Presentation and outcome of sacral agenesis: 20 years experience
|
|
- Anna McKenzie
- 5 years ago
- Views:
Transcription
1 Presenttion nd outcome of scrl genesis: 20 yers experience Jo M Wilmshurst MRCP; Rosemry Kelly RSCN; Mlgorzt Borzyskowski* FRCP FRCPCH, Deprtment of Peditric Neurology, Newcomen Centre, Guy s Hospitl, St Thoms Street, London SE1 9RT, UK. *Correspondence to lst uthor t ddress bove. The underlying risk fctors, presenting fetures, nd outcome of 22 children with scrl genesis nd ssocited neuropthic bldder were studied retrospectively. The ge of children t presenttion ws bimodlly distributed, with peks below 1 yer nd between 4 nd 5 yers of ge. Ten ptients presented fter 1 yer. The oldest ws dignosed t 12 yers of ge. In 12 children there ws mternl dibetes, orthopedic nomlies in 14, skin defects in 11, nd norectl/trcheooesophgel nomlies in three. Most children hd persistent dribbling of urine on presenttion ssocited with frequency, urgency, recurrent urinry trct infections, filure to respond to mediction, nd/or constiption. Twenty-one children hd bnorml neurology in the lower limbs. Videourodynmics showed neuropthic vesicourethrl dysfunction in ll children nd vesicoureteric reflux in 10. Nineteen hd history of urinry trct infections. Seven hd renl scrring, with renl impirment in three t presenttion. Clen intermittent ctheteriztion ws recommended for 20 of the children. Bldder or bowel surgery hs been crried out in seven nd neurosurgery performed in two. Twenty of the 22 children underwent opertive procedures. Ten opertions were performed before scrl genesis ws dignosed. Over third of the children hve required psychologicl support. The combintion of urinry symptomtology nd ny of the bove risk fctors should give rise to high level of suspicion nd low threshold to perform investigtions to exclude scrl genesis. All these children hve bnorml bldder nd urethrl function which not only cuses incontinence but puts the kidneys t risk. Erly detection llows effective multidisciplinry input specificlly imed t continence, preservtion of renl function, nd dequte psychologicl support. Scrl genesis is rre disorder with reported incidence of 0.09 to 0.43% (Guzmn et l. 1983). It hs been clssified into four types: types 1 nd 2 refer to prtil scrl genesis, where prt of the scrum remins; types 3 nd 4 refer to totl bsence of scrum, i.e. complete scrl genesis, type 4 lso involves the bsence of one or more lumbr vertebre (Renshw 1978). Erly detection is importnt s there is significnt ssocition with neuropthic bldder (Gotoh et l. 1991). Delyed dignosis increses the risk of renl impirment, recurrent urinry trct infections, nd incontinence. Evidence exists to suggest this cn be progressive neurologicl disorder due to growth nd trction or pressure on bnormlly positioned scrl roots, or in ssocition with tethered cord (which my be due to thickened filum terminle, lipom, or distemtomyeli) (Gotoh et l. 1991). Key fetures include constiption nd urologicl symptoms of persistent dy- nd night-time wetting, recurrent urinry trct infections, nd difficulty voiding urine. Physicl exmintion my revel flttening of the buttocks, loss of glutel cleft, widely spced buttock dimples, or plpble scrl defect or groove (Fig. 1). Older children my hve widely bsed flt-footed git or pescvus. Neurologicl exmintion cn be completely norml (Koff nd Deridder 1977). Previous history often revels orthopedic bnormlities especilly equinovrus bnormlity (Borrelli et l. 1985). The ssocition with mternl dibetes is well recognized nd 1% of infnts born to dibetic mothers hve scrl genesis, while 12 to 16% of infnts with scrl genesis hve mothers with dibetes (Guzmn et l. 1983). Any defect of the scrum which ffects more thn one vertebr cn cuse neuropthic bldder. However, defect between S2 nd S4 is most likely to led to bldder dysfunction. In ddition, it is not possible to predict the form of bldder nd urethrl bnormlity from the neurologicl dysfunction itself (Koff nd Deridder 1977, Boemers et l. 1996). We hve reviewed children referred to the peditric neurourology service t Guy s Hospitl in London, UK over the lst 20 yers with scrl genesis. Fifteen children were referred with the dignosis, while in seven scrl genesis ws identified t Guy s Hospitl. We ttempted to specificlly exmine risk fctors, presenting fetures, nd resulting outcome vribles. Method A retrospective ssessment ws mde of ll the medicl records of the ptients with dignosis of scrl genesis mnged by the Guy s neurourology deprtment over the pst 20 yers. We documented referrl source, with or without confirmtion of the dignosis of scrl genesis, ges t referrl (Fig. 2), nd resons for referrl (Tble I). A totl of 22 children (11 mle nd 11 femle) with scrl genesis were identified. There were two pek ges of presenttion below 1 yer of ge nd between 4 nd 5 yers (see Fig. 2). Ten children presented lte, i.e. fter 1 yer; the oldest ws dignosed t 12 yers of ge. The frequency of ssocited risk fctors linked to scrl genesis ws reviewed, nmely mternl dibetes, orthopedic bnormlities, lumboscrl skin defects, norectl/trcheooesophgel bnormlities, nd bnorml lowerlimb neurology (Tble II). The orthopedic nd neurologicl 806 Developmentl Medicine & Child Neurology 1999, 41:
2 nomlies were ssessed in further detil, noting the required mobility supports. Videourodynmics (VUD), which ssesses bldder nd urethrl function, nd ssessment of renl function were performed in ll children. The VUD studies were crried out using stndrd techniques nd consist of filling nd voiding cystometrogrm combined with micturting cystourethrogrm. The two imges re superimposed on television screen nd recorded on to videotpe so tht events occurring in the bldder nd the urethr could be correlted with pressure chnges nd vice vers. Definitions were from Andersen s guidelines (Andersen 1988). Neuroimging of the spinl cord ws performed if pplicble. Full neurologicl nd urologicl ssessments were completed for ll children. The ssessments nd investigtions, prticulrly urodynmic findings (Tble III), were compred with the results of neuroimging nd outcome in terms of renl function, bldder or bowel surgery, neurosurgery; nd behviourl problems requiring psychologicl support (Tble II) were noted. The degree of continence for both bldder nd bowel nd resons for filure if incontinence remined n issue were scertined. The different types of surgery performed on ll our subjects nd whether surgery ws crried out before or fter confirmtion of the dignosis were noted, i.e. frequency of cosmetic, norectl, urologicl, orthopedic, nd neurosurgicl procedures (Tble IV). Results At the strt of this study the children s ges rnged from 2 to 24 yers (medin 10.5 yers). Most ptients hd persistent dribbling of urine on presenttion ssocited with frequency, urgency, recurrent urinry trct infections, filure to respond to mediction, nd/or constiption (see Tble I). There ws no difference in the presenting fetures of the groups presenting with or without previous dignosis of scrl genesis. Number of subjects Age (y) Figure 2: Age t referrl of ptients to specilist neurourology clinic. Figure 3: MRI of the spine, sgittl view, confirming syrinx T11 L3, with tethered cord terminting in ftty filum. Figure 1: Clinicl ppernce of scrl genesis in stnding position. Note scrl defect. Presenttion nd Outcome of Scrl Agenesis Jo M Wilmshurst et l. 807
