Bhavisha A. Bakrania, PhD

Transcription

1 DATE OF BIRTH: September 10, 1989 Bhavisha A. Bakrania, PhD CITIZENSHIP: VISA: ERA COMMONS ID: ADDRESS: Dual citizenship Australia and United Kingdom J1 - Exchange Visitor Visa BBAKRANIA Department of Physiology, University of Mississippi Medical Center 2500 N State St, Jackson, MS (601) bbakrania@umc.edu ACADEMIC HISTORY Feb 2008 Nov 2010 Feb 2011 Nov 2011 Jan 2012 Jul 2015 Jul 2015 Jun 2018 Bachelor of Health Science Griffith University Gold Coast, QLD, Australia Master of Medical Research (Advisor: Andrew C. Bulmer, PhD) Heart Foundation Research Centre Griffith University Gold Coast, QLD, Australia Doctor of Philosophy (Advisor: Andrew C. Bulmer, PhD) Heart Foundation Research Centre Griffith University Gold Coast, QLD, Australia Dissertation: Bilirubin induced cardioprotection: From endogenous protection to therapeutic potential Postdoctoral Research Fellow (Mentor: Joey P. Granger, PhD) Cardiovascular-Renal Research Center University of Mississippi Medical Center Jackson, MS, USA RESEARCH POSITIONS Mar 2014 Apr 2014 May 2014 Jul 2014 Jul 2018 present Visiting PhD Student (Advisor: Kevin J. Ashton, PhD) Faculty of Health Sciences and Medicine Bond University, Gold Coast, Australia Visiting PhD student (Advisor: Karl-Heinz Wagner, PhD) Department of Nutritional Science University of Vienna, Vienna, Austria Visiting PhD student (Advisor: Joey P. Granger, PhD) Department of Physiology and Biophysics University of Mississippi Medical Center, Jackson, MS, USA Instructor Cardiovascular-Renal Research Center Department of Physiology and Biophysics University of Mississippi Medical Center, Jackson, MS, USA AWARDS AND HONORS 2011 Academic Excellence Awarded by Griffith University for achieving a GPA greater than 6.0/ Australian Postgraduate Award Awarded by the Australian Government, Department of Education and Training 2013 Travel Award Awarded by the American Association of Anatomists, Experimental Biology 2014 Langman Graduate Student Platform Presentation Award Awarded by the American Association of Anatomists, Experimental Biology 2014 Conference Travel Award Awarded by Griffith Graduate Research School Updated: August 16,

2 2014 Higher Degree Research Grant Awarded by Griffith University, International Experience Incentive Scheme 2014 Best Abstract Award Awarded by 8th Int. Conference on Heme Oxygenases, BioIron & Oxidative Stress 2014 Young Investigator Award Awarded by the Society of Free Radical Research Australasia 2017 Postdoctoral Research Distinction Award Awarded by the American Physiological Society Water Electrolyte Homeostasis Section 2018 Postdoctoral Fellowship Award Awarded by the American Heart Association COLLABORATORS International: Dr. Karl-Heinz Wagner, PhD University of Vienna, Vienna, Austria Project: The effects of endogenous and exogenous elevated bilirubin on ischemia-reperfusion injury 2014 Present Dr. Kevin J. Ashton, PhD Bond University, Gold Coast, Australia Project: Modifications to cardiac gene expression in response to chronic hyperbilirubinemia Present Dr. Peter Sandner, PhD Bayer AG, Wuppertal, Germany Project: Soluble guanylyl cyclase as a therapeutic target for the treatment of preeclampsia National: Present Dr. Michael Hall, MD University of Mississippi Medical Center, Jackson, MS Project: Long term cardiovascular risk in placental ischemic rats Present Dr. Romain Harmancey, PhD University of Mississippi Medical Center, Jackson, MS Project: Changes in cardiac function and stress resistance in response to placental ischemia PROFESSIONAL MEMBERSHIPS 2012 Present American Heart Association 2012 Present American Physiological Society 2012 Present American Association of Anatomists PROFESSIONAL SERVICE Reviewer, International Journal of Cardiology Reviewer, Scientific Reports INSTITUTIONAL SERVICE Jan 2016 Dec 2016 Director, Maternal-Fetal Medicine Research Group, University of Mississippi Medical Center Jan Present July Laboratory manager in Dr. Joey Granger s lab. Duties include organizing and conducting weekly meetings with lab members, and working with animal and biochemistry/molecular technicians to maintain the lab and its productivity. Membership Committee, Group of Women in Medicine and Science, University of Mississippi Medical Center TEACHING Jul 2013 Jul 2012 Nov 2014 Feb 2013 Jun 2015 Laboratory Tutor (2 week intensive winter course - 80 hours) Clinical Laboratory Science School of Medical Science, Griffith University Gold Coast, QLD, Australia Problem Based Learning Facilitator (9 hours per week) Pathophysiology Student Experience of Teaching Score: 4.8/5 School of Medical Science, Griffith University Gold Coast, QLD, Australia Laboratory facilitator (9 hours per week) Anatomy and Physiology School of Medical Science, Griffith University Gold Coast, QLD, Australia Updated: August 16,

