24 Hour Holter Report

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1 Mass Veterinary Cardiology Services Inc 35 Suffield St Agawam, MA / Exam Date: SEP :25am Record No: 7332 Provider: NANCY MORRIS DVM, DACVIM-C Medical Record Notes Patient: GRIFFON Age: 6 yrs 6.5 mns Weight: lbs. kg ALISSA WEAVER Problem: HOLTER STUDY BREEDING CLEAR Location: No Entry Species: CANINE Breed: DOBERMAN PINSCHER Provider: NAM Record: Page: 1 Gender: M DOB: FEB 2 7 Age: 6 yrs 6.5 mns Weight: lbs. kg 24 Hour Holter Report Date study performed: 8/28/13 The total holter scan time was 24:1. The time analyzed was: 21:1. The scan quality was good. Mean Heart Rate: 86 High Heart Rate: 23. Low Heart Rate: 44. Total Heart Beats/24 hrs: 1898 There were a total of 13,333, Ventricular Premature Beats (VPC s or PVC s) during the monitoring period. Of the total VPC s there were singular VPC s, 34 couplets and 89 triplets. There were 48 runs of parosymal ventricular tachycardia during the monitoring period. The longest run of VT was 114 beats which occurred at 6:5 am day 2 of the recording. The fast run of VT was 11 beats duration at a rate of 38 BPM which occurred 5:54 pm day 2 of the recording All other periods of slow heart rate (Bradycardia) and fast heart rate (Tachycardia) correlated appropriately with the activity reported in the diary. Diagnosis: Marked worsening of arrhythmias on higher dose of Mexilitine, proarrhythmia effect. Recommendations: Our next step is to reduce the Mexilitine dose to 15 mg by mouth every 8 hours and add in Sotalol 8 mg--1/2 tab twice daily. We should recheck at least an ECG as his arrhythmias are currently severe enough that we should be able to see improvement on ECG and once this looks good, perform another holter study. Doberman Pinschers should have a baseline echocardiogram and 24 hour holter monitoring study between 1-2 years of age. From 2-4 years of age, annual echo and holter monitoring is suggested. From 4 years onward, in dogs used for breeding purposes, it is ideal to perform an echo and holter study every 6 months. Clinical research in Dobermans has shown that the24 hour holter test may provide the earliest indication in a Doberman with cardiomyopathy. This test maybe abnormal before the echocardiogram is abnormal in some dogs. More than 5 singular ventricular premature beats (VPC s), or any couplets, triplets or runs of ventricular tachycardia found on a holter test, has been correlated with Dobermans that go on to experience sudden death or develop dilated cardiomyopathy and congestive heart failure later in life.

2 Patient Name: GRIFFIN ALBA MEDICAL SYSTEMS, INC CANINE HOLTER MONITORING REPORT Holter Monitor Report Physician: Date of Birth: Scan Number: ID #: 2 Date Recorded: 8/28/213 Age: 6 Years Date Processed: 8/3/213 Sex: M Recorder Num: Analyst: HookupTech: Interp.Physician: Indications: DOBERMAN Alissa Weaver Medications: GRIFFIN was monitored for a total of 24:1 hours. The total time analyzed was 21:1 hours. Start time was 7:1PM1. There were a total of 1898 Beats. Mean Heart Rate: 86 Maximum Heart Rate: 23 at 6:35:11PM2 Minimum Heart Rate: 44 at 1:37:38AM2 Pauses: (Greater than 5 sec.) Ventricular Ectopy Supraventricular Ectopy Total: Total: 73 Single: Single: 73 Pairs: 34 Pairs: Total Runs: 137 Total Runs: Beats in Runs: 616 Beats in Runs: # # Longest Run: 6:5AM2 25 Longest :PM1 Fastest Run: 5:54PM2 38 Fastest :PM Comments: VPB SUMMARY: SINGLES, 34 PAIRS, 89 TRIPLETS, 48 RUNS. Physician's Signature:

3 Patient: GRIFFIN Page 2 GENERAL PROFILE INTERVAL HEART RATE TOTAL VPB VPB RUNS SVPB SVPB RUNS TIME STARTING LO MEAN HI BEATS TOTAL PAIRS VT TOTAL PAIRS SVT PAUSES ANALYZED 7:1PM :4 8:PM :58 9:PM :54 1:PM :53 11:PM :57 12:AM :58 1:AM :59 2:AM :59 3:AM :58 4:AM :58 5:AM :58 6:AM :48 7:AM *** :32 8:AM :55 9:AM :46 1:AM :58 11:AM :57 12:PM :55 1:PM :56 2:PM :55 3:PM :49 4:PM :52 5:PM *** :18 6:PM :47 7:PM :9 SUMMARY : :1

