Curriculum Vitae of Prof Sias Hamman

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1 Prof Sias Hamman

2 Curriculum Vitae of Prof Sias Hamman 1. General information Title, name and surname: Prof Sias Hamman Date of birth: 1970/02/05 Citizenship: Professional registrations: 2. Contact details Organisation where based: Faculty or School: RSA SAPC, PSSA North-West University (NWU) Faculty of Health Sciences: Pharmacen Work telephone number: +27 (0) Work fax number: +27 (0) Cell phone number: +27 (0) address: Website address: Work postal address: Private Bag X6001 Potchefstroom 2520 Work physical address: North-West University (NWU) Potchefstroom Campus Building G2, Room G16 Potchefstroom 3. Qualifications (Start with most recent) Qualification type: Field of study: Institution: PhD Year obtained: 2001 Qualification type: Field of study: Institution: Pharmaceutics North-West University (PU for CHE) MSc Year obtained: 1997 Qualification type: Field of study: Institution: Pharmaceutics North-West University (PU for CHE) B Pharm Year obtained: 1995 Pharmacy North-West University (PU for CHE) 4. Employment history (From current backwards. Not more than five) Position: Organisation Appointed from to: Research Professor Potchefstroom Campus of the North-West University (NWU) Professor Tshwane University of Technology (TUT) Current Professor Technikon Pretoria Senior Lecturer Technikon Pretoria

3 5. Research expertise Scientific domain: Main research field: Pharmaceutics Drug delivery Fields of specialisation: Drug absorption enhancement, herb-drug pharmacokinetic interactions NRF rating and year rated: C2, Publications (List publications over the last three years) International publications: Scholtz J.C., Van der Colf J., Steenekamp J.H., Stieger N., Hamman J.H More good news about polymeric plantand algae-derived biomaterials in drug delivery systems. Current Drug Targets, accepted for publication. Marais E., Hamman J., Du Plessis L., Lemmer R., Steenekamp, J Eudragit L100/N-trimethylchitosan chloride microspheres for oral insulin delivery. Molecules, 18: Buys G.M., Du Plessis L.H., Marais A.F., Kotzé A.F., Hamman J.H Direct compression of chitosan: Process and formulation factors to improve powder flow and tablet performance. Current Drug Delivery, 10: Lemmer R., Hamman J.H Paracellular drug absorption enhancement through tight junction modulation. Expert Opinion on Drug Delivery, 10: Beneke C., Viljoen A., Hamman J Modulation of drug efflux by Aloe materials: An in vitro investigation across rat intestinal tissue. Pharmacognosy Magazine, 9: Nkabinde L.A., Shoba-Zikhali L.N.N., Semete-Makokotlela B., Kalombo L., Swai H.S., Hayeshi R., Naicker B., Hillie T.K., Hamman J.H Permeation of PLGA nanoparticles across different in vitro models. Current Drug Delivery, 9: Gouws C., Steyn D., Du Plessis L., Steenekamp J., Hamman J Combination therapy of Western drugs and herbal medicines: recent advances in understanding interactions involving metabolism and efflux. Expert Opinion in Drug Metabolism and Toxicity, 8: Lebitsa T., Viljoen A., Lu Z., Hamman J In vitro drug permeation enhancement potential of Aloe gel materials. Current Drug Delivery, 9: Beneke C., Viljoen A., Hamman J In vitro drug absorption enhancement effects of Aloe vera and Aloe ferox. Scientiae Pharmaceutica, 80: Hamman J.H., and Steenekamp J.H Excipients with specialised functions for effective drug delivery. Expert Opinion on Drug Delivery, 9(2): Ojewole E., Mackraj I., Akhundov K., Hamman J., Viljoen A., Olivier E., Wesley-Smith J. and Govender T Investigating the effect of Aloe vera gel on the buccal permeability of didanosine. Planta Medica,78: Shikanga E.A., Hamman J.H., Chen W., Combrinck S., Gericke N., Viljoen A.M In vitro permeation of mesembrine-alkaloids from Sceletium tortuosum across porcine buccal, sublingual and intestinal mucosa. Planta Medica, 78: Tarirai C., Viljoen A.M. and Hamman JH Effects of dietary fruits, vegetables and a herbal tea on the in vitro transport of cimetidine: Comparing the Caco-2 model with porcine jejunum tissue. Pharmaceutical Biology, 50(2): Fox L.T., Gerber M., Du Plessis J., and Hamman J.H

