FOOT & ANKLE MEDLINEUNITE PRE-HYDRATED BIOIMPLANT TECHNOLOGY EVANS & COTTON WEDGE SYSTEM

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1 EVANS & COTTON WEDGE SYSTEM

2 PRODUCT OVERVIEW FEATURES & BENEFITS FEATURE BENEFIT PRE-HYDRATED & PRE-SHAPED Increased OR efficiency as there is no need to shape or hydrate the graft intraoperatively 100% DENSE CANCELLOUS ALLOGRAFT BONE Strong, osteoconductive scaffold resists crumbling and is easier to remove than porous titanium 5 YEAR SHELF LIFE STORED AT ROOM TEMP No thawing required, can remain on shelf for longer than most other implants prior to expiration PIN DISTRACTOR + EVANS & COTTON PLATES Precise, unobstructed exposure to osteotomies along with ancillary plate fixation options if desired

3 COMPARISON OF OPTIONS EVANS & COTTON OSTEOTOMY PRE-HYDRATED PRE-SHAPED WEDGE FREEZE-DRIED PRE-SHAPED WEDGE FREEZE-DRIED ILIUM TRICORTICAL WEDGE POROUS TITANIUM WEDGE TITANIUM WEDGE PLATE Patent-pending aqueous calcium chloride solution eliminates wait time associated with hydrating a freeze-dried wedge and preserves structural integrity of graft. Pre-hydration enables a screw to be placed across wedge for rotational control without crumbling. Frequent issues with cracking or crumbling upon insertion as the graft requires an unrealistic hydration time for best results (up to 60 minutes according to manufacturers). Lack of hydration inhibits use of screw across the wedge. Requires even more OR time for rehydration and intraoperative shaping. Slow resorbtion rate for cortical rim. Lack of hydration inhibits use of screw across the wedge. Difficult hardware removal due to bony ingrowth. Ancillary plate fixation suggested by manufacturer. Cannot place a screw through the implant for rotational control. Frequently requires additional bone graft (putty). Potential irritation of peroneal tendon in some patients. Plate fixation procedure/technique takes longer than a standalone wedge. Frequently requires additional bone graft (wedge or putty). Medline Foot & Ankle has the only pre-hydrated bioimplant technology for flatfoot correction Wright, Stryker, Integra, Synthes (MTF), Paragon 28, Some tissue banks Most tissue banks and orthopaedic/spine companies Wright (BIOFOAM), Arthrex (BIOSYNC), Integra, Zimmer- Biomet, 4WEB Medline, Wright, Stryker, Arthrex, Paragon 28

4 PATENT-PENDING AQUEOUS CALCIUM CHLORIDE SOLUTION Technology evaluated in a study conducted at Vanderbilt University Orthopaedic Biomechanics Laboratory Structural bone allografts preserved in an aqueous calcium-chloride solution were found to be tougher compared to grafts that had been freeze-dried Calcium-chloride-preserved grafts were less brittle and more elastic Calcium-chloride preservation technology also outperformed cryopreservation and saline-based preservation

5 MEDLINEUNITE ANCILLARY IMPLANTS & INSTRUMENTATION Articulating Pin Distractor Provides controlled distraction and unobstructed access to the osteotomy for placement of the selected Pre-Hydrated Evans or Cotton Bioimplant. Evans & Cotton Plates Low-profile locking titanium plate options provide ancillary fixation if desired. 3.5mm Screws Fully threaded cortical and partially threaded cannulated screw options provide rotational control when placed directly across the Pre-Hydrated Evans or Cotton Bioimplant.

6 OPTIONS & DIMENSIONS REF# DESCRIPTION (A) Thickness at Proximal Cortex of Osteotomy (B) Depth/ Length (C) Dorsal Width (Cotton) Lateral Height (Evans) (D) Plantar Width (Cotton) Medial Height (Evans) MWCT0005 BIOIMPLANT, PRE-HYDRATED, COTTON, 5MM 5mm 22mm 14mm 10mm B A C MWCT0006 BIOIMPLANT, PRE-HYDRATED, COTTON, 6MM 6mm 22mm 14mm 10mm MWCT0007 BIOIMPLANT, PRE-HYDRATED, COTTON, 7MM 7mm 22mm 14mm 10mm MWEV0006 BIOIMPLANT, PRE-HYDRATED, EVANS, 6MM 6mm 22mm 22mm 18mm MWEV0008 BIOIMPLANT, PRE-HYDRATED, EVANS, 8MM 8mm 22mm 22mm 18mm MWEV0010 BIOIMPLANT, PRE-HYDRATED, EVANS, 10MM 10mm 22mm 22mm 18mm MWEV0012 BIOIMPLANT, PRE-HYDRATED, EVANS, 12MM 12mm 22mm 22mm 18mm D MWUT0012 BIOIMPLANT, PRE-HYDRATED, UTILITY, 12MM 12mm 20mm Varies* Varies* *The Utility Wedge is a Pre-Hydrated Ilium Tricortical Wedge. Some dimensions vary by donor, but are at least 12mm thick and 20mm deep/long.

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