Education/Training: (Begin with entry into college and include postdoctoral training)

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1 BIOGRAPHICAL SKETCH (PI) Name: Hideshi Okada Degree(s): M.D., Ph.D. Position/Title: Postdoctoral Fellow Education/Training: (Begin with entry into college and include postdoctoral training) Institution and Location Dates Attended Degree Conferred (mm/yyyy) Field of Study Gifu University School of Medicine, Gifu, Japan M.D. 03/1998 Medicine Hyogo Prefectural Amagasaki Hospital, Hyogo, Japan Internship 05/2000 Internal Medicine Hyogo Prefectural Amagasaki Hospital, Hyogo, Japan Residency 05/2001 Cardiology Gifu University Hospital, Gifu Japan Medical Staff 03/2002 Cardiology Gifu University Graduate School of Medicine, Gifu Japan Advanced Critical Care Center, Gifu University Hospital, Gifu, Japan The Scripps Research Institute, La Jolla, CA, USA Veterans Medical Research Foundation, San Diego, CA, USA 1) Positions / employment Ph.D. 03/2005 Cardiology Assitant Professor 01/2007 Cardiology, Emergent Medicine Research Associate 01/2008 Immunology Postdoctoral Fellow Cardiology Apr Jan Feb Jan Feb Assistant Professor - Advanced Critical Care Center, Gifu University Hospital, Gifu, Japan, Professor. Shin-ji Ogura Research Associate Immunology The Scripps Research Institute, La Jolla, CA Professor. Jiahuai Han Postdoctoral Fellow Cardiology Veterans Medical Research Foundation, San Diego, CA, Professor. Robert Scott Ross Memberships / Honors 1) American Heart Association 2) Japanese Circulation Society 3) The Japanese Heart Failure Society 4) The Japanese Society of Internal Medicine 5) Japanese Society of Interventional Cardiology 6) The Japanese Society for Oriental Medicine 7) The Japan Society of Acupuncture and Moxibustion Page_1_ Hideshi Okada, M.D., Ph.D.

2 BIOGRAPHICAL SKETCH (PI) continued 2) Peer Reviewed Publications (in English) 1. Li L, Okada H (equally contribute), Takemura G, Esaki M, Kobayashi H, Kanamori H, Kawamura I, Maruyama R, Fujiwara T, Fujiwara H, Tabata Y, Minatoguchi S. Sustained release of erythropoietin using biodegradable gelatin hydrogel microspheres persistently improves lower leg ischemia. J Am Coll Cardiol Jun 23;53(25): Okada H, Takemura G, Kosai K, Tsujimoto A, Esaki M, Takahashi T, Nagano S, Kanamori H, Miyata S, Li Y, Ohno T, Maruyama R, Ogino A, Li L, Nakagawa M, Nagashima K, Fujiwara T, Fujiwara H, Minatoguchi S. Combined therapy with cardioprotective cytokine administration and anti-apoptotic gene transfer in postinfarction heart failure. Am J Physiol Heart Circ Physiol Mar;296(3):H Nakagawa M, Takemura G, Kanamori H, Goto K, Maruyama R, Tsujimoto A, Ohno T, Okada H, Ogino A, Esaki M, Miyata S, Li L, Ushikoshi H, Aoyama T, Kawasaki M, Nagashima K, Fujiwara T, Minatoguchi S, Fujiwara H. Mechanisms by which late coronary reperfusion mitigates postinfarction cardiac remodeling. Circ Res. 103(1): Okada H, Takemura G, Li Y, Ohno T, Li L, Maruyama R, Esaki M, Miyata S, Kanamori H, Ogino A, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H. Effect of a long-term treatment with a low-dose granulocyte colony-stimulating factor on post-infarction process in the heart. J Cell Mol Med. 12(4): Esaki M, Takemura G, Kosai K, Takahashi T, Miyata S, Li L, Goto K, Maruyama R, Okada H, Kanamori H, Ogino A, Ushikoshi H, Minatoguchi S, Fujiwara T, Fujiwara H.Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 294(2):H Ogino A, Takemura G, Kanamori H, Okada H, Maruyama R, Miyata S, Esaki M, Nakagawa M, Aoyama T, Ushikoshi H, Kawasaki M, Minatoguchi S, Fujiwara T, Fujiwara H. Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling. Am J Physiol Heart Circ Physiol. 293(4): H Li Y, Takemura G, Okada H, Miyata S, Maruyama R, Esaki M, Kanamori H, Li L, Ogino A, Ohno T, Kondo T, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H. Molecular signaling mediated by angiotensin II type 1A receptor blockade leading to attenuation of renal dysfunction-associated heart failure. J Card Fail. 13(2): Li L, Takemura G, Li Y, Miyata S, Esaki M, Okada H, Kanamori H, Ogino A, Maruyama R, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H. Granulocyte colony-stimulating factor improves left ventricular function of doxorubicin-induced cardiomyopathy. Lab Invest. 87(5): Page_2_ Hideshi Okada, M.D., Ph.D.

