YY, Shih JY, Tsai LM, Chen JH. Post-systolic strain index is associated with delayed diastolic lengthening and diastolic dysfunction of the left ventricle in untreated hypertension. J Hypertens

5 2012; 30: Chen JY, Chou CH, Tsai WC (correspondence), Wang MC, Ho CS, Li YH, Tsai YS, Tsai LM. Effects of increased systemic inflammation and central obesity on arterial stiffness in patients with non-alcoholic fatty liver disease. J Am Soc Hypertens 2012; accepted. 31. Su CT, Liu YW, Lin JW, Chen SI, Yang CS, Chen JH, Hung KY, Tsai WC (correspondence), Huang JW. Increased procollagen type I C-terminal peptide (PICP) levels indicate diastolic dysfunction in end-stage renal disease patients undergoing maintenance dialysis therapy. J Am Soc Echocardiogr 2012; accepted.

6 The role of cardiac strain imaging for CAD 劉嚴文醫師 The echocardiographic assessment of coronary artery disease (CAD) is mainly based on the detection of regional wall motion abnormalities, lack of myocardial thickening, and visualization of scar tissue. However, this approach is highly subjective, requires considerable operator experience, and strongly depends on image quality. Two-dimensional speckle-tracking echocardiography with myocardial deformation imaging analysis (2D strain imaging analysis) has been introduced as an objective and semi-automated method for the evaluation of global and segmental cardiac function. It is strongly suggested that left ventricular (LV) longitudinal strain measurements based on speckle tracking algorithm are able to detect small alterations of myocardial contractility, especially at an earlier stage of ischemia. Our recent studies proved global LV systolic longitudinal strain can detect the decline of LV systolic function, measure the magnitude of regional, active myocardial deformation, and thus allow for the identification of the abnormal LV segments with decreased myocardial contractility. Furthermore, 2D strain were proved to provide strong prognostic information in patients after acute myocardial infarction.

7 CURRICULUM VITAE Name: Shih-Hung Chan MD Date of Birth: 25 th Jul Office Address: Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan City, Taiwan TEL: FAX: Address: Home Address: 11F-5, 399 Sec. 2 Min-Sheng Road, Cetral-Western Dist., 704, Tainan City, Taiwan Home TEL: Place of Birth: Taiwan, Republic of China Citizenship: Taiwan, Republic of China Education: 1985~1992 MD, Kaohsiung Medical University, Taiwan Postdoctoral Training: 1991~1992 Internship in National Taiwan University Hospital, Tainan, Taiwan 1992~1994 Army service 1994~1997 Resident of Internal Medicine in National Cheng Kung University Hospital, Taipei, Taiwan 1997~1999 Fellowship in Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan 1999~present Physician of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan Oct 2005~Mar 2007: Research Fellow, Biosignal Research Center, Kobe University, Japan Academic Appointments: 2004~present : Instructor in Medicine, National Cheng Kung University Hospital Appointments: 1999~present : Attending Physician, National Taiwan University Hospital, Tainan, Taiwan Board Certification: 1991 Certification of Doctor

8 1997 The Society of Internal Medicine, Republic of China 1999 Taiwan Society of Cardiology 2001 Taiwan Society of Critical Care Medicine Professional Affiliations: 1. The Society of Internal Medicine, Republic of China 2. Taiwan Society of Cardiology 3. Taiwan Society of Critical Care Medicine

9 Li- tan Yang No. 138, Sheng Li Road, East Dist., Tainan City, Taiwan, 704, Republic of China. Tel: Educational background 06 / 2007 Internship in Internal Medicine, National Cheng 05 / 2008 Kung University Hospital 07 / 2006 Clerkship in St James's University Hospital (Leeds 08 / 2006 Teaching Hospitals NHS Trust), Leeds, UK 09/ Department of Medicine, College of Medicine, 06 / 2007 National Cheng Kung University, Taiwan 09 / 1998 Kaohsiung Municipal Kaohsiung Girls' Senior 06 / 2001 High School, Taiwan Work Experience 08 / Fellow, Division of Cardiology, Department of To Date Internal Medicine, National Cheng Kung University Medical Center 08 / 2008 Resident, Department of Internal Medicine, 07 / 2011 National Cheng Kung University Medical Center 07 / 2005 Pre-clerkship, Taiwan Medical Corps in 08 / 2005 Ekwendeni Hospital, Mzuzu, Malawi 06 / 2005 Pre-clerkship, Lanyu Township Public Health 07 / 2005 Station, Taitung County Extracurricular Activities 09 / 2004 Sub-chairman, Student Association of Department 08 / 2005 of Medicine, College of Medicine, National Cheng Kung University, Taiwan 09 / Leader of Swimming Club, Department of 08 / 2006 Medicine, College of Medicine, National Cheng Kung University, Taiwan 09/ 2002 Member of Women s Swimming Team, National 08 / 2005 Cheng Kung University, Taiwan 08 / 2003 General Assembly of International Federation of Medical Students' Associations, Macedonia 09/ Leader of Watson English Club in College of 08 / 2003 Medicine, National Cheng Kung University,

10 Taiwan Award 2006 Scholarship from Rheumatology Association, Taiwan Best Resident April, 2012 Oral presentation for case competition in Angioplasty Summit of Transcatheter Cardiovascular Therapeutics Asia Pacific, Seoul, Korea May, 2012 Poster in General Assembly of Taiwan Society of Cardiology May, 2012 Oral presentation in Cardiac Image Case Competition in Asian Pacific Society of Cardiology Subspecialty Congress in Taiwan May, 2012 Oral presentation in General Assembly of Taiwan Society of Thrombosis and Hemostasis