3 In 12 subjects there ws history of mternl dibetes, 14 hd ssocited orthopedic nomlies, 11 hd skin defects, nd three hd norectl/trcheooesophgel defects (Tble II). Of the six subjects referred by peditricins, without dignosis of scrl genesis, hlf hd skin defects, two mternl dibetes, nd one orthopedic bnormlities, wheres in the one subject referred by peditric surgeon, without dignosis of scrl genesis, the only ssocited risk fctor ws n overlying skin bnormlity. Fourteen children hd orthopedic nomlies consisting of tlipes equinovrus (N=11), clwed toes (N=2), vrus knee deformities (N=2), dislocted hip (N=1), nd scoliosis (N=1). Twenty-one of the 22 children hd bnorml neurologicl fetures in the lower limbs, consisting of ltered deep tendon reflexes (N=19), muscle wekness (N=9) nd wsting (N=8), nd ltered senstion (N=3). Twenty of the 22 children hve hd imging of the spinl cord, two children s prents refused the investigtion, nd for the three who were investigted elsewhere we could not trce the imges. Abnormlities were detected in 11 subjects, consisting of cord tethering in six, syrinx in four, distemtomyeli in one, nd lipom within the cord in two (Fig. 3). Assessment of renl function showed tht seven hd renl scrring nd three hd renl impirment ssocited with reduced glomerulr filtrtion rte nd rised cretinine t the time of referrl. Videourodynmics showed bldder nd urethrl dysfunction in ll ptients; vesicoureteric reflux (VUR) in 10, reduced bldder cpcity in 16, incomplete bldder emptying in 15, detrusor sphincter dyssynergi (DSD) in 14, nd hyperreflexi in 19 (see Tble III). No ssocition ws noted between type of scrl genesis, neurologicl deficit, nd VUD fetures. The mngement of the neuropthic bldder ws determined by the videourodynmic findings, pre- nd post-bldder-emptying ultrsounds, nd the result of renl investigtions. Anticholinergic drugs were prescribed in ll subjects t some time. Twenty of the children were felt to require clen intermittent ctheteriztion (CIC) both to protect the kidneys nd improve continence. Of these, 14 were ctively nd successfully using CIC. Six of the children remined vribly wet dy nd night. Of these six, two were still lerning to ctheterize, three children hd refused in ssocition with behviour problems, nd one hd recurrent blnitis. In the remining two children, one ws still in nppies (dipers) nd the other hd vesicostomy to protect his kidneys. Bldder or bowel surgery hd been crried out in seven nd neurosurgery performed in two. Not ll the children with bnorml MRIs were thought to require surgicl intervention on neurosurgicl ssessment. Over third of the children required psychologicl support for combintion of soiling, refusing to ctheterize, nd behviourl outbursts (Tble II). Soiling usully occurred in reltion to underlying neuropthic bowel, however, proportion of children required psychologicl support for excerbted symptoms or cler behviourl element. Twenty of the 22 children hd undergone surgery which rnged from cosmetic to neurosurgicl procedures. Ten of these opertions were performed before the dignosis of scrl genesis ws mde (Tble IV). One child ws wheelchir-dependent nd eight required nkle foot orthoses for mobility. Tble I: Resons for referrl to specilized neurourology clinic Antentl Dribbling Dy/night Poor Frequency of Urgency of UTIs Constiption dignosis or urine wetting strem micturition micturition Ptients (N) UTI, urinry trct infection. Tble II: Presenting risk fetures nd summry of subsequent findings Age t presenttion (y) <1 1 <4 4 5 >5 Totl Mternl dibetes Orthopedic bnormlities Skin defects Anorectl bnormlities Abnorml neurology Type of scrl genesis Complete Prtil UTIs Vesicoureteric reflux Renl scrring Abnorml renl function Bldder/bowel surgery Neurosurgery Behviourl problems Developmentl Medicine & Child Neurology 1999, 41:
4 The following two cses illustrte the rnge of presenttions in our subjects. SUBJECT 2 This boy ws born t 35 weeks gesttion to dibetic mother whose pregnncy hd been complicted by polyhydrmnios. He spent the first 2 weeks of his life in specil cre bby unit with problems of hypoglycemi. Over the following yers he ws never continent of urine, lwys pssing poor strem nd being described s continuously dribbling. At 4 yers 6 months he presented with urinry incontinence, one previous urinry trct infection, nd constiption ssocited with soiling. In ddition behviour ws becoming problem. Renl ultrsound nd dimercptosuccinic cid scn (DMSA) were reported norml with no evidence of reflux or renl scrring. Micturting cystourethrogrm hd shown thickwlled bldder nd the possibility of posterior urethrl vlves. He ws dmitted to the peditric nephrology wrd for plnned urethrl stretch ged 4 yers 9 months. On rrivl, suspicions rose following the history nd the findings of bnorml nkle reflexes. X-ry of the spine confirmed spin bifid occult L5 nd scrl dysgenesis. VUD demonstrted grossly bnorml bldder with extensive trbecultion nd sccultion suggestive of high intrvesicl pressure. Bldder cpcity ws only 76mL. He hd wide posterior urethr with incomplete intermittent opening of the sphincter. Detrusor hyperreflexi ws noted. No evidence of reflux ws seen. MRI of the spine demonstrted cvity in the thorcic cord extending from T3 to the distl cord which ws truncted nd terminted t T12. Neurosurgicl intervention ws not indicted. His renl function remins stble nd he is currently intermittently ctheterizing, tkes oxybutynin, nd is dry. However, his bowels remined significnt problem, resulting in n ntegrde colonic enem (ACE) procedure being performed with good result. SUBJECT 17 This girl ws referred to the peditric neurourology service t Guy s Hospitl t 7 yers of ge fter being seen by severl doctors nd lredy hving undergone number of procedures. There ws strong fmily history of dibetes with her mother, brother, nd mternl grndmother being ffected. Equinus deformities of her feet were noted from birth. Three opertions were performed on her feet, the lst of which ws yer before referrl. She ws investigted for constiption nd required evcutions of her bowel on two occsions nd rectl biopsy which proved negtive for Tble III: Results of videourodynmics Subject Age t Cpcity Residue DSD Hyper- OBN Reflux VUD (y:mo) (ml) (ml) reflexi 1 1: Y Y N N 2 4: Y Y Y N 3 4: Y Y Y Y 4 4: Y Y Y N 5 4: N N Y N 6 1: Y Y Y N 7 5: N Y Y Y 8 2: Y Y N N 9 11: N Y Y N 10 1: N Y Y Y 11 1: N Y N Y 12 7: N Y Y N 13 4: Y Y Y Y 14 5: Y Y Y N 15 13: Y Y N N 16 1: Y Y N Y 17 7: Y Y N N 18 1: Y Y Y Y 19 3: N N N Y 20 6: N Y Y Y 21 3: Y Y Y N 22 7: Y Y Y Y VUD, videourodynmics; DSD, detrusor sphincter dyssynergi; OBN, open bldder neck; N, no; Y, yes. Norml bldder cpcity for up to 12 yers (ml) = (ge in yers 30) + 50 (Rickwood 1990). Figure 4: X-ry ppernce of complete scrl genesis. Note feces in position of usul rdiogrphic site of scrum. Without lterl film this child could esily be missed. Presenttion nd Outcome of Scrl Agenesis Jo M Wilmshurst et l. 809