3 9. Kanamori H, Takemura G, Li Y, Okada H, Maruyama R, Aoyama T, Miyata S, Esaki M, Ogino A, Nakagawa M, Ushikoshi H, Kawasaki M, Minatoguchi S, Fujiwara H. Inhibition of Fas-associated apoptosis in granulation tissue cells accompanies attenuation of postinfarction left ventricular remodeling by olmesartan. Am J Physiol Heart Circ Physiol. 292(5):H Li Y, Takemura G, Okada H, Miyata S, Kanamori H, Maruyama R, Esaki M, Li L, Ogino A, Ohno T, Kondo T, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H. G II type 1A receptor signaling causes unfavorable scar dynamics in the postinfarct heart. Am J Physiol Heart Circ Physiol. 292(2):H Takemura G, Miyata S, Kawase Y, Okada H, Maruyama R, Fujiwara H. Autophagic degeneration and death of cardiomyocytes in heart failure. Autophagy. 2(3) Li Y, Takemura G, Okada H, Miyata S, Maruyama R, Li L, Higuchi M, Minatoguchi S, Fujiwara T, Fujiwara H. Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure. Cardiovasc Res. 71(4) Koda M, Takemura G, Okada H, Kanoh M, Maruyama R, Esaki M, Li Y, Miyata S, Kanamori H, Li L, Ogino A, Kondo T, Minatoguchi S, Fujiwara T, Fujiwara H. Nuclear hypertrophy reflects increased biosynthetic activities in myocytes of human hypertrophic hearts. Circ J Jun;70(6): Miyata S, Takemura G, Kawase Y, Li Y, Okada H, Maruyama R, Ushikoshi H, Esaki M, Kanamori H, Li L, Misao Y, Tezuka A, Toyo-Oka T, Minatoguchi S, Fujiwara T, Fujiwara H. Autophagic Cardiomyocyte death in Cardiomyopathic Hamsters and Its Prevention by Granulocyte Colony-stimulating Factor. Am J Pathol. 168(2) Li L, Takemura G, Li Y, Miyata S, Esaki M, Okada H, Kanamori H, Khai NC, Maruyama R, Ogino A, Minatoguchi S, Fujiwara T, Fujiwara H. Preventive Effect of Erythropoietin on Cardiac Dysfunction in Doxorubicin-induced Cardiomyopathy. Circulation. 113(4) Li Y, Takemura G, Okada H, Miyata S, Esaki M, Maruyama R, Kanamori H, Li L, Ogino A, Misao Y, Khai NC, Mikami A, Minatoguchi S, Fujiwara T, Fujiwara H. Treatment with Granulocyte Colony-stimulating Factor Ameliorates Chronic Heart Failure. Lab Invest. 86(1) Okada H, Takemura G, Koda M, Kanoh M, Kawase Y, Minatoguchi S, Fujiwara H.Myocardial Apoptotic Index Based on In Situ DNA Nick End-labeling of Endomyocardial Biopsies Dose Not Predict Prognosis of Dilated Cardiomyopathy. Chest (2): Okada H, Takemura G, Kosai K, Li Y, Takahashi T, Esaki M, Yuge K, Miyata S, Maruyama R, Mikami A, Minatoguchi S, Fujiwara T, Fujiwara H. Postinfarction Gene Therapy Against Transforming Growth Factor-β Signal Modulates Infarct Tissue Dynamics and Attenuates Left Ventricular Remodeling and Heart Failure. Circulation 2005;111(19): Page_3_ Hideshi Okada, M.D., Ph.D.

