AFSHARI, Arash AHLSWEDE, Beth Anne AHLSWEDE, Karl M AMES, Bruce N ANDERSON, Lucy M ANDERSON, D...

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1 AUTHOR INDEX AFSHARI, Arash AHLSWEDE, Beth Anne AHLSWEDE, Karl M ALLEN, James W..., 379, 59 AMES, Bruce N ANDERSON, Lucy M ANDERSON, D ARMENT!, Vincent J BARNETI, Lois B BRENT, Robert L , 355 BUCKLEY, Jonathan CANNON, Ronald E CHRISTIANI, David C COLLINS, Barabara W CORRELL, Anthony DING, Min EHLING, Udo H FAVOR, Jack ,23 FORD, Judith H FRAGA, Cesar G

2 FRIEDMAN, Jan M , 385 FUSCOE, James C GANDLEY, Robin E GIOMETTI, Carol S HAGEN, Tory M HALES, Barbara F , 105 HAN, Tie Lan HENDRY, Jolyon H HOYES, Katharine P JACKSON, Harold JACKSON, N. Colin JARRELL, Bruce E KASPRZAK, Kazimierz S KHETCHUMOV A, Rita M KNIGHT, Julia A LEWIS, Susan E... 71, 359 LI, Baolue MAKARY AN, Aida S MARRETT, Loraine D MATIISON, Donald R MC GREGOR, Pamela W MILLER, Robert W MORITZ, Michael MORRIS, Ian D MOTCHNIK, Paul

3 MULVIHILL, John J NAGAO, Tetsuji , 359 NOMURA, Taisei NIEDZIELA, Linda S OLSHAN, Andrew F PERREAULT, Sally ,359 PETERS, Greg RADCLIFFE, Jennifer M ,397 RICE, Jerry M RICHARDS, Jeanne ROBAIRE, Bernard... 93, 105, 359 RUSSELL, Liane B ,379 SAVITZ, David ,371 SCHNITZER, Patricia G SCHRADER, Steven M SELBY, Paul B SHARMA, Harbans L SHELBY, Michael D SHIGENAGA, Mark K SILBERGELD, Ellen K TREMAINE, Maureen VARTANIAN, Margaret V WEBB, Graham WEIR, Hannah K WILEY, Lynn M ,

4 WOYCHIK, Richard P , 379 WYROBEK, Andrew J , 359 XU, Xiping ZENICK, Harold

5 SUBJECT INDEX Aging,243 Aneuploidy tests, 59 Animal studies, 221 Antioxidants, 243 Antioxidants protection against disease, 251 dietary, 251 cancer, 252 Assessing male reproduction, 7 Atomic bomb exposure abnormal pregnancy outcome, 206 FI mortality, 206 cytogenetics, 206 mutations, 206 doubling dose, 206 Biological factors, 209 Biologic filtration, 213 Biological markers, 7, 10, 13, 83,266,359,363 Biological plausibility imprinting, 229 mechanisms, 228 mutagens, 228 animal and human data, 229 Cancer survivors offspring, 218 reproductive outcomes, 197 sex ratio, 201 Central nervous system, 141 Childhood cancer, 169 imprinting, 173 Me-C deamination, 174 metals, 171 pesticides, In preferential allele loss, 173 solvents, 171 Chimera assay, 81, 82 Chromosome aberrations, 225 Concepts of abnormal outcome, 1 Congenital malformations etiology, 214 heritability, 123 Cotofor, 328 Cyclophosphamide, 105 heritability of developmental toxicity, 109 reversibility of developmental toxicity, 109 Developmental toxicology, 75 DNA target, 87 Dominant lethal assay, 187, 188, 190 cataract, 50 multiple endpoint, 51 mutations, 49, 375, 390, state of, 50 Dominant visible mutations, 32 Drugs acting on spermatozoa, 99 Drugs in male reproductive tract, 93, 94, 95, 97 Drugs with toxic effects on sperm, 11 Education, 294, 385 Embryo death mechanisms of peri-implantation, 1U, 119 Embryonic cell proliferation disadvantage, 81 Endpoint characterization, 374 Epidemiologic data secular trends, 221, 371 Epididymis, 98 Ethylnitrosourea, 117,297 Evidence for paternal origin, 3, 5 Exposure characterization, 366, 3n, 373 Fetal loss mechanisms, 188 genetic effects, 188 epigenetic effects, 190 epidemiologic studies, 191 measurement of exposure, 192 Fluorescence in situ hybridization, 64, 307 Gender based policy, 285 Generation of targeted mutations, 76 Genetic effects, 381 Genetic risk estimation, 390 Germ cells differential sensitivity, 118 stage effects,

