Young-Guk Ko, M.D. Severance Cardiovascular Hospital, Yonsei University Health System,

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1 Young-Guk Ko, M.D.,

2 Dangas G, J Am Coll Cardiol Intv 2012;5:1071

3 All-cause Mortality Dangas Severance G, J Am Coll Cardiovascular Cardiol Intv Hospital, 2012;5:1071 Yonsei University Health System

4 Aneurysm-related Mortality Dangas Severance G, J Am Coll Cardiovascular Cardiol Intv Hospital, 2012;5:1071 Yonsei University Health System

5 Reintervention Rates 2yrs Dangas Severance G, J Am Coll Cardiovascular Cardiol Intv Hospital, 2012;5:1071 Yonsei University Health System

6 Real World: Medicare data Jackson RS, JAMA. 2012;307:1621

7 Survival After Open vs Endovascular Repair of AAA Jackson RS, JAMA. 2012;307:1621

8 Overall and Cause-Specific Mortality Mortality rate per 1000 Person-Years of Follow-up Jackson RS, JAMA. 2012;307:1621

9 Numbers of Events for Open and Endovascular Repair Jackson RS, JAMA. 2012;307:1621

10 Diagnosis Associated With Repeat Repair Jackson RS, JAMA. 2012;307:1621

11 The Number of Open and Endovascular AAA Repairs in the US Medicare Population Sachs T, J Vasc Surg 2011;54:881

12 Sachs T, J Vasc Surg 2011;54:8 Mortality Rates: EVAR vs. Open Techniques in the Medicare Population

13 Suitable AAA Morphology for EVAR Aortic neck - Diameter: 18~32 mm - Length: >10~15 mm - Shape: straight, non-conical - Angulation <45~60 - Minimal thrombus or calcification CIA - Length: >20 mm - Diameter: 8 ~ 22 mm EIA - Diamter: > 7 mm - minimal Ca. & tortuosity

14

15

16 2011/11

17 Post-day 3

18 Bilateral CIA Aneurysm M / 76 JTH (# ) 55 mm

19 Bilateral CIA Aneurysm 2 Days F/U Type 2 Endoleak JTH

20 Limitations of Current Devices Limitations Hostile neck Inability of reposition Large device profile Endoleak Juxta- or suprarenal AAA Required Improvement Flexibilty and conformability Controllable deployment Migration resistance Low profile Long-term durability Fenestrated/branched endograft

21 Current Delivery System Profiles Outer diameters

22 Excluder & C3 Delivery System (Gore)

23 Zenith Low Profile (Cook) Device profile: Fr ID => 16Fr ID Nitinol instead of Stainless New suprarenal stent design New capless constraint New Stent configuration Woven polyester fabric New Dilator tip and Cannula

24 Ovation (Trivascular) CE Mark Approved August F OD Aortic Body 13F OD Iliac Limbs Tri-modular design Suprarenal stent with integral anchors Inflatable sealing rings Low viscosity, radiopaque biocompatible fill polymer Kink resistant iliac limbs Hydrophilic catheter coating

25 Anaconda (Vascutek, Terumo) Modular type: - Avoid mechanical coupling of perirenal aorta to iliacs - Avoid longitudinal rigidity - Enhance radial support Transmural Hooks Advanced deployment methodology: - Repositionalbe - Contralateral limb: magnet assisted cannulation

26 Repositionable Deployed Collapsed Re-deployed

27 Newer Divices Profiles

28 Nellix (Endologix) Dual balloon expandable endoframes Polymer filled endobags => obliterate aneurysm sac, provide support and eliminate endoleak space Fixation is not dependent on proximal neck and iliac arteries Common iliac aneuryms are treated with preservation of internal iliac

29 EndoStples (Aptus)

30 Fenestrated/Branched Stent Grafts (Cook)

31 Conclusion EVAR for AAA is achieved with relatively high success rate. EVAR is associated with relatively low peri-procedural mortality and morbidity rates. Currently, EVAR is indicated only for AAA with suitable anatomic criteria. However, newer devices will expand application of EVAR in AAA patients with complex anatomy

32 What is Better? EVAR VS.

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