COMBINED TECHNIQUE CHIMNEY + FENESTRATED ENDOGRAFT FOR COMPLEX ANEURYSMS ERIC DUCASSE - MD PHD FEVBS CHU BORDEAUX
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1 COMBINED TECHNIQUE CHIMNEY + FENESTRATED ENDOGRAFT FOR COMPLEX ANEURYSMS ERIC DUCASSE - MD PHD FEVBS CHU BORDEAUX
2 DISCLOSURE SPEAKER NAME: PR. E. DUCASSE I HAVE THE FOLLOWING POTENTIAL CONFLICTS OF INTEREST TO REPORT: CONSULTING EMPLOYMENT IN INDUSTRY STOCKHOLDER OF A HEALTHCARE COMPANY OWNER OF A HEALTHCARE COMPANY OTHER(S) X I DO NOT HAVE ANY POTENTIAL CONFLICT OF INTEREST
3 OUR ALGORYTHM Off-the-shelf availability + +
4 45 consecutive patients Combined CG FEVAR July 2010 July 2016 Emergent Setting 25 patients CM FEVAR + CG 20 patients Home-Made FEVAR + CG CM Zenith fenestrated endograft planned without the fenestration to 1 renal when renal origin-sma <2 hrs or renal origin-proximal edge of the graft <15 mm If acutely angled aortic neck fenestration was planned on the side where good endograft to wall apposition was anticipated CGs were used to revascularize remaining target vessels When aneurysm treatment could not be delayed a physician-modified endograft using standard Zenith or Endurant graft was planned with only one HM fenestration for one renal artery
5 HOLE CREATED IN THE FABRIC WITH CUTTERING PEN
6 SNARE USED AS A RADIO-OPACIFIER AND SEWN WITH 5/0 PROLÈNE SUTURE
7 DEVICE IS RESHEATHED AND CHECKED RADIOGRAPHICALLY MEAN PREPARATION TIME 15 MIN
8 DETAILS OF RECONSTRUCTED VESSELS Mean number of target vessels/patient : 2.9
9 DETAILS OF RECONSTRUCTED VESSELS Most represented configurations were : a scallop for the SMA or an open chimney an open or covered CG for the highest renal artery and a fenestration (Custom-made or HM) for the other Mean oversizing : 20% CG F-EVAR Operative Time (min) 183.6±8.2 Fluoroscopy Time (min) 55.3±18.9 Kerma-Area-Product (Gy/cm 2 ) 13.0±4.8 Contrast Volume (ml) 97.8±23.3
10 POST-OPERATIVE OUTCOMES Perioperative successful aneurysm exclusion : 44 patients (97.8%) 1 low-flow type Ia EL 1 No open conversion x Target vessels successfully reconstructed : 98.5% (128/130) 98.5% 107/109vessels if scallops were excluded One HM fenestration did not open properly in a patient presenting with a ruptured aneurysm, he went into haemorrhagic shock during the procedure and the left renal artery had to be abandoned A second HM fenestration was successfully targeted but it was impossible to push the stent inside the left renal artery because of severe downward angulation Perioperative technical success : 93.3% (42/45) 1. Donas et al. J Vasc Surg 2012; 55:
11 SURVIVAL 30-day mortality : 5 (11%) In-Hospital mortality : 6 (13%) Median follow-up 11.2 months (range 1-42 months) 89% 86% 2 (4%) after elective procedures 1 haemorrhagic shock caused by an EIA rupture (despite early coverage) history of type Ia/III ELs treated 2 years ago by cuff extension+additional limb grafts after migration 1 mesenteric ischemia (early occlusion of SMA open chimney) 3 (7%) after emergency procedures 2 haemorrhagic shocks 1 acute mesenteric ischemia despite patent chimney to SMA due to large mesenteric hematoma Mid-term mortality 4 myocardial infarctions 1 urothelial carcinoma No aneurysm rupture No graft migration 1 subdural hematoma
12 ENDOLEAKS Type Ia EL 4 (9%) Median follow-up 11.2 months (range 1-42 months) 95% 86% 2 Coil embolization + Cuff extension 1 Conversion of open chimney into covered one + ballon dilation 1 remaining type Ia EL under close surveillance: stability