5 Tble IV: Surgicl interventions Subject Cosmetic Anorectl/ Urologicl Orthopedic Neurologicl opertions/other oesophgotrchel 1 Bilterl tendochilles trnsfers 2 ACE procedure Circumcision 3 Cystoplsty 4 Right orchidopexy 5 Mnul evcution nd rectl biopsy. ACE stom 6 Equinus feet deformity repir spinl strightening 7 Lminectomy L4,5, S1 for bifid conus 8 Prophylctic cord untethering 9 Clm cystoplsty Equinus feet correction 10 Mlrottion 11 Refused cystoplsty Bilterl equinus deformity opertion 12 Fllots repir Oesophgel tresi nd TOF repir 13 Lipom spinl opertion superficil 14,b Lprotomy for bdominl pin Urethrl dilttion ACE procedure Foot opertion 17 Mnul evcution 2, tlipes equinovrus 3 rectl biopsy 18 Anl tresi opertion Vesicostomy 19 Rectl biopsy Loop colostomy followed by Clm cystoplsty Relese of tendochilles ACE procedure 22 Relese of tendochilles Procedure predignosis of scrl genesis; b confirmed UTI, lprotomy norml; ACE stom/procedure, ntegrde colonic enem; TOF, trcheooesophgel fistul. Tble V: Literture review Author Current Borrelli Brren Gotoh Guzmn Koff nd Sito study et l. nd Jones et l. et l. Derridder et l. (1985) (1979) (1991) (1983) (1977) (1991) Number of cses Incidence per yer Presenting ges (y) > < Dignosed under 1 y 12 ~ Key presenting complint Incontinence Incontinence UTI Incontinence Incontinence Incontinence Incontinence Constiption 16 (73) 1 4 (28) 2 (15) Neurologicl deficit 21 (95) 13 (93) 13 (81) 4 (30) 11 (73) VUDs performed Hyperreflexi 19 (86) 5 (50) 6 (46) 9 (100) 10 (66) DSD 14 (64) 3 (30) 5 (38) 9 (100) 13 (87) VUR 19 (45) 5 (50) 8 (56) 5 (33) Scrring 7 (32) 4 (28) Renl impirment 3 (14) 1 1 (7) 1 (7) 1 (6) Bldder/bowel surgery 7 (32) 9 (24) 2 5 (36) 3 (18) 5 (38) 2 (13) Neurosurgery 2 (9) (56) (33) Achieved continence 14 (64) 27 (80) 7 (50) 12 (75) 5 (38) 11 (73), dt not recorded; percentges re in prentheses; UTI, urinry trct infection; VDU, videourodynmics; DSD, detrusor sphincter dyssynergi; VUR, vesicoureteric reflux. 810 Developmentl Medicine & Child Neurology 1999, 41:
6 Hirschsprung disese. She ws described s continuously dribbling, being wet both dy nd night, nd pssing poor urinry strem. There were no proven urinry trct infections. She qulified for dditionl support in school becuse of her incontinence nd impired git. An X-ry of her spine detected possible spin bifid but no mention ws mde of the scrl views. She ws referred becuse of persistent incontinence nd constiption by her generl peditricin. Cliniclly, she ppered constipted with full bldder. Her spine ws short to plption with ftty swelling over the bse. She hd bnorml lower-limb neurology, with wsting of her left clf, brisk knee reflexes, nd reduced left nkle jerk. Senstion ppered intct, lthough nl reflex ws bsent. MRI of her spine confirmed scrl genesis with n expnded cvity in the distl thorcic cord from T9 to T11. The cord terminted t L1 with ftty strek to L4. There ws no evidence of distemtomyeli. Renl function ws norml with no evidence of reflux or scrring, VUD demonstrted detrusor sphincter dyssynergi with incomplete emptying. At the current time, it is felt tht neurosurgery is not required, but she is being monitored nd is lerning how to self-ctheterize. Discussion Few published studies cover the neurourologicl spects of scrl genesis (Tble V). Most hve been in urologicl journls with little documenttion in the peditric literture. Mny reports in the orthopedic literture discuss the bony bnormlities of the condition but not the neurourologicl spects. Comprison with our study confirmed the low incidence of scrl genesis with round one cse per yer presenting to urology centre (Koff nd Deridder 1977, Borrelli et l. 1985, Gotoh et l. 1991, Sito et l. 1991). In these studies, ge t presenttion ws wide, s in our study. In only one study ws the dignosis mde in hlf the cses in the newborn period (Guzmn et l. 1983). Presenting fetures in most studies quoted incontinence s the most common complint (Koff nd Deridder 1977, Borrelli et l. 1985, Gotoh et l. 1991, Sito et l. 1991). However, constiption ws surprisingly rrely noted. VUDs hve been performed in the more recent studies, confirming neuropthic bldder in most ptients. Findings of hyperreflexi nd DSD vried but overll echoed our results. Better correltion occurred for VUR nd renl scrring. Four ptients hd reduction of renl function (Koff nd Deridder 1977, Gotoh et l. 1991, Sito et l. 1991) with deteriortion in one severe enough to require dilysis (Brren nd Jones 1979). The number of children in our study requiring bldder or bowel surgery ws similr to recent studies (Koff nd Deridder 1977, Guzmn et l. 1983, Borrelli et l. 1985). Neurosurgicl intervention ws rre in most studies except for one where eight of 14 ptients underwent procedure either for prophylctic resons or fter deteriortion in neurologicl signs, little chnge occurred in urologicl function fter intervention (Gotoh et l. 1991). The number of children who becme continent s result of intervention rnged from under hlf (Koff nd Deridder 1977) to nerly ll (Borrelli et l. 1985). The reminder ttined figures closer to our study (Guzmn et l. 1983, Gotoh et l. 1991, Sito et l. 1991). Dt from VUD ided pproprite use of nticholinergic drugs, progressing to CIC where necessry. In ddition, bldder surgery ws performed to protect compromised renl function nd promote continence (Guzmn et l. 1983, Borrelli et l. 1985, Borzyskowski nd Mundy 1988, Gotoh et l. 1991, Sito et l. 1991). Mny of our subjects presented with long-stnding symptoms nd clinicl signs highly suggestive of neuropthic bldder ssocited with scrl genesis. Lte dignosis my result in dely in control of symptoms nd renl impirment. To mke the dignosis lterl s well s ntero-posterior X-ry of the lumboscrl spine is essentil, proceeding to MRI of the spine if there is high level of suspicion. It is importnt to exclude neurosurgicl trget such s tethering nd thus ll subjects should hve imging of the spine nd neurosurgicl opinion sought if pproprite. However, neurosurgicl intervention rrely improves bldder function, lthough it is thought tht it my prevent further progression or evolution of lower-limb neurology (Sito et l. 1991). Figure 4 demonstrtes how esy it would be to miss cse, prticulr close exmintion is necessry in order not to miss the defect on X- ry. Lte dignosis is persistent problem highlighted by this study. Children hd in some cses lredy hd cosmetic surgery for overlying skin defects without the possibility of scrl genesis or closed spin bifid being considered. Others hve hd extensive orthopedic procedures but no investigtions for incontinence (Tble IV). An verge of 5 yers hs been quoted between onset of urologicl symptoms nd dignosis of neuropthic bldder (Brren nd Jones 1979, Borrelli et l. 1985). Renl dmge my be irreversible by the time of presenttion. We noted two pek ges t presenttion with hlf our subjects being dignosed before they were 1 yer of ge. The other pek occurred between 4 nd 5 yers of ge, which ws relted to strting school nd continence becoming n issue. Peditricins need to be wre of the dignosis of scrl genesis nd its ssocition with risk fctors. This requires high level of suspicion in ny incontinent child prticulrly if ny of the risk fctors re present. Associted fetures include mternl dibetes, n infnt with known orthopedic problems (especilly dislocted hips nd equinovrus deformities), skin defects, nd norectl nomlies (Guzmn et l. 1983). Severe constiption is lso significnt erly finding. These were similrly echoed in our study. Urologicl fetures re persistent dy nd night wetting, frequency, poor urinry strem, nd recurrent urinry trct infections. Although bnorml neurology is sid to be rre (Koff nd Deridder 1977), most of our ptients hd some bnormlities of the lower limbs, lbeit minor. The neurologicl fetures were subtle in most but demonstrble with thorough exmintion. We did not detect ny difference in incidence of presenting ge in the different types of scrl genesis. No correltion ws found between symptoms, neurologicl deficit, nd bldder dysfunction. This is in keeping with the findings in children with closed spin bifid who lso hve only minor neurologicl deficits but very bnorml, dngerous bldders with high risk of renl dmge (Johnson nd Borzyskowski 1998). Thus ll children require videourodynmics to identify risk fctors to the kidney (DSD, VUR, reduced complince, poor emptying nd high pressure) nd ssessment of renl function. All of our ptients hd bnormlities on their VUD studies indictive of significnt bldder nd urethrl dysfunction with most hving smll, hyper-reflexic bldders with DSD nd high incidence of reflux. Renl impirment, ssocited with reduced glomerulr filtrtion rte nd Presenttion nd Outcome of Scrl Agenesis Jo M Wilmshurst et l. 811
7 rised cretinine t the time of referrl, occurred in three (ll detected below 4 yers). However, seven children (32%) hd evidence of renl scrring on DMSA exmintion. Mngement is imed t protecting the kidneys nd improving continence, this usully requires nticholinergic drugs nd CIC. If the bove mesures fil then urologicl surgery my be required (Borzyskowski nd Mundy 1988). Mny of the children were constipted from n erly ge. Most improved with stndrd medicl therpy but few required surgicl intervention (three hd ACE procedures nd two hd surgery for norectl mlformtions). Three children underwent rectl biopsies for Hirschsprung disese (ll negtive) before the dignosis of scrl genesis. Erlier confirmtion in these children would hve spred them unnecessry surgicl intervention. There ws high incidence of psychologicl or behviourl problems. Children suffered from number of complints including temper tntrums, school refusl, soiling, nd refusing to ctheterize. The persisting bldder nd bowel problems understndbly led to gret strin within the fmily, often resulting in not just individul but fmily therpy. Further, the need to tech prents how to ctheterize their child until they re old enough to self-ctheterize or the child to self-ctheterize my cuse strin nd conflict. Input from specilist liison nurse is essentil to void these problems nd to id in the detection of the need for forml psychologicl support. Gotoh T, Shinno Y, Kobyshi S, Wtri Y, Koynyi T. (1991) Dignosis nd mngement of scrl genesis. Europen Urology 20: Guzmn L, Buer SB, Hllett M, Khoshbin S, Colodny AH, Retik AB. (1983) Evlution nd mngement of children with scrl genesis. Urology XXII : Johnson L, Borzyskowski M. (1998) Bldder dysfunction nd neurologicl disbility t presenttion in closed spin bifid. Archives of Disese in Childhood 79: Koff SA, Deridder PA. (1977) Ptterns of neurogenic bldder dysfunction in scrl genesis. Journl of Urology 118: Renshw TS. (1978) Scrl genesis. Journl of Bone nd Joint Surgery A60: Rickwood AMK. (1990) Investigtions. In: Borzyskowski M, Mundy AR, editors. Neuropthic Bldder in Childhood. Clinics in Developmentl Medicine No London: Mc Keith Press. p Sito M, Kondo A, Kto K. (1991) Dignosis nd tretment of neurogenic bldder due to prtil scrl genesis. British Journl of Urology 67: Conclusion It is importnt for peditricins to hve high level of suspicion of scrl genesis in ny child presenting with persistent wetting nd constiption, prticulrly if there is history of mternl dibetes, spinl or skin defects, or lower-limb bnormlities. There should be low threshold to perform spinl X-rys nd MRI, to confirm the dignosis nd exclude neurosurgicl trget. All should hve VUD t the time of dignosis s the vesicourethrl dysfunction cnnot be predicted from the neurologicl bnormlities nd it is importnt to identify those children whose kidneys re t risk. It my be prticulrly difficult to mnge the vesicourethrl dysfunction in this group of children. Erly dignosis enbles erly intervention to void renl dmge, improve continence (bldder nd bowel), nd thus improve the qulity of life for the child nd fmily. It should be emphsized tht this requires multidisciplinry pproch nd life-long follow-up. Accepted for publiction 31st My References Andersen JT. (1988) Urodynmics terminology nd norml vlues in children, femles nd mles. Scndinvin Journl of Urology nd Nephrology 114: (Suppl.) Boemers TML, Beek FJA, vn Gool JD, de Jong TPVM, Bx KMA. (1996) Urologicl problems in norectl mlformtions. Prt 1: urodynmic findings nd significnce of scrl nomlies. Journl of Peditric Surgery 31: Borrelli M, Bruschini H, Nhs WC, Figueiredo JA, Prdo MJ, Spinol R, Wlligor M, Freire GC, Menezes de Goes G. (1985) Scrl genesis: why is it so frequently misdignosed? Urology XXVI: Borzyskowski M, Mundy AR. (1988) The mngement of the neuropthic bldder in childhood. Peditric Nephrology 2: Brren V, Jones WB. (1979) Scrl genesis: dignosis, tretment nd follow-up of urologicl complictions. Journl of Urology 121: Developmentl Medicine & Child Neurology 1999, 41:
Neurogenic lower urinary tract dysfunction: the role of urodynamics
Neurogenic lower urinry trct dysfunction: the role of urodynmics The min im in mnging neurogenic lower urinry trct dysfunction is preservtion of the upper trcts y ensuring optiml ldder function. Krlheinz
More informationXII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV
XII. HIV/AIDS Knowledge bout HIV Trnsmission nd Misconceptions bout HIV One of the most importnt prerequisites for reducing the rte of HIV infection is ccurte knowledge of how HIV is trnsmitted nd strtegies
More informationBright Futures Medical Screening Reference Table 2 to 5 Day (First Week) Visit
Bright Futures Medicl Reference Tle 2 to 5 Dy (First Week) Visit Universl Action Metolic nd Verify documenttion of neworn metolic screening results, pproprite rescreening, nd needed follow-up. Document
More informationLATE RESULTS OF TRANSFER OF THE TIBIAL TUBERCLE FOR RECURRENT DISLOCATION OF THE PATELLA1
LATE RESULTS OF TRANSFER OF THE TIBIAL TUBERCLE FOR RECURRENT DISLOCATION OF THE PATELLA1 W. G. J. HAMPSON nd P. HILL, BRISTOL, ENGLAND The uthors wished to determine the lte results of the Huser opertion,
More informationSEIZURES AND EPILEPSY
SEIZURES AND EPILEPSY CONTENT CREATED BY Lern more t www.helth.hrvrd.edu TALK WITH YOUR DOCTOR Tble of Contents WHAT IS A SEIZURE? 4 WHAT IS EPILEPSY? 6 TESTING 7 TREATMENT OPTIONS 9 ANTI-SEIZURE MEDICATION
More informationCord Injuries. on admission, and intermittent catheterization. (IC) was carried out until spontaneous voiding occurred.