4 Transdermal drug delivery enhancement by compounds of natural origin. Molecules, 16: Jambwa N.T., Viljoen, A.M., Hamman J.H Matrix forming excipients from natural origin for controlled release matrix type tablets. Journal of Drug Delivery Science and Technology, 21(5): Vermaak I., Viljoen A.M., Hamman J.H Natural products in anti-obesity therapy. Natural Product Reports, 28: Vermaak I., Viljoen A.M., Chen W., Hamman J.H In vitro transport of the steroidal glycoside P57 from H. gordonii across porcine intestinal and buccal tissue. Phytomedicine, 18: Vermaak I., Hamman J.H. and Viljoen A.M Hoodia gordonii: An up-to-date review of a commercially important anti-obesity plants. Planta Medica, 77: Tarirai C., Enslin G.M., Steenekamp J.H. and Hamman J.H Moulded cross-linked chitosan matrix systems for controlled drug release. Pharmaceutical Development and Technology, 16(4): Hamman J.H Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems. Marine Drugs, 8: Tarirai C., Viljoen A.M. and Hamman J.H Herb-drug pharmacokinetic interactions reviewed. Expert Opinion in Drug Metabolism and Toxicity, 6(12):1-24. Lu Z., Chen W., Viljoen A., and Hamman J Effect of sinomenine on the in vitro intestinal epithelial transport of selected compounds. Phytotherapy Research, 24: Lu Z., Chen W. and Hamman J.H Chitosanpolycarbophil interpolyelectrolyte complex as a matrix former for controlled release of poorly water-soluble drugs I: in vitro evaluation. Drug Development and Industrial Pharmacy, 36: Vermaak I., Hamman J.H. and Viljoen A.M A rapid spectroscopic method for quantification of P57 in Hoodia gordonii raw material. Food Chemistry, 120: Vermaak I., Hamman J.H. and Viljoen A.M High performance thin layer chromatography as a method to authenticate Hoodia gordonii raw material and products. South African Journal of Botany, 76: Vermaak I., Viljoen A.M., Hamman J.H., Baranska M The potential application of FT-Raman spectroscopy for the quantification and mapping of the steroidal glycoside P57 in Hoodia gordonii. Phytochemistry Letters, 3: Chen W., Lu Z., Viljoen A. and Hamman J Intestinal drug transport enhancement by Aloe vera. Planta Medica, 75: Beneke C.E., Viljoen A.M., and Hamman J.H Polymeric plant-derived excipients in drug delivery. Molecules, 14: Vermaak I., Viljoen A.M., Hamman J.H. and Van Vuuren S.F The effect of simulated gastrointestinal conditions on the antimicrobial activity and chemical composition of indigenous South African plant extracts. South African Journal of Botany, 75: Vermaak I., Viljoen A.M., Hamman J.H. and Van Vuuren S.F Effect of simulated gastrointestinal conditions and epithelial transport on extracts of Green tea and Sage. Phytochemistry Letters, 2: Ojewole, E., Mackraj, I., Akhundov, K., Hamman, J., Viljoen, A. and Govender T Exploring the effect of aloe vera 3

5 National publications: gel on the buccal permeability of didanosine: permeability and histomorphological studies. Journal of Pharmacy and Pharmacology, 61(Supplement 1):A34-A35. Brown L., Heyneke O., Brown D., van Wyk J.P.H. and Hamman J.H Impact of traditional medicinal plant extracts on antiretroviral drug absorption. Journal of Ethnopharmacology, 119: Enslin G.M., Kotzé A.F. and Hamman J.H Intestinal drug absorption enhancers: synergistic effects of combinations. Drug Development and Industrial Pharmacy, 34: Hamman J.H Composition and applications of Aloe vera leaf gel. Molecules, 13: Lu Z., Chen W., Olivier E.I. and Hamman J.H Matrix polymeric excipients: comparing a novel interpolyelectrolyte complex with hydroxypropylmethylcellulose. Drug Delivery, 15: Huang M.J., Du Plessis J., Du Preez J., Hamman J.H. and Viljoen A.M Transport of aspalathin, a Rooibos tea flavonoid, across the skin and intestinal epithelium. Phytotherapy Research, 22: Lu Z., Chen W., Hamman J.H., Ni J. and Zhai X Chitosan-polycarbophil interpolyelectrolyte complex as an excipient for bioadhesive matrix systems to control macromolecular drug delivery. Pharmaceutical Development and Technology, 13: Jambwa, T., Viljoen, A.M. and hamman, J.H Aloe gel and whole leaf raw materials: promising excipients for the production of matrix-type tablets. South African Pharmaceutical Journal. 78(1): Papers delivered (List papers over the last three years) International papers: Hamman J.H., Viljoen A.M Pharmacokinetic interactions between botanicals and drugs: in vitro investigations. 59 th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research. (Antalya, Turkey). Beneke C.E., Hamman J.H., Viljoen A.M The effect of aloe materials on the transepithelial electrical resistance of pig and rat intestinal tissue. 59 th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research. (Antalya, Turkey). Shikanga E.A., Viljoen A.M., Chen W., Hamman J.H., Combrinck S. Gericke N An investigation of the in vitro transport of Sceletium tortuosum alkaloids across porcine buccal, sublingual and intestinal membranes. 59 th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research. (Antalya, Turkey) (Poster). Hamman J.H., Viljoen A.M., Tarirai C Impact of plant extracts on drug transport across intestinal mucosa. 58 th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research. (Berlin, Germany). Tarirai C., Viljoen A.M., Chinyemba P., Khatib A., Jiyane P.P., Rakomane S.J., Chetty N., Hamman J.H In vitro evaluation of the effect of selected herbal extracts on drug transport across porcine jejunal tissue. 58 th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research. (Berlin, Germany). Chen, W., Lu, Z., Viljoen, A,M., Hamman, J.H Intestinal drug transport enhancement by Aloe vera. 58 th 4

