Paul C Johnson Ph D, Dr Med (hon)

Transcription

1 Paul C Johnson Ph D, Dr Med (hon) Education L L Wright High School Ironwood MI Diploma 1946 Gogebic Community College Ironwood Mi Assoc. Eng Univ of Michigan, Ann Arbor MI BS (Physics) 1951 Univ of Michigan, Ann Arbor MI Ph D (Physiology) 1955 Positions Teaching Fellow, University of Michigan, Department of Physiology Instructor, University of Michigan, Department of Physiology Instructor, Western Reserve University, Department of Physiology Assistant Professor, Indiana University, Department of Physiology Associate Professor, Indiana University, Department of Physiology Professor and Head, University of Arizona, Department of Physiology Professor, University of Arizona, Department of Physiology 1994 present Professor Emeritus, University of Arizona, Department of Physiology Adjunct Professor, U. C San Diego, Department of Bioengineering Honors 2005 Honorary Professor, Peking Union Medical College, Beixing, China 2005 Fellow, Biomedical Engineering Society 2000 Distinguished Service Award, Chairs of Departments of Physiology 1990 Honorary Member, Hungarian Physiological Society 1986 Doctor of Medicine Honoris Causa, Univ. of Maastricht, The Netherlands 1984 Fogarty International Fellowship, NIH 1984 Fellow, American Association for the Advancement of Science 1982 Alice & Mason Guest Lecture, Univ. of Texas, Galveston 1981 Carl J. Wiggers Award, American Physiological Society 1976 Eugene M. Landis Research Award, Microcirculatory Society 1976 Distinguished Physiologist Lecture, Univ. Texas-Dallas 1974 AOA Faculty Award, Univ. of Arizona President, US Microcirculatory Society. Professional Activities 1964 Guest Editor, Circulation Research Supplement on Autoregulation Member, Physiology Study Section, National Institutes of Health (NIH) Member of Council. American Physiological Society 1984 Chair, Association of Chairs of Departments of Physiology Chair, Publications Committee, American Physiological Society Chair, Editorial Board, News In Physiological Sciences (also served as Chair, Research Committee of the Arizona Heart Association, Chair of Circulation Section of APS, Finance Committee of the APS,and refereed papers in the area of circulation for APS and other journals.

2 B. Selected Peer-Reviewed Publications (of 134): Johnson, P.C. and J.W. Bean. "Effect of sympathetic blocking agents on the toxic action of oxygen at high pressure." American Journal of Physiology 188: 593, Selkurt, E.E. and P.C. Johnson. "Effect of acute elevation of portal venous pressure on mesenteric blood volume, interstitial fluid volume and hemodynamics." Circ. Res. 6(5): 592, Johnson, P.C. "Myogenic nature of increase in intestinal vascular resistance with venous pressure elevation." Circ. Res. 6: 992, Johnson, P.C. "Autoregulation of intestinal blood flow." American Journal of Physiology199: 311,1960. Johnson, P.C. and K.M. Hanson. "Effect of arterial pressure on arterial and venous resistance of intestine." J. AppI. Physiol. 17: 503, Johnson, P.C. and K.M. Hanson. Relation between venous pressure and blood volume in the intestine." American Journal of Physiology 204: 31, Johnson, P.C., W.H. Waugh and L.B. Hinshaw. "Autoregulation of blood flow." Science 140: 203, Johnson, P.C. "Review of previous studies and current theories of autoregulation."circ. Res. 15 (Suppl. 1): 2, Johnson, P.C. "Origin, localization and homeostatic significance of autoregulation in the intestine." Circ. Res. 15 (Suppl. 1): 225, Johnson, P.C. "Effect of venous presssure on mean capillary pressure and vascular resistance in the intestine." Circ. Res. 16: 294, Johnson, P.C. and W.H. Greatbatch, Jr. "The angiometer: A flying spot microscope for measurement of blood vessel diameter." Methods in Med. Res. 11: 220, Johnson, P.C. and K.M. Hanson. "Capillary filtration in the small intestine of the dog." Circ. Res. 19: 766, Thulesius, O. and P.C. Johnson. "Pre- and post-capillary resistance in skeletal muscle." American Journal of Physiology 210: 869, Hanson, K.M. and P.C. Johnson. "Local control of hepatic arterial and portal venous flow in the dog." American Journal of Physiology 211: 712, Wayland, H. and P.C. Johnson. "Erythrocyte velocity measurement in micro-vessels by a twoslit photometric method." J. AppI. Physiol. 2: 333, 1967.

3 Johnson, P.C. and H. Wayland. "Regulation of blood flow in single capillaries." American Journal of Physiology 212: , Johnson, P.C. "Measurement of microvascular dimensions in vivo." J.AppI. Physiol. 23: 593, Johnson, P.C. "Autoregulatory responses of cat mesenteric arterioles measured in vivo." Circ. Res. 2: 199, Richard, D. and P.C. Johnson. "A comparison of autoregulatory escape and autoregulation in the intestinal vascular bed." American Journal of Physiology 217: 586, Johnson, P.C. "Red cell separation in the mesenteric capillary network." American Journal of Physiology 221: 99, Burton, K.S. and P.C. Johnson. "Reactive hyperemia in single capillaries of mammalian skeletal muscle." Arnerican Journal of Physiology 223: 517, Johnson, P.C. Brief review: Renaissance in the microcirculation. Circ. Res. 31: 817, Johnson, P.C. "Photometric scanning techniques for measurement of blood vessel dimensions." Microvasc. Res , Johnson, P.C., D.L. Hudnall and J.H. Dial. "Measurement of capillary hematocrit by photometrc techniques." Microvasc. Res. 5: 351, Johnson, P.C. and D.R. Richardson. "The influence of venous pressure on filtration forces in the intestine. "Microvasc. Res. 7: , Johnson, P.C and H.A Henrich. ".Metabolic and myogenic factors in local regulation of the microcirculation. " Fed. Proc. 34: , Prewitt, R.L. and P.C. Johnson. "The effect of oxygen on arteriolar red cell velocity and capillary density in the rat cremaster muscle." Microvasc. Res. 12: 59-70, Johnson, P.C. and M. Intaglietta. "Contributions of pressure and flow sensitivity to autoregulation in mesenteric arterioles." American Journal of Physiology 231: , Johnson, P.C. Landis Award Lecture, The myogenic response and the microcirculation. Microvasc. Res. 13: 1-18., Klabunde, R.E. and P.C. Johnson. "Capillary velocity and tissue P02 changes during reactive hyperemia in skeletal muscle." American Journal of Physiology 233: H379-H383, Bohlen, H.G., H.A. Henrich, R.W. Gore and P.C. Johnson. "Flow in the intestinal microcirculation.". J. Physiol.: Heart Circ. Physiol. 4(1): H40-H45, Johnson, P. "The myogenic response." Chapter 15, Physiology Handbook, Eds., David F. Bohr, Andrew P. Somlyo and Harvey V. Sparks, Jr., Exec. Ed., Stephen R. Geiger. American Physiological Society, Bethesda, 1980

4 Sullivan, S.M. and P. Johnson. "Effect of oxygen on arteriolar dimensions and blood flow in cat sartorius muscle." American Journal of Physiology 241(10): H547-H556, Carlson, E.C., Burrows, M.E. & Johnson, P.C Electron microscopic studies of cat mesenteric arterioles: A structure-function analysis. Microvasc. Res., 24: , Burrows, M.E. & Johnson, P.C. Autoregulatory responses of mesenteric arterioles to arterial pressure reduction. Am.J. Physiol., 245: H796-H807, Johnson, P.C. Autoregulation of blood flow. Circ. Res. 59(5): , Reinke, W., Gaehtgens, P. & Johnson, P.C. Blood viscosity in small tubes: effect of shear rate, aggregation and sedimentation. Am. J. Physiol., 253: H540-H547, Boegehold, M.A. & Johnson, P.C. Response of the arteriolar network of skeletal muscle to sympathetic nerve stimulation. Am. J. Physiol., 254: H919-H928, Smiesko, V., D.J. Lang and P.C. Johnson. Dilator response of rat mesenteric arcading arterioles to increased flow. Am. J. Physiol. 257:(Heart Circ. Physiol. 26) H1958-H1965, Dodd, L.R. and P.C. Johnson. Arteriolar network regulation of resistance during sympathetic stimulation and muscle contraction. Am. J. Physiol. 260: H662-H670, Ping, P. and P.C. Johnson. Role of the myogenic response in enhancing autoregulation of blood flow during sympathetic nerve stimulation. Am. J. Physiol. 263: H1177-H1184, Ping, P. and P.C. Johnson. Mechanism of the enhanced myogenic response in arterioles during sympathetic nerve stimulation. Am. J. Physiol. 263: H1185-H1189, Popel, A.S., P.C. Johnson, M.V. Kameneva, and M.A. Wild. Capacity for red blood cell aggregation is higher in athletic mammalian species than in sedentary species. J. Appl. Physiol. 77: , Shonat, R.D., K.N. Richmond, and P.C. Johnson. Phosphorescence quenching and the microcirculation: an automated multipoint oxygen tension measuring instrument. Rev. Sci. Instrum. 66: , Toth, A., M. Pal, M.E. Tischler and P.C. Johnson. Are there oxygen-deficient regions in resting skeletal muscle? Am. J. Physiol. 270: H1933-H1939, Cabel, M., H.J. Meiselman, A.S. Popel, and P.C. Johnson. Contribution of red blood cell aggregation to venous vascular resistance in skeletal muscle. Am. J. Physiol. 272: H1020- H1032, Pál, M, A. Tóth, P Ping, and P.C. Johnson. Capillary blood flow and tissue metabolism in skeletal muscle during sympathetic trunk stimulation. Am. J. Physiol. 274: H430-H440, 1998.

5 Tsai, A.G., B. Friesnecker, M.D. Mazzoni, H. Kerger, D.G. Buerk, P.C. Johnson and M. Intaglietta. Microvascular and tissue oxygen gradients in the rat mesentery. Proc. Nat. Acad. Sci., USA 95: , Richmond, K., R.D. Shonat, R.M. Lynch and P.C. Johnson. Critical PO 2 of skeletal muscle in vivo. Am. J. Physiol. 277:H1831-H1840, Bishop, J.J., Popel, S., Intaglietta, M., and P.C.Johnson. Rheological effects of red blood cell aggregation in the venous network: A review of recent studies. Biorheology 38: , Bishop, J. J., Nance, P. R., Popel, A. S., Intaglietta, M. and Johnson, P. C.: Effects of erythrocyte aggregation on velocity profiles in venules. Am. J. Physiol. 279:H222-H Tsai, A.G., Johnson, P.C., and M. Intaglietta. Oxygen gradients in the microcirculation. Physiol Reviews 83: , Popel, A.S. and Johnson, P.C. Microcirculation and hemorheology. Ann. Rev. in Fluid Mechanics 37:43-69, Johnson, P.C., Vandegriff, K., Tsai, A.G., and Intaglietta, M. Effect of acute hypoxia on microcirculatory and tissue oxygen levels in rat cremaster muscle. J. Appl. Physiol. 98: , Bagchi, P., Johnson, P.C. and Popel, A.S. Computational fluid dynamic simulation of aggregation of deformable cells in a shear flow. J Biomech Eng. 127: Martini, J., Tsai, A.G., Cabrales, P., Johnson, P.C., and Intaglietta, M. Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window model. Am. J. Physiol. Heart Circ. Physiol. 291:H , Kim, S., Kong, R.L., Popel, A.S., Intaglietta, M., and Johnson, P.C. A computer-based method for determination of the cell-free layer width in microcirculation. Microcirculation 13: , Kim S, Zhen J, Popel AS, Intaglietta M, Johnson PC. Contributions of collision rate and collision efficiency to erythrocyte aggregation in postcapillary venules at low flow rates.am J Physiol Heart Circ Physiol. 293(3):H , 2007 Kim S, Kong RL, Popel AS, Intaglietta M, Johnson PC.Temporal and spatial variations of cellfree layer width in arterioles. Am J Physiol Heart Circ Physiol.;293(3):H Tóth A, Pal M, Intaglietta M, Johnson PC.Contribution of anaerobic metabolism to reactive hyperemia in skeletal muscle. : Am J Physiol Heart Circ Physiol. 2007, 292:H Zhang J, Johnson PC, Popel AS An immersed boundary lattice Boltzmann approach to simulate deformable liquid capsules and its application to microscopic blood flows. Phys Biol. 2007, 4:

6 Salazar Vazquez BY, Cabrales P, Tsai AG, Johnson PC, Intaglietta M Lowering of Blood Pressure by Increasing Hematocrit with non Nitric Oxide Scavenging Red Blood Cells. Am J Respir Cell Mol Biol : J. Zhang, P.C. Johnson and A.S. Popel. Lattice Boltzmann simulations of multiple deformable red blood cells in shear flows. J. Biomech., 41:47 55, B. Chung, S. Kim, P.C. Johnson and A.S. Popel. Computational fluid dynamics of aggregating red blood cells in postcapillary venules. Computer Methods in Biomechanics and Biomedical Engineering, 12: , J. Zhang, P.C. Johnson, and A.S. Popel. Simulating microscopic hemodynamics and hemorheology with the Immersed Boundary Lattice Boltzmann method. In: Computational Hydrodynamics of Capsules and Biological Cells, C. Pozrikidis, Ed., Chapman & Hall/CRC, in press. Books and Monographs Autoregulation of Blood Flow. Johnson, P.C. Editor,American Heart Association Monograph No.8, 1964, 291 pages, Peripheral Circulation. Johnson, P.C. Editor John Wiley & Sons, 420 pages (Also translated into Russian, 1982).. Biomechanics. R.H. Gallagher, B. Simon, P.C. Johnson, and J. Gross, Editors. John Wiley & Sons, 404 pages, Microvascular Networks. Experimental and Theoretical Studies. P.C. Johnson and Aleksander S. Popel, Editors. Karger. A.G., Basel. 220 pages 1986.