4 19. Saijo M, Takemura G, Koda M, Okada H, Miyata S, Ohno Y, Kawasaki M, Tsuchiya K, Nishigaki K, Minatoguchi S, Goto K, Fujiwara H: Cardiomyopathy with prominent autophagic degeneration, accompanied by an elevated plasma brain natriuretic level despite the lack of overt heart failure. Intern Med. 2004;43(8): Li Y, Takemura G, Kosai K, Takahashi T, Okada H, Miyata S, Yuge K, Nagano S, Esaki M, Khai NC, Goto K, Mikami A, Maruyama R, Minatoguchi S, Fujiwara T, Fujiwara H: Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure. Circ Res. 2004;95(6): Hayakawa K, Takemura G, Kanoh M, Li Y, Koda M, Kawase Y, Maruyama R, Okada H, Minatoguchi S, Fujiwara T, Fujiwara H: Inhibition of granulation tissue cell apoptosis during the subacute stage of myocardial infarction improves cardiac remodeling and dysfunction at the chronic stage. Circulation. 2003;108(1): Sato Y, Taniguchi R, Nagai K, Makiyama T, Okada H, Yamada T, Matsumori A, Takatsu Y: Measurements of cardiac troponin T in patients with hypertrophic cardiomyopathy. Heart. 2003;89(6): Li Y, Takemura G, Kosai K, Yuge K, Nagano S, Esaki M, Goto K, Takahashi T, Hayakawa K, Koda M, Kawase Y, Maruyama R, Okada H, Minatoguchi S, Mizuguchi H, Fujiwara T, Fujiwara H: Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice. Circulation. 2003;107(19): Sato Y, Taniguchi R, Makiyama T, Nagai K, Okada H, Yamada T, Matsumori A, Takatsu Y: Serum cardiac troponin T and plasma brain natriuretic peptide in patients with cardiac decompensation. Heart. 2002;88(6): Sato Y, Yamada T, Taniguchi R, Nagai K, Makiyama T, Okada H, Kataoka K, Ito H, Matsumori A, Sasayama S, Takatsu Y: Persistently increased serum concentrations of cardiac troponin T in patients with idiopathic dilated cardiomyopathy are predictive of adverse outcomes. Circulation. 2001;103(3): Nakamura Y, Okada H, Wada Y, Kajiyama K, Koshiyama H: Lymphocytic hypophysitis: its expanding features. J Endocrinol Invest. 2001;24(4): Sato Y, Taniguchi R, Yamada T, Nagai K, Makiyama T, Okada H, Matsumori A, Sasayama S, Takatsu Y: Measurement of serum concentrations of cardiac troponin T in patients with hypereosinophilic syndrome: a sensitive non-invasive marker of cardiac disorder. Intern Med. 2000;39(4):350. Page_4_ Hideshi Okada, M.D., Ph.D.

5 Abstracts 1. Okada H, Takemura G, Kosai K, Li Y, Esaki M, Takahashi T, Kanamori H, Ogino A, Miyata S, Minatoguchi S, Fujiwara T, Fujiwara H. Combination Therapy with Granulocyte- Colony Stimulating Factor and Antiapoptotic Soluble Fas Gene Delivery in Postinfarction Heart Failure. AHA 79, Chicago, USA, Okada H, Takemura G, Li Y, Maruyama R, Kanamori H, Li L, Misao Y, Minatoguchi S, Fujiwara T, Fujiwara H. G-CSF Displays Its Beneficial Effects on Postinfarction Cardiac Function by Cardiomyocyte Hypertrophy and Anti-fibrosis, But Not by Angiogenesis, Regeneration, or Anti-apoptosis of Cardiomyocytes. AHA 78, Dallas, USA, Okada H, Takemura G, Kosai K, Li Y, Takahashi T, Esaki M, Yuge K, Miyata S, Maruyama R, Mikami A, Minatoguchi S, Fujiwara T, Fujiwara H. Postinfarction Gene Therapy Against Transforming Growth Factor-β Signal Modulates Infarct Tissue Dynamics and Attenuates Left Ventricular Remodeling and Heart Failure. AHA 77, New Orleans, USA, ) Research Support (last three years) 1. Award with Grant for outstanding young researchers Funding agency: Gifu University School of Medicine Title of project : Cytokine Therapy in Postinfarct Heart Failure Date of Award : Jan G-CSF displays its beneficial effects on postinfarction cardiac function by cardiomyocyte hypertrophy and anti-fibrosis, but not by angiogenesis, regeneration, or anti-apoptosis of cardiomyocytes. 2. Award for outstanding young researchers Funding Agency: Gifu University School of Medicine alumni society Title of project : Postinfarction Gene Therapy Against TGF-β Signal Date of Award : May Postinfarction gene therapy against Transforming Growth Factor-β signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure. 3. Principal investigator: Award with Grant for outstanding young researchers Funding Agency: Gifu University School of Medicine Title of project : Decorin Gene Delivery in Postinfarct Heart Failure Date of Award : Jun Decorin gene delivery inhibit cardiac fibrosis of infarct tissue and attenuates left ventricular remodeling and heart failure. Page_5_ Hideshi Okada, M.D., Ph.D.

6 4. Lilly International fellowship: Grant from the Eli Lilly foundation Funding Agency: Eli Lilly Japan K.K. Title of project : Analysis of TNF-α expression from macrophage Date of Award : Jun We use retrovirus insertion-mediated random mutagenesis and identify the candidate molecule which is necessary for TNF-α production by LPS stimulation from macrophage. 5. The Uehara Memorial Foundation: Grant from The Uehara Memorial Foundation Funding Agency: The Uehara memorial foundation Title of project : Analysis of TNF-α expression from macrophage Date of Award : Dec We use retrovirus insertion-mediated random mutagenesis and identify the candidate molecule which is necessary for TNF-α production by LPS stimulation from macrophage. Page_6_ Hideshi Okada, M.D., Ph.D.