13 ENDOLEAKS Late Type II EL 10 (22%) Median follow-up 11.2 months (range 1-42 months) 93% No secondary/late type II EL 4 spontaneously disappeared 3 treated by embolization
14 SIZE OF ANEURYSM SAC Median follow-up 11.2 months (range 1-42 months) Figure 4. Maximum aneurysmal diameter s evolution Diminution 5mm : 18 (55%) Stability : 15 (45%) Mean aneurysm sac regression/patient 63.3± ± ± 6.9 mm (range:0-24)
15 PATENCY OF TARGET VESSELS 96% 95%
16 DISCUSSION : PER-OPERATIVE DATA COMBINED CG-FEVAR Procedure time: 184 min Fluoroscopy time: 55 min Amount of contrast: 98 ml PERICLES (CG-EVAR) 13 centers 517 patients 898 chimney grafts Procedure time: 233 min Fluoroscopy time: 61 min Amount of contrast: 162 ml FEVAR Linsen et al. J Vasc Surg. 2012;56: Meta-analysis : 9 centers 629 patients 1622 target vessels Procedure time: min Fluoroscopy time: min Amount of contrast: mL
17 DISCUSSION : SURVIVAL COMBINED CG-FEVAR But 33% were in emergent setting 30-day mortality : 11% 4.5% excluding ruptured aneurysms Survival: 18 months FEVAR PERICLES (CG-EVAR) 13 centers 517 patients 898 chimney grafts 30-day mortality : 4.9% 3.7% excluding ruptured aneurysms Survival : 17.1 months Linsen et al. J Vasc Surg. 2012;56: Meta-analysis : 9 centers 629 patients 1622 target vessels 30-day mortality: 2.1% (1.2%-3.7%) Survival : 15 months Di et al. Ann Vasc Surg. 2013;27: Meta-analysis : 12 centers 776 patients 1728 target vessels 30-day mortality : 2.5% (1.6%-4.1%)
18 DISCUSSION : TECHNICAL SUCCESS COMBINED CG-FEVAR PERICLES (CG-EVAR) 13 centers 517 patients 898 chimney grafts 502/517 cases : 97.1% 42/45 cases : 93.3% FEVAR Linsen et al. J Vasc Surg. 2012;56: Meta-analysis : 9 centers 629 patients 1622 target vessels 90.7% (87.7%-92.5%) Di et al. Ann Vasc Surg. 2013;27: Meta-analysis : 12 centers 776 patients 1728 target vessels 92.8%
19 DISCUSSION : TARGET VESSELS PATENCY FEVAR PERICLES (CG-EVAR) 13 centers 517 patients 898 chimney grafts 17.1 months KM Estimates : 1 year 2 years 3 years COMBINED CG-FEVAR 2 cannulation failures : HM fen Hostile anatomy (small target arteries + severe downward angulation) Absence of diameter- reducing ties in this early experience KM Estimates (excluding scallops) : 1 year 2 years Mastracci et al. J Vasc Surg. 2015;61: patients 1679 target vessels KM Estimates : 1 year 5 years Linsen et al. J Vasc Surg. 2012;56: Meta-analysis : 9 centers 629 patients 1622 target vessels 15 months Di et al. Ann Vasc Surg. 2013;27: Meta-analysis : 12 centers 776 patients 1728 target vessels 12-month
20 DISCUSSION : ENDOLEAKS Type Ia EL COMBINED CG-FEVAR CG-EVAR 8.9% PERICLES Intraoperatively : 7.9% Moulakakis et al. J Vasc Surg. 2012;55: Meta-analysis : 15 reports 93 patients 14.0% FEVAR Mastracci et al. J Vasc Surg. 2015;61: patients 1679 target vessels Up to 10.4% Wilson et al. Br J Surg. 2013;100: Meta-analysis : 14 studies 176 patients Postoperative CTA : 10.2% Linsen et al. J Vasc Surg. 2012;56: Meta-analysis : 9 centers 629 patients 1622 target vessels type I and III endoleaks : 4.6%
21 CONCLUSION Combined CG-FEVAR shows good technical feasibility number of eligible patients when standard FEVAR is predicted to be technically difficult or contra-indicated could be a straightforward and effective approach in emergent settings but also in elective cases A single home-made fenestration is more easily shaped and more rapidly delivered Results in larger series and other experimented centres as well as longer-term follow-up are awaited and should be compared to those of CG-EVAR and FEVAR
22 THANK YOU FOR YOUR ATTENTION
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