3 MENTORING Jan 2012 Dec 2012 Dec 2012 Feb Nov 2014 Oct Dec 2015 Feb 2017 Mar 2018 Jun 2017 Aug 2018 June 2018 Present July Present Izabela Bilska, Undergraduate Research Project student Griffith University Elizabeth Hamilton, Undergraduate Summer Research student Griffith University Michael Schachtal, Undergraduate Summer Research student Griffith University Pradeep Cholan, Research Honors Program Griffith University Nina Paauw, visiting graduate student University of Mississippi Medical Center Fieke Terstappen, visiting graduate student University of Mississippi Medical Center Adam Travis, Undergraduate Summer Research student University of Mississippi Medical Center Bijalben Patel, Medical Student Research Program University of Mississippi Medical Center Weiwei Yang, visiting Associate Professor University of Mississippi Medical Center COMMUNITY OUTREACH Nov 2010 Jun 2015 Honorary vice-chair person, honorary volunteer co-ordinator and ward-visiting volunteer Radio Lollipop Gold Coast University Hospital, QLD, Australia 2012, 2013 Organizer, Heart Foundation Fundraiser with School of Medical Science, Gold Coast, Australia Nov 2015 Physiology Understanding (PhUn) week, Mississippi Children s Museum, Jackson, MS Apr 2016 Group of Women In Medicine and Science activity at Highland Bluff Elementary, Jackson, MS Apr 2016 Discovery U, Mississippi Children s Museum, Jackson, MS Nov 2017 Physiology Understanding (PhUn) week, Mississippi Children s Museum, Jackson, MS PUBLICATIONS Peer-reviewed articles: Boon A-C, Hawkins CL, Bisht K, Coombes JS, Bakrania B, Wagner K-H, Bulmer AC. Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert's syndrome. Free Radic Biol Med. 52: , PMCID: PMC Bisht K, Tampe J, Shing C, Bakrania B, Wagner K-H, Bulmer A.C. Endogenous tetrapyrroles influence leukocyte responses to lipopolysaccharide in human blood: Pre-clinical evidence demonstrating the anti-inflammatory potential of biliverdin. J Clin Cell Immunol. 5: 1-12, PMCID: PMC Bakrania B, Du Toit EF, Ashton KJ, Kiessling CJ, Wagner K-H, Headrick JP, Bulmer AC. Hyperbilirubinemia modulates myocardial function, aortic ejection, and ischemic stress resistance in the Gunn rat. Am J Physiol Heart Circ Physiol. 307: H1142-9, PMID: Bakrania B, Du Toit EF, Wagner K-H, Headrick JP, Bulmer AC. Pre- or post-ischemic bilirubin ditaurate treatment reduces oxidative tissue damage and improves cardiac function. Int J Cardiol. 202:27-37, PMID: Bakrania B, Granger JP, Harmancey, R. Methods for the determination of rates of glucose and fatty acid oxidation in the isolated working rat heart. J Vis Exp Paauw N, Joles J, Spradley FT, Bakrania B, Zsengeller, ZK, Franx A, Verhaar M, Granger J, Lely T. Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats. Am J Physiol Regul Integr Comp Physiol. 312: R664-R670, 2017 Updated: August 16,

4 Bakrania B, Du Toit EF, Ashton KJ, Wagner K-H, Headrick JP, Bulmer AC. Chronically elevated bilirubin protects from cardiac reperfusion injury in the male Gunn rat. Acta Physiol (Oxf). 220: , 2017 Bakrania B, Granger JP, Duncan J, Warrington J. The ETA receptor as a potential therapeutic target in preeclampsia Int J Mol Sci. 18:3, 2017 Bakrania B, Spradley FT, Satchell S, Stec DE, Rimoldi J, Gadepalli R, Granger JP. Heme oxygenase- 1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells. Am J Physiol Regul Integr Comp Physiol PMCID: PMC Bulmer AC, Bakrania BA, Du Toit EF, Boon AC, Clark PJ, Powell LW, Wagner KH, Headrick JP. Bilirubin acts as a multi-potent guardian of cardiovascular integrity: More than just a radical idea. Am J Physiol Heart Circ Physiol Epub ahead of print. PMID: Granger JP, Spradley FT, Bakrania BA. The endothelin system: A critical player in the pathophysiology of preeclampsia. Curr Hypertens Rep. 20:32, PMID: Abstracts: Bakrania B, Beaman C, Headrick J, Bulmer AC. The effects of aging on systolic function and tissue deformation in male mice assessed using echocardiography. GCHMRC Bakrania B, Bulmer AC. Effects of elevated bilirubin on cardioprotection and ischemia-reperfusion injury. GCHMRC Bakrania B, Du Toit EF, Wagner K-H, Headrick J, Bulmer AC. Hyperbilirubinaemia modulates myocardial function and stress resistance in the Gunn rat. GCHMRC Bakrania B, Du Toit EF, Headrick J, Bulmer AC. Bilirubin loading of the heart: A novel treatment for myocardial ischemia-reperfusion injury. GCHMRC Bakrania B, Du Toit EF, Headrick J, Bulmer AC. Bilirubin ditaurate loading of the heart: A novel treatment for myocardial ischemia-reperfusion injury. FASEBJ. 28:667.5, 2014 Bulmer AC, Bakrania B, Boon A-C, Headrick JP, Wagner K-H, Du Toit E. Bilirubin: A novel endogenous hypolipidemic and hypotensive agent preventing cardiovascular disease. Hypertension. 63: H071, Bakrania B, Du Toit EF, Headrick J, Bulmer AC. Bilirubin loading of the heart: A novel treatment for ischemia-reperfusion injury. Int Conference HMOX Bakrania B, Du Toit EF, Headrick J, Bulmer AC. Hyperbilirubinaemia modulates myocardial function and stress resistance in the Gunn rat. SFRRA Bakrania B, Du Toit EF, Headrick J, Bulmer AC. Bilirubin loading of the heart: A novel treatment for myocardial ischemia-reperfusion injury. SFRRA Bakrania B, Spradley FT, Satchell S, Stec DE, Granger JP. Heme oxygenase-1 attenuates the production of endothelin-1 from human glomerular endothelial cells induced by serum from placental ischemic hypertensive rats. FASEBJ. 30:1214.7, Updated: August 16,