JOURNAL OF CLINICAL MICROBIOLOGY, Nov. 1982, P. 856-860 0095-1137/82/110856-05$02.00/0 Copyright 1982, Americn Society for Microbiology Vol. 16, No. 5 Pseudomons eruginos Coloniztion in Ptients with Spinl
More informationClinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number
EudrCT Number 2012-001531-31 A Phse I, Rndomised, Open-lbel, 3-wy Cross-over Study in Helthy Volunteers to Demonstrte the Bioequivlence of the Nloxegol 25 mg Commercil nd Phse III Formultions nd to Assess
More informationAnus,Rectum and Colon
JOURNAL OF THE Anus,Rectum nd Colon http://journl-rc.jp CASE REPORT Anl Cnl Dupliction Associted with Prescrl Cyst in n Adult Tkyuki Toyong 1), Hiromitsu Mtsud 1), Ryuichi Miu 1), Yohei Toming 1), Keiji
More informationThe diagnosis of autism and Asperger syndrome: findings from a survey of 770 families
The dignosis of utism nd Asperger syndrome: findings from survey of 770 fmilies Ptrici Howlin*, Deprtment of Psychology, St George s Hospitl Medicl School, London; Ann Asghrin, Deprtment of Psychology,
More informationURINARY incontinence is an important and common
Urinry incontinence in older people in the community: neglected problem? Helen Stoddrt, Jenny Donovn, Elise Whitley, Deborh Shrp nd In Hrvey SUMMARY Bckground: The prevlence nd impct of urinry incontinence
More informationComparison of three simple methods for the
J. clin. Pth. (1967), 2, 5 Comprison of three simple methods for the ssessment of 'free' thyroid hormone T. M. D. GIMLETTE1 From the Rdio-Isotope Lbortory, St. Thoms's Hospitl, London SYNOPSIS A dilysis
More informationAnalysis of Risk Factors for the Development of Incisional and Parastomal Hernias in Patients after Colorectal Surgery
Originl Article Journl of the Koren Society of J Koren Soc Coloproctol 2012;28(6):299-303 http://dx.doi.org/10.3393/jksc.2012.28.6.299 pissn 2093-7822 eissn 2093-7830 Anlysis of Risk Fctors for the Development
More informationPNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 :
PNEUMOVAX 23 is recommended y the CDC for ll your pproprite dult ptients t incresed risk for pneumococcl disese 1,2 : Adults ged
More informationInput from external experts and manufacturer on the 2 nd draft project plan Stool DNA testing for early detection of colorectal cancer
Input externl experts nd mnufcturer on the 2 nd drft project pln Stool DNA testing for erly detection of colorectl cncer (Project ID:OTJA10) All s nd uthor s replies on the 2nd drft project pln Stool DNA
More informationGlobal Intellectual Deficits in Cystinosis
Americn Journl of Medicl Genetics 49:83-87 (1994) Globl Intellectul Deficits in Cystinosis Brbr L.H. Willims, Jerry A. Schneider, nd Doris A. Truner Deprtments of Neurosciences (B.L.H.W.. D.A.T.) nd Peditrics
More informationCommunity. Profile Big Horn County. Public Health and Safety Division
Community Helth Profile 2015 Big Horn County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl
More informationBENIGN ulceration along the greater curvature of the pars media of the
BENIGN ULCERS OF THE GREATER CURVATURE OF THE STOMACH Report of Two Cses CHARLES H. BROWN, M.D. Deprtment of Gstroenterology nd ANTHONY D. INTRIERE, M.D.* BENIGN ulcertion long the greter curvture of the
More informationThe potential future of targeted radionuclide therapy: implications for occupational exposure? P. Covens
The potentil future of trgeted rdionuclide therpy: implictions for occuptionl exposure? Introduction: Trgeted Rdionuclide Therpy (TRT) Systemic tretment Molecule lbelled with rdionuclide delivers toxic
More informationCommunity. Profile Powell County. Public Health and Safety Division
Community Helth Profile 2015 Powell County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk
More informationImpact of Pharmacist Intervention on Diabetes Patients in an Ambulatory Setting
Impct of Phrmcist Intervention on Dibetes Ptients in n Ambultory Setting Julie Stding, PhrmD, CDE, Jmie Herrmnn, PhrmD, Ryn Wlters, MS, Chris Destche, PhrmD, nd Aln Chock, PhrmD Dibetes is the seventh-leding
More informationCommunity. Profile Yellowstone County. Public Health and Safety Division
Community Helth Profile 2015 Yellowstone County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl
More informationCommunity. Profile Anaconda- Deer Lodge County. Public Health and Safety Division
Community Helth Profile 2015 Ancond- Deer Lodge County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12
More informationCommunity. Profile Lewis & Clark County. Public Health and Safety Division
Community Helth Profile 2015 Lewis & Clrk County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl
More informationCommunity. Profile Missoula County. Public Health and Safety Division
Community Helth Profile 2015 Missoul County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk
More informationof comorbid conditions, interventions Diagnosis and treatment, treatment reduction of risk factors for CVD to slow disease progression,
Tble 5.1. NKF Clssifiction of Chronic Kidney Disese nd Clinicl Fetures Stge Description GFR (ml/ min/1.73 m 2 ) U.S. Prevlence, b # Affected (%) Clinicl Fetures Action Pln c At incresed risk for CKD >60
More informationSummary of Package Insert 1
Summry of Pckge Insert 1 For Sttes with Non-Published Policies Indictions Non-infected prtil nd full-thickness skin ulcers due to VSU 2 of greter thn 1 month durtion nd which hve not dequtely responded
More informationMultiple sclerosis (MS) affects approximately. Triaging Patients with Multiple Sclerosis in the Emergency Department. Room for Improvement
Systemtic Review of Tools for Anxiety in MS MS CARE DELIVERY: CHALLENGES AND INVATIONS Triging Ptients with Multiple Sclerosis in the Emergency Deprtment Room for Improvement Heshm Abboud, MD, PhD; Krin
More informationIdentical twins with borderline lepromatous leprosy mimicking extensive alopecia areata: A rare presentation
Lepr Rev (2018) 89, 301 305 CASE REPORT Identicl twins with orderline lepromtous leprosy mimicking extensive lopeci ret: A rre presenttion RUBINA JASSI*, KRISHNA DEB BURMAN**, BHAVYA SWARNKAR** & RADHIKA
More informationI SOLATED observations regarding the occurrence of paresis of dorsiflexion
MUSCLE WEAKNESS AND WASTING IN SCIATICA DUE TO FOURTH LUMBAR OR LUMBO- SACRAL DISC HERNIATIONS* ERIC KUGELBERG, M.D., AND INGEMAR PETERSI~N Deprtment of Clinicl Neurophysiology, Serfimerlsreet, Stockholm,
More informationEfficacy of Pembrolizumab in Patients With Advanced Melanoma With Stable Brain Metastases at Baseline: A Pooled Retrospective Analysis
Efficcy of Pembrolizumb in Ptients With Advnced Melnom With Stble Brin Metstses t Bseline: A Pooled Retrospective Anlysis Abstrct 1248PD Hmid O, Ribs A, Dud A, Butler MO, Crlino MS, Hwu WJ, Long GV, Ancell
More informationOriginal Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract:
Fridpur Med. Coll. J. 214;9(2):61-67 Originl Article Nebuliztion by Isotonic Mgnesium Sulphte Solution with Provide Erly nd Better Response s Compred to Conventionl Approch ( Plus Norml Sline) in Acute
More informationCommunity. Profile Carter County. Public Health and Safety Division
Community Helth Profile 2015 Crter County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk
More informationBody mass index, waist-to-hip ratio, and metabolic syndrome as predictors of middle-aged men's health
Originl Article - Sexul Dysfunction/Infertility pissn 2005-6737 eissn 2005-6745 Body mss index, wist-to-hip rtio, nd metbolic syndrome s predictors of middle-ged men's helth Jung Hyun Prk *, In-Chng Cho
More informationSupplementary Online Content
Supplementry Online Content Zulmn DM, Pl Chee C, Ezeji-Okoye SC, et l. Effect of n intensive outptient progrm to ugment primry cre for high-need Veterns Affirs ptients: rndomized clinicl tril. JAMA Intern
More informationPAQUITO RAMIREZ RAMIREZ
PAQUITO RAMIREZ PET OWNER: RAMIREZ SPECIES: Cnine BREED: Chihuhu GENDER: Mle AGE: 12 Yers PATIENT ID: 103557 A Byshore Veterinry Clinic 2043 NE 140th. Street 305-940-2287 ACCOUNT #: 13855 ATTENDING VET:
More informationTHE natural course of sciatica 22,17,23 is favourable in most
Predicting the outcome of scitic t short-term follow-up Ptrick C A J Vroomen, M C T F M de Krom nd J A Knottnerus Originl ppers SUMMARY Bckground: The prognostic vlue of the clinicl findings elicited in
More informationLeft ventricular dysfunction in the fetus: relation to aortic valve anomalies and endocardial
Br Hert J 199 1;66:419-24 Deprtment of Perintl rdiology, Guy's Hospitl, London G K Shrlnd S K hit L D lln Deprtment of Pthology, Guy's Hospitl, London N L K Fgg ook Deprtment of Peditric rdiology, Guy's
More informationCheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer
CheckMte 53: Rndomized Results of Continuous vs -Yer Fixed-Durtion Nivolumb in Ptients With Advnced Non-Smll Cell Lung Cncer Abstrct 297O Spigel DR, McCleod M, Hussein MA, Wterhouse DM, Einhorn L, Horn
More informationUsing Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids
Using Pcloutrzol to Suppress Inflorescence Height of Potted Phlenopsis Orchids A REPORT SUBMITTED TO FINE AMERICAS Linsey Newton nd Erik Runkle Deprtment of Horticulture Spring 28 Using Pcloutrzol to Suppress
More informationSafety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA
Sfety nd Tolerbility of Subcutneous Srilumb nd Intrvenous Tocilizumb in Ptients With RA Pul Emery, 1 Jun Rondon, 2 Anju Grg, 3 Hubert vn Hoogstrten, 3 Neil M.H. Grhm, 4 Ming Liu, 4 Nncy Liu, 3 Jnie Prrino,
More informationFactors influencing help seeking in mentally distressed young adults: a cross-sectional survey
L Biddle, D Gunnell, D Shrp nd J L Donovn Fctors influencing help seeking in mentlly distressed young dults: cross-sectionl survey Lucy Biddle, Dvid Gunnell, Debbie Shrp nd Jenny L Donovn SUMMARY Bckground:
More informationAssessment of Depression in Multiple Sclerosis. Validity of Including Somatic Items on the Beck Depression Inventory II
Assessment of Depression in Multiple Sclerosis Vlidity of Including Somtic Items on the Beck Depression Inventory II Peggy Crwford, PhD; Noh J. Webster, MA Signs nd symptoms of multiple sclerosis (MS)
More informationT.S. Kurki a, *,U.Häkkinen b, J. Lauharanta c,j.rämö d, M. Leijala c
Europen Journl of Crdio-thorcic Surgery 20 (2001) 1183 1187 www.elsevier.com/locte/ejcts Evlution of the reltionship between preopertive risk scores, postopertive nd totl length of stys nd hospitl costs
More informationUrinary Tract Infection in Men
C H A P T E R 1 9 Urinry Trct Infection in Men Toms L. Griebling, MD Associte Professor & Vice Chir of Urology University of Knss Knss City, Knss Contents INTRODUCTION........................................623
More informationPaper-based skin patch for the diagnostic screening of cystic fibrosis
Electronic Supplementry Mteril (ESI) for ChemComm. This journl is The Royl Society of Chemistry 2015 Supplementry informtion Pper-bsed skin ptch for the dignostic screening of cystic fibrosis Xun Mu,*
More informationInvasive Pneumococcal Disease Quarterly Report. July September 2017
Invsive Pneumococcl Disese Qurterly Report July September 2017 Prepred s prt of Ministry of Helth contrct for scientific services by Rebekh Roos Helen Heffernn October 2017 Acknowledgements This report
More informationClinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population
Originl Article Clinicl sttistics nlysis on the chrcteristics of pneumoconiosis of Chinese miner popultion Mei-Fng Wng 1 *, Run-Ze Li 2 *, Ying Li 2, Xue-Qin Cheng 1, Jun Yng 1, Wen Chen 3, Xing-Xing Fn
More informationUltrasound-guided antegrade access during laparoscopic pyeloplasty in infants less than one year of age: A point of technique
How I Do It Differently Ultrsound-guided ntegrde ccess during lproscopic pyeloplsty in infnts less thn one yer of ge: A point of technique Arvind Gnpule, Amit Bhttu, Shshiknt Mishr, Mhesh R Desi Deprtment
More informationColonoscopic decompression of childhood sigmoid and cecal volvulus
CASE REPORT Colonoscopic decompression of childhood sigmoid nd cecl volvulus Irj Shhrmin 1, Ali Bzi 1,2, Dnil Edti 3, Krim Rostmi 3, Mojt Delrmns 1,2 1 Peditric Digestive nd Heptic Reserch Center, Zol
More informationPerforation Following Colorectal Endoscopy: What Happens Beyond the Endoscopy Suite?