6 National papers: International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research. (Berlin, Germany). Tarirai, C., Viljoen, A.M., Hamman J.H Evaluation of selected fruit, vegetable and herb extracts on cimetidine efflux across Caco-2 cell monolayers. 7 th World meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. (Valetta, Malta). Ojewole, E., Mackraj, I., Akhundov, K., Hamman, J., Viljoen A., Govender, T Exploring the effect of Aloe vera gel on the buccal permeability of didanosine: Permeability and Histomorphological studies. British Pharmaceutical Conference. (Manchester Central, UK). Tarirai, C., Viljoen, A.M., Hamman J.H The effect of selected foods on P-glycoprotein mediated cimetidine efflux. 5 th International Conference on Pharmaceutical and Pharmacological Sciences. (Potchefstroom, South Africa). Chen, W., Hamman, J.H., Lu, Z., Viljoen, A.M Drug absorption enhancing properties of Aloe vera across intestinal epithelium. World Conference on Medicinal and Aromatic Plants. (Cape Town, South Africa). Chen, W., Hamman, J.H., Lu, Z., Viljoen, A.M Drug absorption enhancing properties of Aloe vera across intestinal epithelium. Annual Congress of the Society for Medicinal Plant Research (7 th Joint Meeting of AFERP, ASP, GA, PSE & SIF). (Athens, Greece). E. Marais, J.H. Hamman and J.H. Steenekamp Development and characterisation of Eudragit L100-Ntrimethyl chitosan chloride microspheres. 33 rd Annual Conference of the Academy of Pharmaceutical Sciences. Grahamstown. K. Roos, M.M. Malan and J.H. Hamman Effect of plant extracts and phytoconstituents on the intestinal transport of the antiretroviral drug, indinavir. 33 rd Annual Conference of the Academy of Pharmaceutical Sciences. Grahamstown. N.T. Jambwa, A Viljoen and J Hamman Aloe extracts as excipients in controlled release matrix type tablets. 31 st Annual Conference of the Academy of Pharmaceutical Sciences. Polokwane. Vermaak, A. Viljoen, J Hamman In vitro permeability of the steroidal glycoside P57 from H. gordonii through porcine buccal and intestinal mucosa. 31 st Annual Conference of the Academy of Pharmaceutical Sciences. Polokwane. J. Hamman, A. Viljoen, C. Tarirai Impact of plant extracts on drug transport across intestinal mucosa. 31 st Annual Conference of the Academy of Pharmaceutical Sciences. Polokwane. M. Sandasi, I. Vermaak, C.M. Leonard, J.H. Hamman and A.M. Viljoen Antimicrobial activity and gastrointestinal stability of Agathosma betulina ( buchu ) extracts. Indigenous Plant Use Forum. Graaff-Reinet. T. Lebitsa, A.M. Viljoen and J.H. Hamman Intestinal absorption enhancement potential of aloe gel and whole leaf extracts. Indigenous Plant Use Forum. Graaff- Reinet. Vermaak, A. Viljoen and J. Hamman The Effect of Simulated Gastrointestinal Conditions on the Antimicrobial Activity and Stability of Medicinal Plant Extracts. Academy of Pharmaceutical Sciences 29 th Annual Conference. Rustenburg. G. Mphoso, L. Mokhethi, P. Demana, S. Hamman and 5

7 G. Enslin Effect of N-trimethyl Chitosan Chloride (TMC), Monocaprin (MC) and Melittin (MT) on the Transport of Insulin Across Caco-2 Cell Monolayers. Academy of Pharmaceutical Sciences 29 th Annual Conference. Rustenburg. L. Brown, O. Heyneke, D. Brown, J. Van Wyk and J. Hamman Influence of Rifampicin and Traditional Medicinal Plant Extracts on the Transport of Zidovudine Across Intestinal Epithelial Cells. Academy of Pharmaceutical Sciences 29 th Annual Conference. Rustenburg. 6

Curriculum Vitae: Karen van der Merwe July Curriculum Vitae

Curriculum Vitae: Karen van der Merwe July Curriculum Vitae Curriculum Vitae 1. General information Title, name and surname: Dr Karen van der Merwe Maiden name: De Waal ID nr: 541116 0083 089 Date of birth: 1954-11-16 Gender: Female Race: White Marital status: