CURRICULUM VITAE Michela Masè

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1 CURRICULUM VITAE Michela Masè Vital statistics: Born: Tione di Trento (Trento), Italy, May 14, 1978 Education: 2002: Master Degree in Physics (cum laude) at the University of Trento (Italy) Thesis: Temporal Dynamics of Atrial Fibrillation: Analysis of Atrial Intervals and Organization. Data recording in collaboration with the Department of Cardiology of the S. Chiara Hospital of Trento. 2006: PhD in Physics (evaluation Excellent) at the University of Trento (Italy) Thesis: Synchronization of the Electrical Activity in the Heart during Atrial Arrhythmias. Data Analysis and Computer Modeling. Professional experience: - September December 2002 Grant-holder of the Biosignal Laboratory, Department of Physics, University of Trento. Recording and elaboration of data from atrial fibrillation patients in collaboration with S. Chiara Hospital in Trento. - December February 2006 Research activity developed at the Biosignals Laboratory, Department of Physics, University of Trento. Development of new methodologies for the quantitative characterization of the electrical activity of the heart during atrial arrhythmias. Quantification of the degree of organization and synchronization of atrial fibrillation. Realization of mathematical models for the simulations of atrial arrhythmias. Cellular automaton models for the simulation of propagation of the electrical impulse during atrial arrhythmias. Data recording in collaboration with the Division of Cardiology of the Hospitals of Trento and Asti. - June September 2003 Collaboration with local biomedical industries (et medical devices, Cavareno). Testing and assessment of a prototype device for the noninvasive measurement of arterial blood pressure.

2 - March 2006 September 2006 Grant-holder of the Biosignal Laboratory of the Department of Physics of the University of Trento. Spatial characterization of the electrical activity in chronic atrial fibrillation. Collaboration with the Department of Preclinic Sciences, University of Milan (Dr. A. Porta): application of nonlinear analysis indexes for the characterization of heart rate variability in 24h Holter recordings. - September 2006 present Postdoctoral Fellow of the Biosignal Laboratory of the Department of Physics of the University of Trento for the project: Integration of cardiac multimodal maps for ablation treatment of atrial fibrillation, sponsored by Fondazione Caritro. Integration of electrophysiological and anatomical properties of the human atrium in chronic atrial fibrillation patients. Development of mathematical model for simulation of electrical propagation in real atrial geometry. Data recording in collaboration with S. Chiara Hospital of Trento. Permanence abroad: - May September 2005 Winner of a grant by Fondazione Trentino Università for International Studies ( International Grants 2005 ). Proposed project: Development of new methodologies for the characterization of electrical signals recorded during cardiac arrhythmias. Research period at the Centre for Nonlinear Dynamics in Physiology and Medicine of McGill University (Montreal - CANADA), under the supervision of Prof. Leon Glass. Application of nonlinear analysis techniques for the characterization of atrioventricular conduction during atrial arrhythmias. Development of difference equation models for the simulation of the atrioventricular patterns observed during atrial arrhythmias. - May 2006 June 2006 Period of research/study at Centre for Nonlinear Dynamics in Physiology and Medicine of the Mc Gill University (Montreal - CANADA). Attendance of the Summer School Systems Biology Dynamics from Genes to Organisms. Development of a mathematical model for atrial flutter cycle length variability due to mechano-electrical feedback.

3 Teaching: : Guide for the Museum of Natural Science of Trento : Teaching Assistant in General Physics II (Bachelor Degree in Telecommunication Engineering, Faculty of Engineering, University of Trento) : Teaching Assistant in General Physics III (Bachelor Degree in Telecommunication Engineering, Faculty of Engineering, University of Trento) : Teaching Assistant in General Physics III (Master Degree in Physics and Biomedical Technologies, Faculty of Physics, University of Trento). Scientific Activity: Membership Societies: - Italian Society of Chaos and Complexity (SICC) - Istituto Nazionale di Fisica della Materia (INFM) Awards: - International grant from the Fondazione Trentino Università for a period of study/research abroad, in the context International Grants 2005 Third Edition. - Poster prize as best presentation in content and layout at the congress Cardiovascular Physics - Model Based Data Analysis of Heart Rhythm (Bad Honnef - Germany, 9-11 May 2005). - Grant from the Marie Curie Conferences and Training Courses Program of the EU to attend the Summer School "Biomedical Modeling and Cardiovascular-Respiratory Control: Theory and Practice, in the context Mathematic Modeling of Human Physiological Systems with Biomedical Applications. - Grant from the Marie Curie Conferences and Training Courses Program of the EU to attend the Summer School "Stochastic Differential Equation Models with Applications to > the Insulin-Glucose System and Neuronal Modelling, in the context Mathematic Modeling of Human Physiological Systems with Biomedical Applications. Collaborations: - Department of Physiology, McGill University, Montreal, Canada (Prof. L. Glass).