credits vilble for this rticle see pge 88. Originl RESEARCH & CONTRIBUTIONS Perfortion Following Colorectl Endoscopy: Wht Hppens Beyond the Endoscopy Suite? Michel S Tm, MD; Mher A Abbs, MD, FACS, FASCRS
More informationHealth-Related Quality of Life and Symptoms of Depression in Extremely Obese Persons Seeking Bariatric Surgery
Oesity Surgery, 15, 3-39 Helth-Relted Qulity of Life nd Symptoms of Depression in Extremely Oese Persons Seeking Britric Surgery Anthony N. Frictore, PhD; Thoms A. Wdden, PhD; Dvid B. Srwer, PhD; Myles
More informationORIGINAL ARTICLE. Diagnostic Signs of Accommodative Insufficiency. PILAR CACHO, OD, ÁNGEL GARCÍA, OD, FRANCISCO LARA, OD, and M A MAR SEGUÍ, OD
1040-5488/02/7909-0614/0 VOL. 79, NO. 9, PP. 614 620 OPTOMETRY AND VISION SCIENCE Copyright 2002 Americn Acdemy of Optometry ORIGINAL ARTICLE Dignostic Signs of Accommodtive Insufficiency PILAR CACHO,
More informationC reactive protein: an aid to assessment and
C rective protein: n id to ssessment nd monitoring of cute pncretitis J Clin Pthol 1984;37:27-211 AD MAYR,* MJ McMAHON,* MARGART BOWN,t H COOPRt From the *University Deprtment ofsurgery, Generl Infrmry,
More informationMetabolic Syndrome and Health-related Quality of Life in Obese Individuals Seeking Weight Reduction
Metbolic Syndrome nd Helth-relted Qulity of Life in Obese Individuls Seeking Weight Reduction Adm Gilden Tsi 1, Thoms A. Wdden 1, Dvid B. Srwer 1, Robert I. Berkowitz 1, Leslie G. Womble 1, Louise A. Hesson
More informationReducing the Risk. Logic Model
Reducing the Risk Logic Model ETR (Eduction, Trining nd Reserch) is nonprofit orgniztion committed to providing science-bsed innovtive solutions in helth nd eduction designed to chieve trnsformtive chnge
More informationFeeding state and age dependent changes in melaninconcentrating hormone expression in the hypothalamus of broiler chickens
Supplementry Mterils Epub: No 2017_23 Vol. 65, 2018 https://doi.org/10.183/bp.2017_23 Regulr pper Feeding stte nd ge dependent chnges in melninconcentrting hormone expression in the hypothlmus of broiler
More informationRecall Bias in Childhood Atopic Diseases Among Adults in The Odense Adolescence Cohort Study
Syddnsk Universitet Recll Bis in Childhood Atopic Diseses Among Adults in The Odense Adolescence Cohort Study Mørtz, Chrlotte G; Andersen, Klus Ejner; Bindslev-Jensen, Crsten Published in: Act Dermto-Venereologic
More informationSurgical Neurology International
Surgicl Neurology Interntionl SNI: Peditric Neurosurgery, supplement to Surgicl Neurology Interntionl OPEN ACCESS For entire Editoril Bord visit : http://www.surgiclneurologyint.com Spinl dorsl derml sinus
More informationSYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT
Finl Arevited Clinicl Study Report Nme of Sponsor/Compny: Bristol-Myers Squi Ipilimum Individul Study Tle Referring to the Dossier (For Ntionl Authority Use Only) Nme of Finished Product: Yervoy Nme of
More informationBlood pressure and diurnal variation in sodium, potassium, and water excretion
Journl of Humn Hypertension (1998) 12, 363 371 1998 Stockton Press. All rights reserved 0950-9240/98 $12.00 http://www.stockton-press.co.uk/jhh ORIGINAL ARTICLE Blood pressure nd diurnl vrition in sodium,
More informationThe Effects of Small Sized Rice Bowl on Carbohydrate Intake and Dietary Patterns in Women with Type 2 Diabetes
Originl Article doi: 10.4093/kdj.2010.34.3.166 pissn 1976-9180 eissn 2093-2650 The Effects of Smll Sized Rice Bowl on Crbohydrte Intke nd Dietry Ptterns in Women with Type 2 Dibetes Hee-Jung Ahn 1, *,
More informationInfluence of lateral cephalometric radiography in orthodontic diagnosis and treatment planning
Originl Article Influence of lterl cephlometric rdiogrphy in orthodontic dignosis nd tretment plnning An Reis Durão ; Ali Alqerbn b ; Afonso Pinhão Ferreir c ; Reinhilde Jcobs d ABSTRACT Objective: To
More informationWSU Tree Fruit Research and Extension Center, Wenatchee (509) ext. 265;
FINAL REPORT WTFRC Project # AH-1-5 WSU Project # 13C-355-3 Project title: PI: Orgniztion: Coopertors: of Sunburn in Apples with RAYNOX Lrry Schrder, Horticulturist WSU Tree Fruit Reserch nd Extension
More informationCows' milk sensitive enteropathy in cystic fibrosis
Archives of Disese in Childhood, 1989, 64, 1251-1255 Cows' milk sensitive enteropthy in cystic fibrosis S M HILL, A D PHILLIPS, M MEARNS, AND J A WALKER-SMITH Acdemic Deprtment of Child Helth, Queen Elizbeth
More informationCME/SAM. Study on Hyperuricemia in HBV-Associated Glomerulonephritis
AJCP / Originl Article Study on Hyperuricemi in HBV-Associted Glomerulonephritis Yongze Zhung, MD, PhD, 1 Yingho Yu, MD, PhD, 2 Yingfng Hung, MD, 3 nd Xiorong Zhong, MD 1 From the 1 Deprtment of Nephrology,
More informationEpidemiological survey and analysis of asthma in children aged 0-14 years old in urban and rural areas of Chengdu region
Originl Article Epidemiologicl survey nd nlysis of sthm in children ged 0-14 yers old in urbn nd rurl res of Chengdu region Min Li 1, Qiong Zhng 2, Wei-Jun Shi 2, Ln Li 1, Yn Li 2, Ying Png 1, Bin Yo 1,
More informationFibromuscular dysplasia (FMD) is an uncommon
Top 8 Lessons Lerned From the US Registry for FMD Understnding the impct of registry dt on clinicl prctice. By Srh O Connor; Jeffrey W. Olin, DO; nd Hether L. Gornik, MD Fibromusculr dysplsi (FMD) is n
More informationRelationship between serum irisin, glycemic indices, and renal function in type 2 diabetic patients
J Renl Inj Prev. 2017; 6(2): 88-92. http://journlrip.com Journl of Renl Injury Prevention DOI: 10.15171/jrip.2017.17 Reltionship between serum irisin, glycemic indices, nd renl function in type 2 dibetic
More informationA series of recent studies and meta-analyses confirm
Originl Reserch Clinicl Medicine & Reserch Volume 11, Number 4: 210-218 2013 Mrshfield Clinic clinmedres.org Brest nd Prostte Cncer Survivors in Dibetic Cohort: Results from the Living With Dibetes Study
More informationEffect on Glycemic, Blood Pressure, and Lipid Control according to Education Types
Originl Article http://dx.doi.org/10.4093/dmj.2011.35.6.580 pissn 2233-6079 eissn 2233-6087 D I A B E T E S & M E T A B O L I S M J O U R N A L Effect on Glycemic, Blood Pressure, nd Lipid Control ccording
More informationPreliminary Findings of a Randomized Controlled Trial of an Interdisciplinary Military Pain Program
MILITARY MEDICINE, 174, 3:270, 2009 Preliminry Findings of Rndomized Controlled Tril of n Interdisciplinry Militry Pin Progrm Robert J. Gtchel, PhD * ; Donld D. McGery, PhD ; Aln Peterson, PhD ; Mysti
More informationSeasonal influenza vaccination programme country profile: Ireland
Sesonl influenz vccintion progrmme country profile: Irelnd 2012 13 Seson Bckground informtion Influenz immunistion policy nd generl fcts bout Irelnd Volume indices of GDP per cpit in 2011 nd 2013 (EU-
More informationEfficacy of biofeedback training in improving faecal
Gut, 199, 31, 1395-142 Deprtment of Peditrics, niversity of Iow, Iow City, Iow, SA V Loening-Bucke Correspondence to: Dr V Loening-Bucke, Deprtment of Peditrics, niversity of Iow Hospitls nd Clinics, Iow
More informationA survey of atrial fibrillation in general practice: the West Birmingham Atrial Fibrillation Project
Originl ppers A survey of tril fibrilltion in generl prctice: the West Birminghm Atril Fibrilltion Project GREGORY Y H LIP DANIEL J GOLDING MASOOD NAZIR D GARETH BEEVERS DAVID L CHILD R IAN FLETCHER SUMMARY
More informationpatients with Wilms' tumour after nephrectomy
1462 Archives ofdisese in Childhood 1992; 67: 1462-1466 Birminghm Children's Hospitl, Birminghm C Mpofu J R Mnn rrespondence to: Dr C Mpofu, Twm Hospitl, PO Box 15258, Al Ain, Abu Dhbi, United Arb Emirtes.