6 Homologous recombination, 76 Human reproduction, 2, 4 Imprinting, 375 Indium-114m, 319 Induced mutation frequencies, 31 Infant health, 182 Ionizing radiation, 81, 84, 117 anomaly rate, 224 chromosome translocations, 223 sperm effects, 222 Laboratory methods, 379 Lead male fertility, 145 developmental toxicity, 148 Low birth weight, 177,314,315 Male-mediated teratogenesis, 297 Male reproductive toxicants, 142 Male transplant recipients, 335 Mechanisms, 355 Media, 293 Meiotic irregularity, 306 Metals neoplasia, 129 assay of effects, 130 toxicity, 131 tumorigenicity, 132 mutation, 134 epimutation, 134 oncogene activation, 136 Metaphase II hyperploidy, 61,62 Metazin, 328 Methylnitrosourea, 297 Miscarriage, 177, 185 mercury, 178 anesthetic gases, 179 solvents, 179 ionizing radiation, 180 smoking, 180 occupation, 193, 219 Misconceptions, 386 Multidisciplinary approaches, 397 Mutation detection, 349 structural nature, 41 different germ cell stages, 44 Neoplasia in offspring, 129 Neurodevelopmental effects epidemiological, 143 experimental, 143 animal models, 144 Nonseminoma, 343 Occupational exposure toxic effect on sperm, 12 mechanism of action, 14 Oxidants, 245 Oxidant stress, 246 sperm damage, 246 Oxidative damage, 244 Paternal occupation agricultural, 164 birth defects, 153, 159 chemical, 164 electronics, 165 epidemiologic findings, 153, 159 machinists, 165 mechanics, 164 metal,164 painters, 164 printers, 163 transportation related, 164 wood related, 164 Patient counselling, 295 Patient education, 293 Physician education, 293 Phenotypic abnormalities, 365 Post-meiotic selection, 305 Post -testicular mechanisms, 93 Pregnancy outcome, 213 Pregnancy registry, 335 Preterm delivery, 177 Pronuclear microinjection, 75 Protein electrophoresis, 349 Quantification of genetic risk, 52 Radiosensitive target, 87 Reproductive risks in humans, 210 Reproductive toxicity testing, 142 Risk assessment, 261, 285, 287, 389 assumptions, 288 Risk management, 389 Science policy, 285 Seminoma, 342 Specific locus mutation, 23, 24 Specific locus test, 40 Sperm aneuploidy, 305 Sperm cells mouse, 23, 24 Spermatid micronuclei, 63 Spermatogenic cell type, 37 Spontaneous mutation frequencies, 31 Stillbirth, 177 Susceptibility, 366 Symm-triazine pesticides, 325 Testicular cancer, 339 Testing multiple endpoint systems, 71 Textile workers, 311 Toxicological studies, 186 Transgenic mice, 75 Transgenic mouse mode genetic toxicology, 77 developmental toxicology, 77 Trisomy,

AN ESTIMATE OF THE DOUBLING DOSE OF IONIZING RADIATION FOR HUMANS

- 23 - AN ESTIMATE OF THE DOUBLING DOSE OF IONIZING RADIATION FOR HUMANS James V. Neel Department of Human Genetics University of Michigan Medical School Ann Arbor, Michigan 48109-0618 Since 1946 a continuing