Early and One-year Outcomes of Aortic Root Surgery in Marfan Syndrome Patients
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1 Early and One-year Outcomes of Aortic Root Surgery in Marfan Syndrome Patients A Prospective, Multi-Center, Comparative Study Joseph S. Coselli, Irina V. Volguina, Scott A. LeMaire, Thoralf M. Sundt, Elizabeth H. Stephens, Luca A. Vricella, Hartzell V. Schaff, Dianna M. Milewicz, Harry C. Dietz, Heidi M. Connolly, Charles G. Minard, D. Craig Miller, on behalf of the Aortic Valve Operative study group
2 Disclosures Coselli LeMaire Miller St. Jude Medical, Inc. (speaker, research support) Vascutek Terumo (educational grant, consultant, royalties) Medtronic, Inc. (research support, speaker, Steering Committee) Medtronic, Inc. (consultant/advisory board) Medtronic, Inc. (consultant) Edwards LifeSciences (consultant, research grant) No disclosures: Connolly, Dietz, Hartzell, Milewicz, Minard, Stephens, Sundt, Volguina, Vricella
3 Ascending Aorta in Marfan Patients
4 Aortic Root Replacement: Valve-replacing Technique (AVR) Modified Bentall Procedure
5 Aortic Root Replacement: Valve-sparing Technique (AVS) David V Procedure David & Feindel JTCVS 1992;103: Original David procedure 10 patients; 5 with MFS
6 Aortic Valve Operative Outcomes in Marfan Patients (AVOOMP) Prospective, multicenter, international registry study Goal: Compare the outcomes of AVS and AVR root replacement Enrollment: March 2005 Nov subjects enrolled Primary endpoint: Major adverse valve-related events
7 Enrollment criteria - Marfan syndrome diagnosis based on 1996 Ghent criteria (De Paepe et al, Am J Med Genet) - In need of aortic root replacement - Observational registry Treatment not assigned type of operation determined by clinical factors and on surgeon and patient preference Follow-up at 6 months and at 1, 2, and 3 years Clinical follow-up: 98% complete at 1+ years Imaging follow-up: 93% complete at 1+ years
8 Enrolling Sites Institution PI Enrolled Subjects Mayo Clinic, Rochester Sundt / Schaff 55 Stanford University Miller 49 Johns Hopkins Hospital Gott / Vricella 32 New York Presbyterian-Cornell Hospital Girardi 29 University of Pennsylvania Bavaria 28 International sites 6 sites 70 Baylor College of Medicine Coselli 15 Washington University Moon 14 Other US sites 6 sites 24
9 Definitions Major adverse valve-related events (MAVRE), 2008 guidelines Akins et al. - JTCVS Valve-related mortality - Valve-related morbidity - Need for new permanent pacemaker or defibrillator within 14 days after operation
10 Definitions Valve-related mortality Death caused by valve-related morbid event reintervention on operated valve Sudden unexplained death Akins et al. - JTCVS 2008
11 Definitions Valve-related morbidity Structural valve deterioration (SVD) Nonstructural dysfunction (NSD) Operated valve endocarditis Valve thrombosis Embolism Bleeding after discharge Aortic regurgitation 2+ SVD/NSD Akins et al. - JTCVS 2008
12 Analysis Analysis based on intent-to-treat principles Univariate analysis for group comparisons - Student t and Mann-Whitney U tests for continuous variables - Chi-square and Fisher exact tests for categorical variables Cox regression analysis to determine whether type of operation was a risk factor for valve-related complications
13 316 Patients Age, y 35 ± 13 (range, 4-70) Male sex 203 (64%) Acute dissection 13 (4%) Chronic dissection 17 (5%) Rupture 1 Endocarditis 2
14 316 Patients Preoperative Characteristics AVR (n = 77) AVS (n = 239) P Value Age, y 39 ± ± 13 <0.01 Male sex 55 (71%) 148 (62%) 0.1 Sinuses of Valsalva, mm <0.01 LV ejection fraction, % Acute dissection 7 (9%) 6 (3%) <0.01 Chronic dissection 11 (12%) 6 (3%) <0.01 Previous CV surgery 17 (14%) 12 (5%) <0.01