11 履歷表 (Curriculum Vitae) 中文姓名 : 黃成偉 英文姓名 : Chen-Wei Huang 姓 別 : 男 籍 貫 : 臺灣省台南市 出生日期 : 民國 72 年 7 月 17 日 婚 姻 : 未婚 電 話 : EXIT 7192 電子信箱 : s @gmail.com 學 歷 : 陽明大學醫學系學士 ( ) 經歷 : 成功大學醫學院附設醫院內科住院醫師 ( ) 成功大學醫學院附設醫院心臟內科總醫師 (2011- ) 資歷 : 中華民國國家醫師考試合格 (2007 ) 中華民國內科專科醫師考試合格 (2011 ) 現職 : 成功大學醫學院附設醫院心臟內科總醫師 會員 : 臺灣內科醫學會 臺灣醫學會 中華民國心臟學會

12 CURRICULUM VITAE Po-Sheng Chen, M.D. Current Position Attending Physicain, Department of Internal Medicne, National Cheng Kung University Hospital Current Address Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan 704, Taiwan Telephone: ext 2382 Fax: E mail: mdcps@seed.net.tw Date and Place of Birth: June 27, 1974, Tainan, Taiwan Education: MD. National Cheng Kung University Medical Collage, Tainan, Taiwan Clinical Training: Resident, Department of Internal Medicine, National Cheng Kung University Hospital Chief Resident, Department of Internal Medicine, National Cheng Kung University Hospital Fellow, Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital Fellow, Division of Critical Care Medicine, Department of Internal Medicine, National Cheng Kung University Hospital. Professional Appointment: 2007-Now Attending Physician, Department of Internal Medicine, National Cheng Kung University Medical Center

13 Board Certification: 1999 Registered Physician-Taiwan 2004 Board of Internal Medicine-Taiwan 2006 Board of Adult Cardiologist-Taiwan 2008 Board of Critical Care Medicine-Taiwan Membership in National Societies Member of Society of Internal Medicine-Taiwan Member of Formosan Medical Association-Taiwan Member of Society of Cardiology-Taiwan Member of the Society of Ultrasound in Medicine of the Republic of China-Taiwan Member of Taiwan Society of Critical Care Medicine-Taiwan Member of the Gerontological Society of Taiwan-Taiwan Member of Taiwan Hypertension Society-Taiwan Member of Taiwan Society of Echocardiography-Taiwan

14 Update information of pulmonary arterial hypertension 國立成功大學附設醫院 許志新醫師 Pulmonary arterial hypertension (PAH) is characterized by a progressive rise in pulmonary vascular resistance resulting from vascular remodeling, vasoconstriction, and cellular proliferation. The prognosis of PAH is poor, with an approximately 9-15 % annual mortality rate. The goal of medical therapy is to improve survival and patients quality of life. Although PAH is an orphan disease with high mortality and for which there is no cure, current treatment strategies have led to considerable gains. General managements include avoidance of salt in the diet, oxygen, appropriate vaccinations and general health maintenance, and avoidance of pregnancy. Traditional treatments include warfarin, diuretics, and calcium channel blockers (if patients are deemed responders during cardiac catheterization). Currently three classes of drugs are approved for the treatment of PAH based on results from clinical trials prostacyclin analogues, endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors. Guidelines recommend initiating therapy even in patients with early disease, as evidence suggests that early treatment is a critical component of optimal disease management. An equally important element of a treat-to-target approach is the use of combination therapy. In the current era of clinical practice, goal-oriented treatment algorithms for PAH are becoming more important. Clinical practice patterns shift in favor of earlier diagnosis, aggressive front line treatment, and upfront versus stepwise combination therapy. Future drug development targeting other molecular pathways of pulmonary vascular disease are essential for advancing our understanding of this disease.

15 個人簡歷 姓名 : 許志新現職 : 國立成功大學附設醫院內科部主治醫師暨臨床講師住址 : 台南市勝利路 138 號國立成功大學附設醫院心臟科電話 : (06) 分機 2388 傳真 : (06) 電子信箱 : cool.hsu@msa.hinet.net 生日 : 西元 1972 年 9 月 16 日出生地 : 台灣台南學歷 : 私立中國醫藥學院醫學系畢業 ( ) 國立成功大學臨床醫學研究所博士班 (2007-) 經歷 : 國立高雄榮民總醫院實習醫師 ( ) 中科院附設石園醫院醫官 ( ) 國立成功大學附設醫院內科部住院醫師 ( ) 國立成功大學附設醫院內科部總醫師 ( ) 國立成功大學附設醫院心臟科臨床研究員 ( ) 國立成功大學附設醫院內科部主治醫師 (2004-) 美國 UCLA 醫學中心心臟移植及心衰竭臨床研究員 (2005) 國立成功大學附設醫院心臟移植小組醫師 (2005-) 國立成功大學醫學院講師 (2006-) 美國芝加哥大學肺高壓中心訪問學者 ( ) 證書 : 中華民國醫師證書中華民國内科醫師證書中華民國心臟內科專科證書中華民國高級心臟救命術指導員

16 中華民國重症醫學專科醫師中華民國教育部部定大專講師中華民國老年醫學專科醫師中華民國老年急重症專科醫師中華民國肥胖醫學專科醫師中華民國醫用超音波專科醫師中華民國介入性心臟血管專科醫師台灣心臟超音波學會專科醫師台灣心臟超音波學會專科指導醫師中華民國重症醫學專科指導醫師台灣醫學教育學會考官 加入學會 : 臺灣醫學會臺灣內科醫學會中華民國心臟學會中華民國醫用超音波學會中華民國介入性心臟血管學會中華民國老人醫學會中華民國重症醫學會中華民國急救加護醫學會中華民國老年急重症醫學會中華民國肥胖醫學會台灣移植醫學會美國重症醫學會歐洲心衰竭協會