4 - Department of Preclinic Sciences, University of Milan, Milan (Dr. A. Porta). - Instituto Nacional de Cardiología Ignacio Chávez (Dr. Claudia Lerma). - Cardiology Divisions, Hospitals of Trento and Asti. Scientific field of interest: - Cardiac electrophysiology - Biosignal modelling and analysis - Nonlinear dynamics - Mechanisms of arrhythmias - Mechano-electrical feedback Schools and Congress Attendance - Trento, 21 December 2001: Corso pratico di Ablazione Atriale: Metodica Transettale in Atrio Sinistro. - Trento, January 2003, Trento Cardiologia 2003: 3 o Convegno Nazionale di Aggiornamento Cardiologico. - Bressanone, 8-13 September 2003, Scuola Nazionale di Biofisica 2003-XI Ciclo: Biofisica della Cellula. - Padova, June 2004, Entropy and Relative Entropy in the Mathematical, Physical, and Engineering Sciences. - Montreal (Canada), 16 September 2005, International Workshop on Biological Rhythmicity: From Data to Mathematical Modeling. - Montreal (Canada), 23 May - 2 June 2006, Summer School Systems Biology Dynamics from Genes to Organisms, organized by the Centre for Nonlinear Dynamics, McGill University. - Graz (Austria), 22 July 1 August 2007, Summer School Biomedical Modeling and Cardiovascular-Respiratory Control: Theory and Practice. - Graz (Austria), 2 4 August 2007, Workshop Biomedical Modeling and Cardiovascular- Respiratory Control: Theory and Practice.

5 Scientific Communications - Trento September 2002, SIBPA 2002: XVI National Congress of the Italian Society for Pure ad Applied Biophysics and 1 st Italian-Slovenian Workshop of Biophysics (poster presentation). - Badajoz (Spain), October 2003, Aphys First International Meeting on Applied Physics (oral communication). - Chicago (Usa), September 2004, Computers in Cardiology (oral communication). - Genova, 4-5 November 2004, 2 o Workshop Il Sistema Cuore: Segnali, Metodi, Modelli (poster presentation). - Bad Honnef (Germany), 9-11 May 2005, 346 WE-Heraeus-Seminar Cardiovascular Physics - Model Based Data Analysis of Heart Rhythm (poster presentation, best poster prize). - Montreal (Canada), 2 Giugno 2005, Seminar Series in Quantitative Biology - Centre for Nonlinear Dynamics - McGill University (invited seminar, Cardiac arrhythmias: data analysis and modeling ). - Valencia (Spagna), Settembre 2006, Computers in Cardiology (oral communication). - Oxford (UK), 31 March-4 April 2007, Cardiac MEF and Arrhythmias (poster presentation). - Trento (Italy), 29 November-1 December 2007, 80 meeting Società Italiana Biologia Sperimentale (poster presentation). - Parma (Italy), 4-8 April 2008, ESGCO 2008 (oral presentation). Pubblications A). Extended Pubblications 1. Masè M, Ravelli F, Faes L, Antolini R, Nollo G. Quantitative Assessment of Synchronization during Atrial Fibrillation by Shannon Entropy Characterization of Propagation Delays, Comp Cardiol 2004, 31, Masè M, Faes L, Antolini R, Scaglione M, Ravelli F. Quantification of synchronization during atrial fibrillation by Shannon entropy: validation in patients and computer model of atrial arrhythmias. Physiol Meas 26: , 2005.

6 3. Masè M, Faes L, Nollo G, Antolini R, Ravelli F. Determination Of Synchronization Of Electrical Activity In The Heart By Shannon Entropy Measure, in "Recent Advances in Interdisciplinary Applied Physics", Masé M, Glass L, Ravelli F. Quantification of phase recurrences in atrioventricular (AV) conduction during atrial arrhythmias. Comp Cardiol 2006, 33, Ravelli F, Masé M, Del Greco M, Faes L, Disertori M. Deterioration of organization in the first minutes of atrial fibrillation: a beat-to-beat analysis of rate and wave similarity. J Cardiovasc Electrophysiol, 18(1): 60-65, Porta A, Faes L, Masè M, D Addio G, Pinna G, Maestri R, Montano N, Furlan R, Guzzetti S, Nollo G, Malliani A. An integrated approach based on uniform quantization for the evaluation of complexity of short-term heart period variability: application to 24h Holter recordings. Chaos 17(1):015117, Cristoforetti A, Masè M, Faes L, Nollo G, Centonze M, Del Greco M, Antolini R, Nollo G, Ravelli F. A stochastic approach for automatic registration and fusion of left atrial electroanatomic maps with 3D CT anatomical images. Phys Med Biol, 52: Masè M, Glass L, Ravelli F. A Model for Mechano-Electrical Feedback Effects on Atrial Flutter Interval Variability. Bull Math Biol 2008 Mar 18; [Epub ahead of print]. DOI: /s x 9. Ravelli F, Masè M, Disertori M. A Beat-by-beat mechanical modulation of atrial flutter cycle length: MEF effects on atrial reentry. Progr Biophys Mol Biol 2008 Feb 16; [Epub ahead of print]. DOI: /S (03) Masè M and Ravelli F. Respiratory mechanical modulation of atrial intervals during atrial flutter Proceedings of ESGCO 2008, O11, 4-6.

7 11. Nollo G, Faes L, Masè M, Gasperi C, Ravelli F, Cevese A. Low frequency cardiovascular oscillations investigated by causal cross-spectral analysis during α-blockade in healthy humans Proceedings of ESGCO 2008, O12, B). Other Pubblications: Congress Acta 1. Masé M, Faes L, Nollo G, Antolini R, Ravelli F. Determination of atrial fibrillation organization by wave-similarity analysis, SIBPA 2002, Trento Masè M, Faes L, Nollo G, Antolini R, Ravelli F. Determinazione della sincronizzazione dell attività elettrica cardiaca durante fibrillazione atriale - 2 o Workshop Il Sistema Cuore: Segnali, Metodi, Modelli, Genova Masè M, Ravelli F. Integrate-and-fire modeling of atrial flutter cycle length variability" WE-Heraeus-Seminar Cardiovascular Physics - Model Based Data Analysis of Heart Rhythm, Bad Honnef Best poster prize. 4. Masè M, Glass L, Ravelli F. MEF effects on atrial flutter cycle length variability: a mathematical model Cardiac MEF and Arrhythmias, Oxford Ravelli F, Masè M, Cristoforetti A, Marini M, Del Greco M. Effects of acute atrial dilatation on conduction velocity in the human atrium Cardiac MEF and Arrhythmias, Oxford Ravelli F, Masè M, Del Greco M, Marini M, Disertori M. Effects of acute atrial dilatation on conduction velocity and vulnerability to atrial fibrillation in the human atrium XIII World Congress on Cardiac Pacing and Electrophysiology, Rome Masè M, Glass L, Ravelli F. Effects of mechano-electrical feedback on atrial flutter interval: a mathematical model 80 meeting Società Italiana di Biologia Sperimentale, Trento Ravelli F, Masè M, Marini M, Del Greco M. Acute atrial stretch slows conduction velocità in the human atrium 80 meeting Società Italiana di Biologia Sperimentale, Trento 2007.

CLAUDIA RODELLA CURRICULUM VITAE

CLAUDIA RODELLA CURRICULUM VITAE PERSONAL INFORMATION: Date of birth: 16 th May 1988 Place of birth: Brescia (BS) - Italy Nationality: Italian Phone: +39 0303501594 E-mail: claudia.rodella@gmail.com claudia.rodella@cognitiveneuroscience.it