15 Procedures Operative Details AVR (n = 77) AVS (n = 239) P Value Emergent or urgent surgery 18 (23%) 10 (4%) <0.01 Circulatory arrest 22 (29%) 48 (20%) 0.1 CPB time, m <0.01 Aortic clamp time, m <0.01 Concomitant arch 20 (26%) 46 (20%) 0.2 Elephant trunk arch 5 (6%) 4 (2%) 0.03 Concomitant MV replacement 5 (6%) 1 (<1%) <0.01 Concomitant CABG 4 (5%) 9 (4%) 0.6
16 Procedures Final decision to perform AVR or AVS was made intraoperatively in 140 patients (46%) AVR was considered the only suitable option in 55 patients (17%)
17 Early Outcomes 30-day Outcomes AVR (n = 77) AVS (n = 239) P Value Ventilator support time, h 12 8 <0.01 Time in ICU, h Length of hospital stay, d LV ejection fraction, %
18 Early Outcomes 30-day Complications No. Patients (n = 316) Death 2 (1%) Stroke 0 Cardiac complications* 40 (13%) Pulmonary complications 26 (8%) Re-exploration for bleeding 18 (6%) Major adverse valve-related event 21 (7%) * 40 with arrhythmia, 10 with pericardial effusion, 8 with cardiac failure
19 Two Early Deaths Repair POD Comment AVS 1 4-year old girl Bleeding Not valve-related AVR 7 30-year old man Cardiac failure, multiple organ failure Not valve-related
20 Early Outcomes 30-day Outcomes AVR (n = 77) AVS (n = 239) P Value Major valve-related adverse event 6 (8%) 15 (5%) 0.4 Nonstructural dysfunction 1 (1%) 7 (2%) 1.0 Embolism 1 (1%) 3 (1%) 1.0 Bleeding 2 (3%) 3 (1%) 0.6 Permanent pacemaker / 14 days after operation 2 (3%) 3 (1%) 0.6 No valve-related deaths, reinterventions, valve thrombosis, endocarditis
21 Non-structural Valve Dysfunction Six patients with significant postprocedure TEE underwent intraoperative conversion Homograft root (2005) stented bioprosthetic AVR David I (2005) Yacoub remodeling (2006) David V (2008) Mechanical AVR David IV (2009) David V (2010) One patient with coronary artery kinking after Florida sleeve procedure required same-day reintervention One patient with coronary pseudoaneurysm after David V procedure required reintervention on POD 6
22 AVR Operations, % One-year Outcomes Proportion of AVR and AVS Small and declining proportion of AVR operations (24% of all surgeries) % AVR Trend line Study period (6-month intervals)
23 One-year Outcomes Major Adverse Valverelated Events AVR patients (n=8) AVS patients (n=35) P-value MAVRE NSD/SVD 1 (13%) 23 (66%) 0.04 Embolism 2 (25%) 4 (11%) 0.6 Bleeding 5 (63%) 3 (9%) 0.01 Permanent pacemaker by POD 14 2 (25%) 3 (9%) 0.6 Endocarditis 1 (13%) Reintervention 0 1 (3%) 0.6 Valve-related death 1 (13%) 2 (6%) 0.7
24 One-year Deaths Repair POD Comment AVS year-old man Cause unknown Valve related AVR year-old woman Intracranial hemorrhage, sepsis Valve related AVS year-old man Drowning Not valve related AVS year-old girl Cause unknown Valve related
25 One-year Overall Survival P = 0.6 AVR AVS
26 Freedom from bleeding, % One-year Freedom from Bleeding P = 0.01
27 One-year Freedom from Nonstructural Dysfunction / Structural Valve Deterioration P = 0.04 AVR AVS
28 One-year Freedom from Major Adverse Valve-related Events P = 0.5 P = 0.5 AVR AVS
29 Other valve-related complications At 1 year, no difference between AVS and AVR groups in freedom from Valve-related death (1 AVR, 2 AVS) Embolism (2 AVR, 4 AVS) Reintervention (0 AVR, 1 AVS) Endocarditis (1 AVR, 0 AVS) Valve thrombosis (0 AVR, 0 AVS) Valve-related morbidity (7 AVR, 28 AVS)
30 Cox Regression, 1-year Type of surgery was not associated with overall survival MAVRE (HR=0.66, 95% CI: ) any other valve-related outcome
31 Conclusions AVR and AVS similar early outcomes At 1 year, no differences in survival or MAVRE Increased AR 2+ in AVS group at 1 year vs. no AR 2+ in AVR group Follow-up should be continued for 5-10 years
32
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