5 Bakrania B, Spradley FT, Granger JP. Soluble guanylate cyclase modulators attenuate tumor necrosis factor-α induced production of endothelin-1 from human glomerular endothelial cells. AHA Council on Hypertension Paauw N, Joles J, Spradley FT, Bakrania B, Franx A, Verhaar M, Granger J, Lely T. Renal and cardiac disturbances 8 weeks after exposure to placental ischemia in rat dams: Long term consequences for mother and child. Pregnancy Hypertens. 6:79, 2017 Bakrania B, Hall ME, Granger JP. Impact of placental ischemia on cardiac structure and function during pregnancy and post-partum. FASEBJ. 31:851.4, 2017 Bakrania B, Hall ME, Granger JP. Placental ischemia causes cardiac structural and functional abnormalities in the reduced uterine perfusion pressure rat model. Hypertension. 70:AP267, Bakrania BA, Travis AB, Sandner P, Granger JP. Soluble Guanylate Cyclase Stimulators and Activators Attenuate Placental Production of sflt-1. FASEBJ. [epub ahead of print] 2018 Bakrania BA, Spradley FT, Travis AB, Sandner P, Granger JP. Soluble guanylate cyclase activators improve vascular function and attenuate placental ischemia-induced hypertension AHA Council on Hypertension INTERNATIONAL AND NATIONAL ORAL PRESENTATIONS Dec 2012 Dec 2013 Apr 2014 Aug 2014 Oct 2014 Oct 2016 Nov 2016 Dec 2017 Sep 2018 Gold Coast Health and Medical Research Conference - Gold Coast, QLD, Australia Hyperbilirubinemia modulates cardiac function and stress resistance in the Gunn rat Gold Coast Health and Medical Research Conference - Gold Coast, QLD, Australia Bilirubin treatment of myocardial ischemia-reperfusion injury in rats Experimental Biology - San Diego, CA, USA Bilirubin ditaurate loading of the heart: A novel treatment for myocardial ischemia-reperfusion injury Higher Degree Research Seminar Series, Gold Coast, QLD, Australia Bilirubin ditaurate loading of the heart: A novel treatment for myocardial ischemia-reperfusion injury 8 th Int. Conference on Heme Oxygenases, BioIron & Oxidative Stress - Sydney, NSW, Australia Hyperbilirubinemia modulates cardiac function, aortic ejection and ischemic stress tolerance in the Gunn rat Graduate Studies in the Health Sciences Research Day Jackson, MS, USA Soluble guanylyl cyclase modulators attenuate endothelin-1 production from glomerular endothelial cells Physiology Departmental Seminar Series - Jackson MS, USA Impact of preeclampsia on cardiac structure and function during pregnancy and postpartum Physiology Departmental Seminar Series - Jackson MS, USA Soluble guanylate cyclase as a target for the treatment of preeclampsia American Heart Association Council on Hypertension, Chicago, IL, USA Soluble guanylate cyclase activators improve vascular function and attenuate placental ischemia-induced hypertension Updated: August 16,

6 FUNDING American Heart Association Postdoctoral Research Fellowship Principal Investigator 07/18 06/20 Title: Soluble guanylyl cyclase as a therapeutic target for the treatment of preeclampsia Previous: Program Project Grant - Project II Awarded to Dr. Joey P. Granger 07/15 06/18 Title: Renal control of body fluids and circulatory dynamics Australian Postgraduate Award Principal Investigator 01/12 07/15 Title: The effects of endogenous and exogenous elevated bilirubin on ischemia-reperfusion injury Updated: August 16,