4 Patient: GRIFFIN Page Heart9 Rate 8 BPM VPB 6 per 5 MIN VT 2 BEATS15 /MIN SVPB 6 per 5 MIN SVT 2 BEATS15 /MIN 1 5 AF HEART RATE TREND (24 hours) 9pm1 11pm1 1am2 3am2 5am2 7am2 9am2 11am2 1pm2 3pm2 5pm2 7pm2 9pm1 11pm1 1am2 3am2 5am2 7am2 9am2 11am2 1pm2 3pm2 5pm2 7pm2 9pm1 11pm1 1am2 3am2 5am2 7am2 9am2 11am2 1pm2 3pm2 5pm2 7pm2 9pm1 11pm1 1am2 3am2 5am2 7am2 9am2 11am2 1pm2 3pm2 5pm2 7pm2 9pm1 11pm1 1am2 3am2 5am2 7am2 9am2 11am2 1pm2 3pm2 5pm2 7pm2

5 Patient: GRIFFIN Page 4 CRITICAL EVENTS 11pm1 3am2 7am2 11am2 3pm2 7pm2 7:11PM1 VPB 2 1 Total pm1 3am2 7am2 11am2 3pm2 7pm2 7:12PM1 VPB PAIRS 4 2 Total 34 11pm1 3am2 7am2 11am2 3pm2 7pm2 7:11PM1 VTAC 2 1 Total pm1 3am2 7am2 11am2 3pm2 7pm2 1:6PM1 SVPB 5 25 Total 73 11pm1 3am2 7am2 11am2 3pm2 7pm2 SVPB PAIRS NOT PRESENT 2 1 Total 11pm1 3am2 7am2 11am2 3pm2 7pm2 SVT NOT PRESENT 2 1 Total 11pm1 3am2 7am2 11am2 3pm2 7pm2 PAUSES NOT PRESENT 2 1 Total

6 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 5 FULL-SIZED STRIPS 7:11:57PM1 TRIPLET HR = 136 HR2 = :19:38PM1 Early VPB HR = :47:11PM1 TRIPLET HR = 144 HR2 =

7 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 6 8::2PM1 TRIPLET HR = 14 HR2 = ::PM1 Normal HR = ::PM1 One per hour HR =

8 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 7 9:6:25PM1 Early VPB HR = :19:16PM1 VTAC HR = 15 HR2 = :1:52PM1 Early VPB HR =

9 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 8 11::1PM1 Early VPB HR = ::9AM2 One per hour HR = :1:36AM2 Early VPB HR =

10 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 9 6:2:51AM2 Early VPB HR = :5:51AM2 VTAC HR = 77 HR2 = :51:16AM2 End of episode HR =

11 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 1 6:52:53AM2 VTAC HR = 133 HR2 = :52:56AM2 VTAC HR = 135 HR2 = :53:AM2 VTAC HR = 135 HR2 =

12 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 11 6:56:13AM2 VTAC HR = 128 HR2 = :3:2AM2 Early VPB HR = :13:58AM2 VTAC HR =

13 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 12 7:17:8AM2 Early VPB HR = :26:19AM2 Early VPB HR = :42:17AM2 One per hour HR =

14 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 13 1:37:38AM2 Min. heart rate HR = :43:19AM2 SVPB HR = :1:22PM2 SVPB HR =

15 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 14 12:4:8PM2 VTAC HR = 128 HR2 = :43:22PM2 SVPB HR = :1:12PM2 One per hour HR =

16 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 15 3:3:15PM2 Early VPB HR = :14:8PM2 Early VPB HR = :31:36PM2 VTAC HR = 166 HR2 =

17 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 16 5:35:57PM2 VTAC HR = 15 HR2 = :4:6PM2 VTAC HR = :44:22PM2 VTAC HR = 156 HR2 =

18 Patient: GRIFFIN Gain[.5] ECG 25 mm/sec (ALL) Page 17 5:54:38PM2 VTAC HR = :1:39PM2 VTAC HR = 152 HR2 = :35:11PM2 Max. heart rate HR =

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24 Hour Holter Report Mass Veterinary Cardiology Services Inc 35 Suffield St Agawam, MA 11 413-372-5127/413-734-1292 413-372-5127 Exam Date: OCT 2 13-8:19am Record No: 7581 Provider: NANCY MORRIS DVM, DACVIM-C Medical Record

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