17 國際心胸外移植學會 肺動脈高壓協會 獲獎榮耀 : 2004 台灣內科醫學會最佳海報論文獎 2009 成大醫院優良主治醫師獎 2009 成大醫院優良病歷寫作獎 2009, 教學優良主治醫師獎 2010 教學優良主治醫師獎 2010 教學優良琳床醫師獎 期刊論文 1. Hsu CH, Tsai WC, Tsai LM, Chao TC, Huang YY, Lin HW, Li YH. Management of hypertension crisis.(december, 2003).Taiwan Crit. Care Med. 2003;5: Chao TH, Chen JY, Hsu CH, Tsai WC, Li YH, Huang YY, Tsai LM. New insights into the diagnostic approach and prognostic assessment in patients with acute pulmonary embolism.(december, 2003).Taiwan Crit.Care Med. 2003;5: Liu PY, Tsai WC, Lin CC, Hsu CH, Chen JH. Invasive measurements of pulse wave velocity correlate with the degree of echocardiographic aortic valve calcification and severity associated with matrix metalloproteinases among elders with aortic valve stenosis.(october, 2004).Clin Sci 2004; 107: Hsu CH, Liu PY, Chen JH, Yeh TL, Tsai HY, Lin LJ. Electrocardiographic abnormalities as predictor for lithium over-range.(february, 2005) Cardiology

18 2005; 103: Chen JY, Tsai WC, Lin CC, Huang YY, Hsu CH, Liu PY, Chen JH. Stiffness index derived from digital volume pulse as a marker in target organ damage of untreated hypertension. (August, 2005) Blood Pressure 2005; 14: Hsu CH, Chao TH, Tsai WC, Li WT, Tsai LM. Intracardiac thrombosis in multiple chambers and descending aorta manifested as systemic and pulmonary thromboembolism. (September, 2005) Echocardiography 2005; 22: Hsu CH, Tsai WC, Tsai LM, Chen JY, Huang YY, Lin LJ, Chao TH, Liu PY, Chen JH. The effects of left ventricular hypertrophy on the respiratory changes in transmitral Doppler flow patterns of hypertension patients. (November, 2005) Clin Physiol Funct Imaging. 2005; 25: Lee CH, Tsai WC, Hsu CH, Liu PY, Lin LJ, Chen JH. Predictive factors of a fulminant course un acute myocarditis. (April, 2006). Int J Cardiol. 2006; 109: Chen JY, Chao TH, Guo YL, Hsu CH, Huang YY, Chen JH, Lin LJ. A simplified clinical model to predict pulmonary embolism in patients with acute dyspnea. (Mar, 2006). Int Heart J. 2006;47: Chen CW, Lin WC, Hsu CH. Pseudo-double-triggering. (Apr,2007) Intensive Care Med. 2007; 33(4): Chen JY, Tsai WC, Wu MS, Hsu CH, Lin CC, Wu HT, Lin LJ, Chen JH. Novel Compliance Index derived from digital volume pulse associated with risk factors and exercise capacity in patients undergoing treadmill exercise tests.(sep, 2007) J Hypertens ; 25(9): Chen CW, Lin WC, Hsu CH, Cheng KS, Lo CS. Detecting ineffective triggering in the expiratory phase in mechanically ventilated patients based on airway flow

19 and pressure deflection: feasibility of using a computer algorithm.(feb,2008) Crit Care Med ;36(2): Roan JN, Hsin HY, Tsai HW, Wu CJ, Hsu CH, Wu SY, Yang YJ, Chang TC. Pulmonary nodules caused by schizophyllum commune after cardiac transplant. (Feb,2009) Journal of Infection.2009; 58: Hsu CH, Chen PS, Chen CW, Li WT, Lin WC. The role of brain peptide and N-terminal natriuretic peptide in critical care. (Apr, 2009) Taiwan Crit.Care Med 2009;10: Liu YW, Tsai WC, Lin CC, Hsu CH, Li WT, Lin LJ, Chen JH Usefulness of real-time three-dimensional echocardiography for diagnosis of infective endocarditis.(dec 2009) Scand Cardiovasc J. 2009;43: Chen PS, Hsu CH, Lee WT, Lin WJ, Chen CW.Predicting fluid responsiveness in mechanically ventilated patients. (Jul, 2009) J Intern Med Taiwan 2009; 20: Chen JY, Li WT, Hsu CH, Tsai HW, Tsai WC, Tsai LM, Lin LJ. Chylous ascites and chylothorax: an unusual manifestation of cardiac amyloidosis. Intern Med. (Aug, 2010) 2010;49(16): Hsu CH, Gomberg-Maitland M, Glassner C, Chen JH. The management of pregnancy and pregnancy-related medical conditions in pulmonary arterial hypertension patients. (Aug, 2011) Int J Clin Prac. 2011, 65,(suppl 172), Hsu CH, Glassner C, Forman A, Agarwal R, Benza R, Frantz R, Gomberg-Maitland M. Treadmill testing improves survival prediction models in pulmonary arterial hypertension.(dec,2011) Am Heart J.2011,1622: Roan JN, Fang SY, Chang SY, Hsu CH, Huang CC, Chiou MH, Tsai YC, Lam CF. Rosuvastatin improves vascular function of arteriovenous fistula in a diabetic

20 rat model. Journal of Vascular Surgery. 2012, accepted. 21. Hsu CH, Glassner C,Hsu HS,Gomberg-Maitland M. Current Therapeutics for Pulmonary Arterial Hypertension. Acta Cardiologica Sinica. 2012, accepted.