More informationComputer-Aided Learning in Insulin Pump Training
Journl of Dibetes Science nd Technology Volume 4, Issue 4, July 2010 Dibetes Technology Society TECHNOLOGY REPORTS Computer-Aided Lerning in Insulin Pump Trining Sergey V., M.Sc., 1 nd Chrles J. George,
More informationAbstract. Background. Aim. Patients and Methods. Patients. Study Design
Impct of the Use of Drugs nd Substitution Tretments on the Antivirl Tretment of Chronic Heptitis C: Anlysis of Complince, Virologicl Response nd Qulity of Life (CHEOBS). Melin, 1 J.-. Lng, D. Ouzn, 3 M.
More informationOptimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality
Optimistion of diets for Atlntic cod (Gdus morhu) roodstock: effect of rchidonic cid on egg & lrvl qulity Dr Gordon Bell, Ms. An Blnco, Dr Bill Roy, Dr Derek Roertson, Dr Jim Henderson nd Mr Richrd Prickett,
More informationcapacity in infants and children
Archives of Disese in Childhood, 1974, 49, 654. DDAVP test for estimtion of renl concentrting cpcity in infnts nd children A. S. ARONSON nd N. W. SVENNINGSEN From the Deprtment of Peditrics, University
More informationHepatitis A virus (HAV) infection contributes approximately
Multiple Fctors Contribute to Positive Results for Heptitis A Virus Immunoglobulin M Antibody Adnn Altoom, MD, PhD; M. Qsim Ansri, MD; Jennifer Cuthbert, MD Context. In the United Sttes, successful vccintion
More informationArthroscopic Anatomy of Shoulder
Arthroscopic Antomy of Shoulder Murt Bozkurt, Mehmet Emin Simsek, nd Hlil İrhim Açr 2 2.1 Introduction In the lst 30 yers, shoulder rthroscopy hs ecome of greter importnce in the dignosis nd tretment of
More informationResults of the Tokyo Consensus Meeting Tokyo Guidelines
J Heptobiliry Pncret Surg (2007) 14:114 121 DOI 10.1007/s00534-006-1163-8 Results of the Tokyo Consensus Meeting Tokyo Guidelines Toshihiko Myumi 1, Tdhiro Tkd 2, Yoshifumi Kwrd 3, Yuji Nimur 4, Mshiro
More informationPredictors of Hospitalization in Male Marine Corps Recruits with Exertional Heat Illness
MILITARY MEDICINE, 169, 3:169, 2004 Predictors of Hospitliztion in Mle Mrine Corps Recruits with Exertionl Het Illness Gurntor: COL John W. Grdner, MC FS USA Contributors: Shilp Hkre, DrPH; COL John W.
More informationEffects of physical exercise on working memory and prefrontal cortex function in post-stroke patients
Effects of physicl exercise on working memory nd prefrontl cortex function in post-stroke ptients M Moriy, C Aoki, K Sktni Grdute School of Helth Sciences Reserch, Mjor of Physicl Therpy, TeikyoHeisei
More informationCardiovascular Disease in a Forward Military Hospital during Operation Iraqi Freedom: A Report from Deployed Cardiologists
MILITARY MEDICINE, 173, 2:193, 2008 Crdiovsculr Disese in Forwrd Militry Hospitl during Opertion Irqi Freedom: A Report from Deployed Crdiologists MAJ Lnce Sullenberger, MC USA*; MAJ Philip J. Gentlesk,
More informationGlucose is the most commonly used osmotic agent in
Peritonel Dilysis Interntionl, Vol. 32, pp. 545 551 doi: 10.3747/pdi.2011.00048 0896-8608/12 $3.00 +.00 Copyright 2012 Interntionl Society for Peritonel Dilysis ULTRAFILTRATION AND DIALYSIS ADEQUACY WITH
More informationFat intake in patients newly diagnosed with type 2 diabetes: a 4-year follow-up study in general practice
Originl ppers Ft intke in ptients newly dignosed with type 2 dibetes: 4-yer follow-up study in generl prctice Floris A vn de Lr, Eloy H vn de Lisdonk, Peter L B J Lucssen, J M H Tigchelr, Sski Meyboom,
More informationImpact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors
Originl Article Impct of Positive Nodl Metstses in Ptients with Thymic Crcinom nd Thymic Neuroendocrine Tumors Benny Weksler, MD, Anthony Holden, MD, nd Jennifer L. Sullivn, MD Introduction: Thymic crcinoms
More informationSurgical Neurology International
Surgicl Neurology Interntionl SNI: Peditric Neurosurgery, supplement to Surgicl Neurology Interntionl OPEN ACCESS For entire Editoril Bord visit : http://www.surgiclneurologyint.com How I Do It: Mngement
More informationEndourology. Youn Chul You, Tae Hyo Kim, Gyung Tak Sung. INTRODUCTION
www.kjurology.org http://dx.doi.org/10.4111/kju.01.53.1.9 Endourology Effect of Bldder Neck Preservtion nd Posterior Urethrl Reconstruction during Robot-Assisted Lproscopic Rdicl Prosttectomy for Urinry
More informationExercise-induced bronchoconstriction, skin sensitivity,
rchives of Disese in Childhood, 1976, 51, 912. Exercise-induced bronchoconstriction, skin sensitivity, nd serum IgE in children with eczem J. F. PRICE, J. J. COGSWELL, M. C. JOSEPH, nd G. M. COCHRNE From
More informationStart ORKAMBI today. INDICATIONS AND USAGE IMPORTANT SAFETY INFORMATION. Sydney Age 4
F O R H E A L T H C A R E P R O F E S S I O N A L S For ptients ge 2 yers nd older who re homozygous for the F508del muttion 1,2 Modify the course. Strt tody. Sydney Age 4 F508del/F508del INDICATIONS AND
More informationOpioid Use and Survival at the End of Life: A Survey of a Hospice Population
532 Journl of Pin nd Symptom Mngement Vol. 32 No. 6 December 2006 NHPCO Originl Article Opioid Use nd Survivl t the End of Life: A Survey of Hospice Popultion Russell K. Portenoy, MD, Un Sibircev, BA,
More informationSummary. Effect evaluation of the Rehabilitation of Drug-Addicted Offenders Act (SOV)
Summry Effect evlution of the Rehbilittion of Drug-Addicted Offenders Act (SOV) The Rehbilittion of Drug-Addicted Offenders Act (SOV) ws lunched on April first 2001. This lw permitted the compulsory plcement
More informationEmerging Options for Thromboprophylaxis After Orthopedic Surgery: A Review of Clinical Data
Emerging Options for Thromboprophylxis After Orthopedic Surgery: A Review of Clinicl Dt Bob L. Lobo, Phrm.D. In four rndomized, controlled studies of ptients undergoing orthopedic surgery, the ntithrombotic
More informationBehavioral profiles of children with infantile nephropathic cystinosis
Behviorl profiles of children with infntile nephropthic cystinosis Gustvo Delgdo MD, Southern Cliforni Permnente Medicl Group; Amy Schtz PhD; Shron Nichols PhD, Deprtment of Neurosciences, School of Medicine;
More informationA cross-sectional and follow-up study of leukopenia in tuberculosis patients: prevalence, risk factors and impact of anti-tuberculosis
Originl Article A cross-sectionl nd follow-up study of leukopeni in tuberculosis ptients: prevlence, risk fctors nd impct of nti-tuberculosis tretment Fei-Shen Lin 1 *, Mei-Ying Wu 2 *, Wen-Jun Tu 3, Hong-Qiu
More informationJournal of Hainan Medical University 2017; 23(2): Journal of Hainan Medical University.
Journl of Hinn Medicl University 2017; 23(2): 151-155 151 Journl of Hinn Medicl University http://www.hnykdxxb.com Reltionship between DEXA bone minerl density mesurement results nd serum cytokines s well
More information