21 成大醫院二尖瓣修補之經驗阮俊能吳宣穎胡佑寧蔡孟達甘宗旦林寶彥楊友任羅傳堯國立成功大學醫學院附設醫院外科部心臟外科 Experiences of Mitral Valve Repair in National Cheng Kung University Hospital Jun-Neng Roan, Shaun-Yin Wu, Yu-Ning Hu, Meng-Ta Tsai, Chung-Dann Kan, Pao-Yen Lin, Yu-Jen Yang, Chwan-Yau Luo Division of Cardiovascular Surgery, Department of Surgery, National Cheng Kung University Hospital Background: Mitral valve repair had been an important treatment for mitral regurgitation (MR) from variable etiologies including degeneration, ischemia and endocarditis. A simplified classification of MR proposed by Doctor Carpentier helps clarifying lesions and locations of the valve. Here, we review our experience and present the mid-term result of mitral valve repair for mitral valve regurgitation. Materials and Methods: From January 2001 to December 2011, 59 (39 males and 20 females) patients underwent mitral valve repair for MR. The mean age was 57.4±16.0 ( ). The etiologies of mitral valve disease included degeneration in 36 (61.0%), infective endocarditis in 11 (18.6%), ischemic mitral valve regurgitation in 11 (18.6%), and congenital in 1 (1.7%). Results: The mean follow-up time was 29.0±26.8 ( ) months. The overall survival rate was 88.1% without in-hospital mortality in our series. There was no re-operation for mitral valve regurgitation during the follow-up. There were 7 mortality cases with underlying degenerative or ischemic mitral etiologies: 5 patients died of non-cardiac causes (pneumonia, sepsis or ischemic bowel disease) and 2 died of de-compensated heart failure. The freedom from moderate to severe MR (>2+) at 12 and 60 months are 94% and 92% respectively. The procedure time was not associated with the postoperative survival. There is a significantly decreased survival when the left ventricular end-systolic dimension is greater than 40mm (P=0.019). Conclusions: Mitral valve repair is feasible in most patients with mitral regurgitation and is associated with low mortality and low rates of valve related events. Left ventricular end-systolic diameter of more than 40mm predicts a higher mortality during the midterm follow-up.

22 CURRICULUM VITAE NAME: Roan Jun-Neng Clinical & Research Interest: Vascular physiology Vascular intervention Adult cardiac surgery Pediatric or adult ECMO care MEDICAL EDUCATION National Cheng Kung University, Tainan, Taiwan POST-GRADUATE TRAINING& SERVICE 成大外科住院醫師 成大心血管外科住院醫師及總醫師 Aug. 成大心血管外科 Fellowship Aug. 成大醫院院聘主治醫師 成大斗六分院兼任主治醫師 Aug. 台南市立醫院心臟血管外科主任 成大醫院兼任主治醫師成功大學兼任講師 ~present 成大醫院院聘主治醫師台南市立醫院兼任主治醫師 MEDICAL & SCIENTIFIC SOCIETIES 1. Society of Surgery, Taiwan 2. Society of Thoracic and Cardiovascular Surgery, Taiwan 3. Society of Vascular surgery, Taiwan 4. Society of Transplantation, Taiwan 5. Taiwan Society of Cardiology Awards 2006 優良教學總醫師 2012 青年醫師研究獎 Young Investigator Award Taiwan Society of Cardiology 2012 優良教學主治醫師 (internship) BIBLIOGRAPHY PAPERS (original and referred) 1. Roan Jun-Neng, Chang Shih-Wei, Fang Shih-Yuan, Huang Chien-Chi, Tsai

23 Yu-Chuan, Lam Chen-Fuh. Rosuvastatin improves vascular function in a diabetic rat model. J Vasc Surg 2012 (Original article, SCI, IF: 3.853, in press) 2. Hsu Cheng-Yuan, Fang Shin-Yuan, Chen Ying-Zeng, Roan Jun-Neng, Chang Shih-Wei, Huang Chien-Chi, Liu Yen-Chin, Tsai Yu-Chuan, Lam Chen-Fuh. Cardiovascular protection of activating K ATP channel during ischemia-reperfusion acidosis. Shock 2012;37(6): (Original article, SCI, IF: 3.203) 3. Roan Jun-Neng, Tsai YC, Chang SW, Huang CC, Liu YC, Lam CF. Inhibition of cyclooxygenase-2 modulates phenotypic switching of vascular smooth muscle cells during increased aortic blood flow. Heart and Vessels 2012;27: (Original article, SCI, IF: 1.882) 4. Roan Jun-Neng, Tsai YC, Jiang-Shieh YF, Lee CH, Huang CC, Lam CF. Functional Dilatation and Medial Remodeling of Renal Artery in Response to Chronic Increased Blood Flow. Kidney and Blood Pressure Research 2011;34(6): (Original article, SCI, IF: 1.500) 5. Chen-Fuh Lam, Roan Jun-Neng (Co-first author), Chou-Hwei Lee, Pei-Jung Chang, Chien-Chi Huang, Yen-Chin Liu, Meei-Jyh Jiang, Yu-Chuan Tsai. Transplantation of Endothelial Progenitor Cells Improves Pulmonary Endothelial Function and Gas Exchange in Rabbits with Endotoxin-Induced Acute Lung Injury. Anesth Analg 2011;112: (Original article, SCI, IF: 3.274) 6. Roan Jun-Neng, Wu MH. Esophageal Perforation Caused by External Air-Blast Injury. J Cardiothorac Surg. 2010;5(1):130. (Case report, SCI, IF:0.908) 7. Luo YH, Chuang WJ, Wu JJ, Lin MT, Liu CC, Lin PY, Roan Jun-Neng, Wong TW, Chen YL, Lin YS. Molecular mimicry between streptococcal pyrogenic exotoxin B and endothelial cells. Lab Invest. 2010;90: (Original article, SCI, IF: 4.405). 8. Roan Jun-Neng, Hsieh Hsin-Yi, Tsai Hung-Wen, Wu Chi-Jung, Hsu Chih-Hsin, Wu Shien-Yin, Yang Yu-Jen, Chang Tsung-Chain. Pulmonary Nodules Caused by Schizophyllum commune after Cardiac Transplantation. Journal of Infection 2009;58, (Case report, SCI, IF: 3.805) 9. Roan Jun-Neng, Wen-Chien Ko, Chwan-Yau Luo. Abdominal septic aortic pseudoaneurysm caused by Campylobacter jejuni infection: report of a case. Surgery Today 2009; 39: (Case report, SCI, IF: 1.057) 10. Roan Jun-Neng, Kan Chun-Dann, Yang Yu-Jen. Coronary Arteriovenous Fistula with Aneurysm Formation. Ann Thorac Surg 2008;86(4):1382. (Case report, SCI, IF: 3.792) 11. Roan Jun-Neng, Hsu Chih-Hsin, Tsai Hung-Wen, Wu Shien-Yin, Kan Chung-Dann, Wen Jih-Sheng, Luo Chwan-Yau, Yang Yu-Jen. The role of brain natriuretic peptide in cardiac transplantation patients. Heart, Lung and Circulation 2008;17:S37 (Abstract, SCI, IF: 1.330) 12. Hsu Chih-Hsin, Li Wei-Ting, Roan Jun-Neng, Chen Po-Sheng, Liu Yen-Wen, Chen Chang-Wen, Lin Li-Jen, Tsai Liang-Minn. The characteristics in critical heart failure Heart, Lung and Circulation 2008;17:S19 S20. (Abstract, SCI, IF:1.330) 13. Wu Shien-Yin. Yang Yu-Jen. Lai Chou-Han. Roan Jun-Neng. Luo Chwan-Yau. Kan Chun-Dann. Bilateral persistent sciatic arteries complicated with acute left lower limb ischemia. J Formos Med Assoc 2007;106(12): (Case report, SCI, IF: 1.125) 14. Roan Jun-Neng, Lai Chao-Han, Wen Jih-Sheng, Lin Pao-Yen, Luo Chwan-Yau, Wu Jing-Ming, Yang Yu-Jen. Correction of Tetralogy of Fallot with Absent

24 Pulmonary Valve Syndrome in a Young Infant Using a Bicuspid Equine Pericardial Tube. J Formos Med Assoc 2006;105(4): (Case report, SCI, IF: 1.125) 15. Kan Chun-Dann, Roan Jun-Neng, Yang Yu-Jen. Relief of Compromised Translocated Right Coronary Artery Blood Flow by Clockwise Rotation of the Heart in a Jatene Procedure. Ann Thorac Surg 2006;81: (Case report, SCI, IF: 3.792) 16. Roan Jun-Neng, Kan Chun-Dann, Yang Yu-Jen. J Emerg Crit Care Med 2004;15(4): (Image, non-sci) 17. Chang Ting-Tsung, Chang Tsuey-Yu, Chen Cheng-Chen, Young Kung-Chia, Roan Jun-Neng, Lee Yen-Chien, Cheng Pin-Nan, and Wu Hua-Lin. Existence of Hepatitis C Virus in Culex quinquefasciatus after Ingestion of Infected Blood: Experimental Approach to Evaluating Transmission by Mosquitoes. Journal of Clinical Microbiology 2001;39(9): (Original article, SCI)

25 Trends of acute myocardial infarction in Taiwan: Incidence, treatment and mortality in recent 10 years Yi-Heng Li, MD, PhD, FESC, FACC Professor of Medicine Hospital & College of Medicine National Cheng Kung University, Tainan, Taiwan Cardiovascular disease is a major leading cause of death in Taiwan and continues to be an important public health issue in the near future. In Taiwan, acute myocardial infarction (AMI) is one of the common cardiovascular diseases and carries a high morbidity and mortality. AMI is commonly caused by acute thrombus formation on a ruptured atherosclerotic plaque in coronary artery resulting in the occlusion of coronary artery and myocardial necrosis. By using the National Health Insurance Research Database in Taiwan, we analyzed the trends of AMI in Taiwan in recent 10 years. In 1999, there were 6,290 patients admitted due to AMI with an age-adjusted incidence rate of 41 patients/100,000 persons in man and 13 patients/100,000 persons in woman. The AMI incidence increased progressively in recent 10 years. In 2008, 14,485 patients admitted due to AMI. The age-adjusted incidence rate increased to 76 patients/100,000 persons in man and 31 patients/100,000 persons in woman. The in-hospital use of dual antiplatelet therapy increased from 68.3% to 84.9% and the in-hospital use of statin also increased from 32.1% to 50.1%. About 60% patients were treated with beta-blocker and 70% treated with RAS inhibitor during hospitalization in these years. PCI during hospitalization was performed in 40.5% of these patients in 1999 and increased to 61.3% in 2009; while CABG was performed in about 6% of these patients. Through these efforts, the in-hospital mortality of AMI in Taiwan significantly decreased from about 11% in 2000 to 7.4% in Currently, we are analyzing the major factors that contribute to the reduction of in-hospital mortality in these patients. The follow up data of these patients after discharge will also be analyzed.

26 CURRICULUM VITAE Yi - Heng Li, M.D. 李貽恆 Current Position: Professor, Division of Cardiology, Department of Internal Medicine, College of Medicine, National Cheng Kung University. Current Address: Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan 70428, Taiwan. Telephone: ext 2392 Fax: t025215@ms17.hinet.net Date and Place of Birth: August 19, 1963, Taipei, Taiwan Education: M.D. Kaohsiung Medical College, Kaohsiung, Taiwan Ph.D. Graduate Institute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan, Taiwan Research fellow, Section of Cardiovascular Sciences and Debakey Heart Center, Baylor College of Medicine, Houston, Texas, USA Clinical Training: Internship, National Taiwan University Hospital Military Service Resident in Internal Medicine, Department of Internal Medicine, National Taiwan University Hospital Fellow, Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital. Professional Appointment: Attending Physician, Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital Lecturer, Department of Internal Medicine, College of Medicine, National Cheng Kung University Associate Professor, Department of Internal Medicine, College of Medicine, National Cheng Kung University 2008-up to now Professor, Department of Internal Medicine, College of Medicine, National Cheng Kung University

27 Board Certification: 1988 Registered Physician-Taiwan 1994 Board of Internal Medicine-Taiwan 1996 Board of Cardiology-Taiwan 1996 Board of Critical Care Medicine-Taiwan Membership in National Societies: Since 1991 Member of Formosan Medical Association-Taiwan Since 1994 Member of Society of Internal Medicine-Taiwan Since 1994 Member of Society of Cardiology-Taiwan Since 1994 Member of Society of Ultrasound in Medicine-Taiwan Since 1994 Member of Society of Critical Care and Emergency Medicine -Taiwan Honors: 1997 Young Investigator Award, Taiwan Society of Cardiology 1999 Best Paper of the Year, College of Medicine, National Cheng Kung University 2000 Special Grant for Excellent Research, the 64th Annual Scientific Meeting of the Japanese Circulation Society 2000 Medical Research Award, Taiwan Society of Vascular Disease and Atherosclerosis 2001 Excellent Service Award, National Cheng Kung University 2005 Excellent Teacher for Postgraduate Resident, National Cheng Kung University Hospital 2007 Fellow of the European Society of Cardiology (FESC) 2007 Excellent Research Abstract Award, Taiwan Society of Lipids & Atherosclerosis 2008 Fellow of the American College of Cardiology (FACC) 2008 Special Grant for Excellent Research, the 64th Annual Scientific Meeting of the Japanese Atherosclerosis Society Reviewer for journals: Journal of the American College of Cardiology American Journal of Cardiology Thrombosis and Haemostasis Journal of Biomedical Science Journal of Formosan Medical Association Acta Cardiologica Sinica

28 李貽恆醫師簡歷 : 現職 : 1. 國立成功大學醫學院附設醫院心臟內科主治醫師 2. 國立成功大學醫學院內科學科教授 二 學歷 : 1. 高雄醫學大學醫學系醫學士 09/1981~ 06/ 國立成功大學醫學院基礎醫學研究所博士 09/1996~06/2000 三 經歷 : 1. 國立台灣大學醫學院附設醫院內科部住院醫師 1990 年 9 月至 1995 年 8 月 2. 國立成功大學醫學院附設醫院內科部主治醫師 1995 年 8 月至 1996 年 8 月 3. 國立成功大學醫學系內科學科講師 1996 年 8 月至 2000 年 8 月 4. 國立成功大學醫學系內科學科副教授 2000 年 8 月至 2008 年 8 月 5. 國立成功大學醫學系內科學科教授 2008 年 8 月迄今 6. 中華民國心臟學會副秘書長 7. 中華民國血脂及動脈硬化學會理事 四 研究主題 1. 動脈硬化的病態生理學 2. 高血壓 高脂血症 冠狀動脈心臟病的分子遺傳研究 3. 血管生物學 五 研究成果 已發表九十多篇研究論文於國際 SCI 醫學期刊, 包括 Journal of the American College of Cardiology, European Heart Journal, Chest, American Journal of Cardiology, Thrombosis and Haemostasis 等

29 CURRICULUM VITAE Cheng-Han Lee, M.D. Current Position: Attending Physician, Division of Cardiology, National Cheng Kung University Hospital Assistant Professor, Department of Internal Medicine, College of Medicine, National Cheng Kung University. Current Address: Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan 704, Taiwan. Telephone: ext 2383 Fax: Date and Place of Birth: July 10, 1975, Tainan, Taiwan Education: MD. National Taiwan University, Taipei, Taiwan Institute of Clinical Medicine, School of Medical College, National Cheng Kung University Institute of Pharmaceutical Science, School of Medical College, National Cheng Kung University Clinical Training: Internship, National Taiwan University Hospital Resident in Internal Medicine, Department of Internal Medicine, Chi-Mei Medical Center Resident in Internal Medicine, Department of Internal Medicine, National Cheng Kung University Hospital Chief-resident in Internal Medicine, Department of Internal

30 Medicine, National Cheng Kung University Hospital Fellow, Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital. 2008/7-2008/8 Fellow, Division of Cardiology, Sekishinkai Sayama Hospital Professional Appointment: 2005-Now Attending Physician, Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital Clinical Instructor, Department of Internal Medicine, College of Medicine, National Cheng Kung University Now Clinical Assistant Professor, Department of Internal Medicine, College of Medicine, National Cheng Kung University. Board Certification: 2000 Registered Physician-Taiwan 2004 Board of Internal Medicine-Taiwan 2005 Board of Cardiology-Taiwan 2007 Board of Interventional Cardiology-Taiwan Membership in National Societies: Since 2004 Member of Formosan Medical Association-Taiwan Since 2003 Member of Society of Internal Medicine-Taiwan Since 2005 Member of Society of Cardiology-Taiwan Since 2005 Member of Society of Critical Care Medicine-Taiwan Since Member of American Society of Echocardiography-USA Honors: 2004 Best Resident Paper Award, Taiwan Society of Internal Medicine 2006 Best Research Attending Physician, Department of Internal Medicine, National Cheng Kung University Hospital 2006 Travel grants, 70 th Anniversary Annual Scientific Meeting of Japanese Circulation Society, March 24-26, 2006, Nagoya 2007 Best Young Investigator of Clinical Medicine, College of Medicine, National Cheng Kung University

31 Publication List (A) Refereed Paper 1. Lee CH, Liu PY and Tsai LM. Contemporary Insights into Prognostic Assessment and Therapy in Patients with Hypertrophic Obstructive Cardiomyopathy. J Intern Med Taiwan 2004;15: Liu PY, Lee CH, Lin LJ and Chen JH. Refractory Anaphylactic Shock Associated with Ketoconazole Treatment: a Case Report. Annals of Pharmacology 2005 Mar;39(3): (SCI) 3. Lee CH, Tsai LM. Transesophageal Echocardiographic Recognition of Mitral Valve Aneurysm. J Ultrasound Med 2005;24: (SCI) 4. Lee CH, Tsai WC, Kan CD, Lin LJ. Acute Aortic Regurgitation after Blunt Chest Trauma and Cardiac Catheterization. Injury Extra 2005;36: Lee CH, Tsai LM. An Aneurysm of Posterior Mitral Valve Masquerading a Huge Vegetation. International Journal of Cardiology 2006;107(2): (SCI) 6. Lee CH, Tsai WC, Hsu CS, Liu PY, Lin LJ, Chen JH. Predictive Factors of a Fulminant Course in Acute Myocarditis. International Journal of Cardiology 2006;109(1): (SCI) 7. Lee CH, Chao TS, Tsai LM, Lin PY, Yan JJ. Transesophageal Echocardiographic Recognition of Infiltrative Cardiac Sarcoma Mimicking Mitral Stenosis. International Journal of Cardiovascular Imaging 2006;22(3-4): (SCI) 8. Lee CH, Liu PY, Lin LJ, Chen JH, Tsai LM. Clinical Course and Outcome of Apical Hypertrophic Cardiomyopathy in Taiwan. Cardiology 2006;106: (SCI) 9. Lee CH, Cheng LL, Wu JM, Lin LJ. Failure of Pacemaker Implantation Due to Occlusion of the Left Brachiocephalic Vein. Acta Cardiol Sin 2006; 22(1): Lee CH, Tsai LM, Lin LJ. Intrathoracic Kidney Secondary to Congenital Diaphragmatic Hernia Identified by transthoracic Echocardiography. Int J Cardiol Nov 18;113(3):E73-5. (SCI) 11. Lee CH, Liu PY, Lin LJ, Chen JH, Tsai LM. Clinical characteristics and outcomes of hypertrophic cardiomyopathy in Taiwan--a tertiary center experience. Clin Cardiol. 2007; 30(4): (SCI) 12. Liu PY, Chung HC, Chen JY, Lee CH, Chan SH, Li YH, Lin LJ, Chen JH. Platelet-activating factor acetylhydrolase (PLA2G7) A379V (Exon 11) gene

32 polymorphism is functionally associated with coronary artery disease severity but not the onset of acute coronary syndrome. Acta Cardiol Sin 2006; 22(4): Lee CH, Hung SF, Chen JY, Chao TH, Li YH, Lin LJ, Tsai LM. The efficacy and safety of Angio-Seal percutaneous femoral artery closure device after diagnostic and therapeutic cardiac catheterizations --- A single center s experience. Acta Cardiol Sin 2007;23(4): Chen Ju-Yi, Tsai WC, Lee CH, Li YH, Tsai LM, Chen JH, Lin LJ, High premature atrial complex loads indicate a high central aortic pressure index in young low-risk patients. Acta Cardiol Sin 2007; 23: Liu YW, Liu PY, Tyan YC, Liao PC, Lee CH. Proteomic analysis of pericardial effusion: characteristics of tuberculosis-related proteins. Proteomics-Clinical Applications.2008;2: (SCI) 16. Lee CH, Liu PY, Tsai LM, Tsai WC, Ho MT, Chen JH, Lin LJ. Characteristics of Hospitalized Patients with Atrial Fibrillation in Taiwan: A Nationwide Observation. American Journal of Medicine 2007;120(9):819.e1-7. (SCI) 17. Lee CH, Tsai WC, Tsai LM, Liu PY, Ho MT, Chen JH, Lin LJ. Epidemiologic features of adult infective endocarditis, a nationwide study in Taiwan. American Journal of Cardiology 2007;100(8): (SCI) 18. Chen Ju-Yi, Tsai Wei-Chuan, Lee Yung-Ling, Lee CH, Tsai Liang-Miin, Chao Ting-Hsing, Li Yi-Heng, Chen Jyh-Hong, Lin Li-Jen, Association of premature ventricular complexes with central aortic pressure indices and pulse wave velocity. American Heart Journal 2008; 155(3):500.e1-6. (SCI) 19. Lin LJ, Cheng MH, Lee CH, Wung DC, Cheng CL, Yang KYH. Compliance with Antithrombotic Prescribing Guidelines for Patients with Atrial Fibrillation A Nationwide Descriptive Study in Taiwan. Clinical Therapeutics 2008; 30(9): (SCI) 20. Tsai WC, Lin CC, Chen JY, Huang YY, Lee CH, Li WT, Weng CM, Chen JH. Association of adiponectin with procollagen type I carboxyterminal propeptide in non-diabetic essential hypertension. Blood Press. 2008;31:1-6. (SCI) 21. Tsai WC, Lee CH, Lin CC, Liu YW, Huang YY, Li WT, Chen JY, Lin LJ. Association of Left Atrial Strain and Strain Rate Assessed by Speckle Tracking Echocardiography with Paroxysmal Atrial Fibrillation. Echocardiography (10): (SCI)

33 22. Tsai WC, Huang YY, Lin CC, Li WT, Lee CH, Chen JY, Chen JH. Uric acid is an independent predictor of arterial stiffness in hypertensive patients. Heart Vessels Sep;24(5): Chen JY, Lee YL, Tsai WC, Lee CH, Li YH, Tsai LM, Chen JH, Lin LJ. Cardiac autonomic functions derived from short-term heart rate variability recordings associated with nondiagnostic results of treadmill exercise testing. Int Heart J Mar;51(2): Lee CH, Lin LJ, Cheng CL, Chen JY, Tsai LM, Kao YH Incidence and Cumulative Recurrent Rates of Venous Thromboembolism in the Taiwanese Population. Journal of Thrombosis and Haemostasis 2010;8: Tsai WC, Liu YW, Huang YY, Lin CC, Lee CH, Tsai LM. Diagnostic value of segmental longitudinal strain by automated function imaging in coronary artery disease without left ventricular dysfunction. Journal of American Society of Echocardiography 2010; 23(10): Lee CH, Cheng CL, Lin LJ, Tsai LM, Kao YH. Epidemiology and Predictors of Short-term Mortality in Symptomatic Venous Thromboembolism A Nationwide Population-based Study. Circulation Journal 2011;75(8): Cheng CL, Kao YH, Lin SJ, Lee CH, Lai ML. Validation of the national health insurance research database with ischemic stroke cases in Taiwan. Pharmacoepidemiol Drug Saf Mar;20(3): Lee CH, Cheng CL, Chang CH, Kao Yang YH, Lin LJ, Lin TC, Yang CY. Universal Pharmacological Thromboprophylaxis for Total Knee Arthroplasty May Not be Necessary in Low Risk Populations: a Nationwide Study in Taiwan. J Thromb Haemost. 2012;10: Lee BF, Lee CH, Chiu NT, Liao MH, Shen LH. Utilization of Myocardial Perfusion Scan under Taiwan s Universal Health Insurance Program from 1997 to Ann Nucl Med Sci in press (B) Conference Paper 1. 李政翰, 黃偉修, 莊世松, 黃健泰.Adult T-cell Leukemia/Lymphoma Associated with Conscious Disturbance due to Hypercalcemia. The Hematology Society of Taiwan, March 17-8, Tainan. 2. Lee CH, Tsai WC, Hsu CS, Cheng LY, Liu PY. Predictors of Mortality in Patients with Acute Myocarditis. Proceedings of the 34 th Annual Scientific

34 Session of the Republic of China Society of Cardiology, July 24-25, Taipei, Taiwan. Acta Cardiol Sin 19 (suppl). P Lee CH, Chao TS, Tsai LM, Lin PY, Yan JJ. Primary Unclassified Cardiac Sarcoma Mimicking Mitral Stenosis. (2004 年台灣醫學週 ) 4. Lee CH, Tsai WC, Kan CD. Acute Traumatic Aortic Regurgitation after Blunt Chest Trauma and Cardiac Catheterization. (2004 年台灣醫學週 ) 5. Hsu CH, Tsai WC, Tsai LM, Lee CH, Lee WT, Chen JY, Lin LJ, Chen JH. Influences of Left Ventricular Hypertrophy on Transmitral Flow Pattern and Aortic Stiffness in Hypertension. International Journal of Cardiology 2004; 97 (supp.2):s62 6. Lee CH, Tsai WC, Hsu CS, Cheng LY, Liu PY. Predictors of Mortality in Patients with Acute Myocarditis. International Journal of Cardiology 2004; 97 (supp.2):s60 7. Lee CH, Tsai WC, Hsu CS, Liu PY, Lin LJ, Chen JH. Predictive Factors of a Fulminant Course in Acute Myocarditis. European Heart Failure 2005, June 11-14, Lisbon, Portugal. 8. Lee CH, Liu PY, Tsai LM, Lin LJ, Chen JH. Gender Differences in Clinical Features and Outcome of Hypertrophic Cardiomyopathy in Taiwan. European Society Cardiolgy Congress 2005, Stockholm, Sweden. 9. Lee CH, Tsai LM. A Case of Pontine Infarction Accompanied by Cor Tritriatum Dexter and Patent Foramen Ovale.(2005 年台灣醫學週 ) 10. Lee CH, Tsai LM, Liu PY, Chen JH, Lin LJ. Incidence, Age Distribution, and Gender of Patients with Atrial Fibrillation Related to Hospitalization in Taiwan, a Nationwide Experience from 1997 to 2002.(2005 年台灣醫學週 ) 11. Lee CH, Liu PY, Tsai LM, Lin LJ, Chen JH. Gender Differences in Clinical Features and Outcome of Hypertrophic Cardiomyopathy in Taiwan.(2005 年台灣醫學週 ) 12. Lee CH, Tsai LM, Liu PY, Ho MT, Chen JH, Lin LJ. Incidence, Age Distribution, and Gender of Hospitalized Patients with Atrial Fibrillation in Taiwan, a Nationwide Experience from 1997 to Circulation Journal Supplement 2006 Vol.70 I: 184. (Japanese Circulation Society 2006, Nagoya, Japan) 13. Lee CH, Tsai LM, Liu PY, Ho MT, Chen JH, Lin LJ. Epidemiologic Features of

35 Infective Endocarditis in Taiwan, a Six-Year Experience (1997~2002). Circulation Journal Supplement 2006 Vol.70 I: 184. (Japanese Circulation Society 2006, Nagoya, Japan) 14. Lee CH, Tsai WC, Tsai LM, Ho MT, Chen JH, Lin LJ. Epidemiologic Features of Deep Vein Thrombosis in Taiwan, a Nationwide Study from 1997 through World Congress of Internal Medicine 2006, Nov , Taipei, Taiwan. 15. Lee CH, Hong SF, Chen JY, Chao TH, Li YH, Lin LJ, Tsai LM. The efficacy and safety of Angio-Seal percutaneous femoral artery closure device after diagnostic and therapeutic cardiac catheterizations --- A single center s experience. 16th Asian Pacific Congress of Cardiology 2007, Dec , Taipei, Taiwan. 16. Lee CH, Cheng CL, Lin LJ, Kao Yang YH. Postdischarge oral anticoagulation following venous thromboembolism in Taiwan-A nationwide experience. The 3 rd Asian Conference on Pharmacoepidemiology-Korea 2008, Nov. 3-5, Seoul, Korea. 17. Lee CH, Kao YH, Lin LJ, Cheng CL. The relationship between the length of oral anticoagulation and recurrence of venous thromboembolism in Taiwan - a nationwide population-based study. 25th International Conference on Pharmacoepidemiology & Therapeutic Risk Management in Providence, Rhode Island on August 16-19, Lee CH, Kao YH, Lin LJ, Cheng CL, Cheng JY, Tsai LM. Epidemiology and Predictors of Short-term Mortality in Symptomatic Venous Thromboembolism A Nationwide Population-based Study. 台灣內科醫學會 Kao YH, Lee CH, Lin LJ, Cheng CL, Lin TC, Chang CH, Yang CY. Epidemiology of venous thromboembolism following knee replacement surgery in the Taiwanese Population A ten-year nationwide experience. 26th International Conference on Pharmacoepidemiology & Therapeutic Risk Management in England on August 18-21, 2010.